KEGG   PATHWAY: caty04014
Entry
caty04014                   Pathway                                
Name
Ras signaling pathway - Cercocebus atys (sooty mangabey)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
caty04014  Ras signaling pathway
caty04014

Other DBs
GO: 0032318
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571434  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105576539  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105599949  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105595795  FGF2; fibroblast growth factor 2 [KO:K18497]
105577303  FGF3; fibroblast growth factor 3 [KO:K04358]
105577304  FGF4; fibroblast growth factor 4 [KO:K04358]
105601381  FGF20; fibroblast growth factor 20 [KO:K04358]
105579245  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105588213  FGF7; fibroblast growth factor 7 [KO:K04358]
105581649  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105581863  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105581939  FGF16; fibroblast growth factor 16 [KO:K04358]
105583515  FGF10; fibroblast growth factor 10 [KO:K04358]
105591678  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105591918  FGF9; fibroblast growth factor 9 [KO:K04358]
105576825  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105577305  FGF19; fibroblast growth factor 19 [KO:K22603]
105595256  FGF21; fibroblast growth factor 21 [KO:K22429]
105582993  FGF23; fibroblast growth factor 23 [KO:K22428]
105596338  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105572781  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105583006  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
105595271  NTF4; neurotrophin-4 [KO:K12457]
105577261  INS; insulin [KO:K04526]
105573305  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105577264  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105571784  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105572960  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105588762  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105597890  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105594352  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105596830  KITLG; kit ligand [KO:K05461]
105595290  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105591224  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105577498  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105590861  PGF; placenta growth factor isoform X1 [KO:K16859]
105597772  VEGFC; vascular endothelial growth factor C [KO:K05449]
105574688  FIGF; vascular endothelial growth factor D [KO:K05449]
105583213  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105584496  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105594196  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105582199  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
105593509  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105593511  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105593518  EFNA1; ephrin-A1 [KO:K05462]
105591709  EFNA2; ephrin-A2 [KO:K05462]
105576658  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
105588269  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105590801  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105577985  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105585485  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105581716  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105579459  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
105594539  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105584243  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105589163  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105594004  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105592013  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105589876  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105589873  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105591986  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105597061  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105597064  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105590424  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105591984  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105598476  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105591300  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105599438  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
105577731  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105580774  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
105578686  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
105585292  LOW QUALITY PROTEIN: SHC-transforming protein 1-like [KO:K06279]
105585293  LOW QUALITY PROTEIN: SHC-transforming protein 1-like [KO:K06279]
105593504  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105591876  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
105584282  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
105588205  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
105573167  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
105586728  SOS2; son of sevenless homolog 2 [KO:K03099]
105597205  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105588401  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105589398  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105574148  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
105577479  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
105578391  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105594542  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
105593887  uncharacterized protein LOC105593887 [KO:K10784]
105584618  uncharacterized protein LOC105584618 [KO:K10785]
105584628  uncharacterized protein LOC105584628 [KO:K10785]
105589715  uncharacterized protein LOC105589715 [KO:K10785]
105583698  ZAP70; tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
105598543  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
105587141  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105594434  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105584442  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105583036  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105597720  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105601141  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105586615  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105577543  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105580742  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105592180  GNG11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105581531  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105601524  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
105595886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105592179  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105579462  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105593561  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105601580  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105584148  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105571720  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105599137  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
105580611  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105572154  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105585127  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
105600970  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105594435  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
105595186  CALM3; calmodulin isoform X1 [KO:K02183]
105596563  CALM1; calmodulin [KO:K02183]
105581752  calmodulin-like [KO:K02183]
105597438  CALML3; calmodulin-like protein 3 [KO:K02183]
105597439  CALML5; calmodulin-like protein 5 [KO:K02183]
105590605  CALM2; calmodulin [KO:K02183]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105586388  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105595298  RRAS; ras-related protein R-Ras [KO:K07829]
105595718  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105589413  NF1; neurofibromin isoform X1 [KO:K08052]
105599108  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
105586356  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
105584971  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
105593387  ras GTPase-activating protein 4 isoform X1 [KO:K17630]
105593268  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
105573156  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
105580924  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
105601611  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
105573725  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
105576666  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
105588450  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
105575576  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105584356  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105575821  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105588572  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105578700  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105575136  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
105598444  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105594236  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
105582086  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
105574159  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
105573691  RHOA; transforming protein RhoA [KO:K04513]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105573773  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105581830  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105595759  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105571369  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105577432  RELA; transcription factor p65 isoform X1 [KO:K04735]
105577493  BAD; bcl2-associated agonist of cell death [KO:K02158]
105582236  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105586123  FOXO4; forkhead box protein O4 [KO:K12358]
105597557  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105589072  RALGAPA1; LOW QUALITY PROTEIN: ral GTPase-activating protein subunit alpha-1 [KO:K25768]
105582012  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
105582378  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
105594177  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
105575634  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
105575857  ral-GDS-related protein-like [KO:K08732]
105599414  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
105580181  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
105593421  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
105597017  RALA; ras-related protein Ral-A [KO:K07834]
105588111  RALB; ras-related protein Ral-B [KO:K07835]
105586073  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105583465  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
105596401  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
105600541  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105576429  REL; proto-oncogene c-Rel [KO:K09254]
105590417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105591436  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105576775  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105579322  RALBP1; ralA-binding protein 1 [KO:K08773]
105595026  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105571986  cell division control protein 42 homolog [KO:K04393]
105597489  MLLT4; afadin isoform X1 [KO:K05702]
105577895  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105589731  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
105571426  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105595050  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105595052  PLA2G5; calcium-dependent phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105595053  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105595054  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105595055  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
105595056  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105572203  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105597315  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
105590935  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105575741  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105579889  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105595443  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
105574211  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574213  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105574214  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574265  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105575872  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
105577518  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105577519  HRASLS2; HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105590499  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105582631  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
105575442  ETS2; protein C-ets-2 [KO:K21932]
105573168  BRAP; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
105591499  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
105592764  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
105595373  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
105594391  RAP1A; ras-related protein Rap-1A [KO:K04353]
105600503  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
105587002  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105586076  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105595654  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105577394  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
105576174  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
105580801  ABL2; LOW QUALITY PROTEIN: Abelson tyrosine-protein kinase 2 [KO:K08887] [EC:2.7.10.2]
105578300  RAB5A; ras-related protein Rab-5A [KO:K07887]
105578386  ras-related protein Rab-5B [KO:K07888]
105587349  RAB5B; ras-related protein Rab-5B [KO:K07888]
105579663  RAB5C; ras-related protein Rab-5C [KO:K07889]
105586590  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
caty04010  MAPK signaling pathway
caty04015  Rap1 signaling pathway
caty04020  Calcium signaling pathway
caty04144  Endocytosis
caty04151  PI3K-Akt signaling pathway
caty04660  T cell receptor signaling pathway
caty04720  Long-term potentiation
caty04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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