KEGG   PATHWAY: gmu04510
Entry
gmu04510                    Pathway                                
Name
Focal adhesion - Girardinichthys multiradiatus (darkedged splitfin)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
gmu04510  Focal adhesion
gmu04510

Other DBs
GO: 0005925
Organism
Girardinichthys multiradiatus (darkedged splitfin) [GN:gmu]
Gene
124864205  collagen alpha-1(I) chain-like [KO:K06236]
124879892  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
124874764  col1a1b; collagen, type I, alpha 1b isoform X1 [KO:K06236]
124862227  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
124856630  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
124872161  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
124871385  col4a2; collagen alpha-2(IV) chain [KO:K06237]
124871386  col4a1; collagen alpha-1(IV) chain [KO:K06237]
124884727  col4a4; collagen alpha-4(IV) chain [KO:K06237]
124884751  col4a3; collagen alpha-5(IV) chain [KO:K06237]
124880402  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
124880403  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
124869775  col6a1; collagen alpha-1(VI) chain [KO:K06238]
124869944  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
124871003  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
124871346  collagen alpha-3(VI) chain-like isoform X1 [KO:K06238]
124865899  col6a4a; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
124866382  collagen alpha-6(VI) chain-like [KO:K06238]
124858578  collagen alpha-1(IX) chain-like [KO:K08131]
124879036  col9a2; collagen alpha-2(IX) chain [KO:K08131]
124879156  collagen alpha-1(IX) chain-like isoform X1 [KO:K08131]
124868470  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
124868683  col9a3; collagen alpha-3(IX) chain [KO:K08131]
124857968  lama1; laminin subunit alpha-1 [KO:K05637]
124882274  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
124869873  laminin subunit alpha-3-like [KO:K06240]
124867105  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
124882256  lama4; laminin subunit alpha-4 [KO:K06241]
124883086  lamb1b; laminin subunit beta-1b [KO:K05636]
124856453  lamb1a; laminin subunit beta-1a [KO:K05636]
124870699  lamb2; laminin subunit beta-2 [KO:K06243]
124868992  lamb2l; laminin subunit beta-1 isoform X1 [KO:K06243]
124857262  laminin subunit beta-3-like isoform X1 [KO:K06244]
124855322  lamb4; laminin subunit beta-4 isoform X1 [KO:K06245]
124869293  lamc1; laminin subunit gamma-1 [KO:K05635]
124869968  lamc2; laminin subunit gamma-2 [KO:K06246]
124872698  lamc3; laminin subunit gamma-3 [KO:K06247]
124875341  chad; chondroadherin [KO:K06248]
124884274  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
124855701  thrombospondin-1-like [KO:K16857]
124882460  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
124877323  thbs4a; thrombospondin-4a [KO:K04659]
124865906  thbs3a; thrombospondin-3a [KO:K04659]
124873120  thbs4b; thrombospondin-4-B [KO:K04659]
124859250  thbs2a; thrombospondin-2 [KO:K04659]
124874104  cartilage oligomeric matrix protein [KO:K04659]
124875235  thrombospondin-2-like [KO:K04659]
124871206  fn1a; fibronectin 1a [KO:K05717]
124866598  fn1b; fibronectin 1b isoform X1 [KO:K05717]
124876072  vtnb; vitronectin b [KO:K06251]
124884569  vtna; vitronectin a [KO:K06251]
124870398  tnr; tenascin-R [KO:K06252]
124864097  tenascin-like [KO:K06252]
124877713  tenascin-like [KO:K06252]
124872595  tnca; tenascin isoform X1 [KO:K06252]
124879976  tenascin isoform X1 [KO:K06252]
124880306  tenascin-like [KO:K06252]
124880307  tenascin-like [KO:K06252]
124880460  fibronectin-like [KO:K06252]
124869264  tnn; tenascin-N [KO:K06252]
124877858  vwf; von Willebrand factor [KO:K03900]
124872694  itga1; integrin alpha-1 isoform X1 [KO:K06480]
124877142  itga2.2; integrin alpha-2 [KO:K06481]
124863593  integrin alpha-IIb-like [KO:K06476]
124865050  integrin alpha-IIb-like [KO:K06476]
124863994  integrin alpha-3-like isoform X1 [KO:K06482]
124875513  itga3b; integrin alpha-3b [KO:K06482]
124862474  integrin alpha-3-like isoform X1 [KO:K06482]
124871156  itga4; integrin alpha-4 [KO:K06483]
124857580  integrin alpha-5-like [KO:K06484]
124866656  itga5; integrin alpha-5 [KO:K06484]
124870596  integrin alpha-6-like isoform X1 [KO:K06485]
124871343  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
124860784  integrin alpha-6-like isoform X1 [KO:K06485]
124869391  LOW QUALITY PROTEIN: integrin alpha-6-like [KO:K06485]
124857144  itga7; integrin alpha-7 isoform X1 [KO:K06583]
124865341  itga8; integrin alpha-8 [KO:K06584]
124859482  itga9; integrin alpha-9 [KO:K06585]
124862414  itga10; integrin alpha-10 [KO:K06586]
124879046  integrin alpha-11-like isoform X1 [KO:K06587]
124866469  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
124870788  itgav; integrin alpha-V [KO:K06487]
124857996  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
124875034  integrin beta-3-like [KO:K06493]
124862399  integrin beta-3-like [KO:K06493]
124875045  itgb4; integrin beta-4 isoform X1 [KO:K06525]
124871223  itgb5; integrin beta-5 isoform X1 [KO:K06588]
124867393  itgb6; integrin beta-6 isoform X1 [KO:K06589]
124879346  itgb8; integrin beta-8 [KO:K06591]
124862374  epithelial membrane protein 2-like [KO:K26256]
124862252  epithelial membrane protein 2-like [KO:K26256]
124863813  epithelial membrane protein 2-like [KO:K26256]
124863463  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
124863714  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
124867911  platelet-derived growth factor subunit A-like [KO:K04359]
124869167  si:ch211-79m20.1; uncharacterized protein si:ch211-79m20.1 [KO:K17386]
124883537  pdgfd; platelet-derived growth factor D [KO:K05450]
124859797  pdgfc; platelet-derived growth factor C [KO:K05450]
124860567  egf; pro-epidermal growth factor [KO:K04357]
124876646  igf3; insulin-like growth factor 3 [KO:K05459]
124883008  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
124860596  vegfba; vascular endothelial growth factor B isoform X1 [KO:K05448]
124882425  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
124856012  pgfb; placenta growth factor isoform X1 [KO:K16859]
124882351  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
124867445  vegfd; vascular endothelial growth factor D [KO:K05449]
124867938  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
124861298  vascular endothelial growth factor C-like [KO:K05449]
124857843  hepatocyte growth factor [KO:K05460]
124882706  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
124873707  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
124876578  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
124860432  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
124885065  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
124866795  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
124874157  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
124858134  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
124869445  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
124858000  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
124860351  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
124860198  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
124858154  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
124875242  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
124868165  emp1; epithelial membrane protein 1 [KO:K26255]
124870123  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
124856497  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
124876380  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
124883753  arhgap35a; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
124855170  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
124870836  rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
124857154  transforming protein RhoA-like [KO:K04513]
124865806  rho-related GTP-binding protein RhoA-D [KO:K04513]
124865817  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
124867807  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
124860278  protein diaphanous homolog 1 isoform X1 [KO:K05740]
124870088  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
124882189  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
124855144  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
124856367  myl2a; myosin regulatory light chain 2a [KO:K10351]
124877393  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
124878037  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
124856629  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
124869929  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
124857704  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
124863300  myosin regulatory light chain 2, skeletal muscle [KO:K12758]
124864707  myosin regulatory light chain 2, skeletal muscle [KO:K12758]
124875615  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
124862833  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
124855846  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
124864323  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
124877642  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
124880276  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
124875557  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
124882879  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
124885009  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
124868649  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
124875168  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
124863206  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
124870315  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
124865037  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124871629  mylka; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
124873397  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124869951  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
124865684  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
124872231  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
124878416  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
124879472  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
124874392  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
124877225  actin, cytoplasmic-like [KO:K05692]
124863544  actin, cytoplasmic 1 [KO:K05692]
124863674  actin, cytoplasmic 1 [KO:K05692]
124877540  actin, muscle-like [KO:K05692]
124868339  actb1; actin, cytoplasmic 1 [KO:K05692]
124878464  actin, cytoplasmic 1-like [KO:K05692]
124856944  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
124867205  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
124858622  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
124868214  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
124883810  alpha-actinin-4 isoform X1 [KO:K05699]
124855379  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
124883894  tln2b; talin-2 [KO:K06271]
124872309  tln1; talin-1 [KO:K06271]
124866955  tln2a; talin-2a isoform X1 [KO:K06271]
124875603  flna; filamin-A isoform X1 [KO:K04437]
124856484  filamin-B isoform X1 [KO:K27392]
124856467  mucin-5AC-like isoform X1 [KO:K05760]
124878085  proline-rich protein 36-like isoform X1 [KO:K05760]
124883803  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
124876711  ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
124865653  zyx; zyxin [KO:K06273]
124884060  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
124859235  vinculin-like isoform X1 [KO:K05700]
124875402  vinculin isoform X1 [KO:K05700]
124884016  parvb; beta-parvin isoform X1 [KO:K06275]
124884926  parvaa; parvin, alpha a [KO:K06275]
124878951  parvg; gamma-parvin isoform X1 [KO:K06275]
124875685  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
124883780  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124858601  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124867765  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124855241  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124871205  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
124865659  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
124879475  catenin beta-1-like isoform X1 [KO:K02105]
124862966  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
124864797  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
124867838  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124862727  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
124864744  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124868119  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
124866124  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124866061  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
124878855  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
124870477  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124884243  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124873577  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
124880409  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
124875686  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
124870480  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
124877742  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
124872596  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124873683  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
124873763  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
124869460  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124859385  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124875231  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124869628  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
124857923  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
124872509  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
124869132  proto-oncogene vav-like isoform X1 [KO:K05730]
124863148  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
124864617  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124874627  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124875407  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124869199  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
124875062  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
124855774  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
124873465  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
124875948  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
124883970  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
124882079  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
124855875  serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05735] [EC:2.7.11.1]
124881990  serine/threonine-protein kinase PAK 4-like isoform X1 [KO:K05735] [EC:2.7.11.1]
124856632  cell division control protein 42 homolog [KO:K04393]
124865607  cell division control protein 42 homolog [KO:K04393]
124865608  cell division control protein 42 homolog [KO:K04393]
124879429  cell division control protein 42 homolog [KO:K04393]
124867548  cell division control protein 42 homolog isoform X1 [KO:K04393]
124877544  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
124876940  adapter molecule crk-like [KO:K04438]
124884098  crk; adapter molecule crk [KO:K04438]
124872914  crkl; crk-like protein isoform X1 [KO:K04438]
124874821  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
124877125  rap guanine nucleotide exchange factor 1-like [KO:K06277]
124872361  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
124856820  ras-related protein Rap-1A [KO:K04353]
124875123  ras-related protein Rap-1b [KO:K04353]
124882697  ras-related protein Rap-1b [KO:K07836]
124872468  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124859135  mapk8a; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
124860150  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124875307  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124870122  transcription factor Jun-like [KO:K04448]
124873148  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
124873314  jun; transcription factor AP-1 [KO:K04448]
124883025  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
124860670  cav1; caveolin-1 [KO:K06278]
124856557  caveolin-2-like [KO:K12958]
124857020  cav4a; caveolin-2 [KO:K12958]
124877888  cav2; caveolin-2 [KO:K12958]
124874684  cav4b; caveolin-2 [KO:K12958]
124856558  cav3; caveolin-3 [KO:K12959]
124855451  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
124881897  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
124865598  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
124874121  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
124872742  shc3; SHC-transforming protein 3 [KO:K17448]
124867254  SHC-transforming protein 4-like [KO:K17449]
124863357  growth factor receptor-bound protein 2 [KO:K04364]
124863971  growth factor receptor-bound protein 2 [KO:K04364]
124868143  son of sevenless homolog 1-like isoform X1 [KO:K03099]
124855236  sos2; son of sevenless homolog 2 [KO:K03099]
124882413  GTPase HRas [KO:K02833]
124866030  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
124856513  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124863274  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124864295  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124877799  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124868529  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
124867399  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
124883234  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
124863462  G1/S-specific cyclin-D1-like [KO:K10151]
124864841  G1/S-specific cyclin-D1-like [KO:K10151]
124878098  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
124856377  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
124876393  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
124859842  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
124880840  badb; BCL2 associated agonist of cell death b [KO:K02158]
124870196  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
124858074  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
gmu04010  MAPK signaling pathway
gmu04060  Cytokine-cytokine receptor interaction
gmu04070  Phosphatidylinositol signaling system
gmu04110  Cell cycle
gmu04310  Wnt signaling pathway
gmu04512  ECM-receptor interaction
gmu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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