KEGG   PATHWAY: gmu04510
Entry
gmu04510                    Pathway                                
Name
Focal adhesion - Girardinichthys multiradiatus (darkedged splitfin)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
gmu04510  Focal adhesion
gmu04510

Other DBs
GO: 0005925
Organism
Girardinichthys multiradiatus (darkedged splitfin) [GN:gmu]
Gene
124855144  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
124855170  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
124855236  sos2; son of sevenless homolog 2 [KO:K03099]
124855241  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124855322  lamb4; laminin subunit beta-4 isoform X1 [KO:K06245]
124855379  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
124855451  [KO:K05703] [EC:2.7.10.2]
124855701  [KO:K16857]
124855774  [KO:K04410] [EC:2.7.11.1]
124855846  [KO:K06269] [EC:3.1.3.16]
124855875  [KO:K05735] [EC:2.7.11.1]
124856012  pgfb; placenta growth factor isoform X1 [KO:K16859]
124856367  myl2a; myosin regulatory light chain 2a [KO:K10351]
124856377  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
124856453  lamb1a; laminin subunit beta-1a [KO:K05636]
124856467  [KO:K05760]
124856484  [KO:K27392]
124856497  [KO:K05704] [EC:2.7.10.2]
124856513  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124856557  [KO:K12958]
124856558  cav3; caveolin-3 [KO:K12959]
124856629  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
124856630  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
124856632  [KO:K04393]
124856820  [KO:K04353]
124856944  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
124857020  cav4a; caveolin-2 [KO:K12958]
124857144  itga7; integrin alpha-7 isoform X1 [KO:K06583]
124857154  [KO:K04513]
124857262  [KO:K06244]
124857580  [KO:K06484]
124857704  [KO:K12757]
124857843  [KO:K05460]
124857923  [KO:K05730]
124857968  lama1; laminin subunit alpha-1 [KO:K05637]
124857996  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
124858000  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
124858074  [KO:K02161]
124858134  [KO:K04361] [EC:2.7.10.1]
124858154  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
124858578  [KO:K08131]
124858601  [KO:K04456] [EC:2.7.11.1]
124858622  [KO:K03853] [EC:3.4.22.53]
124859135  mapk8a; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
124859235  [KO:K05700]
124859250  thbs2a; thrombospondin-2 [KO:K04659]
124859385  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124859482  itga9; integrin alpha-9 [KO:K06585]
124859797  pdgfc; platelet-derived growth factor C [KO:K05450]
124859842  [KO:K04725] [EC:2.3.2.27]
124860150  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
124860198  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
124860278  [KO:K05740]
124860351  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
124860432  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
124860567  egf; pro-epidermal growth factor [KO:K04357]
124860596  vegfba; vascular endothelial growth factor B isoform X1 [KO:K05448]
124860670  cav1; caveolin-1 [KO:K06278]
124860784  [KO:K06485]
124861298  [KO:K05449]
124862227  [KO:K06236]
124862252  [KO:K26256]
124862374  [KO:K26256]
124862399  [KO:K06493]
124862414  itga10; integrin alpha-10 [KO:K06586]
124862474  [KO:K06482]
124862727  [KO:K19662] [EC:2.7.11.13]
124862833  [KO:K06269] [EC:3.1.3.16]
124862966  [KO:K02677] [EC:2.7.11.13]
124863148  [KO:K04392]
124863206  [KO:K00907] [EC:2.7.11.18]
124863274  [KO:K04371] [EC:2.7.11.24]
124863300  [KO:K12758]
124863357  [KO:K04364]
124863462  [KO:K10151]
124863463  [KO:K04359]
124863544  [KO:K05692]
124863593  [KO:K06476]
124863674  [KO:K05692]
124863714  [KO:K04359]
124863813  [KO:K26256]
124863971  [KO:K04364]
124863994  [KO:K06482]
124864097  [KO:K06252]
124864205  [KO:K06236]
124864295  [KO:K04371] [EC:2.7.11.24]
124864323  [KO:K06269] [EC:3.1.3.16]
124864617  [KO:K04392]
124864707  [KO:K12758]
124864744  [KO:K19662] [EC:2.7.11.13]
124864797  [KO:K02677] [EC:2.7.11.13]
124864841  [KO:K10151]
124865037  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124865050  [KO:K06476]
124865341  itga8; integrin alpha-8 [KO:K06584]
124865598  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
124865607  [KO:K04393]
124865608  [KO:K04393]
124865653  zyx; zyxin [KO:K06273]
124865659  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
124865684  [KO:K00889] [EC:2.7.1.68]
124865806  [KO:K04513]
124865817  [KO:K04513]
124865899  col6a4a; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
124865906  thbs3a; thrombospondin-3a [KO:K04659]
124866030  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
124866061  [KO:K05725] [EC:2.7.10.2]
124866124  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
124866382  [KO:K06238]
124866469  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
124866598  fn1b; fibronectin 1b isoform X1 [KO:K05717]
124866656  itga5; integrin alpha-5 [KO:K06484]
124866795  [KO:K05087] [EC:2.7.10.1]
124866955  tln2a; talin-2a isoform X1 [KO:K06271]
124867105  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
124867205  [KO:K04349]
124867254  [KO:K17449]
124867393  itgb6; integrin beta-6 isoform X1 [KO:K06589]
124867399  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
124867445  vegfd; vascular endothelial growth factor D [KO:K05449]
124867548  [KO:K04393]
124867765  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124867807  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
124867838  [KO:K02677] [EC:2.7.11.13]
124867911  [KO:K04359]
124867938  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
124868119  [KO:K19662] [EC:2.7.11.13]
124868143  [KO:K03099]
124868165  emp1; epithelial membrane protein 1 [KO:K26255]
124868214  [KO:K03853] [EC:3.4.22.53]
124868339  actb1; actin, cytoplasmic 1 [KO:K05692]
124868470  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
124868529  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
124868649  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
124868683  col9a3; collagen alpha-3(IX) chain [KO:K08131]
124868992  lamb2l; laminin subunit beta-1 isoform X1 [KO:K06243]
124869132  [KO:K05730]
124869167  si:ch211-79m20.1; uncharacterized protein si:ch211-79m20.1 [KO:K17386]
124869199  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
124869264  tnn; tenascin-N [KO:K06252]
124869293  lamc1; laminin subunit gamma-1 [KO:K05635]
124869391  [KO:K06485]
124869445  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
124869460  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124869628  [KO:K05730]
124869775  col6a1; collagen alpha-1(VI) chain [KO:K06238]
124869873  [KO:K06240]
124869929  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
124869944  [KO:K06238]
124869951  [KO:K00889] [EC:2.7.1.68]
124869968  lamc2; laminin subunit gamma-2 [KO:K06246]
124870088  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
124870122  [KO:K04448]
124870123  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
124870196  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
124870315  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
124870398  tnr; tenascin-R [KO:K06252]
124870477  [KO:K00922] [EC:2.7.1.153]
124870480  [KO:K02649]
124870596  [KO:K06485]
124870699  lamb2; laminin subunit beta-2 [KO:K06243]
124870788  itgav; integrin alpha-V [KO:K06487]
124870836  [KO:K04513]
124871003  [KO:K06238]
124871156  itga4; integrin alpha-4 [KO:K06483]
124871205  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
124871206  fn1a; fibronectin 1a [KO:K05717]
124871223  itgb5; integrin beta-5 isoform X1 [KO:K06588]
124871343  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
124871346  [KO:K06238]
124871385  col4a2; collagen alpha-2(IV) chain [KO:K06237]
124871386  col4a1; collagen alpha-1(IV) chain [KO:K06237]
124871629  mylka; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
124872161  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
124872231  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
124872309  tln1; talin-1 [KO:K06271]
124872361  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
124872468  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124872509  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
124872595  tnca; tenascin isoform X1 [KO:K06252]
124872596  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124872694  itga1; integrin alpha-1 isoform X1 [KO:K06480]
124872698  lamc3; laminin subunit gamma-3 [KO:K06247]
124872742  shc3; SHC-transforming protein 3 [KO:K17448]
124872914  crkl; crk-like protein isoform X1 [KO:K04438]
124873120  thbs4b; thrombospondin-4-B [KO:K04659]
124873148  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
124873314  jun; transcription factor AP-1 [KO:K04448]
124873397  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
124873465  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
124873577  [KO:K00922] [EC:2.7.1.153]
124873683  [KO:K02649]
124873707  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
124873763  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
124874104  [KO:K04659]
124874121  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
124874157  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
124874392  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
124874627  [KO:K04392]
124874684  cav4b; caveolin-2 [KO:K12958]
124874764  col1a1b; collagen, type I, alpha 1b isoform X1 [KO:K06236]
124874821  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
124875034  [KO:K06493]
124875045  itgb4; integrin beta-4 isoform X1 [KO:K06525]
124875062  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
124875123  [KO:K04353]
124875168  [KO:K00907] [EC:2.7.11.18]
124875231  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
124875235  [KO:K04659]
124875242  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
124875307  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124875341  chad; chondroadherin [KO:K06248]
124875402  [KO:K05700]
124875407  [KO:K04392]
124875513  itga3b; integrin alpha-3b [KO:K06482]
124875557  [KO:K06269] [EC:3.1.3.16]
124875603  flna; filamin-A isoform X1 [KO:K04437]
124875615  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
124875685  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
124875686  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
124875948  [KO:K05733] [EC:2.7.11.1]
124876072  vtnb; vitronectin b [KO:K06251]
124876380  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
124876393  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
124876578  [KO:K05089] [EC:2.7.10.1]
124876646  igf3; insulin-like growth factor 3 [KO:K05459]
124876711  ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
124876940  [KO:K04438]
124877125  [KO:K06277]
124877142  itga2.2; integrin alpha-2 [KO:K06481]
124877225  [KO:K05692]
124877323  thbs4a; thrombospondin-4a [KO:K04659]
124877393  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
124877540  [KO:K05692]
124877544  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
124877642  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
124877713  [KO:K06252]
124877742  [KO:K02649]
124877799  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124877858  vwf; von Willebrand factor [KO:K03900]
124877888  cav2; caveolin-2 [KO:K12958]
124878037  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
124878085  [KO:K05760]
124878098  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
124878416  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
124878464  [KO:K05692]
124878855  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
124878951  parvg; gamma-parvin isoform X1 [KO:K06275]
124879036  col9a2; collagen alpha-2(IX) chain [KO:K08131]
124879046  [KO:K06587]
124879156  [KO:K08131]
124879346  itgb8; integrin beta-8 [KO:K06591]
124879429  [KO:K04393]
124879472  [KO:K00889] [EC:2.7.1.68]
124879475  [KO:K02105]
124879892  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
124879976  [KO:K06252]
124880276  [KO:K06269] [EC:3.1.3.16]
124880306  [KO:K06252]
124880307  [KO:K06252]
124880402  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
124880403  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
124880409  [KO:K00922] [EC:2.7.1.153]
124880460  [KO:K06252]
124880840  badb; BCL2 associated agonist of cell death b [KO:K02158]
124881897  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
124881990  [KO:K05735] [EC:2.7.11.1]
124882079  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
124882189  [KO:K17388] [EC:2.7.11.1]
124882256  lama4; laminin subunit alpha-4 [KO:K06241]
124882274  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
124882351  pgfa; vascular endothelial growth factor A isoform X1 [KO:K16859]
124882413  [KO:K02833]
124882425  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
124882460  thbs1b; thrombospondin-1 isoform X1 [KO:K16857]
124882697  [KO:K07836]
124882706  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
124882879  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
124883008  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
124883025  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
124883086  lamb1b; laminin subunit beta-1b [KO:K05636]
124883234  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
124883537  pdgfd; platelet-derived growth factor D [KO:K05450]
124883753  arhgap35a; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
124883780  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
124883803  [KO:K06272] [EC:2.7.11.1]
124883810  [KO:K05699]
124883894  tln2b; talin-2 [KO:K06271]
124883970  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
124884016  parvb; beta-parvin isoform X1 [KO:K06275]
124884060  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
124884098  crk; adapter molecule crk [KO:K04438]
124884243  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124884274  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
124884569  vtna; vitronectin a [KO:K06251]
124884727  col4a4; collagen alpha-4(IV) chain [KO:K06237]
124884751  col4a3; collagen alpha-5(IV) chain [KO:K06237]
124884926  parvaa; parvin, alpha a [KO:K06275]
124885009  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
124885065  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
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J Cell Sci 115:3729-38 (2002)
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Nat Rev Mol Cell Biol 6:56-68 (2005)
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Curr Opin Cell Biol 15:565-71 (2003)
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Curr Opin Genet Dev 14:92-101 (2004)
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Cell Signal 14:381-95 (2002)
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Nat Cell Biol 2:E231-6 (2000)
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Related
pathway
gmu04010  MAPK signaling pathway
gmu04060  Cytokine-cytokine receptor interaction
gmu04070  Phosphatidylinositol signaling system
gmu04110  Cell cycle
gmu04310  Wnt signaling pathway
gmu04512  ECM-receptor interaction
gmu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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