KEGG   PATHWAY: dsp04014
Entry
dsp04014                    Pathway                                
Name
Ras signaling pathway - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
dsp04014  Ras signaling pathway
dsp04014

Other DBs
GO: 0032318
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122127051  Egf; pro-epidermal growth factor [KO:K04357]
122125176  Tgfa; protransforming growth factor alpha [KO:K08774]
122118224  Fgf1; fibroblast growth factor 1 [KO:K18496]
122119078  Fgf2; fibroblast growth factor 2 [KO:K18497]
122127554  Fgf20; fibroblast growth factor 20 [KO:K04358]
122096618  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122112831  Fgf9; fibroblast growth factor 9 [KO:K04358]
122097662  Fgf16; fibroblast growth factor 16 [KO:K04358]
122106885  Fgf5; fibroblast growth factor 5 [KO:K04358]
122114692  Fgf7; fibroblast growth factor 7 [KO:K04358]
122122838  Fgf22; fibroblast growth factor 22 [KO:K04358]
122099887  Fgf3; fibroblast growth factor 3 [KO:K04358]
122115956  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122101870  Fgf18; fibroblast growth factor 18 [KO:K04358]
122117016  Fgf10; fibroblast growth factor 10 [KO:K04358]
122102809  Fgf6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
122125586  Fgf21; fibroblast growth factor 21 [KO:K22429]
122102807  Fgf23; fibroblast growth factor 23 [KO:K22428]
122118375  Ngf; beta-nerve growth factor [KO:K02582]
122117755  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122102605  Ntf3; neurotrophin-3 [KO:K04356]
122125884  Ntf4; neurotrophin-4 [KO:K12457]
122102073  Ins; insulin [KO:K04526]
122119198  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122102070  Igf2; insulin-like growth factor II [KO:K13769]
122113621  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122123581  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
122104212  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122097855  Pdgfc; platelet-derived growth factor C [KO:K05450]
122109178  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122119178  Kitlg; kit ligand isoform X1 [KO:K05461]
122125712  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122101493  Vegfa; vascular endothelial growth factor A [KO:K05448]
122104926  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
122118724  Pgf; placenta growth factor isoform X1 [KO:K16859]
122108520  Vegfd; vascular endothelial growth factor D [KO:K05449]
122126084  Vegfc; vascular endothelial growth factor C [KO:K05449]
122111940  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
122102398  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
122125262  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
122120328  Angpt4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
122122829  Efna2; ephrin-A2 [KO:K05462]
122109403  Efna1; ephrin-A1 [KO:K05462]
122109474  Efna3; ephrin-A3 isoform X1 [KO:K05462]
122109523  Efna4; ephrin-A4 isoform X1 [KO:K05462]
122118247  Efna5; ephrin-A5 isoform X1 [KO:K05462]
122112209  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122107616  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122126852  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122100692  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122096494  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122103503  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122109658  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122122111  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122119565  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122123999  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122106871  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122118168  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122118243  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122106872  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122112631  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122096363  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
122112548  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122115490  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
122106648  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122121823  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122121294  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122099158  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122128376  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
122127211  Gab1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
122116519  Gab2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
122109169  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
122122823  Shc2; SHC-transforming protein 2 [KO:K17447]
122113790  Shc3; SHC-transforming protein 3 [KO:K17448]
122114464  Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
122098592  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
122104519  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122106484  Sos2; son of sevenless homolog 2 [KO:K03099]
122120202  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
122114558  Rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
122104915  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122102090  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122097593  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
122125452  uncharacterized protein LOC122125452 [KO:K10784]
122125471  uncharacterized protein LOC122125471 [KO:K10784]
122121358  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
122096304  Lat; linker for activation of T-cells family member 1 [KO:K07362]
122115827  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
122127332  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
122113749  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
122099244  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
122114508  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
122106523  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
122105120  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
122113060  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
122105860  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122122831  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122115548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122115891  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122099305  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
122125901  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
122104437  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
122113091  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
122121653  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
122111861  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
122104327  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122101888  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
122111933  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
122102139  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
122104508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122119798  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
122123393  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
122117332  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122102555  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
122123837  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
122101235  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122118832  Calm1; calmodulin-1 [KO:K02183]
122104536  Calm2; calmodulin-2 [KO:K02183]
122113235  Calml3; calmodulin-like protein 3 [KO:K02183]
122113280  Calml5; calmodulin-like protein 5 [KO:K02183]
122122996  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122124059  calmodulin-1-like [KO:K02183]
122125740  Calm3; calmodulin-3 [KO:K02183]
122126861  calmodulin-like [KO:K02183]
122095011  Hras; GTPase HRas isoform X1 [KO:K02833]
122098841  Kras; GTPase KRas isoform X1 [KO:K07827]
122118367  Nras; GTPase NRas [KO:K07828]
122095273  Mras; ras-related protein M-Ras [KO:K07831]
122125793  Rras; ras-related protein R-Ras [KO:K07829]
122117759  Rras2; ras-related protein R-Ras2 [KO:K07830]
122117803  Nf1; neurofibromin isoform X1 [KO:K08052]
122117115  Rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
122095267  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
122122890  Rasa3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
122113520  Rasa4b; ras GTPase-activating protein 4B [KO:K17630]
122111365  Syngap1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
122098590  Rasal1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
122103717  Rasal2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
122100329  Rasal3; RAS protein activator like-3 isoform X1 [KO:K17634]
122095693  Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
122109145  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
122120207  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
122114257  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
122113510  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122119204  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122099403  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122115583  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122097055  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
122116371  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
122097586  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
122120469  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
122114535  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
122095683  Rhoa; transforming protein RhoA [KO:K04513]
122115017  transforming protein RhoA-like [KO:K04513]
122095294  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122121501  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122107232  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122123339  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
122108047  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
122100872  Pik3r2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122117343  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122097416  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122101263  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122126696  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122097005  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122115917  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122107663  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122127164  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122105094  Rela; transcription factor p65 isoform X1 [KO:K04735]
122105036  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
122120267  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
122120618  Foxo4; forkhead box protein O4 [KO:K12358]
122103807  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122106541  Ralgapa1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
122096025  Ralgapa2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
122120215  Ralgapb; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
122120732  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120746  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120747  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120774  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120806  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120809  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120812  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120814  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120818  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120862  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120901  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120903  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122120905  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122114492  uncharacterized protein LOC122114492 isoform X1 [KO:K08732]
122114847  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122124476  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
122109018  Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
122103694  Rgl1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
122111082  Rgl2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
122120863  Rala; ras-related protein Ral-A [KO:K07834]
122112437  Ralb; ras-related protein Ral-B [KO:K07835]
122107290  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
122108633  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
122108400  Exoc2; exocyst complex component 2 [KO:K17637]
122124190  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
122117480  Rel; proto-oncogene c-Rel [KO:K09254]
122097824  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122115378  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122116492  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122110944  Ralbp1; ralA-binding protein 1 [KO:K08773]
122119115  cell division control protein 42 homolog [KO:K04393]
122115178  Cdc42; cell division control protein 42 homolog [KO:K04393]
122101899  Afdn; afadin isoform X1 [KO:K05702]
122116038  Shoc2; leucine-rich repeat protein SHOC-2 [KO:K19613]
122107826  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122114391  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122099331  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122095844  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122096287  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122099218  Pla1a; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
122127155  Pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122095888  Pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122099052  Pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122115232  Pla2g2d; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122115288  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
122115300  Pla2g5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
122115334  Pla2g2c; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122115335  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122115336  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122123709  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122116562  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
122103830  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122114427  Pla2g4e; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
122114429  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122114610  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
122114616  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
122125680  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
122119146  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
122105326  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122098786  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
122104225  Ets1; protein C-ets-1 isoform X1 [KO:K02678]
122114271  Ets2; protein C-ets-2 [KO:K21932]
122098554  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
122119725  Ksr1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
122099025  Ksr2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
122112132  Rapgef5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
122104391  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
122124042  Rap1b; ras-related protein Rap-1b [KO:K07836]
122115929  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
122128350  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
122116145  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122110671  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
122105113  Rin1; ras and Rab interactor 1 isoform X1 [KO:K17638]
122108952  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
122103748  Abl2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
122108082  Rab5a; ras-related protein Rab-5A [KO:K07887]
122124350  Rab5b; ras-related protein Rab-5B [KO:K07888]
122103267  Rab5c; ras-related protein Rab-5C [KO:K07889]
122100607  ras-related protein Rab-5C-like [KO:K07889]
122106461  Arf6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
dsp04010  MAPK signaling pathway
dsp04015  Rap1 signaling pathway
dsp04020  Calcium signaling pathway
dsp04144  Endocytosis
dsp04151  PI3K-Akt signaling pathway
dsp04660  T cell receptor signaling pathway
dsp04720  Long-term potentiation
dsp04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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