Entry Name Hepatitis C - Ochotona princeps (American pika)
Description Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Disease Organism Ochotona princeps (American pika) [GN:
opi ]
Gene 101517311 APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084 ]
101517982 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101518461 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
101518605 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
101519449 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101522715 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
101525092 EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250 ]
101525476 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
101526820 PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294 ]
101527218 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
101528266 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
101528287 STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692 ]
101528938 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
101530204 BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726 ]
101530319 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
101531037 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
101531084 RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045 ]
101531298 PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698 ]
101531611 NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
101532354 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101533024 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101533099 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
101533552 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354 ]
101533851 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922 ] [EC:2.7.1.153 ]
101535531 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456 ]
101536685 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
Title Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
Journal Reference Authors Yamauchi Y, Helenius A
Title Virus entry at a glance.
Journal Reference Authors Feneant L, Levy S, Cocquerel L
Title CD81 and hepatitis C virus (HCV) infection.
Journal Reference Authors Dubuisson J, Helle F, Cocquerel L
Title Early steps of the hepatitis C virus life cycle.
Journal Reference Authors Liang TJ, Ghany MG
Title Current and future therapies for hepatitis C virus infection.
Journal Reference Authors Scheel TK, Rice CM
Title Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
Journal Reference Authors Holmes JA, Thompson AJ
Title Interferon-free combination therapies for the treatment of hepatitis C: current insights.
Journal Reference Authors Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
Title Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
Journal Reference Authors Horner SM, Gale M Jr
Title Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Journal Reference Authors Lemon SM
Title Induction and evasion of innate antiviral responses by hepatitis C virus.
Journal Reference Authors Horner SM, Gale M Jr
Title Regulation of hepatic innate immunity by hepatitis C virus.
Journal Reference Authors Ortega-Prieto AM, Dorner M
Title Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
Journal Reference Authors Yang DR, Zhu HZ
Title Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
Journal Reference Authors Gale M Jr, Foy EM
Title Evasion of intracellular host defence by hepatitis C virus.
Journal Reference Authors Bode JG, Brenndorfer ED, Haussinger D
Title Subversion of innate host antiviral strategies by the hepatitis C virus.
Journal Reference Authors Panteva M, Korkaya H, Jameel S
Title Hepatitis viruses and the MAPK pathway: is this a survival strategy?
Journal Reference Authors Pang R, Tse E, Poon RT
Title Molecular pathways in hepatocellular carcinoma.
Journal Reference Authors Macdonald A, Harris M
Title Hepatitis C virus NS5A: tales of a promiscuous protein.
Journal Reference Authors He Y, Staschke KA, Tan SL
Title HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
Journal Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference Authors Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
Title HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
Journal Reference Authors Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
Title Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
Journal Reference Authors Hassan M, Ghozlan H, Abdel-Kader O
Title Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
Journal Reference Authors Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
Title p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
Journal Reference Authors Yamanaka T, Uchida M, Doi T
Title Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
Journal Reference Authors Lim EJ, Chin R, Angus PW, Torresi J
Title Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
Journal Reference Authors Fischer R, Baumert T, Blum HE
Title Hepatitis C virus infection and apoptosis.
Journal Reference Authors Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
Title Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
Journal Reference Authors Koike K
Title Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
Journal Reference Authors Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
Title Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
Journal Reference Authors Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
Title Viral hepatocarcinogenesis: from infection to cancer.
Journal Related opi04620 Toll-like receptor signaling pathway
opi04622 RIG-I-like receptor signaling pathway
KO pathway
