KEGG   PATHWAY: lve05163
Entry
lve05163                    Pathway                                
Name
Human cytomegalovirus infection - Lipotes vexillifer (Yangtze River dolphin)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
lve05163  Human cytomegalovirus infection
lve05163

Disease
H00368  Cytomegalovirus infection
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068413  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
103068473  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103068617  [KO:K05414]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103068686  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103068692  CXCR2; c-X-C chemokine receptor type 2 [KO:K05050]
103068734  NRAS; GTPase NRas [KO:K07828]
103068747  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103069101  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
103069136  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103069156  [KO:K08738]
103069181  [KO:K05414]
103069235  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
103069314  PTGER2; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP2 subtype [KO:K04259]
103069500  [KO:K04542]
103069618  [KO:K07208]
103069739  [KO:K05414]
103069848  [KO:K14021]
103070103  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103070292  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103070387  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103070408  E2F1; transcription factor E2F1 [KO:K17454]
103070424  CX3CL1; fractalkine [KO:K05508]
103070451  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103070472  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
103070526  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103070686  B2M; beta-2-microglobulin [KO:K08055]
103070943  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103070953  [KO:K08055]
103071473  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103071564  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
103071696  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103071897  [KO:K10031]
103071905  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103072092  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103072143  TMEM173; stimulator of interferon genes protein [KO:K12654]
103072156  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
103072166  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103072461  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103072667  CDKN2A; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 [KO:K06621]
103072682  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103072764  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103072948  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
103073013  CXCR4; c-X-C chemokine receptor type 4 [KO:K04189]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103073066  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103073219  [KO:K05414]
103073645  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103073772  [KO:K05415]
103073819  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103073874  TAPBP; LOW QUALITY PROTEIN: tapasin [KO:K08058]
103074112  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103074114  TAPBPL; tapasin-related protein [KO:K28445]
103074541  [KO:K02183]
103074707  CCL2; c-C motif chemokine 2 [KO:K14624]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103074739  IL10RB; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135]
103074746  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103074817  CALML5; calmodulin-like protein 5 [KO:K02183]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103075051  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
103075153  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
103075350  TSC2; tuberin [KO:K07207]
103075492  [KO:K04542]
103075495  [KO:K08738]
103075499  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103075612  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
103075713  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
103075748  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103075954  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103075978  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103076182  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103076235  [KO:K06751]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076541  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103076924  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
103077054  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103077256  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103077308  GNAI2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103077464  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103077530  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103077564  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103077579  KRAS; GTPase KRas [KO:K07827]
103078049  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103078095  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
103078301  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103078515  PXN; paxillin-like isoform X1 [KO:K05760]
103078531  BID; BH3-interacting domain death agonist [KO:K04726]
103078639  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103078677  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103078697  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103078710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103078845  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
103079172  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103079287  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103079294  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103079514  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103079638  [KO:K08738]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079915  CALML6; calmodulin-like protein 6 [KO:K02183]
103079935  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103080104  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103080185  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103080271  RHEB; GTP-binding protein Rheb [KO:K07208]
103080339  FADD; FAS-associated death domain protein [KO:K02373]
103080733  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103080762  CALM1; calmodulin isoform X1 [KO:K02183]
103080835  CCR1; c-C chemokine receptor type 1 [KO:K04176]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103081110  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103081338  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103081367  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
103081393  CCR3; c-C chemokine receptor type 3 [KO:K04178]
103081431  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103081507  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
103081539  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103081545  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
103081641  [KO:K04433] [EC:2.7.12.2]
103081662  CCR5; c-C chemokine receptor type 5 [KO:K04180]
103081780  E2F2; transcription factor E2F2 [KO:K09389]
103081811  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103081814  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103082420  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103082438  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103082455  [KO:K04514] [EC:2.7.11.39]
103082644  CALR; calreticulin [KO:K08057]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103082839  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103082954  MB21D1; LOW QUALITY PROTEIN: cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
103083060  [KO:K06751]
103083166  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103083173  [KO:K08738]
103083209  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103083231  TNF; tumor necrosis factor [KO:K03156]
103083306  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103083433  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103083833  ARHGEF12; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532]
103083884  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
103083889  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103084028  [KO:K04386]
103084066  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103084472  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103084615  TAP1; LOW QUALITY PROTEIN: antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103084817  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103084826  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103085165  [KO:K06751]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103085385  [KO:K04632]
103085711  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103085845  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103085882  E2F3; transcription factor E2F3 [KO:K06620]
103086171  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103086219  IL8; interleukin-8 [KO:K10030]
103086280  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103086495  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103086653  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103086745  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
103086977  [KO:K06751]
103087008  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103087072  ITGAV; integrin alpha-V [KO:K06487]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103087479  CALM2; calmodulin [KO:K02183]
103087905  CRK; adapter molecule crk isoform X1 [KO:K04438]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103088182  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103088278  TSC1; hamartin isoform X1 [KO:K07206]
103088500  CCL5; c-C motif chemokine 5 [KO:K12499]
103088613  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103088738  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103088923  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
103089051  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
103089070  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103089095  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103089296  CCL3; LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3 [KO:K05408]
103089570  [KO:K05408]
103089724  [KO:K04548]
103089745  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103089752  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
103089823  CCL4; c-C motif chemokine 4 [KO:K12964]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103089962  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103090358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103090427  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103090463  CRKL; crk-like protein [KO:K04438]
103090549  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103090661  [KO:K05414]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103090784  IL1B; interleukin-1 beta [KO:K04519]
103091025  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
103091030  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
103091114  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103091169  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
103091202  [KO:K05414]
103091388  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
103091628  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103091655  CALM3; calmodulin [KO:K02183]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
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Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
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Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
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Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
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Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
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Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
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Lee S, Chung YH, Lee C
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US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
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Biomol Ther (Seoul) 25:69-79 (2017)
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PLoS One 7:e48935 (2012)
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Couty JP, Gershengorn MC
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G-protein-coupled receptors encoded by human herpesviruses.
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Trends Pharmacol Sci 26:405-11 (2005)
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Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
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Human cytomegalovirus gene expression in long-term infected glioma stem cells.
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PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
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PMID:24445563
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Vischer HF, Siderius M, Leurs R, Smit MJ
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Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
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Nat Rev Drug Discov 13:123-39 (2014)
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PMID:20398729
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Mol Cell Endocrinol 331:179-84 (2011)
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Nat Immunol 2:116-22 (2001)
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PMID:16352349
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Vischer HF, Leurs R, Smit MJ
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HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
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Trends Pharmacol Sci 27:56-63 (2006)
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PMID:25805993
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Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
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Front Pharmacol 6:40 (2015)
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Biochim Biophys Acta 1768:952-63 (2007)
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Virus Res 157:144-50 (2011)
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Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
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Viruses 9:249 (2017)
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Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
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HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
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Cell Rep 15:1542-1553 (2016)
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Wang X, Sanchez J, Stone MJ, Payne RJ
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Angew Chem Int Ed Engl 56:8490-8494 (2017)
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Related
pathway
lve00590  Arachidonic acid metabolism
lve03050  Proteasome
lve04010  MAPK signaling pathway
lve04064  NF-kappa B signaling pathway
lve04110  Cell cycle
lve04150  mTOR signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04210  Apoptosis
lve04612  Antigen processing and presentation
lve04623  Cytosolic DNA-sensing pathway
lve04630  JAK-STAT signaling pathway
lve04668  TNF signaling pathway
lve04810  Regulation of actin cytoskeleton
KO pathway
ko05163   

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