KEGG   PATHWAY: biu05164
Entry
biu05164                    Pathway                                
Name
Influenza A - Bos indicus (zebu cattle)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
biu05164  Influenza A
biu05164

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109578813  LOW QUALITY PROTEIN: tryptase-2-like [KO:K01340] [EC:3.4.21.59]
109578824  tryptase-2 isoform X1 [KO:K01340] [EC:3.4.21.59]
109564099  PLG; LOW QUALITY PROTEIN: plasminogen [KO:K01315] [EC:3.4.21.7]
109557708  cationic trypsin-like [KO:K01312] [EC:3.4.21.4]
109557710  cationic trypsin [KO:K01312] [EC:3.4.21.4]
109557837  anionic trypsin-like [KO:K01312] [EC:3.4.21.4]
109560553  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
109570040  TMPRSS4; LOW QUALITY PROTEIN: transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
109560040  TMPRSS11D; transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
109578560  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109570926  2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
109571283  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
109571284  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
109570705  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
109561493  DNAJB1; dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
109566917  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
109565977  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
109565265  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
109573862  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]
109562815  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
109567061  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
109569836  NLRX1; NLR family member X1 [KO:K12653]
109567183  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
109553086  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109553353  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109572576  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
109575581  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109560296  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109554392  RELA; transcription factor p65 [KO:K04735]
109573970  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
109553388  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
109561728  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
109575564  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109559273  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109570721  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
109572224  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
109578349  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
109559852  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
109563399  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
109555486  TLR7; toll-like receptor 7 [KO:K05404]
109576356  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
109559201  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109566132  IL1A; interleukin-1 alpha [KO:K04383]
109566133  IL1B; interleukin-1 beta [KO:K04519]
109558077  IL6; interleukin-6 [KO:K05405]
109564477  IL12A; interleukin-12 subunit alpha [KO:K05406]
109561305  IL12B; interleukin-12 subunit beta [KO:K05425]
109577428  TNF; tumor necrosis factor [KO:K03156]
109560575  C-X-C motif chemokine 15-like isoform X1 [KO:K10030]
109560570  CXCL8; interleukin-8 [KO:K10030]
109574464  C-C motif chemokine 2 [KO:K14624]
109574467  CCL5; C-C motif chemokine 5 [KO:K12499]
109560594  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
109561581  intercellular adhesion molecule 1 [KO:K06490]
109562847  interferon alpha-H [KO:K05414]
109562638  interferon alpha-G-like [KO:K05414]
109562641  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
109562644  interferon alpha-F [KO:K05414]
109562652  interferon alpha-A [KO:K05414]
109562656  interferon alpha-H-like [KO:K05414]
109562659  interferon alpha-H-like [KO:K05414]
109562660  interferon alpha-H-like [KO:K05414]
109562665  interferon alpha-B-like [KO:K05414]
109562668  interferon alpha-2-like [KO:K05414]
109562670  interferon alpha-2-like [KO:K05414]
109562673  interferon alpha-3-like [KO:K05414]
109562852  interferon beta-2-like [KO:K05415]
109562853  interferon beta-1-like [KO:K05415]
109562855  interferon beta-1 [KO:K05415]
109562667  LOW QUALITY PROTEIN: interferon beta-3-like [KO:K05415]
109562671  interferon beta-2-like [KO:K05415]
109562674  interferon beta-2 [KO:K05415]
109562675  interferon beta-2-like [KO:K05415]
109570535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109572614  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109556202  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109561587  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
109574319  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
109568771  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109559357  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
109564781  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
109560528  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
109560515  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
109575524  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
109558719  IFNG; interferon gamma [KO:K04687]
109563984  IFNGR1; interferon gamma receptor 1 [KO:K05132]
109569763  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109562906  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109578694  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
109576545  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109576596  HLA class II histocompatibility antigen, DO alpha chain-like isoform X1 [KO:K06752]
109577038  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109577039  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
109577041  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577042  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109576666  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577307  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109577316  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
109576780  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109561926  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
109578833  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
109570010  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
109569934  IL18; interleukin-18 isoform X1 [KO:K05482]
109562893  IL33; interleukin-33 [KO:K12967]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109556345  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109577151  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109559308  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
109558203  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
109558018  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
109563119  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
109570480  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109579171  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109559729  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109572519  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109554562  FADD; FAS-associated death domain protein [KO:K02373]
109569521  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109559782  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109559783  BH3-interacting domain death agonist-like isoform X1 [KO:K04726]
109571977  apoptosis regulator BAX [KO:K02159]
109571778  BAX; apoptosis regulator BAX [KO:K02159]
109577301  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
109562011  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
109561148  ADP/ATP translocase 1-like [KO:K05863]
109571027  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
109553455  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
109566483  cytochrome c [KO:K08738]
109566484  cytochrome c [KO:K08738]
109557512  cytochrome c [KO:K08738]
109559418  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
109570433  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
109553316  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
109578100  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
109573362  CPSF4L; LOW QUALITY PROTEIN: putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
109564800  PABPN1; polyadenylate-binding protein 2 [KO:K14396]
109575992  embryonic polyadenylate-binding protein 2-like isoform X1 [KO:K14396]
109573001  PABPN1L; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
109554394  NXF1; nuclear RNA export factor 1 [KO:K14284]
109555062  nuclear RNA export factor 3-like [KO:K14284]
109554829  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
109554900  nuclear RNA export factor 3-like [KO:K14284]
109568054  NXT1; NTF2-related export protein 1 [KO:K14285]
109555445  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
109572294  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
109567306  RAE1; mRNA export factor isoform X1 [KO:K14298]
109569188  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
109566416  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
109553630  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109561751  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109573916  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109578544  ACTB; actin, cytoplasmic 1 [KO:K05692]
109564694  RAB11A; ras-related protein Rab-11A [KO:K07904]
109561666  RAB11B; ras-related protein Rab-11B [KO:K07905]
109566195  XPO1; exportin-1 [KO:K14290]
109555154  KPNA1; importin subunit alpha-5 [KO:K23940]
109574292  KPNA2; importin subunit alpha-1 [KO:K15043]
109578238  KPNA7; importin subunit alpha-8 [KO:K15043]
109563789  KPNA5; importin subunit alpha-6 [KO:K15042]
109572457  KPNA6; importin subunit alpha-7 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
biu00900  Terpenoid backbone biosynthesis
biu03013  Nucleocytoplasmic transport
biu03015  mRNA surveillance pathway
biu04010  MAPK signaling pathway
biu04110  Cell cycle
biu04144  Endocytosis
biu04210  Apoptosis
biu04620  Toll-like receptor signaling pathway
biu04621  NOD-like receptor signaling pathway
biu04622  RIG-I-like receptor signaling pathway
biu04630  JAK-STAT signaling pathway
biu05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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