KEGG   PATHWAY: mjv05205
Entry
mjv05205                    Pathway                                
Name
Proteoglycans in cancer - Manis javanica (Malayan pangolin)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
mjv05205  Proteoglycans in cancer
mjv05205

Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108408433  CD44; CD44 antigen isoform X1 [KO:K06256]
108401592  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108407295  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
108390012  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108388194  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108401794  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108394631  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
118967667  GTPase HRas-like isoform X1 [KO:K02833]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108398047  NRAS; GTPase NRas [KO:K07828]
108400295  RRAS; ras-related protein R-Ras [KO:K07829]
108393784  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
108406677  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108387830  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108394305  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108398550  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108403848  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108401876  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
108405771  ESR1; estrogen receptor [KO:K08550]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108399416  ACTB; actin, cytoplasmic 1 [KO:K05692]
108409874  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108387997  FLNA; filamin-A isoform X2 [KO:K04437]
118967041  filamin-A isoform X1 [KO:K04437]
108384279  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108387898  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
108393666  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
108383250  transforming protein RhoA [KO:K04513]
108391302  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.1]
108409101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
108383769  ANK2; ankyrin-2 isoform X1 [KO:K09255]
108384203  ANK3; ankyrin-3 isoform X6 [KO:K09259]
108409341  GAB1; GRB2-associated-binding protein 1 isoform X6 [KO:K09593]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108395975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108383513  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
108407321  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108393155  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
108400557  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
108408094  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
108396329  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X3 [KO:K17457]
108396063  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
108393532  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108395952  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108403293  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
108402938  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
108385398  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108394027  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
108398760  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108400883  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
108392209  NANOG; homeobox protein NANOG [KO:K10164]
108390226  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
108386293  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
108386068  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108407243  TWIST2; twist-related protein 2 [KO:K09069]
118973047  TWIST1; twist-related protein 1 [KO:K09069]
108406554  homeobox protein Hox-D10 [KO:K09295]
118972801  homeobox protein Hox-D10 [KO:K09295]
108391667  DCN; decorin [KO:K04660]
108410340  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
108403280  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108390746  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108399811  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
108393161  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
108401175  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
108402987  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
108400412  RPS6; 40S ribosomal protein S6 [KO:K02991]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108399323  CAV1; caveolin-1 isoform X1 [KO:K06278]
108399324  CAV2; caveolin-2 isoform X1 [KO:K12958]
118973391  caveolin-2-like [KO:K12958]
108401772  CAV3; caveolin-3 [KO:K12959]
108395927  CD63; CD63 antigen [KO:K06497]
108385913  cyclin-dependent kinase inhibitor 1 [KO:K06625]
118970122  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
108389793  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
108383720  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
108390634  TLR2; toll-like receptor 2 [KO:K10159]
108400680  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108390280  PDCD4; programmed cell death protein 4 isoform X1 [KO:K16865]
108397877  TNF; tumor necrosis factor [KO:K03156]
108409190  IL12B; interleukin-12 subunit beta [KO:K05425]
108398133  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
108400921  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
108399996  MYC; myc proto-oncogene protein [KO:K04377]
108387548  CTNNB1; catenin beta-1 [KO:K02105]
108404522  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
108406466  TFAP4; transcription factor AP-4 isoform X2 [KO:K09108]
108407135  VEGFA; vascular endothelial growth factor A [KO:K05448]
108400781  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108399322  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108409307  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
108392201  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
108400147  THBS1; thrombospondin-1 [KO:K16857]
108387896  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
108392902  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
108391666  LUM; lumican [KO:K08122]
108401438  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108394490  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108404266  TP53; cellular tumor antigen p53 [KO:K04451]
118974052  cellular tumor antigen p53 [KO:K04451]
108403151  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
108400736  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
108394108  HPSE; heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
108385480  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
108398766  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
108408859  PLAUR; urokinase plasminogen activator surface receptor isoform X3 [KO:K03985]
108398405  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
108385124  COL1A1; collagen alpha-1(I) chain [KO:K06236]
108386296  ITGA2; integrin alpha-2 [KO:K06481]
108397161  integrin beta-1 isoform X1 [KO:K05719]
118970953  integrin beta-1-like [KO:K05719]
108396937  VTN; vitronectin [KO:K06251]
108396573  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108401068  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108407058  FN1; fibronectin isoform X1 [KO:K05717]
108410150  ITGB5; integrin beta-5 [KO:K06588]
108399212  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108383443  WNT1; proto-oncogene Wnt-1 [KO:K03209]
108386027  FZD7; frizzled-7 [KO:K02432]
108384294  frizzled-1 [KO:K02432]
118972654  frizzled-1 [KO:K02432]
108403667  FZD2; frizzled-2 [KO:K02235]
108406043  FZD3; frizzled-3 [KO:K02329]
108395112  FZD4; frizzled-4 [KO:K02354]
108395847  FZD5; frizzled-5 [KO:K02375]
108397709  FZD8; frizzled-8 [KO:K02375]
108386613  FZD6; frizzled-6 isoform X3 [KO:K02376]
108397276  FZD9; frizzled-9 [KO:K02842]
108399714  FZD10; frizzled-10 [KO:K02842]
108408507  ITGA5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
108395517  SDC2; syndecan-2 isoform X3 [KO:K16336]
108392602  EZR; ezrin [KO:K08007]
108407034  RDX; radixin isoform X1 [KO:K05762]
108404241  radixin-like [KO:K05762]
108390646  MSN; moesin isoform X1 [KO:K05763]
108384925  SDC4; syndecan-4 [KO:K16338]
118970218  syndecan-4-like [KO:K16338]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108405521  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
108405695  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
108391894  SOS2; son of sevenless homolog 2 [KO:K03099]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108407248  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108400464  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108387768  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108395733  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108386874  NUDT16L1; tudor-interacting repair regulator protein [KO:K16867]
118971740  tudor-interacting repair regulator protein-like [KO:K16867]
108397691  PXN; paxillin isoform X1 [KO:K05760]
108394624  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
108392132  HBEGF; proheparin-binding EGF-like growth factor [KO:K08523]
108383842  GPC1; glypican-1 isoform X1 [KO:K08107]
108402612  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
108396072  GPC3; glypican-3 [KO:K08109]
108393959  WNT2; protein Wnt-2 [KO:K00182]
108398947  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
108388938  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
108398816  WNT3A; protein Wnt-3a [KO:K00312]
108391532  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
108397016  WNT5B; protein Wnt-5b isoform X3 [KO:K00444]
108403168  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
108390505  WNT6; protein Wnt-6 [KO:K00445]
108404182  WNT7A; protein Wnt-7a isoform X2 [KO:K00572]
108410319  WNT8A; protein Wnt-8a [KO:K00714]
108409584  WNT8B; protein Wnt-8b [KO:K00714]
108398815  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
108388856  WNT9B; protein Wnt-9b [KO:K01064]
108390506  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
108383428  WNT10B; protein Wnt-10b [KO:K01357]
108405770  WNT11; protein Wnt-11 [KO:K01384]
108406833  WNT16; protein Wnt-16 [KO:K01558]
108406980  SHH; sonic hedgehog protein [KO:K11988]
108392422  IHH; indian hedgehog protein [KO:K11989]
108383415  PTCH1; protein patched homolog 1 isoform X3 [KO:K06225]
108409883  SMO; smoothened homolog isoform X1 [KO:K06226]
108391519  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
108404831  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
108404832  cathepsin L1-like isoform X2 [KO:K01365] [EC:3.4.22.15]
108398556  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
118967047  CTSV; cathepsin L2 isoform X1 [KO:K01365] [EC:3.4.22.15]
108388261  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108395598  MAPK12; mitogen-activated protein kinase 12 isoform X9 [KO:K04441] [EC:2.7.11.24]
108394635  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
108394636  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108396504  HSPB2; heat shock protein beta-2 [KO:K09543]
108384835  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X3 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
mjv04010  MAPK signaling pathway
mjv04020  Calcium signaling pathway
mjv04066  HIF-1 signaling pathway
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04310  Wnt signaling pathway
mjv04340  Hedgehog signaling pathway
mjv04350  TGF-beta signaling pathway
mjv04370  VEGF signaling pathway
mjv04510  Focal adhesion
mjv04520  Adherens junction
mjv04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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