KEGG   PATHWAY: cpoc04015
Entry
cpoc04015                   Pathway                                
Name
Rap1 signaling pathway - Cavia porcellus (domestic guinea pig)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
cpoc04015  Rap1 signaling pathway
cpoc04015

Other DBs
GO: 0007264
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100713608  Rap1a; ras-related protein Rap-1A [KO:K04353]
100713271  ras-related protein Rap-1b-like [KO:K07836]
100734094  Rap1b; ras-related protein Rap-1b [KO:K07836]
100731678  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
100733128  Rapgef5; rap guanine nucleotide exchange factor 5 [KO:K08019]
100716726  Dock4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
100301989  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X4 [KO:K05208]
100727265  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100731840  Grin2b; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100728342  Calml3; calmodulin-like protein 3 [KO:K02183]
100730149  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100734544  Calm1; calmodulin-1 [KO:K02183]
100728625  calmodulin-4 [KO:K02183]
100729712  calmodulin-like [KO:K02183]
106027819  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100169692  Calm3; calmodulin [KO:K02183]
100724214  Calm2; calmodulin [KO:K02183]
100719323  F2r; proteinase-activated receptor 1 [KO:K03914]
100730527  F2rl3; proteinase-activated receptor 4 [KO:K04236]
100135592  P2ry1; P2Y purinoceptor 1 [KO:K04270]
100712629  LOW QUALITY PROTEIN: fMet-Leu-Phe receptor [KO:K04172]
100715007  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100719671  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
100730869  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
100735335  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
100135473  Adora2a; adenosine receptor A2a [KO:K04266]
100727842  Adora2b; adenosine receptor A2b [KO:K04267]
100732158  neuroendocrine secretory protein 55-like [KO:K04632]
100732436  guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
100715672  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100731999  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100725667  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100715532  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100714732  Adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100731224  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100726699  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100722340  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100717226  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100723672  Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014]
100730964  Rapgef4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
100714586  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100729394  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100714143  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
100727662  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100730572  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100712845  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100722152  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
100714471  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
100727152  Fgf1; fibroblast growth factor 1 isoform X2 [KO:K18496]
100721182  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100722934  Fgf5; fibroblast growth factor 5 isoform X2 [KO:K04358]
100730085  Fgf10; fibroblast growth factor 10 [KO:K04358]
100723648  Fgf16; fibroblast growth factor 16 [KO:K04358]
100730876  Fgf6; fibroblast growth factor 6 [KO:K04358]
100727356  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100718957  Fgf7; fibroblast growth factor 7 [KO:K04358]
100715152  Fgf18; fibroblast growth factor 18 [KO:K04358]
100732836  Fgf20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
100727609  Fgf9; fibroblast growth factor 9 [KO:K04358]
100716446  Fgf3; fibroblast growth factor 3 [KO:K04358]
100730350  Fgf4; fibroblast growth factor 4 [KO:K04358]
100721186  Fgf22; fibroblast growth factor 22 [KO:K04358]
100728398  Fgf21; fibroblast growth factor 21 [KO:K22429]
100717518  Fgf23; fibroblast growth factor 23 [KO:K22428]
100733367  Ngf; beta-nerve growth factor [KO:K02582]
100379579  Ins; insulin precursor [KO:K04526]
100135551  Igf1; insulin-like growth factor I precursor [KO:K05459]
100731469  Pdgfb; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100722571  Pdgfc; platelet-derived growth factor C [KO:K05450]
100713757  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
100732898  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100721734  Kitlg; kit ligand isoform X1 [KO:K05461]
100713483  Vegfa; vascular endothelial growth factor A isoform X2 [KO:K05448]
100724743  Vegfb; vascular endothelial growth factor B isoform X2 [KO:K16858]
100734450  Pgf; placenta growth factor isoform X3 [KO:K16859]
100724469  Vegfc; vascular endothelial growth factor C [KO:K05449]
100733371  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
100730730  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
100716420  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
100716962  Angpt2; angiopoietin-2 [KO:K05466]
100714243  angiopoietin-4 [KO:K05467]
100735338  Efna5; ephrin-A5 isoform X1 [KO:K05462]
100732408  Efna1; ephrin-A1 [KO:K05462]
100734666  Efna2; ephrin-A2 [KO:K05462]
100713685  Efna4; ephrin-A4 [KO:K05462]
100714142  Efna3; ephrin-A3 isoform X1 [KO:K05462]
100725363  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100731156  Fgfr1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100379152  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
100732948  Fgfr3; fibroblast growth factor receptor 3 isoform X9 [KO:K05094] [EC:2.7.10.1]
100733523  Fgfr4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100716626  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100718484  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100734840  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100726209  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100726506  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100726053  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100726397  Kit; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
100732326  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100715831  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100726761  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100718790  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100713324  Tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100712747  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100718486  Crk; adapter molecule crk [KO:K04438]
100723968  Crkl; crk-like protein [KO:K04438]
100727953  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277]
100713475  Bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
100726210  Cdh1; cadherin-1 [KO:K05689]
100732604  Ctnnb1; catenin beta-1 [KO:K02105]
100734036  Magi1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
100726657  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
100716414  Magi3; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112]
100725604  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2-like [KO:K08018]
100726875  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2-like [KO:K08018]
100725331  rap guanine nucleotide exchange factor 2-like [KO:K08018]
100725060  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X3 [KO:K08018]
100733383  Rapgef6; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 6 [KO:K08020]
100723774  Lat; linker for activation of T-cells family member 1 isoform X3 [KO:K07362]
100715602  Fyb1; FYN-binding protein 1 isoform X1 [KO:K17698]
100718602  Lcp2; lymphocyte cytosolic protein 2 [KO:K07361]
100720505  Skap1; src kinase-associated phosphoprotein 1 [KO:K17699]
100716986  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100713627  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100717697  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100733947  Prkcg; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100717067  Prkd2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
100712662  Prkd3; serine/threonine-protein kinase D3 isoform X2 [KO:K06070] [EC:2.7.11.13]
100722138  Prkd1; LOW QUALITY PROTEIN: serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
100732584  Drd2; D(2) dopamine receptor isoform X1 [KO:K04145]
100169690  Cnr1; cannabinoid receptor 1 [KO:K04277]
100135528  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100135529  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100135530  Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100716648  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
100725658  Rap1gap; rap1 GTPase-activating protein 1 isoform X3 [KO:K17700]
100725933  Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
100731279  Sipa1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
100732957  Sipa1l2; signal-induced proliferation-associated 1-like protein 2 isoform X3 [KO:K17702]
100731274  Sipa1l3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
100734662  Id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
100727882  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
100722725  Ralgds; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
100718312  Rala; ras-related protein Ral-A isoform X2 [KO:K07834]
100715093  Ralb; ras-related protein Ral-B [KO:K07835]
100727219  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100731468  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
100736181  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100734595  Apbb1ip; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
100730922  Tln1; talin-1 isoform X4 [KO:K06271]
100716884  Tln2; talin-2 isoform X1 [KO:K06271]
100727374  Itga2b; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
100731365  Itgb3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
101787807  profilin-1-like [KO:K05759]
100723625  Pfn1; profilin-1 [KO:K05759]
100719338  Pfn4; profilin-4 [KO:K05759]
101787241  Pfn3; profilin-3 [KO:K05759]
100717681  Pfn2; profilin-2 isoform X1 [KO:K05759]
100722137  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100720009  Enah; protein enabled homolog isoform X3 [KO:K05746]
100730315  Evl; ena/VASP-like protein isoform X2 [KO:K23487]
100731713  Actg1; actin, cytoplasmic 2 [KO:K05692]
100135470  Actb; actin, cytoplasmic 1 [KO:K05692]
100721743  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100733542  Rhoa; transforming protein RhoA [KO:K04513]
100728509  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100724219  Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082]
100717195  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100713221  Vav1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
100714719  Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100728155  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100735633  Tiam1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100721421  Pard3; partitioning defective 3 homolog isoform X25 [KO:K04237]
100728300  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
100732023  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100723981  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
100734946  Prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100731983  Prkci; protein kinase C iota type isoform X2 [KO:K06069] [EC:2.7.11.13]
100720687  Afdn; afadin isoform X2 [KO:K05702]
100734878  Ctnnd1; catenin delta-1 isoform X4 [KO:K05690]
100731041  Krit1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
100728156  Rgs14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
100716188  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
100713143  Itgal; integrin alpha-L [KO:K05718]
100135561  Itgam; LOW QUALITY PROTEIN: integrin alpha-M [KO:K06461]
100727919  integrin beta-2 [KO:K06464]
100727643  LOW QUALITY PROTEIN: integrin beta-2-like [KO:K06464]
100719502  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100717765  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100720110  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100712888  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100728923  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100715180  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100725692  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100726100  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100731419  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100724974  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100723285  Mapk14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100729280  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100720622  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100727986  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100735084  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100734206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100730242  Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100734044  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100719925  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100714724  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100724315  Akt3; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100721203  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100735038  Hras; GTPase HRas isoform X1 [KO:K02833]
100716262  Kras; GTPase KRas isoform X3 [KO:K07827]
100135584  Nras; GTPase NRas [KO:K07828]
100725452  Rras; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
cpoc04010  MAPK signaling pathway
cpoc04014  Ras signaling pathway
cpoc04020  Calcium signaling pathway
cpoc04151  PI3K-Akt signaling pathway
cpoc04510  Focal adhesion
cpoc04520  Adherens junction
cpoc04660  T cell receptor signaling pathway
cpoc04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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