KEGG   PATHWAY: gvr05022
Entry
gvr05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Galeopterus variegatus (Sunda flying lemur)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
gvr05022  Pathways of neurodegeneration - multiple diseases
gvr05022

Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103604174  APP; amyloid beta A4 protein [KO:K04520]
103598652  MAPT; microtubule-associated protein tau [KO:K04380]
103595843  SNCA; alpha-synuclein [KO:K04528]
103599994  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
103610076  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
103585524  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
103595596  ATXN2L; ataxin-2-like protein [KO:K23625]
103594719  HTT; huntingtin isoform X1 [KO:K04533]
103610856  LOW QUALITY PROTEIN: ataxin-1-like [KO:K23616]
103597208  ATXN1L; ataxin-1-like [KO:K23616]
103587971  ATXN1; ataxin-1 [KO:K23616]
103594735  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
103595532  PRNP; major prion protein [KO:K05634]
103591105  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103586690  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103584462  muscarinic acetylcholine receptor M5 [KO:K04133]
103597458  muscarinic acetylcholine receptor M5-like [KO:K04133]
103595563  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
103592255  metabotropic glutamate receptor 1 [KO:K04603]
103600566  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
103587098  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103588545  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
103596484  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
103591300  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
103586228  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103606378  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103606318  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103599847  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103592574  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103583388  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103599669  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103603474  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
103605689  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
103598637  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103597698  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103591479  RYR1; ryanodine receptor 1 [KO:K04961]
103587713  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
103599866  RYR3; ryanodine receptor 3 [KO:K04963]
103593246  PDYN; proenkephalin-B [KO:K15840]
103591442  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
103593496  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
103590387  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
103592420  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
103603698  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
103587773  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
103602798  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
103606746  GRIA2; glutamate receptor 2 [KO:K05198]
103591966  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
103606234  glutamate receptor 4 [KO:K05200]
103604574  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
103595029  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103603077  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
103602700  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
103597229  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103596644  STX1A; syntaxin-1A [KO:K04560]
103585251  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
103588685  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
103595592  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
103587272  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
103599728  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
103600283  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
103596037  DERL1; derlin-1 [KO:K11519]
103598423  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
103606030  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
103595441  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
103588961  UBB; polyubiquitin-B [KO:K04551]
103591776  UBC; polyubiquitin-C [KO:K08770]
103591424  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
103604862  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
103591960  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
103588756  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
103609600  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
103585508  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
103594622  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
103601265  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
103588417  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
103586708  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
103597027  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
103601030  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
103585564  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
103584968  LOW QUALITY PROTEIN: proteasome subunit beta type-1-like [KO:K02732] [EC:3.4.25.1]
103606963  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
103592437  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
103607775  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
103581897  26S protease regulatory subunit 4 [KO:K03062]
103598284  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
103585849  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
103600918  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
103595639  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
103593906  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
103603276  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
103598092  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
103606161  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
103585486  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
103589195  PSMD11; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
103582372  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
103586594  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
103602154  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
103600035  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
103590837  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
103593233  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14-like [KO:K03030]
103591476  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
103588763  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
103585547  SHFM1; 26S proteasome complex subunit DSS1 [KO:K10881]
103587125  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
103608787  LOW QUALITY PROTEIN: ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
103592331  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
103589542  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
103598060  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
103592199  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
103592204  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
103605958  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
103594868  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
103586078  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
103599326  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
103587523  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
103601320  GPR37; prosaposin receptor GPR37 [KO:K04243]
103608381  SEPT5; septin-5 [KO:K04557]
103600871  SNCAIP; synphilin-1 [KO:K04558]
103588305  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
103582651  vesicle-associated membrane protein-associated protein B/C [KO:K10707]
103599776  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
103591149  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
103594198  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
103588209  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
103603263  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103610047  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103610988  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103591967  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103596394  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103582610  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
103603521  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103585627  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103606635  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103598580  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103601352  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
103593352  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103599295  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103606824  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
103606177  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
804978  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
804979  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
804971  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
804968  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
804972  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
804980  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
804970  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103597995  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
103605247  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
103607466  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
103581319  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
103605455  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
103601439  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103606874  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
103596097  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
103592075  NDUFA4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 [KO:K03948]
103588939  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
103591833  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103599762  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
103589935  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
103593617  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
103609893  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
103586913  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
103602496  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
103603478  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103588127  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
103594734  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
103596179  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
103606578  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103596263  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103584460  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
103586777  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
103603406  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
103585144  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
103595679  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
103583202  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
103597760  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
103592332  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
103607103  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
103596554  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
103600926  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
103597123  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
103597330  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
103584995  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103598152  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
103586711  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
103597992  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
103592478  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
103608283  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
103585136  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
103595526  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
103598851  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
103594389  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
103600935  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
804976  CYTB; cytochrome b [KO:K00412]
103589664  cytochrome c1, heme protein, mitochondrial [KO:K00413]
103584920  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
103603703  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
103585471  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
103586941  cytochrome b-c1 complex subunit 7 [KO:K00417]
103589608  cytochrome b-c1 complex subunit 8 [KO:K00418]
103592711  cytochrome b-c1 complex subunit 9 [KO:K00419]
103606023  cytochrome b-c1 complex subunit 10 [KO:K00420]
804977  COX3; cytochrome c oxidase subunit III [KO:K02262]
804975  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
804969  COX2; cytochrome c oxidase subunit II [KO:K02261]
103586635  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
103594089  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
103603975  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103586621  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
103587800  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
103601446  cytochrome c oxidase subunit 6B1 [KO:K02267]
103606739  cytochrome c oxidase subunit 6B2 [KO:K02267]
103587990  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
103591773  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103592799  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
103593735  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103609950  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103610882  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
103590559  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
103592680  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
103600619  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
103586725  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
103608876  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
804974  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103589884  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
103605536  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
103593064  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
103587444  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
103585162  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
103589048  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
103604170  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
804973  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103606686  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103592400  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103601574  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
103596548  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
103607297  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
103601309  calmodulin-like protein 3 [KO:K02183]
103601310  CALML5; calmodulin-like protein 5 [KO:K02183]
103588449  CALM1; calmodulin [KO:K02183]
103601992  calmodulin-like [KO:K02183]
103591330  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
103592983  CALM3; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
103599723  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
103591114  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
103598106  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103598210  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103604521  PPP3R2; calcineurin subunit B type 2 isoform X1 [KO:K06268]
103586204  BAD; bcl2 antagonist of cell death [KO:K02158]
103605950  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103607184  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103605154  FADD; FAS-associated death domain protein [KO:K02373]
103597790  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103594881  BID; BH3-interacting domain death agonist [KO:K04726]
103587762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103599851  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103586022  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
103593845  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
103595035  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
103605434  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
103589264  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103602232  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103589291  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103597742  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
103586826  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
103607906  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
103610678  cytochrome c, somatic [KO:K08738]
103590229  cytochrome c, somatic-like [KO:K08738]
103590490  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
103590595  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103589530  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103596761  HIP1; huntingtin-interacting protein 1 [KO:K04559]
103604214  IFT57; intraflagellar transport protein 57 homolog isoform X1 [KO:K04638]
103592126  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
103601972  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
103609572  PARK7; protein DJ-1 [KO:K05687] [EC:3.5.1.124]
103594063  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103586785  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
103605139  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
103603348  OPTN; optineurin isoform X1 [KO:K19946]
103600669  SQSTM1; sequestosome-1 [KO:K14381]
103581725  LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
103589305  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
103598197  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
103590122  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103590836  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
103595657  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
103585298  SMCR8; smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
103588267  protein C9orf72 homolog isoform X1 [KO:K23609]
103603072  RAB8A; ras-related protein Rab-8A [KO:K07901]
103606483  RAB39B; ras-related protein Rab-39B [KO:K07925]
103608983  RAB1A; ras-related protein Rab-1A [KO:K07874]
103601062  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
103592037  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
103585223  ATG101; autophagy-related protein 101 [KO:K19730]
103603378  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
103607123  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
103603380  activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
103594994  beclin-2-like [KO:K08334]
103582423  LOW QUALITY PROTEIN: beclin-1-like [KO:K08334]
103589852  BECN1; beclin-1 isoform X1 [KO:K08334]
103589918  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
103593656  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
103587985  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
103582433  nuclear receptor-binding factor 2-like [KO:K21246]
103603652  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103596358  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
103605887  ATG2B; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog B [KO:K17906]
103591875  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
103587817  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
103599887  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
103601878  ALS2; alsin [KO:K04575]
103599706  RAB5A; ras-related protein Rab-5A [KO:K07887]
103594082  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103590181  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
103602959  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
103601961  SPG11; spatacsin [KO:K19026]
103592383  TNF; tumor necrosis factor [KO:K03156]
103605365  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103605089  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
103597950  DAXX; death domain-associated protein 6 [KO:K02308]
103599172  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103583282  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103607428  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103607442  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587477  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587478  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103593457  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
103595565  CCS; copper chaperone for superoxide dismutase [KO:K04569]
103601261  GPX2; LOW QUALITY PROTEIN: glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
103595284  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
103610387  GPX8; probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
103583108  LOW QUALITY PROTEIN: glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
103584312  glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
103584947  GPX1; LOW QUALITY PROTEIN: glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
103597834  GPX5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
103606472  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
103599945  GPX3; LOW QUALITY PROTEIN: glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
103581443  CAT; catalase [KO:K03781] [EC:1.11.1.6]
103599044  PRPH; peripherin [KO:K07607]
103604829  NEFL; neurofilament light polypeptide [KO:K04572]
103604830  NEFM; neurofilament medium polypeptide [KO:K04573]
103594204  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
103599398  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
103586730  KIF5B; kinesin-1 heavy chain [KO:K10396]
103602712  KLC2; kinesin light chain 2 [KO:K10407]
103585745  KLC4; kinesin light chain 4 [KO:K10407]
103606913  KLC3; kinesin light chain 3 [KO:K10407]
103593490  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
103594311  TUBA3E; LOW QUALITY PROTEIN: tubulin alpha-3E chain [KO:K07374]
103594858  TUBA8; tubulin alpha-8 chain [KO:K07374]
103588844  tubulin alpha-1B chain [KO:K07374]
103581279  tubulin alpha-3 chain [KO:K07374]
103602901  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
103602998  tubulin alpha-4A chain [KO:K07374]
103603000  tubulin alpha-1D chain-like [KO:K07374]
103598672  tubulin alpha-1C chain [KO:K07374]
103608962  TUBB1; tubulin beta-1 chain [KO:K07375]
103581838  tubulin beta-3 chain [KO:K07375]
103604454  tubulin beta-1 chain-like [KO:K07375]
103598173  TUBB6; tubulin beta-6 chain [KO:K07375]
103592552  TUBB; tubulin beta chain [KO:K07375]
103592926  TUBB4A; tubulin beta-4A chain [KO:K07375]
103593487  tubulin beta chain [KO:K07375]
103595392  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103592292  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
103593132  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
103592372  CSNK2B; casein kinase II subunit beta [KO:K03115]
103599960  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103593860  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
103594203  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
103605687  DCTN3; dynactin subunit 3 [KO:K10425]
103602778  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
103586914  DCTN5; dynactin subunit 5 [KO:K10427]
103591173  DCTN6; dynactin subunit 6 [KO:K10428]
103588105  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
103586622  ACTR1B; beta-centractin [KO:K16575]
103601264  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
103589182  HAP1; huntingtin-associated protein 1 [KO:K04647]
103581462  DNAH7; LOW QUALITY PROTEIN: dynein heavy chain 7, axonemal [KO:K10408]
103595965  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
103602911  dynein heavy chain 12, axonemal-like [KO:K10408]
103590354  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
103591028  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
103591255  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
103585950  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
103586692  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
103606781  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
103593651  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
103587583  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
103602808  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
103583468  axonemal dynein light intermediate polypeptide 1-like [KO:K10410]
103606452  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
103601921  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
103599843  DNAL1; dynein light chain 1, axonemal [KO:K10411]
103585797  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
103585816  dynein light chain 4, axonemal-like [KO:K10412]
103595135  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
103583890  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
103585039  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
103592962  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
103609904  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
103607537  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
103589194  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
103585103  CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
103589128  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
103588329  DKK2; dickkopf-related protein 2 [KO:K02165]
103608849  DKK1; dickkopf-related protein 1 [KO:K02165]
103589273  DKK4; LOW QUALITY PROTEIN: dickkopf-related protein 4 [KO:K02165]
103588854  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103597215  WNT2; protein Wnt-2 [KO:K00182]
103593776  WNT2B; protein Wnt-2b [KO:K00182]
103597574  WNT3; proto-oncogene Wnt-3 [KO:K00312]
103605695  protein Wnt-3a [KO:K00312]
103598980  protein Wnt-4 [KO:K00408]
103590234  WNT5B; protein Wnt-5b [KO:K00444]
103597246  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
103600246  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
103609951  WNT7B; protein Wnt-7b [KO:K00572]
103590674  WNT7A; protein Wnt-7a [KO:K00572]
103588804  WNT8B; protein Wnt-8b [KO:K00714]
103605402  WNT8A; protein Wnt-8a [KO:K00714]
103597576  WNT9B; protein Wnt-9b [KO:K01064]
103605697  WNT9A; protein Wnt-9a [KO:K01064]
103607489  protein Wnt-9b-like [KO:K01064]
103588855  WNT10B; protein Wnt-10b [KO:K01357]
103600247  WNT10A; protein Wnt-10a [KO:K01357]
103590450  WNT11; protein Wnt-11 [KO:K01384]
103605007  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
103596055  FZD1; frizzled-1 [KO:K02432]
103597620  FZD7; LOW QUALITY PROTEIN: frizzled-7 [KO:K02432]
103595017  FZD2; frizzled-2 [KO:K02235]
103604077  FZD3; frizzled-3 [KO:K02329]
103590315  FZD4; frizzled-4 [KO:K02354]
103586698  FZD5; frizzled-5 [KO:K02375]
103594788  FZD6; frizzled-6 [KO:K02376]
103596654  FZD9; frizzled-9 [KO:K02842]
103596735  FZD10; frizzled-10 [KO:K02842]
103588008  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
103594136  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
103585809  CSNK1E; casein kinase I isoform epsilon isoform X1 [KO:K08960] [EC:2.7.11.1]
103594862  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
103591440  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
103593898  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
103590897  FRAT1; proto-oncogene FRAT1 [KO:K03069]
103590898  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
103604797  AXIN1; axin-1 isoform X1 [KO:K02157]
103597471  AXIN2; axin-2 isoform X1 [KO:K04385]
103608971  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
103586841  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103600945  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103597115  CSNK1A1; casein kinase I isoform alpha isoform X1 [KO:K08957] [EC:2.7.11.1]
103603632  AGER; LOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor [KO:K19722]
103583660  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
103610513  HRAS; GTPase HRas isoform X1 [KO:K02833]
103599501  KRAS; GTPase KRas [KO:K07827]
103589329  NRAS; GTPase NRas [KO:K07828]
103594183  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
103596180  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103590618  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103596129  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103600170  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103602394  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
103593579  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
103594290  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
103595334  RELA; transcription factor p65 [KO:K04735]
103597025  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103604568  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
103592767  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103585928  IL6; interleukin-6 [KO:K05405]
103595826  IL1A; interleukin-1 alpha [KO:K04383]
103595825  IL1B; interleukin-1 beta [KO:K04519]
103585638  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
PMID:28279350
  Authors
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:32204380
  Authors
Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
  Title
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases.
  Journal
Int J Mol Sci 21:E2108 (2020)
DOI:10.3390/ijms21062108
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:27873462
  Authors
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
  Journal
J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
Reference
PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
gvr00190  Oxidative phosphorylation
gvr03050  Proteasome
gvr04020  Calcium signaling pathway
gvr04120  Ubiquitin mediated proteolysis
gvr04137  Mitophagy - animal
gvr04140  Autophagy - animal
gvr04141  Protein processing in endoplasmic reticulum
gvr04142  Lysosome
gvr04210  Apoptosis
gvr04310  Wnt signaling pathway
gvr04724  Glutamatergic synapse
gvr04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

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