KEGG   PATHWAY: cpla04010
Entry
cpla04010                   Pathway                                
Name
MAPK signaling pathway - Chiloscyllium plagiosum (whitespotted bambooshark)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cpla04010  MAPK signaling pathway
cpla04010

Other DBs
GO: 0000165
Organism
Chiloscyllium plagiosum (whitespotted bambooshark) [GN:cpla]
Gene
122552384  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
122564768  probable voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
122559424  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
122559001  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
122562009  voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854]
122560529  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122542112  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
122562953  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
122561717  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
122559124  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
122559255  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
122559589  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
122539790  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122550015  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
122551757  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
122562279  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
122542106  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
122560444  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
122562354  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
122562280  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
122554117  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122552173  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
122562281  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122560735  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
122560793  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
122542251  guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346]
122554407  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122539543  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122556672  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122541750  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122543003  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
122553113  calcineurin subunit B type 1 isoform X1 [KO:K06268]
122540878  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
122559051  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122553731  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
122542873  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
122552667  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122539311  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122563942  nf1a; neurofibromin isoform X1 [KO:K08052]
122559261  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
122556231  rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
122563040  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
122559705  ras-related protein Rap-1b [KO:K07836]
122553658  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
122542966  protransforming growth factor alpha-like [KO:K08774]
122539529  amphiregulin-like [KO:K09782]
122556507  fibroblast growth factor 1-like isoform X1 [KO:K18496]
122539338  fgf2; fibroblast growth factor 2 [KO:K18497]
122561280  fgf8b; fibroblast growth factor 8b isoform X1 [KO:K04358]
122554861  fgf9; fibroblast growth factor 4A [KO:K04358]
122555186  fgf24; fibroblast growth factor 24 [KO:K04358]
122555464  fgf10a; fibroblast growth factor 10a [KO:K04358]
122555650  fibroblast growth factor 9-like [KO:K04358]
122555792  fgf5; fibroblast growth factor 5 [KO:K04358]
122562966  fibroblast growth factor 6-like isoform X1 [KO:K04358]
122557358  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
122550744  fibroblast growth factor 9 isoform X1 [KO:K04358]
122558025  fgf3; fibroblast growth factor 3 [KO:K04358]
122558026  fgf4; fibroblast growth factor 4 [KO:K04358]
122541000  fgf7; fibroblast growth factor 7 [KO:K04358]
122565370  fgf22; fibroblast growth factor 22 [KO:K04358]
122543223  LOW QUALITY PROTEIN: fibroblast growth factor 8-like [KO:K04358]
122558027  fgf19; fibroblast growth factor 19 [KO:K22603]
122561494  fibroblast growth factor 19-like [KO:K22428]
122563343  beta-nerve growth factor-like [KO:K02582]
122557648  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122561636  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
122542172  neurotrophin-4-like isoform X1 [KO:K12457]
122558059  insulin-like [KO:K04526]
122559407  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122542124  insulin-like growth factor II [KO:K13769]
122557927  insulin-like growth factor II [KO:K13769]
122560577  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
122562174  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
122542336  platelet-derived growth factor subunit B-like [KO:K17386]
122550691  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122559361  pdgfc; platelet-derived growth factor C [KO:K05450]
122559814  kitlga; kit ligand a isoform X1 [KO:K05461]
122543984  snake venom vascular endothelial growth factor toxin ICPP-like [KO:K05448]
122548515  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
122542835  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
122554909  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
122556527  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
122557293  vegfc; vascular endothelial growth factor C [KO:K05449]
122561718  hepatocyte growth factor isoform X1 [KO:K05460]
122549249  angpt1; angiopoietin-1 [KO:K05465]
122559884  angpt4; angiopoietin-1 [KO:K05465]
122563725  angpt2b; angiopoietin-2b isoform X1 [KO:K05466]
122541993  angiopoietin-2-like isoform X1 [KO:K05466]
122546130  ephrin-A1-like [KO:K05462]
122565055  ephrin-A5-like [KO:K05462]
122560061  ephrin-A5-like isoform X1 [KO:K05462]
122565287  nrtn; glial cell line-derived neurotrophic factor isoform X1 [KO:K25414]
122554753  artemin-like [KO:K25415]
122549920  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
122539698  receptor tyrosine-protein kinase erbB-2-like isoform X1 [KO:K05083] [EC:2.7.10.1]
122551916  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
122543329  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
122543124  fibroblast growth factor receptor 1-like [KO:K04362] [EC:2.7.10.1]
122561180  fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
122560229  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
122556821  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
122548957  nradd; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
122539962  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
122561340  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
122565433  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
122542552  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122550155  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122556457  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122556473  mast/stem cell growth factor receptor Kit-like [KO:K05091] [EC:2.7.10.1]
122550150  kita; mast/stem cell growth factor receptor kita [KO:K05091] [EC:2.7.10.1]
122550769  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
122557321  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
122550771  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122556469  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122550135  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122559685  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122563494  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
122540272  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
122541730  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122561952  growth factor receptor-bound protein 2 [KO:K04364]
122553582  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122553001  son of sevenless homolog 1 isoform X1 [KO:K03099]
122557741  GTPase HRas [KO:K02833]
122561572  GTPase KRas isoform X1 [KO:K07827]
122542641  GTPase HRas-like [KO:K07827]
122563298  nras; GTPase NRas [KO:K07828]
122557788  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
122542118  ras-related protein R-Ras2-like [KO:K07830]
122551778  mrasa; ras-related protein M-Ras [KO:K07831]
122559464  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122558962  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
122540870  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122565176  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122539518  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
122562831  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122554249  MAP kinase-interacting serine/threonine-protein kinase 1-like [KO:K04372] [EC:2.7.11.1]
122565306  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
122554978  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122557103  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122563584  ribosomal protein S6 kinase 2 alpha-like isoform X1 [KO:K04373] [EC:2.7.11.1]
122552908  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
122542265  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122558838  ETS domain-containing protein Elk-1-like [KO:K04375]
122563049  ETS domain-containing protein Elk-4-like isoform X1 [KO:K04376]
122549176  myc proto-oncogene protein-like [KO:K04377]
122548552  serum response factor-like isoform X1 [KO:K04378]
122555597  proto-oncogene c-Fos-like [KO:K04379]
122563604  stathmin-like [KO:K04381]
122563605  stathmin-like isoform X1 [KO:K04381]
122553857  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
122554454  cytosolic phospholipase A2-like isoform X1 [KO:K16342] [EC:3.1.1.4]
122547087  tumor necrosis factor-like [KO:K03156]
122541180  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
122543239  il1b; interleukin-1 beta [KO:K04519]
122552812  tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122555463  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
122542842  transforming growth factor beta-3 proprotein-like [KO:K13377]
122550649  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
122550650  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
122556134  interleukin-1 receptor accessory protein-like isoform X1 [KO:K04723]
122549325  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
122564406  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122551670  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122554602  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
122554794  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
122554795  tumor necrosis factor ligand superfamily member 6-like isoform X1 [KO:K04389]
122561061  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
122560598  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
122542237  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122542238  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
122562137  rac3a; ras-related C3 botulinum toxin substrate 3a isoform X1 [KO:K07861]
122540222  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122558526  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122564593  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
122541173  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
122541513  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
122546399  death domain-associated protein 6-like [KO:K02308]
122548926  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122542363  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122559701  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122557956  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122554776  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
122561793  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122565427  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
122542035  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
122553035  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
122552997  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
122550648  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122557427  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122550933  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
122555720  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
122548300  serine/threonine-protein kinase 3/4 [KO:K04411]
122548834  stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
122550070  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
122549355  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
122551845  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
122548923  map3k22; mitogen-activated protein kinase kinase kinase 22 isoform X1 [KO:K04421] [EC:2.7.11.25]
122540043  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
122553798  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
122542684  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
122553164  mitogen-activated protein kinase kinase kinase 9-like [KO:K17534] [EC:2.7.11.25]
122551456  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
122551555  mitogen-activated protein kinase kinase kinase 20-like [KO:K04424] [EC:2.7.11.25]
122547340  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122563748  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
122546496  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122552974  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
122562746  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
122563993  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
122562031  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
122552163  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
122560779  dual specificity mitogen-activated protein kinase kinase 6-like isoform X1 [KO:K04432] [EC:2.7.12.2]
122562211  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122557706  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
122561776  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
122560460  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
122562862  crkl; crk-like protein [KO:K04438]
122563879  crk; adapter molecule crk [KO:K04438]
122544389  arrestin red cell-like [KO:K04439]
122555759  S-arrestin-like [KO:K04439]
122551082  arrb1; beta-arrestin-1 [KO:K04439]
122556642  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122541809  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122552873  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122561715  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
122561716  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
122563201  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
122563202  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122558886  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
122562588  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
122563149  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
122559149  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04444] [EC:2.7.11.1]
122547382  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
122552879  ribosomal protein S6 kinase alpha-5-like isoform X1 [KO:K04445] [EC:2.7.11.1]
122553352  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
122552681  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
122549204  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
122549585  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
122558447  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122554377  jun; transcription factor AP-1 [KO:K04448]
122539430  transcription factor AP-1-like [KO:K04449]
122565119  transcription factor jun-D-like [KO:K04449]
122551542  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
122543388  tp53; cellular tumor antigen p53 [KO:K04451]
122553768  max; protein max isoform X1 [KO:K04453]
122565453  mef2b; myocyte-specific enhancer factor 2B isoform X1 [KO:K04454]
122559426  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
122562753  si:dkey-1k23.3; heat shock protein beta-1 [KO:K04455]
122564155  hspb1; heat shock protein beta-1 [KO:K04455]
122553568  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122552657  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122542840  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122553470  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
122563227  receptor-type tyrosine-protein phosphatase R-like [KO:K04458] [EC:3.1.3.48]
122559762  receptor-type tyrosine-protein phosphatase R-like isoform X1 [KO:K04458] [EC:3.1.3.48]
122557917  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
122556719  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122543238  dual specificity protein phosphatase 1-A-like [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122561360  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122557954  dual specificity protein phosphatase 8-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122564823  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122542019  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122558945  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122559646  dusp16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122559827  dual specificity protein phosphatase 6-like isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122552857  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122539891  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122542792  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
122543776  protein phosphatase 1B-like [KO:K04461] [EC:3.1.3.16]
122553177  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
122563583  heat shock cognate 71 kDa protein-like [KO:K03283]
122540664  heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
122540665  heat shock cognate 71 kDa protein-like [KO:K03283]
122541506  heat shock cognate 71 kDa protein-like [KO:K03283]
122541507  heat shock 70 kDa protein 1A-like [KO:K03283]
122541569  heat shock 70 kDa protein-like [KO:K03283]
122556249  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
122540900  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122543399  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
122540009  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
122541851  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122543166  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122563950  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
122539548  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
122556673  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
122541742  nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469]
122542783  transcription factor RelB homolog isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cpla04070  Phosphatidylinositol signaling system
cpla04110  Cell cycle
cpla04115  p53 signaling pathway
cpla04210  Apoptosis
cpla04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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