KEGG   PATHWAY: cang04010
Entry
cang04010                   Pathway                                
Name
MAPK signaling pathway - Colobus angolensis palliatus (Angola colobus)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cang04010  MAPK signaling pathway
cang04010

Other DBs
GO: 0000165
Organism
Colobus angolensis palliatus (Angola colobus) [GN:cang]
Gene
105519853  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105522784  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105503912  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105515441  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105518250  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105514987  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105524626  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
105526491  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
105527832  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105504320  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105501674  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
105509667  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
105515471  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
105503909  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105503132  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
105527536  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
105507647  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105512569  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
105517038  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105527821  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105523449  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105503565  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105516254  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105524213  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
105524212  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105524215  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
105521806  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105516624  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105519745  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105503488  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105523456  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105524211  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
105522441  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105522480  guanine nucleotide-binding protein subunit alpha homolog [KO:K04346]
105520803  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
105501948  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105510183  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105512672  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105518142  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105509238  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105506265  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
105504984  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
105512200  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
105507492  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
105519212  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
105524433  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
105508723  NF1; neurofibromin [KO:K08052]
105513383  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
105523397  RASA2; ras GTPase-activating protein 2 [KO:K08053]
105505360  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
105502654  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
105514419  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105514084  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105501302  EREG; proepiregulin [KO:K09784]
105501303  AREG; amphiregulin [KO:K09782]
105510120  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105516422  FGF2; fibroblast growth factor 2 [KO:K18497]
105515618  FGF16; fibroblast growth factor 16 [KO:K04358]
105502192  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
105515843  FGF18; fibroblast growth factor 18 [KO:K04358]
105523862  FGF9; fibroblast growth factor 9 [KO:K04358]
105510170  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105503934  FGF6; fibroblast growth factor 6 [KO:K04358]
105511582  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105525388  FGF10; fibroblast growth factor 10 [KO:K04358]
105506665  FGF20; fibroblast growth factor 20 [KO:K04358]
105527667  FGF22; fibroblast growth factor 22 [KO:K04358]
105507121  FGF8; fibroblast growth factor 8 [KO:K04358]
105512318  FGF19; fibroblast growth factor 19 [KO:K22603]
105514795  FGF21; fibroblast growth factor 21 [KO:K22429]
105503933  FGF23; fibroblast growth factor 23 [KO:K22428]
105505307  NGF; beta-nerve growth factor [KO:K02582]
105507710  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105518596  NTF3; neurotrophin-3 [KO:K04356]
105514785  NTF4; neurotrophin-4 [KO:K12457]
105506748  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105503231  IGF2; insulin-like growth factor II [KO:K13769]
105522469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105527767  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105524451  PDGFC; platelet-derived growth factor C [KO:K05450]
105500952  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105516054  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105525591  KITLG; kit ligand isoform X1 [KO:K05461]
105514768  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105524898  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105512347  VEGFB; vascular endothelial growth factor B [KO:K16858]
105517147  PGF; placenta growth factor isoform X1 [KO:K16859]
105523129  FIGF; vascular endothelial growth factor D [KO:K05449]
105524499  VEGFC; vascular endothelial growth factor C [KO:K05449]
105501675  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105503825  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105525751  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105512796  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105502019  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105502022  EFNA3; ephrin-A3 [KO:K05462]
105502023  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105516973  EFNA5; ephrin-A5 [KO:K05462]
105527681  EFNA2; ephrin-A2 [KO:K05462]
105513505  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105515329  ARTN; artemin [KO:K25415]
105512880  PSPN; persephin [KO:K25416]
105500265  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105503119  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
105500614  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105504791  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105525157  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
105503366  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105508015  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105515122  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105524594  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105502088  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105514498  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105512899  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105523056  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105523780  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
105504227  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105504224  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105525907  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105523475  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
105524018  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105518645  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105525909  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105508514  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105523238  angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105510220  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105520189  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105513930  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105522392  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
105507449  SOS1; son of sevenless homolog 1 [KO:K03099]
105503192  HRAS; GTPase HRas isoform X1 [KO:K02833]
105515217  KRAS; GTPase KRas isoform X1 [KO:K07827]
105504520  GTPase NRas [KO:K07828]
105505387  NRAS; GTPase NRas [KO:K07828]
105514862  RRAS; ras-related protein R-Ras [KO:K07829]
105520521  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105523340  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105509473  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105511179  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105519101  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105510526  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105512832  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105512665  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105515489  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105505634  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105515141  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
105527694  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
105510419  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
105519558  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105506706  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105521370  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
105527761  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
105509476  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105523014  uncharacterized protein LOC105523014 isoform X1 [KO:K04376]
105509076  MYC; myc proto-oncogene protein [KO:K04377]
105524920  SRF; serum response factor [KO:K04378]
105517139  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
105508648  microtubule-associated protein tau isoform X1 [KO:K04380]
105520290  MAPT; microtubule-associated protein tau [KO:K04380]
105505310  LOW QUALITY PROTEIN: stathmin-like [KO:K04381]
105521462  STMN1; stathmin [KO:K04381]
105514894  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
105511116  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
105525430  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
105525434  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105525436  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105506150  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105513728  TNF; tumor necrosis factor [KO:K03156]
105519633  IL1A; interleukin-1 alpha [KO:K04383]
105519632  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
105507882  TGFB1; transforming growth factor beta-1 [KO:K13375]
105502787  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105517128  TGFB3; transforming growth factor beta-3 [KO:K13377]
105518659  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105522167  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105525839  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
105509956  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105525773  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105526354  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105515921  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105510062  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
105506322  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105514391  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
105527808  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105527815  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105505977  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105504584  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105524344  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105522700  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105514226  DAXX; death domain-associated protein 6 [KO:K02308]
105519819  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105521650  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105507588  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
105510802  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105508083  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
105516011  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105527649  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
105527764  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
105515555  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105520832  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
105507444  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105522164  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
105519131  MAP4K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
105509629  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105525510  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105502454  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
105519405  STK3; serine/threonine-protein kinase 3 [KO:K04412]
105512343  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
105521962  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
105512468  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
105512159  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
105511521  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
105515973  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105517204  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
105519235  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105507286  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
105503568  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
105519848  mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105514544  mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
105521349  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
105526172  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105511739  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105506725  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
105502302  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
105510884  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105505645  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105505414  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105512966  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105526517  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
105505905  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105527105  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
105512004  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
105522869  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
105521639  FLNA; filamin-A isoform X1 [KO:K04437]
105515479  CRKL; crk-like protein [KO:K04438]
105521621  CRK; adapter molecule crk isoform X1 [KO:K04438]
105523666  ARRB2; beta-arrestin-2 [KO:K04439]
105511822  ARRB1; beta-arrestin-1 [KO:K04439]
105517705  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
105518701  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105519528  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105511987  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105512012  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105514175  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105514260  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105507937  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
105509458  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105509657  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
105517048  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
105512206  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
105512729  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
105506313  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105504622  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105511418  JUN; transcription factor AP-1 [KO:K04448]
105513158  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105523626  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105500505  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105517267  MAX; protein max isoform X1 [KO:K04453]
105526262  LOW QUALITY PROTEIN: protein max-like [KO:K04453]
105513391  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105518411  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105519178  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105521497  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105526041  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
105502684  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
105508595  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105504338  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
105515851  DUSP1; dual specificity protein phosphatase 1 isoform X1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105501832  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105522205  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105523819  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105503288  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105513640  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105520218  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105505613  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105521617  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
105502807  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105510346  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105526859  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
105507522  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
105501155  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
105519603  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
105513758  HSPA1A; heat shock 70 kDa protein 1A/1B isoform X1 [KO:K03283]
105513759  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
105516737  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
105510517  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105521000  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105503620  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105510391  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105507149  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105525125  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105527033  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105510815  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
105512675  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
105507106  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105512156  RELA; transcription factor p65 [KO:K04735]
105526900  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Annu Rev Biochem 72:609-42 (2003)
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
cang04070  Phosphatidylinositol signaling system
cang04110  Cell cycle
cang04115  p53 signaling pathway
cang04210  Apoptosis
cang04310  Wnt signaling pathway
cang04668  TNF signaling pathway
KO pathway
ko04010   
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