KEGG   PATHWAY: cfa05205
Entry
cfa05205                    Pathway                                
Name
Proteoglycans in cancer - Canis lupus familiaris (dog)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
cfa05205  Proteoglycans in cancer
cfa05205

Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
403939  CD44; CD44 antigen precursor [KO:K06256]
485864  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
610283  CTTN; src substrate cortactin isoform X1 [KO:K06106]
100684969  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
403883  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
483312  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
608060  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
485016  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
479921  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
403735  HRAS; GTPase HRas isoform 1 [KO:K02833]
403871  KRAS; GTPase KRas isoform X1 [KO:K07827]
403872  NRAS; GTPase NRas [KO:K07828]
476413  RRAS; ras-related protein R-Ras [KO:K07829]
476865  RRAS2; ras-related protein R-Ras2 isoform X3 [KO:K07830]
477082  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
475526  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
484648  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
491857  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
478347  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
611939  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
477575  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100855877  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
479050  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
119863888  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
119866928  cell division control protein 42 homolog [KO:K04393]
491860  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
403640  ESR1; estrogen receptor [KO:K08550]
449028  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
403580  ACTB; actin, cytoplasmic 1 [KO:K05692]
475923  ACTG1; actin, cytoplasmic 2 [KO:K05692]
481084  FLNA; filamin-A isoform X1 [KO:K04437]
607885  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
487731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100856354  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X4 [KO:K12330]
403954  RHOA; transforming protein RhoA [KO:K04513]
480181  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
482970  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
487908  ANK2; ankyrin-2 isoform X2 [KO:K09255]
479215  ANK3; ankyrin-3 isoform X1 [KO:K09259]
483808  GAB1; GRB2-associated-binding protein 1 isoform X5 [KO:K09593]
488084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
489644  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
477085  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
609956  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
487235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100856339  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
442964  AKT3; RAC-gamma serine/threonine-protein kinase isoform X8 [KO:K04456] [EC:2.7.11.1]
449021  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
490878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
478171  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
403557  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
403558  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
403609  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
475411  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
490230  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X12 [KO:K12329]
100683226  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
479409  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
486808  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
476548  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
486628  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
481746  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
489050  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
610764  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
612941  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
482687  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100856473  NANOG; homeobox protein NANOG [KO:K10164]
480472  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
119871576  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
490967  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100886143  MIR21; cfa-miR-21 [KO:K16863]
486185  TWIST2; twist-related protein 2 isoform X2 [KO:K09069]
119866614  TWIST1; twist-related protein 1 [KO:K09069]
100885960  MIR10A; cfa-miR-10a [KO:K16864]
100886149  MIR10B; cfa-miR-10b [KO:K17393]
609973  HOXD10; homeobox protein Hox-D10 [KO:K09295]
403904  DCN; decorin precursor [KO:K04660]
610255  IGF1; insulin-like growth factor I precursor [KO:K05459]
442951  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
478232  MTOR; serine/threonine-protein kinase mTOR isoform X5 [KO:K07203] [EC:2.7.11.1]
479875  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
480580  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
610499  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
477600  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
474722  RPS6; 40S ribosomal protein S6 [KO:K02991]
488146  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
100686736  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
106559872  40S ribosomal protein S6-like [KO:K02991]
608772  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like isoform X4 [KO:K02991]
404306  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
403980  CAV1; caveolin-1 [KO:K06278]
475294  CAV2; caveolin-2 [KO:K12958]
484671  CAV3; caveolin-3 [KO:K12959]
474391  CD63; CD63 antigen [KO:K06497]
474890  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
403567  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
403998  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
448807  TLR2; toll-like receptor 2 precursor [KO:K10159]
403417  TLR4; toll-like receptor 4 precursor [KO:K10160]
477818  PDCD4; programmed cell death protein 4 [KO:K16865]
403922  TNF; tumor necrosis factor [KO:K03156]
403976  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
481105  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
488508  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
403924  MYC; myc proto-oncogene protein [KO:K04377]
477032  CTNNB1; catenin beta-1 [KO:K02105]
480348  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
490029  TFAP4; transcription factor AP-4 isoform X2 [KO:K09108]
403802  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
482154  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
403438  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
489369  CBL; E3 ubiquitin-protein ligase CBL isoform X2 [KO:K04707] [EC:2.3.2.27]
481289  TIMP3; metalloproteinase inhibitor 3 precursor [KO:K16866]
487486  THBS1; thrombospondin-1 [KO:K16857]
403733  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
403885  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
482599  LUM; lumican [KO:K08122]
442968  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
486469  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
403693  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
403869  TP53; cellular tumor antigen p53 [KO:K04451]
488596  TGFB2; transforming growth factor beta-2 proprotein isoform X3 [KO:K13376]
480144  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
608707  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
486831  HPSE2; inactive heparanase-2 isoform X5 [KO:K07965] [EC:3.2.1.-]
482986  SDC1; syndecan-1 isoform X1 [KO:K06257]
403426  PLAU; urokinase-type plasminogen activator precursor [KO:K01348] [EC:3.4.21.73]
476446  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
403651  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
403824  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
489208  ITGA2; integrin alpha-2 [KO:K06481]
477956  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
480621  VTN; vitronectin [KO:K06251]
488437  ITGAV; integrin alpha-V isoform X5 [KO:K06487]
403788  ITGB3; integrin beta-3 precursor [KO:K06493]
403845  FN1; fibronectin [KO:K05717]
608977  ITGB5; integrin beta-5 [KO:K06588]
403441  HGF; hepatocyte growth factor precursor [KO:K05460]
486560  WNT1; proto-oncogene Wnt-1 [KO:K03209]
482294  FZD1; frizzled-1 [KO:K02432]
488478  FZD7; frizzled-7 [KO:K02432]
490937  FZD2; frizzled-2 [KO:K02235]
486093  FZD3; frizzled-3 isoform X1 [KO:K02329]
485149  FZD4; frizzled-4 [KO:K02354]
487073  FZD8; frizzled-8 [KO:K02375]
119863906  LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
403610  FZD6; frizzled-6 precursor [KO:K02376]
486232  FZD10; frizzled-10 [KO:K02842]
489809  FZD9; frizzled-9 [KO:K02842]
486493  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
484056  EZR; ezrin [KO:K08007]
479446  RDX; radixin isoform X1 [KO:K05762]
491924  MSN; moesin isoform X1 [KO:K05763]
485893  SDC4; syndecan-4 [KO:K16338]
403857  FGF2; fibroblast growth factor 2 isoform X5 [KO:K18497]
100856477  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
474444  FRS2; fibroblast growth factor receptor substrate 2 isoform X1 [KO:K12461]
477488  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100683481  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
490682  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
485874  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
489692  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
490904  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
489968  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100855828  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
486299  PXN; paxillin isoform X2 [KO:K05760]
475108  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
607007  HBEGF; proheparin-binding EGF-like growth factor isoform X1 [KO:K08523]
486197  GPC1; glypican-1 isoform X1 [KO:K08107]
483664  IGF2; insulin-like growth factor II isoform b precursor [KO:K13769]
481056  GPC3; glypican-3 [KO:K08109]
483220  WNT2B; protein Wnt-2b [KO:K00182]
612141  WNT2; protein Wnt-2 [KO:K00182]
609107  WNT3; proto-oncogene Wnt-3 [KO:K00312]
482208  WNT3A; protein Wnt-3a [KO:K00312]
612367  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
484721  WNT5A; protein Wnt-5a precursor [KO:K00444]
486756  WNT5B; protein Wnt-5b [KO:K00444]
488527  WNT6; protein Wnt-6 [KO:K00445]
481206  WNT7B; protein Wnt-7b isoform X4 [KO:K00572]
607180  WNT7A; protein Wnt-7a [KO:K00572]
486841  WNT8B; protein Wnt-8b [KO:K00714]
100855884  WNT8A; protein Wnt-8a isoform X2 [KO:K00714]
482209  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
490919  WNT9B; protein Wnt-9b [KO:K01064]
488528  WNT10A; protein Wnt-10a [KO:K01357]
486561  WNT10B; protein Wnt-10b [KO:K01357]
485183  WNT11; protein Wnt-11 [KO:K01384]
612328  WNT16; protein Wnt-16 isoform X3 [KO:K01558]
608860  SHH; sonic hedgehog protein [KO:K11988]
488533  IHH; indian hedgehog protein [KO:K11989]
484137  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
482262  SMO; smoothened homolog isoform X1 [KO:K06226]
403440  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
102156614  CTSV; procathepsin L [KO:K01365] [EC:3.4.22.15]
100688895  LOW QUALITY PROTEIN: procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
484140  CTSL3; procathepsin L [KO:K01365] [EC:3.4.22.15]
403556  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
479975  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
403856  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
607019  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
607023  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
612821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
611362  HSPB2; heat shock protein beta-2 [KO:K09543]
486717  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
cfa04010  MAPK signaling pathway
cfa04020  Calcium signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04210  Apoptosis
cfa04310  Wnt signaling pathway
cfa04340  Hedgehog signaling pathway
cfa04350  TGF-beta signaling pathway
cfa04370  VEGF signaling pathway
cfa04510  Focal adhesion
cfa04520  Adherens junction
cfa04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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