KEGG   PATHWAY: morg05171
Entry
morg05171                   Pathway                                
Name
Coronavirus disease - COVID-19 - Microtus oregoni (creeping vole)
Description
Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by  interleukin-6 (IL-6) production. SARS-CoV-2 also activates the innate immune system; macrophage stimulation triggers the overproduction of pro-inflammatory cytokines, including IL-6, and the "cytokine storm", which results in systemic inflammatory response syndrome and multiple organ failure. The combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19.
Class
Human Diseases; Infectious disease: viral
Pathway map
morg05171  Coronavirus disease - COVID-19
morg05171

Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121461865  Tmprss2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
121439480  Ace2; angiotensin-converting enzyme 2 [KO:K09708] [EC:3.4.17.23]
121446972  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
121436287  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
121436320  Ace; LOW QUALITY PROTEIN: angiotensin-converting enzyme [KO:K01283] [EC:3.4.15.1]
121466509  Mas1; proto-oncogene Mas [KO:K04303]
121452947  Agtr1; type-1 angiotensin II receptor [KO:K04166]
121433907  type-1A angiotensin II receptor [KO:K04166]
121442574  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
121442637  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
121450269  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121454688  Rela; transcription factor p65 isoform X1 [KO:K04735]
121435312  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
121439902  Il6; interleukin-6 [KO:K05405]
121460531  Il1b; interleukin-1 beta [KO:K04519]
121452968  Il12a; interleukin-12 subunit alpha [KO:K05406]
121464009  Il12b; interleukin-12 subunit beta [KO:K05425]
121451850  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
121451946  interstitial collagenase A-like [KO:K01388] [EC:3.4.24.7]
121456609  C-C motif chemokine 2-like isoform X1 [KO:K14624]
121456831  C-C motif chemokine 12-like [KO:K14624]
121456969  C-C motif chemokine 12-like [KO:K14624]
121438902  disintegrin and metalloproteinase domain-containing protein 17-like isoform X1 [KO:K06059] [EC:3.4.24.86]
121432399  Adam17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
121435813  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121452602  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
121449504  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
121453319  proheparin-binding EGF-like growth factor [KO:K08523]
121442923  proheparin-binding EGF-like growth factor [KO:K08523]
121459895  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
121451024  Il6r; interleukin-6 receptor subunit alpha [KO:K05055]
121455663  Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
121448662  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121451603  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
121442318  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
121452714  Il2; interleukin-2 [KO:K05429]
121457180  granulocyte colony-stimulating factor-like isoform X1 [KO:K05423]
121442512  granulocyte colony-stimulating factor-like isoform X1 [KO:K05423]
121456106  Csf2; granulocyte-macrophage colony-stimulating factor isoform X1 [KO:K05427]
121460878  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
121455108  40S ribosomal protein S2-like [KO:K02981]
121461725  40S ribosomal protein S2-like [KO:K02981]
121455854  40S ribosomal protein S2-like [KO:K02981]
121463777  40S ribosomal protein S2-like [KO:K02981]
121463795  Rps2; 40S ribosomal protein S2 [KO:K02981]
121438883  40S ribosomal protein S2-like [KO:K02981]
121432298  40S ribosomal protein S2-like [KO:K02981]
121432696  40S ribosomal protein S2-like [KO:K02981]
121432697  40S ribosomal protein S2-like [KO:K02981]
121433153  40S ribosomal protein S2-like [KO:K02981]
121435553  40S ribosomal protein S2-like [KO:K02981]
121452175  40S ribosomal protein S3 [KO:K02985]
121459093  40S ribosomal protein S3 [KO:K02985]
121449505  40S ribosomal protein S3-like [KO:K02985]
121455381  40S ribosomal protein S3a-like [KO:K02984]
121452849  Rps3a; 40S ribosomal protein S3a [KO:K02984]
121466336  40S ribosomal protein S3a-like [KO:K02984]
121445375  40S ribosomal protein S3a-like [KO:K02984]
121443310  40S ribosomal protein S3a-like [KO:K02984]
121458964  40S ribosomal protein S4, X isoform-like [KO:K02987]
121453385  40S ribosomal protein S4, X isoform-like [KO:K02987]
121451703  40S ribosomal protein S4-like [KO:K02987]
121445192  40S ribosomal protein S4, X isoform [KO:K02987]
121442555  40S ribosomal protein S4, X isoform-like [KO:K02987]
121442887  40S ribosomal protein S4 [KO:K02987]
121449396  Rps5; 40S ribosomal protein S5 [KO:K02989]
121454447  40S ribosomal protein S6-like [KO:K02991]
121455927  40S ribosomal protein S6-like [KO:K02991]
121455946  40S ribosomal protein S6-like [KO:K02991]
121452391  40S ribosomal protein S6-like [KO:K02991]
121440057  40S ribosomal protein S6-like [KO:K02991]
121441148  40S ribosomal protein S6-like [KO:K02991]
121448763  Rps6; 40S ribosomal protein S6 [KO:K02991]
121463059  40S ribosomal protein S7-like [KO:K02993]
121432392  Rps7; 40S ribosomal protein S7 [KO:K02993]
121448500  40S ribosomal protein S7-like [KO:K02993]
121441772  40S ribosomal protein S7-like [KO:K02993]
121461220  40S ribosomal protein S8-like [KO:K02995]
121463903  40S ribosomal protein S8-like [KO:K02995]
121439931  40S ribosomal protein S8-like [KO:K02995]
121448169  Rps8; 40S ribosomal protein S8 [KO:K02995]
121435116  40S ribosomal protein S8-like [KO:K02995]
121446828  40S ribosomal protein S9-like [KO:K02997]
121450171  Rps9; 40S ribosomal protein S9 [KO:K02997]
121458427  40S ribosomal protein S10 [KO:K02947]
121438923  40S ribosomal protein S10-like [KO:K02947]
121441818  40S ribosomal protein S10-like [KO:K02947]
121448749  40S ribosomal protein S10-like [KO:K02947]
121435448  Rps10; 40S ribosomal protein S10 [KO:K02947]
121434312  40S ribosomal protein S10-like [KO:K02947]
121465311  40S ribosomal protein S11-like [KO:K02949]
121444501  40S ribosomal protein S11-like isoform X1 [KO:K02949]
121446552  40S ribosomal protein S11-like [KO:K02949]
121449602  40S ribosomal protein S11-like [KO:K02949]
121450071  Rps11; 40S ribosomal protein S11 [KO:K02949]
121455592  40S ribosomal protein S12-like [KO:K02951]
121456302  40S ribosomal protein S12-like [KO:K02951]
121449495  Rps12; 40S ribosomal protein S12 [KO:K02951]
121460789  40S ribosomal protein S13-like [KO:K02953]
121457657  Rps13; 40S ribosomal protein S13 [KO:K02953]
121457930  40S ribosomal protein S13-like [KO:K02953]
121458212  40S ribosomal protein S13-like [KO:K02953]
121453411  40S ribosomal protein S13-like [KO:K02953]
121453625  40S ribosomal protein S13-like [KO:K02953]
121443907  40S ribosomal protein S13-like [KO:K02953]
121444909  40S ribosomal protein S13-like [KO:K02953]
121443489  40S ribosomal protein S13-like [KO:K02953]
121464560  40S ribosomal protein S14-like [KO:K02955]
121445239  40S ribosomal protein S14 [KO:K02955]
121447475  40S ribosomal protein S14-like [KO:K02955]
121440640  Rps14; 40S ribosomal protein S14 [KO:K02955]
121440995  40S ribosomal protein S14-like [KO:K02955]
121459681  Rps15; 40S ribosomal protein S15 [KO:K02958]
121466208  40S ribosomal protein S15-like [KO:K02958]
121436166  40S ribosomal protein S15-like [KO:K02958]
121437698  40S ribosomal protein S15-like [KO:K02958]
121448751  40S ribosomal protein S15-like [KO:K02958]
121460761  40S ribosomal protein S15a [KO:K02957]
121462394  40S ribosomal protein S15a-like [KO:K02957]
121457328  Rps15a; 40S ribosomal protein S15a [KO:K02957]
121465423  40S ribosomal protein S15a-like [KO:K02957]
121459385  40S ribosomal protein S15a-like [KO:K02957]
121437330  40S ribosomal protein S15a-like [KO:K02957]
121437453  40S ribosomal protein S15a-like [KO:K02957]
121439506  40S ribosomal protein S15a-like [KO:K02957]
121432575  40S ribosomal protein S15a-like [KO:K02957]
121447999  40S ribosomal protein S15a [KO:K02957]
121448695  40S ribosomal protein S15a-like [KO:K02957]
121460858  40S ribosomal protein S16-like [KO:K02960]
121464499  40S ribosomal protein S16-like [KO:K02960]
121449403  Rps16; 40S ribosomal protein S16 [KO:K02960]
121443362  40S ribosomal protein S16 [KO:K02960]
121438884  40S ribosomal protein S17-like [KO:K02962]
121432496  40S ribosomal protein S17-like [KO:K02962]
121446930  40S ribosomal protein S17-like [KO:K02962]
121433857  40S ribosomal protein S17-like [KO:K02962]
121449967  Rps17; 40S ribosomal protein S17 [KO:K02962]
121463490  40S ribosomal protein S18-like [KO:K02964]
121441049  40S ribosomal protein S18-like [KO:K02964]
121448717  40S ribosomal protein S18-like [KO:K02964]
121435325  Rps18; 40S ribosomal protein S18 [KO:K02964]
121458104  40S ribosomal protein S19-like [KO:K02966]
121466097  40S ribosomal protein S19-like isoform X1 [KO:K02966]
121466621  40S ribosomal protein S19-like [KO:K02966]
121450944  40S ribosomal protein S19-like [KO:K02966]
121438001  40S ribosomal protein S19 [KO:K02966]
121438706  40S ribosomal protein S19-like [KO:K02966]
121447614  40S ribosomal protein S19-like isoform X1 [KO:K02966]
121449663  40S ribosomal protein S19-like isoform X1 [KO:K02966]
121450125  Rps19; 40S ribosomal protein S19 [KO:K02966]
121462549  40S ribosomal protein S20-like [KO:K02969]
121451964  40S ribosomal protein S20-like [KO:K02969]
121452964  40S ribosomal protein S20 [KO:K02969]
121451745  Rps20; 40S ribosomal protein S20 [KO:K02969]
121434409  40S ribosomal protein S20 [KO:K02969]
121452487  40S ribosomal protein S21 [KO:K02971]
121436601  40S ribosomal protein S21-like [KO:K02971]
121446003  40S ribosomal protein S21 [KO:K02971]
121440876  Rps21; 40S ribosomal protein S21 [KO:K02971]
121460491  40S ribosomal protein S23-like [KO:K02973]
121455838  Rps23; 40S ribosomal protein S23 [KO:K02973]
121462014  40S ribosomal protein S23-like [KO:K02973]
121462398  40S ribosomal protein S23-like [KO:K02973]
121456765  40S ribosomal protein S23 [KO:K02973]
121451977  40S ribosomal protein S23-like [KO:K02973]
121465847  40S ribosomal protein S23-like [KO:K02973]
121453688  40S ribosomal protein S23-like [KO:K02973]
121444497  40S ribosomal protein S23-like [KO:K02973]
121450856  40S ribosomal protein S23-like [KO:K02973]
121439577  40S ribosomal protein S23-like [KO:K02973]
121439639  40S ribosomal protein S23-like [KO:K02973]
121439673  40S ribosomal protein S23-like [KO:K02973]
121432719  40S ribosomal protein S23-like [KO:K02973]
121432862  40S ribosomal protein S23-like [KO:K02973]
121432864  40S ribosomal protein S23-like [KO:K02973]
121455452  Rps24; 40S ribosomal protein S24 isoform X1 [KO:K02974]
121452868  40S ribosomal protein S24-like [KO:K02974]
121437338  40S ribosomal protein S24-like [KO:K02974]
121437538  40S ribosomal protein S24-like [KO:K02974]
121439093  40S ribosomal protein S24-like [KO:K02974]
121439274  40S ribosomal protein S24-like [KO:K02974]
121454615  40S ribosomal protein S24-like [KO:K02974]
121454935  40S ribosomal protein S25-like [KO:K02975]
121461601  40S ribosomal protein S25-like [KO:K02975]
121455634  40S ribosomal protein S25-like [KO:K02975]
121456131  40S ribosomal protein S25-like [KO:K02975]
121462691  40S ribosomal protein S25 [KO:K02975]
121456884  40S ribosomal protein S25 [KO:K02975]
121457071  40S ribosomal protein S25 [KO:K02975]
121453613  40S ribosomal protein S25-like [KO:K02975]
121437271  40S ribosomal protein S25-like [KO:K02975]
121445092  40S ribosomal protein S25-like [KO:K02975]
121437725  40S ribosomal protein S25-like [KO:K02975]
121438350  Rps25; 40S ribosomal protein S25 [KO:K02975]
121445778  40S ribosomal protein S25-like [KO:K02975]
121432358  40S ribosomal protein S25-like [KO:K02975]
121447851  40S ribosomal protein S25-like [KO:K02975]
121447854  40S ribosomal protein S25-like [KO:K02975]
121433464  40S ribosomal protein S25-like [KO:K02975]
121434288  40S ribosomal protein S25-like [KO:K02975]
121441352  40S ribosomal protein S25-like [KO:K02975]
121434908  40S ribosomal protein S25 [KO:K02975]
121448872  40S ribosomal protein S25-like [KO:K02975]
121442702  40S ribosomal protein S25-like [KO:K02975]
121443400  40S ribosomal protein S25-like [KO:K02975]
121434109  40S ribosomal protein S25-like [KO:K02975]
121460694  Rps26; 40S ribosomal protein S26 [KO:K02976]
121455348  40S ribosomal protein S26-like [KO:K02976]
121455967  40S ribosomal protein S26-like [KO:K02976]
121458677  40S ribosomal protein S26-like [KO:K02976]
121458682  40S ribosomal protein S26-like [KO:K02976]
121458691  40S ribosomal protein S26-like [KO:K02976]
121458696  40S ribosomal protein S26-like [KO:K02976]
121465088  40S ribosomal protein S26-like [KO:K02976]
121436587  40S ribosomal protein S26-like [KO:K02976]
121445091  40S ribosomal protein S26-like [KO:K02976]
121450974  40S ribosomal protein S26-like [KO:K02976]
121437633  40S ribosomal protein S26-like [KO:K02976]
121432579  40S ribosomal protein S26-like [KO:K02976]
121434657  40S ribosomal protein S26-like [KO:K02976]
121434661  40S ribosomal protein S26-like [KO:K02976]
121434683  40S ribosomal protein S26-like [KO:K02976]
121455153  40S ribosomal protein S27 [KO:K02978]
121461383  40S ribosomal protein S27-like [KO:K02978]
121462884  40S ribosomal protein S27-like [KO:K02978]
121463494  40S ribosomal protein S27-like [KO:K02978]
121463619  40S ribosomal protein S27-like [KO:K02978]
121464614  40S ribosomal protein S27-like [KO:K02978]
121452724  40S ribosomal protein S27-like [KO:K02978]
121453174  40S ribosomal protein S27-like [KO:K02978]
121466133  Rps27l; 40S ribosomal protein S27-like [KO:K02978]
121450796  Rps27; 40S ribosomal protein S27 [KO:K02978]
121450950  40S ribosomal protein S27-like [KO:K02978]
121445377  40S ribosomal protein S27-like [KO:K02978]
121446494  40S ribosomal protein S27-like [KO:K02978]
121432348  40S ribosomal protein S27-like [KO:K02978]
121433851  40S ribosomal protein S27-like [KO:K02978]
121434005  40S ribosomal protein S27-like [KO:K02978]
121435307  40S ribosomal protein S27-like [KO:K02978]
121449722  40S ribosomal protein S27-like [KO:K02978]
121455938  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121459610  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121445279  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121446349  ubiquitin-40S ribosomal protein S27a [KO:K02977]
121434872  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121441777  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121460960  40S ribosomal protein S28-like [KO:K02979]
121464143  40S ribosomal protein S28-like [KO:K02979]
121458705  40S ribosomal protein S28-like [KO:K02979]
121465133  40S ribosomal protein S28 [KO:K02979]
121459204  Rps28; 40S ribosomal protein S28 [KO:K02979]
121439110  40S ribosomal protein S28 [KO:K02979]
121434619  40S ribosomal protein S28-like [KO:K02979]
121454216  40S ribosomal protein S29-like [KO:K02980]
121455401  40S ribosomal protein S29 [KO:K02980]
121452425  Rps29; 40S ribosomal protein S29 [KO:K02980]
121453718  40S ribosomal protein S29-like [KO:K02980]
121444030  40S ribosomal protein S29-like [KO:K02980]
121437521  40S ribosomal protein S29-like [KO:K02980]
121449982  40S ribosomal protein S29 [KO:K02980]
121444937  40S ribosomal protein S29-like [KO:K02980]
121454485  Fau; ubiquitin-like protein fubi and ribosomal protein S30 [KO:K02983]
121462738  ubiquitin-like protein FUBI [KO:K02983]
121464539  Rpsa; 40S ribosomal protein SA [KO:K02998]
121458953  40S ribosomal protein SA-like [KO:K02998]
121441498  40S ribosomal protein SA-like [KO:K02998]
121450009  40S ribosomal protein SA-like [KO:K02998]
121461210  Rpl3; 60S ribosomal protein L3 [KO:K02925]
121463845  Rpl3l; 60S ribosomal protein L3-like [KO:K02925]
121464482  60S ribosomal protein L3 [KO:K02925]
121438082  60S ribosomal protein L3 [KO:K02925]
121438294  60S ribosomal protein L3-like [KO:K02925]
121432541  60S ribosomal protein L3-like [KO:K02925]
121452309  60S ribosomal protein L4-like [KO:K02930]
121466071  Rpl4; 60S ribosomal protein L4 [KO:K02930]
121434362  60S ribosomal protein L4-like [KO:K02930]
121438920  60S ribosomal protein L5-like [KO:K02932]
121433576  Rpl5; 60S ribosomal protein L5 isoform X1 [KO:K02932]
121448338  60S ribosomal protein L5-like [KO:K02932]
121461370  60S ribosomal protein L6-like [KO:K02934]
121455849  60S ribosomal protein L6-like [KO:K02934]
121462386  60S ribosomal protein L6-like [KO:K02934]
121462438  60S ribosomal protein L6-like [KO:K02934]
121458424  60S ribosomal protein L6-like [KO:K02934]
121465525  60S ribosomal protein L6-like [KO:K02934]
121465731  60S ribosomal protein L6-like [KO:K02934]
121466159  60S ribosomal protein L6-like [KO:K02934]
121444136  60S ribosomal protein L6-like [KO:K02934]
121444565  60S ribosomal protein L6-like [KO:K02934]
121437105  60S ribosomal protein L6-like [KO:K02934]
121437228  60S ribosomal protein L6-like [KO:K02934]
121437528  60S ribosomal protein L6 [KO:K02934]
121444663  60S ribosomal protein L6 [KO:K02934]
121450828  60S ribosomal protein L6-like [KO:K02934]
121445452  60S ribosomal protein L6-like [KO:K02934]
121445465  60S ribosomal protein L6-like [KO:K02934]
121445488  60S ribosomal protein L6-like [KO:K02934]
121445527  60S ribosomal protein L6-like [KO:K02934]
121445687  60S ribosomal protein L6 [KO:K02934]
121445768  60S ribosomal protein L6 [KO:K02934]
121446578  Rpl6; 60S ribosomal protein L6 isoform X1 [KO:K02934]
121440726  60S ribosomal protein L6-like [KO:K02934]
121441069  60S ribosomal protein L6-like [KO:K02934]
121441135  60S ribosomal protein L6-like [KO:K02934]
121434069  60S ribosomal protein L6-like [KO:K02934]
121434275  60S ribosomal protein L6-like [KO:K02934]
121442252  60S ribosomal protein L6-like [KO:K02934]
121442851  60S ribosomal protein L6-like [KO:K02934]
121454512  60S ribosomal protein L7-like [KO:K02937]
121458447  Rpl7; 60S ribosomal protein L7 [KO:K02937]
121438314  60S ribosomal protein L7-like [KO:K02937]
121454115  60S ribosomal protein L7a-like [KO:K02936]
121455294  60S ribosomal protein L7a-like [KO:K02936]
121462669  Rpl7a; 60S ribosomal protein L7a [KO:K02936]
121462873  60S ribosomal protein L7a [KO:K02936]
121462957  60S ribosomal protein L7a-like [KO:K02936]
121464178  60S ribosomal protein L7a-like [KO:K02936]
121458807  60S ribosomal protein L7a-like [KO:K02936]
121453049  60S ribosomal protein L7a [KO:K02936]
121465837  60S ribosomal protein L7a-like [KO:K02936]
121453412  60S ribosomal protein L7a [KO:K02936]
121443656  60S ribosomal protein L7a-like [KO:K02936]
121437844  60S ribosomal protein L7a-like [KO:K02936]
121438366  60S ribosomal protein L7a-like [KO:K02936]
121439040  60S ribosomal protein L7a-like [KO:K02936]
121439726  60S ribosomal protein L7a-like [KO:K02936]
121439747  60S ribosomal protein L7a-like [KO:K02936]
121432694  60S ribosomal protein L7a-like [KO:K02936]
121447249  60S ribosomal protein L7a-like [KO:K02936]
121440715  60S ribosomal protein L7a-like [KO:K02936]
121440990  60S ribosomal protein L7a-like [KO:K02936]
121441814  60S ribosomal protein L7a-like [KO:K02936]
121435878  60S ribosomal protein L7a-like [KO:K02936]
121461259  Rpl8; 60S ribosomal protein L8 [KO:K02938]
121465472  60S ribosomal protein L8-like [KO:K02938]
121460834  Rpl9; 60S ribosomal protein L9 [KO:K02940]
121461136  60S ribosomal protein L9-like [KO:K02940]
121459122  60S ribosomal protein L9-like [KO:K02940]
121453488  60S ribosomal protein L9-like [KO:K02940]
121451509  60S ribosomal protein L9-like [KO:K02940]
121434809  60S ribosomal protein L9-like [KO:K02940]
121452544  Rpl10l; 60S ribosomal protein L10-like isoform X1 [KO:K02866]
121437168  60S ribosomal protein L10-like [KO:K02866]
121440295  60S ribosomal protein L10 [KO:K02866]
121453678  60S ribosomal protein L10a-like [KO:K02865]
121445608  60S ribosomal protein L10a-like [KO:K02865]
121449032  60S ribosomal protein L10a-like [KO:K02865]
121435456  Rpl10a; 60S ribosomal protein L10a isoform X1 [KO:K02865]
121455265  60S ribosomal protein L11 [KO:K02868]
121453247  60S ribosomal protein L11-like [KO:K02868]
121432736  60S ribosomal protein L11-like [KO:K02868]
121448441  Rpl11; 60S ribosomal protein L11 [KO:K02868]
121448927  60S ribosomal protein L11-like [KO:K02868]
121460864  60S ribosomal protein L12 [KO:K02870]
121462590  Rpl12; 60S ribosomal protein L12 [KO:K02870]
121438916  60S ribosomal protein L12-like [KO:K02870]
121443404  60S ribosomal protein L12-like [KO:K02870]
121463031  60S ribosomal protein L13-like [KO:K02873]
121457743  60S ribosomal protein L13-like [KO:K02873]
121447183  Rpl13; 60S ribosomal protein L13 [KO:K02873]
121433015  60S ribosomal protein L13-like [KO:K02873]
121458077  60S ribosomal protein L13-like isoform X1 [KO:K02873]
121447405  Rpl13a; 60S ribosomal protein L13a [KO:K02872]
121464375  Rpl14; 60S ribosomal protein L14 [KO:K02875]
121453241  60S ribosomal protein L14-like [KO:K02875]
121445162  60S ribosomal protein L14-like [KO:K02875]
121454925  Rpl15; 60S ribosomal protein L15 [KO:K02877]
121462812  60S ribosomal protein L15-like [KO:K02877]
121462902  60S ribosomal protein L15-like [KO:K02877]
121463428  60S ribosomal protein L15 [KO:K02877]
121438841  60S ribosomal protein L15-like [KO:K02877]
121440613  60S ribosomal protein L15-like [KO:K02877]
121434147  60S ribosomal protein L15-like [KO:K02877]
121455256  60S ribosomal protein L17-like [KO:K02880]
121463455  60S ribosomal protein L17-like [KO:K02880]
121448560  60S ribosomal protein L17-like [KO:K02880]
121448625  60S ribosomal protein L17-like [KO:K02880]
121435604  60S ribosomal protein L17-like [KO:K02880]
121434382  60S ribosomal protein L17 [KO:K02880]
121438830  Rpl17; 60S ribosomal protein L17 [KO:K02880]
121441619  60S ribosomal protein L17 [KO:K02880]
121443626  60S ribosomal protein L17-like [KO:K02880]
121445198  60S ribosomal protein L17 [KO:K02880]
121453480  60S ribosomal protein L17-like [KO:K02880]
121454155  60S ribosomal protein L17 [KO:K02880]
121457445  Rpl18; 60S ribosomal protein L18 [KO:K02883]
121464265  60S ribosomal protein L18-like [KO:K02883]
121458993  60S ribosomal protein L18 [KO:K02883]
121432446  60S ribosomal protein L18-like [KO:K02883]
121433475  60S ribosomal protein L18-like [KO:K02883]
121462829  Rpl18a; 60S ribosomal protein L18a [KO:K02882]
121462983  60S ribosomal protein L18a-like [KO:K02882]
121458484  60S ribosomal protein L18a-like [KO:K02882]
121461834  60S ribosomal protein L19 [KO:K02885]
121456215  60S ribosomal protein L19 [KO:K02885]
121444557  60S ribosomal protein L19-like [KO:K02885]
121450784  60S ribosomal protein L19 [KO:K02885]
121438937  60S ribosomal protein L19 [KO:K02885]
121442317  60S ribosomal protein L19 [KO:K02885]
121435564  60S ribosomal protein L19-like [KO:K02885]
121453674  60S ribosomal protein L21-like [KO:K02889]
121445167  60S ribosomal protein L21-like [KO:K02889]
121452922  Rpl22l1; 60S ribosomal protein L22-like 1 [KO:K02891]
121453673  60S ribosomal protein L22-like [KO:K02891]
121445191  60S ribosomal protein L22-like [KO:K02891]
121448739  Rpl22; 60S ribosomal protein L22 [KO:K02891]
121448760  60S ribosomal protein L22-like [KO:K02891]
121442845  60S ribosomal protein L22-like [KO:K02891]
121444330  60S ribosomal protein L22-like 1 [KO:K02891]
121444397  60S ribosomal protein L22-like 1 [KO:K02891]
121462429  60S ribosomal protein L22-like 1 [KO:K02891]
121456632  Rpl23; 60S ribosomal protein L23 [KO:K02894]
121437328  60S ribosomal protein L23-like [KO:K02894]
121437456  60S ribosomal protein L23-like [KO:K02894]
121442089  60S ribosomal protein L23-like [KO:K02894]
121442427  60S ribosomal protein L23 [KO:K02894]
121460820  60S ribosomal protein L23a-like [KO:K02893]
121454559  60S ribosomal protein L23a-like [KO:K02893]
121455255  60S ribosomal protein L23a-like [KO:K02893]
121455438  60S ribosomal protein L23a-like [KO:K02893]
121455576  60S ribosomal protein L23a-like [KO:K02893]
121461819  60S ribosomal protein L23a-like [KO:K02893]
121456094  Rpl23a; 60S ribosomal protein L23a [KO:K02893]
121463380  60S ribosomal protein L23a-like isoform X1 [KO:K02893]
121451838  60S ribosomal protein L23a-like [KO:K02893]
121458545  60S ribosomal protein L23a-like [KO:K02893]
121465114  60S ribosomal protein L23a-like isoform X1 [KO:K02893]
121452356  60S ribosomal protein L23a-like [KO:K02893]
121465528  60S ribosomal protein L23a-like [KO:K02893]
121465607  60S ribosomal protein L23a-like [KO:K02893]
121460133  60S ribosomal protein L23a-like [KO:K02893]
121460358  60S ribosomal protein L23a-like [KO:K02893]
121443751  60S ribosomal protein L23a-like [KO:K02893]
121450466  60S ribosomal protein L23a-like [KO:K02893]
121436572  60S ribosomal protein L23a-like [KO:K02893]
121446110  60S ribosomal protein L23a [KO:K02893]
121438969  60S ribosomal protein L23a-like [KO:K02893]
121433254  60S ribosomal protein L23a-like [KO:K02893]
121441042  60S ribosomal protein L23a-like [KO:K02893]
121434692  60S ribosomal protein L23a-like [KO:K02893]
121434856  60S ribosomal protein L23a-like [KO:K02893]
121442804  60S ribosomal protein L23a-like [KO:K02893]
121443505  60S ribosomal protein L23a-like [KO:K02893]
121432833  60S ribosomal protein L23a-like [KO:K02893]
121434289  60S ribosomal protein L23a-like [KO:K02893]
121444025  60S ribosomal protein L23a-like [KO:K02893]
121451288  60S ribosomal protein L23a-like [KO:K02893]
121432564  60S ribosomal protein L23a-like [KO:K02893]
121460336  60S ribosomal protein L23a-like [KO:K02893]
121461831  Rpl24; 60S ribosomal protein L24 [KO:K02896]
121466116  Rsl24d1; probable ribosome biogenesis protein RLP24 [KO:K02896]
121451677  60S ribosomal protein L24-like [KO:K02896]
121445246  60S ribosomal protein L24-like [KO:K02896]
121432632  probable ribosome biogenesis protein RLP24 [KO:K02896]
121439859  60S ribosomal protein L24-like [KO:K02896]
121440678  60S ribosomal protein L24-like [KO:K02896]
121454474  60S ribosomal protein L26-like [KO:K02898]
121461110  60S ribosomal protein L26-like [KO:K02898]
121462407  60S ribosomal protein L26-like [KO:K02898]
121456591  Rpl26; 60S ribosomal protein L26 [KO:K02898]
121463256  60S ribosomal protein L26 [KO:K02898]
121464055  60S ribosomal protein L26-like [KO:K02898]
121451785  60S ribosomal protein L26 [KO:K02898]
121458426  60S ribosomal protein L26 [KO:K02898]
121453349  60S ribosomal protein L26-like [KO:K02898]
121459855  60S ribosomal protein L26-like [KO:K02898]
121466373  60S ribosomal protein L26 [KO:K02898]
121450846  60S ribosomal protein L26 [KO:K02898]
121451035  60S ribosomal protein L26-like 1 [KO:K02898]
121438693  60S ribosomal protein L26-like [KO:K02898]
121432454  60S ribosomal protein L26-like [KO:K02898]
121440156  60S ribosomal protein L26-like [KO:K02898]
121440837  60S ribosomal protein L26-like [KO:K02898]
121434114  60S ribosomal protein L26-like [KO:K02898]
121455943  60S ribosomal protein L27-like [KO:K02901]
121456899  60S ribosomal protein L27-like [KO:K02901]
121463851  60S ribosomal protein L27-like [KO:K02901]
121452744  60S ribosomal protein L27-like [KO:K02901]
121458971  60S ribosomal protein L27-like [KO:K02901]
121466548  60S ribosomal protein L27-like [KO:K02901]
121434730  60S ribosomal protein L27-like [KO:K02901]
121435110  60S ribosomal protein L27-like [KO:K02901]
121442450  Rpl27; 60S ribosomal protein L27 [KO:K02901]
121446489  60S ribosomal protein L27-like [KO:K02901]
121460942  60S ribosomal protein L27a-like [KO:K02900]
121461894  60S ribosomal protein L27a [KO:K02900]
121457088  60S ribosomal protein L27a-like [KO:K02900]
121457737  Rpl27a; 60S ribosomal protein L27a [KO:K02900]
121464030  60S ribosomal protein L27a-like [KO:K02900]
121464534  60S ribosomal protein L27a-like [KO:K02900]
121452186  60S ribosomal protein L27a-like [KO:K02900]
121460401  60S ribosomal protein L27a-like [KO:K02900]
121451081  60S ribosomal protein L27a-like [KO:K02900]
121438794  60S ribosomal protein L27a-like [KO:K02900]
121439043  60S ribosomal protein L27a-like [KO:K02900]
121432989  60S ribosomal protein L27a [KO:K02900]
121441614  60S ribosomal protein L27a-like [KO:K02900]
121448716  60S ribosomal protein L27a-like [KO:K02900]
121448762  60S ribosomal protein L27a-like [KO:K02900]
121435385  60S ribosomal protein L27a-like [KO:K02900]
121449783  60S ribosomal protein L27a-like [KO:K02900]
121435907  60S ribosomal protein L27a-like [KO:K02900]
121455347  60S ribosomal protein L28-like [KO:K02903]
121462954  60S ribosomal protein L28-like [KO:K02903]
121453230  60S ribosomal protein L28-like [KO:K02903]
121459857  60S ribosomal protein L28-like [KO:K02903]
121437346  60S ribosomal protein L28-like [KO:K02903]
121437554  60S ribosomal protein L28-like [KO:K02903]
121450928  60S ribosomal protein L28 [KO:K02903]
121442100  60S ribosomal protein L28-like [KO:K02903]
121449511  Rpl28; 60S ribosomal protein L28 [KO:K02903]
121449594  60S ribosomal protein L28 [KO:K02903]
121451899  60S ribosomal protein L28-like [KO:K02903]
121432783  60S ribosomal protein L29 [KO:K02905]
121433184  60S ribosomal protein L29-like [KO:K02905]
121442832  60S ribosomal protein L29-like [KO:K02905]
121447551  60S ribosomal protein L29-like [KO:K02905]
121452677  60S ribosomal protein L29-like [KO:K02905]
121466128  60S ribosomal protein L29-like [KO:K02905]
121432288  60S ribosomal protein L29-like [KO:K02905]
121450371  60S ribosomal protein L29-like [KO:K02905]
121452016  60S ribosomal protein L29-like [KO:K02905]
121457309  60S ribosomal protein L29-like [KO:K02905]
121463166  60S ribosomal protein L29-like [KO:K02905]
121465395  60S ribosomal protein L29-like [KO:K02905]
121449441  60S ribosomal protein L29-like [KO:K02905]
121459915  60S ribosomal protein L29-like [KO:K02905]
121461373  60S ribosomal protein L30 [KO:K02908]
121456297  60S ribosomal protein L30-like [KO:K02908]
121463043  60S ribosomal protein L30-like [KO:K02908]
121458226  60S ribosomal protein L30-like [KO:K02908]
121465093  60S ribosomal protein L30-like [KO:K02908]
121465421  60S ribosomal protein L30-like [KO:K02908]
121437709  Rpl30; 60S ribosomal protein L30 [KO:K02908]
121440755  60S ribosomal protein L30-like [KO:K02908]
121441729  60S ribosomal protein L30-like [KO:K02908]
121448401  60S ribosomal protein L30-like [KO:K02908]
121443452  60S ribosomal protein L30-like [KO:K02908]
121443479  60S ribosomal protein L30-like [KO:K02908]
121460461  60S ribosomal protein L31 [KO:K02910]
121463738  60S ribosomal protein L31 [KO:K02910]
121464638  60S ribosomal protein L31-like [KO:K02910]
121452006  60S ribosomal protein L31-like [KO:K02910]
121466198  60S ribosomal protein L31-like [KO:K02910]
121444091  60S ribosomal protein L31-like [KO:K02910]
121450904  60S ribosomal protein L31-like [KO:K02910]
121451106  Rpl31; 60S ribosomal protein L31 [KO:K02910]
121441345  60S ribosomal protein L31-like [KO:K02910]
121449687  60S ribosomal protein L31-like [KO:K02910]
121450007  60S ribosomal protein L31-like [KO:K02910]
121453960  60S ribosomal protein L31-like [KO:K02910]
121463516  60S ribosomal protein L31-like [KO:K02910]
121461237  60S ribosomal protein L32 [KO:K02912]
121461790  60S ribosomal protein L32-like [KO:K02912]
121456828  60S ribosomal protein L32 [KO:K02912]
121453697  60S ribosomal protein L32-like [KO:K02912]
121444721  60S ribosomal protein L32 [KO:K02912]
121437681  60S ribosomal protein L32 [KO:K02912]
121446304  60S ribosomal protein L32 [KO:K02912]
121447541  60S ribosomal protein L32-like [KO:K02912]
121441303  60S ribosomal protein L32-like [KO:K02912]
121435190  Rpl32; 60S ribosomal protein L32 [KO:K02912]
121443167  60S ribosomal protein L32-like [KO:K02912]
121461629  60S ribosomal protein L34-like [KO:K02915]
121455965  60S ribosomal protein L34 [KO:K02915]
121444022  60S ribosomal protein L34 [KO:K02915]
121450562  60S ribosomal protein L34-like [KO:K02915]
121437230  60S ribosomal protein L34-like [KO:K02915]
121437404  60S ribosomal protein L34-like [KO:K02915]
121437535  60S ribosomal protein L34-like [KO:K02915]
121437543  60S ribosomal protein L34-like [KO:K02915]
121451028  Rpl34; 60S ribosomal protein L34 [KO:K02915]
121442251  60S ribosomal protein L34 [KO:K02915]
121455804  60S ribosomal protein L35 [KO:K02918]
121462999  Rpl35; 60S ribosomal protein L35 [KO:K02918]
121452457  60S ribosomal protein L35-like [KO:K02918]
121436678  60S ribosomal protein L35-like [KO:K02918]
121437265  60S ribosomal protein L35-like [KO:K02918]
121434948  60S ribosomal protein L35a [KO:K02917]
121455444  60S ribosomal protein L35a-like [KO:K02917]
121440897  60S ribosomal protein L35a-like [KO:K02917]
121445734  60S ribosomal protein L35a-like [KO:K02917]
121451916  60S ribosomal protein L35a-like [KO:K02917]
121453624  60S ribosomal protein L35a-like [KO:K02917]
121457694  60S ribosomal protein L35a-like [KO:K02917]
121461889  Rpl35a; 60S ribosomal protein L35a [KO:K02917]
121463484  60S ribosomal protein L35a-like [KO:K02917]
121464755  60S ribosomal protein L35a-like [KO:K02917]
121465559  60S ribosomal protein L35a-like [KO:K02917]
121466629  60S ribosomal protein L35a-like [KO:K02917]
121463892  60S ribosomal protein L36 [KO:K02920]
121458701  60S ribosomal protein L36-like [KO:K02920]
121459774  Rpl36; 60S ribosomal protein L36 [KO:K02920]
121466074  60S ribosomal protein L36-like [KO:K02920]
121433030  60S ribosomal protein L36 [KO:K02920]
121435518  60S ribosomal protein L36-like [KO:K02920]
121442798  60S ribosomal protein L36-like [KO:K02920]
121444729  60S ribosomal protein L36-like [KO:K02920]
121455594  60S ribosomal protein L36-like [KO:K02920]
121462872  60S ribosomal protein L36-like [KO:K02920]
121455895  60S ribosomal protein L37 [KO:K02922]
121456316  60S ribosomal protein L37-like [KO:K02922]
121452393  60S ribosomal protein L37-like [KO:K02922]
121458959  60S ribosomal protein L37-like [KO:K02922]
121451461  60S ribosomal protein L37-like [KO:K02922]
121433062  Rpl37; 60S ribosomal protein L37 [KO:K02922]
121434299  60S ribosomal protein L37-like [KO:K02922]
121442261  60S ribosomal protein L37-like [KO:K02922]
121434475  60S ribosomal protein L37-like [KO:K02922]
121440575  60S ribosomal protein L37-like [KO:K02922]
121443980  60S ribosomal protein L37-like [KO:K02922]
121448174  60S ribosomal protein L37-like [KO:K02922]
121452465  60S ribosomal protein L37-like [KO:K02922]
121456090  60S ribosomal protein L37-like [KO:K02922]
121463020  60S ribosomal protein L37-like [KO:K02922]
121463144  60S ribosomal protein L37-like [KO:K02922]
121463489  60S ribosomal protein L37-like [KO:K02922]
121455436  60S ribosomal protein L37a-like [KO:K02921]
121462815  60S ribosomal protein L37a-like [KO:K02921]
121453580  60S ribosomal protein L37a-like [KO:K02921]
121453858  60S ribosomal protein L37a-like [KO:K02921]
121453945  60S ribosomal protein L37a-like [KO:K02921]
121432742  60S ribosomal protein L37a-like isoform X1 [KO:K02921]
121447236  Rpl37a; 60S ribosomal protein L37a [KO:K02921]
121447517  60S ribosomal protein L37a-like [KO:K02921]
121433860  60S ribosomal protein L37a-like [KO:K02921]
121441904  60S ribosomal protein L37a-like [KO:K02921]
121435843  60S ribosomal protein L37a [KO:K02921]
121463675  60S ribosomal protein L37a-like [KO:K02921]
121454651  60S ribosomal protein L38-like [KO:K02923]
121460349  60S ribosomal protein L38-like [KO:K02923]
121436227  Rpl38; 60S ribosomal protein L38 [KO:K02923]
121448721  60S ribosomal protein L38 [KO:K02923]
121463589  60S ribosomal protein L39-like [KO:K02924]
121464059  60S ribosomal protein L39-like [KO:K02924]
121458202  60S ribosomal protein L39-like [KO:K02924]
121466241  60S ribosomal protein L39-like [KO:K02924]
121466685  60S ribosomal protein L39-like [KO:K02924]
121443976  60S ribosomal protein L39 [KO:K02924]
121444724  60S ribosomal protein L39-like [KO:K02924]
121447459  60S ribosomal protein L39 [KO:K02924]
121441683  60S ribosomal protein L39 [KO:K02924]
121448913  60S ribosomal protein L39-like [KO:K02924]
121461891  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
121462490  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
121460476  60S ribosomal protein L36a-like [KO:K02929]
121455034  60S ribosomal protein L36a-like [KO:K02929]
121461520  60S ribosomal protein L36a-like [KO:K02929]
121463100  60S ribosomal protein L36a-like [KO:K02929]
121457075  60S ribosomal protein L36a-like [KO:K02929]
121463923  60S ribosomal protein L36a [KO:K02929]
121451909  60S ribosomal protein L36a-like [KO:K02929]
121458210  60S ribosomal protein L36a-like [KO:K02929]
121452367  Rpl36al; 60S ribosomal protein L36a-like [KO:K02929]
121459133  60S ribosomal protein L36a-like [KO:K02929]
121465536  60S ribosomal protein L36a-like [KO:K02929]
121436691  60S ribosomal protein L36a-like [KO:K02929]
121437099  60S ribosomal protein L36a-like [KO:K02929]
121444992  60S ribosomal protein L36a-like [KO:K02929]
121437694  60S ribosomal protein L36a-like [KO:K02929]
121446481  60S ribosomal protein L36a-like [KO:K02929]
121433075  60S ribosomal protein L36a-like [KO:K02929]
121433418  60S ribosomal protein L36a-like [KO:K02929]
121447488  60S ribosomal protein L36a-like [KO:K02929]
121433882  60S ribosomal protein L36a-like [KO:K02929]
121440854  60S ribosomal protein L36a [KO:K02929]
121434800  60S ribosomal protein L36a-like [KO:K02929]
121442264  60S ribosomal protein L36a [KO:K02929]
121449629  60S ribosomal protein L36a [KO:K02929]
121443536  60S ribosomal protein L36a-like [KO:K02929]
121446024  Rplp0; 60S acidic ribosomal protein P0 [KO:K02941]
121434615  60S acidic ribosomal protein P0 [KO:K02941]
121437814  60S acidic ribosomal protein P1-like [KO:K02942]
121462106  60S acidic ribosomal protein P1-like isoform X1 [KO:K02942]
121465170  60S acidic ribosomal protein P1-like isoform X1 [KO:K02942]
121466170  Rplp1; 60S acidic ribosomal protein P1 [KO:K02942]
121445079  60S acidic ribosomal protein P1-like [KO:K02942]
121451164  60S acidic ribosomal protein P1-like [KO:K02942]
121438060  60S acidic ribosomal protein P1-like [KO:K02942]
121438419  60S acidic ribosomal protein P1-like [KO:K02942]
121434443  60S acidic ribosomal protein P1-like [KO:K02942]
121448903  60S acidic ribosomal protein P1-like [KO:K02942]
121435387  60S acidic ribosomal protein P1-like isoform X1 [KO:K02942]
121449937  60S acidic ribosomal protein P1-like [KO:K02942]
121460637  60S acidic ribosomal protein P2 [KO:K02943]
121457866  Rplp2; 60S acidic ribosomal protein P2 [KO:K02943]
121452730  60S acidic ribosomal protein P2-like [KO:K02943]
121459398  60S acidic ribosomal protein P2-like [KO:K02943]
121436339  60S acidic ribosomal protein P2-like [KO:K02943]
121436443  60S acidic ribosomal protein P2-like [KO:K02943]
121435084  60S acidic ribosomal protein P2 [KO:K02943]
121438466  immunoglobulin epsilon heavy chain-like [KO:K06856]
121455102  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06472]
121442024  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06472]
121453505  tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
121444492  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
121464321  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121453059  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121448116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121441780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121455952  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121462841  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121448002  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121460138  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121447066  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
121436286  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121458065  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
121449728  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
121458143  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121464725  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121461212  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121461365  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121435212  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121435574  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
121452676  Tlr2; toll-like receptor 2 [KO:K10159]
121433864  Tlr4; toll-like receptor 4 [KO:K10160]
121464317  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
121444439  toll-like receptor 7 [KO:K05404]
121439389  Tlr7; LOW QUALITY PROTEIN: toll-like receptor 7 [KO:K05404]
121444430  toll-like receptor 8 [KO:K10170]
121439517  Tlr8; toll-like receptor 8 [KO:K10170]
121441443  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
121437200  interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
121440306  interleukin-1 receptor-associated kinase 1-like [KO:K04730] [EC:2.7.11.1]
121465651  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121440550  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121458412  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121466422  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
121455025  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121456117  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121440925  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121452580  Fos; proto-oncogene c-Fos [KO:K04379]
121448148  Jun; transcription factor AP-1 [KO:K04448]
121454691  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121462326  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121437198  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
121440264  NF-kappa-B essential modulator isoform X1 [KO:K07210]
121456818  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
121451709  Casp1; caspase-1 [KO:K01370] [EC:3.4.22.36]
121433854  Tlr3; toll-like receptor 3 [KO:K05401]
121458250  Ddx58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
121443608  ubiquitin-like protein ISG15 [KO:K12159]
121448909  ubiquitin-like protein ISG15 [KO:K12159]
121433247  Ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
121460460  Mavs; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
121434311  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
121446542  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
121461912  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
121451666  Irf3; interferon regulatory factor 3 [KO:K05411]
121466160  Cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
121453596  stimulator of interferon genes protein-like [KO:K12654]
121443011  stimulator of interferon genes protein-like [KO:K12654]
121448125  interferon alpha-12-like [KO:K05414]
121448126  interferon alpha-12-like [KO:K05414]
121448127  interferon alpha-1-like [KO:K05414]
121448197  interferon alpha-12-like [KO:K05414]
121448198  interferon alpha-12-like [KO:K05414]
121448492  interferon alpha-12-like [KO:K05414]
121448496  interferon alpha-12-like [KO:K05414]
121448498  interferon alpha-12-like [KO:K05414]
121448501  interferon alpha-12-like [KO:K05414]
121448502  interferon alpha-12-like [KO:K05414]
121448504  interferon alpha-12 [KO:K05414]
121448505  interferon alpha-12-like [KO:K05414]
121448506  interferon alpha-12-like [KO:K05414]
121448508  interferon alpha-12-like [KO:K05414]
121448509  interferon alpha-12-like [KO:K05414]
121448510  interferon alpha-12-like [KO:K05414]
121448511  interferon alpha-12-like [KO:K05414]
121448512  interferon alpha-12-like [KO:K05414]
121448518  interferon alpha-12-like [KO:K05414]
121448524  interferon alpha-12-like [KO:K05414]
121448832  interferon alpha-1-like [KO:K05414]
121447990  Ifnb1; interferon beta [KO:K05415]
121461778  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
121461923  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
121458866  signal transducer and activator of transcription 1 [KO:K11220]
121442179  signal transducer and activator of transcription 1-like [KO:K11220]
121462696  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
121434950  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
121450554  Adar; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
121444679  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
121445981  Oas3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
121445982  Oas2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
121445994  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
121446177  Oas1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
121446557  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
121461816  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
121461821  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
121432938  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
121433086  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
121449996  C5ar1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
121466040  C3ar1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
121459351  complement C3-like [KO:K03990]
121459724  complement C3 [KO:K03990]
121435234  Cfb; complement factor B [KO:K01335] [EC:3.4.21.47]
121459661  Cfd; complement factor D isoform X1 [KO:K01334] [EC:3.4.21.46]
121462708  complement C5-like [KO:K03994]
121433003  C6; complement component C6 isoform X1 [KO:K03995]
121433089  C7; complement component C7 [KO:K03996]
121448431  C8a; complement component C8 alpha chain [KO:K03997]
121448571  C8b; complement component C8 beta chain [KO:K03998]
121463033  C8g; complement component C8 gamma chain [KO:K03999]
121433090  C9; complement component C9 [KO:K04000]
121454982  P-selectin [KO:K06496]
121440884  Vwf; von Willebrand factor [KO:K03900]
121448439  C1qa; complement C1q subcomponent subunit A [KO:K03986]
121448477  C1qb; complement C1q subcomponent subunit B [KO:K03987]
121448427  C1qc; complement C1q subcomponent subunit C [KO:K03988]
121440981  C1r; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
121443554  C1s; complement C1s subcomponent [KO:K01331] [EC:3.4.21.42]
121435235  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
121435219  complement C4 [KO:K03989]
121435220  complement C4-like [KO:K03989]
121454591  Mbl2; mannose-binding protein C [KO:K03991]
121455280  mannose-binding protein A-like [KO:K03991]
121465105  Masp1; mannan-binding lectin serine protease 1 isoform X1 [KO:K03992] [EC:3.4.21.-]
121447947  mannan-binding lectin serine protease 2 isoform X1 [KO:K03993] [EC:3.4.21.104]
121441736  mannan-binding lectin serine protease 2 isoform X1 [KO:K03993] [EC:3.4.21.104]
121437664  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
121434023  F13a1; coagulation factor XIII A chain [KO:K03917] [EC:2.3.2.13]
121446246  F13b; coagulation factor XIII B chain isoform X1 [KO:K03906]
121453035  Fga; fibrinogen alpha chain [KO:K03903]
121452700  Fgb; fibrinogen beta chain [KO:K03904]
121452711  Fgg; fibrinogen gamma chain isoform X1 [KO:K03905]
Compound
C00027  Hydrogen peroxide
C00046  RNA
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00704  Superoxide
C00873  Angiotensin I
C02135  Angiotensin II
C15850  Angiotensin (1-7)
C20640  Cyclic GMP-AMP
Reference
PMID:33132005
  Authors
Harrison AG, Lin T, Wang P
  Title
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis.
  Journal
Trends Immunol S1471-4906(20)30233-7 (2020)
DOI:10.1016/j.it.2020.10.004
Reference
PMID:33077917
  Authors
Perico L, Benigni A, Casiraghi F, Ng LFP, Renia L, Remuzzi G
  Title
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19.
  Journal
Nat Rev Nephrol 10.1038/s41581-020-00357-4 (2020)
DOI:10.1038/s41581-020-00357-4
Reference
PMID:32820801
  Authors
Battagello DS, Dragunas G, Klein MO, Ayub ALP, Velloso FJ, Correa RG
  Title
Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission.
  Journal
Clin Sci (Lond) 134:2137-2160 (2020)
DOI:10.1042/CS20200904
Reference
PMID:32353634
  Authors
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM
  Title
COVID-19: Immunology and treatment options.
  Journal
Clin Immunol 215:108448 (2020)
DOI:10.1016/j.clim.2020.108448
Reference
PMID:33014208
  Authors
Hojyo S, Uchida M, Tanaka K, Hasebe R, Tanaka Y, Murakami M, Hirano T
  Title
How COVID-19 induces cytokine storm with high mortality.
  Journal
Inflamm Regen 40:37 (2020)
DOI:10.1186/s41232-020-00146-3
Reference
PMID:32544563
  Authors
Mahmudpour M, Roozbeh J, Keshavarz M, Farrokhi S, Nabipour I
  Title
COVID-19 cytokine storm: The anger of inflammation.
  Journal
Cytokine 133:155151 (2020)
DOI:10.1016/j.cyto.2020.155151
Reference
PMID:32635353
  Authors
Farooqi F, Dhawan N, Morgan R, Dinh J, Nedd K, Yatzkan G
  Title
Treatment of Severe COVID-19 with Tocilizumab Mitigates Cytokine Storm and Averts Mechanical Ventilation During Acute Respiratory Distress: A Case Report and Literature Review.
  Journal
Trop Med Infect Dis 5:E112 (2020)
DOI:10.3390/tropicalmed5030112
Reference
PMID:32376392
  Authors
Jamilloux Y, Henry T, Belot A, Viel S, Fauter M, El Jammal T, Walzer T, Francois B, Seve P
  Title
Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions.
  Journal
Autoimmun Rev 19:102567 (2020)
DOI:10.1016/j.autrev.2020.102567
Reference
PMID:32722596
  Authors
Kiselevskiy M, Shubina I, Chikileva I, Sitdikova S, Samoylenko I, Anisimova N, Kirgizov K, Suleimanova A, Gorbunova T, Varfolomeeva S
  Title
Immune Pathogenesis of COVID-19 Intoxication: Storm or Silence?
  Journal
Pharmaceuticals (Basel) 13:E166 (2020)
DOI:10.3390/ph13080166
Reference
PMID:32922297
  Authors
Curran CS, Rivera DR, Kopp JB
  Title
COVID-19 Usurps Host Regulatory Networks.
  Journal
Front Pharmacol 11:1278 (2020)
DOI:10.3389/fphar.2020.01278
Reference
PMID:33055229
  Authors
Quan C, Li C, Ma H, Li Y, Zhang H
  Title
Immunopathogenesis of Coronavirus-Induced Acute Respiratory Distress Syndrome (ARDS): Potential Infection-Associated Hemophagocytic Lymphohistiocytosis.
  Journal
Clin Microbiol Rev 34:e00074-20 (2020)
DOI:10.1128/CMR.00074-20
Reference
PMID:32973803
  Authors
Ahmed-Hassan H, Sisson B, Shukla RK, Wijewantha Y, Funderburg NT, Li Z, Hayes D Jr, Demberg T, Liyanage NPM
  Title
Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections.
  Journal
Front Immunol 11:1979 (2020)
DOI:10.3389/fimmu.2020.01979
Reference
PMID:32346093
  Authors
Tay MZ, Poh CM, Renia L, MacAry PA, Ng LFP
  Title
The trinity of COVID-19: immunity, inflammation and intervention.
  Journal
Nat Rev Immunol 20:363-374 (2020)
DOI:10.1038/s41577-020-0311-8
Reference
PMID:32979938
  Authors
Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY
  Title
Evasion of Type I Interferon by SARS-CoV-2.
  Journal
Cell Rep 33:108234 (2020)
DOI:10.1016/j.celrep.2020.108234
Reference
PMID:32661197
  Authors
Hartenian E, Nandakumar D, Lari A, Ly M, Tucker JM, Glaunsinger BA
  Title
The molecular virology of coronaviruses.
  Journal
J Biol Chem 295:12910-12934 (2020)
DOI:10.1074/jbc.REV120.013930
Reference
PMID:32978971
  Authors
Amor S, Fernandez Blanco L, Baker D
  Title
Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage.
  Journal
Clin Exp Immunol 202:193-209 (2020)
DOI:10.1111/cei.13523
Reference
PMID:32467561
  Authors
Catanzaro M, Fagiani F, Racchi M, Corsini E, Govoni S, Lanni C
  Title
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2.
  Journal
Signal Transduct Target Ther 5:84 (2020)
DOI:10.1038/s41392-020-0191-1
Reference
PMID:32687918
  Authors
Jafarzadeh A, Chauhan P, Saha B, Jafarzadeh S, Nemati M
  Title
Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions.
  Journal
Life Sci 257:118102 (2020)
DOI:10.1016/j.lfs.2020.118102
Reference
PMID:32376901
  Authors
Merad M, Martin JC
  Title
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages.
  Journal
Nat Rev Immunol 20:355-362 (2020)
DOI:10.1038/s41577-020-0331-4
Reference
PMID:32246101
  Authors
South AM, Tomlinson L, Edmonston D, Hiremath S, Sparks MA
  Title
Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic.
  Journal
Nat Rev Nephrol 16:305-307 (2020)
DOI:10.1038/s41581-020-0279-4
Reference
PMID:32433641
  Authors
Furuhashi M, Moniwa N, Takizawa H, Ura N, Shimamoto K
  Title
Potential differential effects of renin-angiotensin system inhibitors on SARS-CoV-2 infection and lung injury in COVID-19.
  Journal
Hypertens Res 43:837-840 (2020)
DOI:10.1038/s41440-020-0478-1
Reference
PMID:32423094
  Authors
Gemmati D, Bramanti B, Serino ML, Secchiero P, Zauli G, Tisato V
  Title
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?
  Journal
Int J Mol Sci 21:E3474 (2020)
DOI:10.3390/ijms21103474
Reference
PMID:33184193
  Authors
Kielian M
  Title
Enhancing host cell infection by SARS-CoV-2.
  Journal
Science 370:765-766 (2020)
DOI:10.1126/science.abf0732
Reference
PMID:32327719
  Authors
Risitano AM, Mastellos DC, Huber-Lang M, Yancopoulou D, Garlanda C, Ciceri F, Lambris JD
  Title
Complement as a target in COVID-19?
  Journal
Nat Rev Immunol 20:343-344 (2020)
DOI:10.1038/s41577-020-0320-7
Reference
PMID:32461141
  Authors
Noris M, Benigni A, Remuzzi G
  Title
The case of complement activation in COVID-19 multiorgan impact.
  Journal
Kidney Int 98:314-322 (2020)
DOI:10.1016/j.kint.2020.05.013
Reference
PMID:32559343
  Authors
Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G, Wallis R, Klavinskis LS, Sacks S
  Title
Rationale for targeting complement in COVID-19.
  Journal
EMBO Mol Med 12:e12642 (2020)
DOI:10.15252/emmm.202012642
Reference
PMID:32439870
  Authors
Teuwen LA, Geldhof V, Pasut A, Carmeliet P
  Title
COVID-19: the vasculature unleashed.
  Journal
Nat Rev Immunol 20:389-391 (2020)
DOI:10.1038/s41577-020-0343-0
Reference
PMID:32643798
  Authors
Jodele S, Kohl J
  Title
Tackling COVID-19 infection through complement-targeted immunotherapy.
  Journal
Br J Pharmacol 178:2832-2848 (2021)
DOI:10.1111/bph.15187
Reference
PMID:32608159
  Authors
Chauhan AJ, Wiffen LJ, Brown TP
  Title
COVID-19: A collision of complement, coagulation and inflammatory pathways.
  Journal
J Thromb Haemost 18:2110-2117 (2020)
DOI:10.1111/jth.14981
Reference
PMID:32558620
  Authors
Colling ME, Kanthi Y
  Title
COVID-19-associated coagulopathy: An exploration of mechanisms.
  Journal
Vasc Med 25:471-478 (2020)
DOI:10.1177/1358863X20932640
Reference
PMID:32586214
  Authors
McFadyen JD, Stevens H, Peter K
  Title
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
  Journal
Circ Res 127:571-587 (2020)
DOI:10.1161/CIRCRESAHA.120.317447
Reference
PMID:32995777
  Authors
Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H
  Title
SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
  Journal
bioRxiv 2020.09.18.302901 (2020)
DOI:10.1101/2020.09.18.302901
Reference
PMID:32693241
  Authors
Paniri A, Akhavan-Niaki H
  Title
Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation.
  Journal
Life Sci 257:118114 (2020)
DOI:10.1016/j.lfs.2020.118114
Reference
PMID:32405269
  Authors
Omarjee L, Janin A, Perrot F, Laviolle B, Meilhac O, Mahe G
  Title
Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19.
  Journal
Clin Immunol 216:108464 (2020)
DOI:10.1016/j.clim.2020.108464
Reference
PMID:32337664
  Authors
Zhang S, Li L, Shen A, Chen Y, Qi Z
  Title
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia.
  Journal
Clin Drug Investig 40:511-518 (2020)
DOI:10.1007/s40261-020-00917-3
Related
pathway
morg03015  mRNA surveillance pathway
morg04144  Endocytosis
morg04270  Vascular smooth muscle contraction
morg04610  Complement and coagulation cascades
morg04611  Platelet activation
morg04613  Neutrophil extracellular trap formation
morg04614  Renin-angiotensin system
morg04620  Toll-like receptor signaling pathway
morg04621  NOD-like receptor signaling pathway
morg04622  RIG-I-like receptor signaling pathway
morg04623  Cytosolic DNA-sensing pathway
morg04630  JAK-STAT signaling pathway
morg04650  Natural killer cell mediated cytotoxicity
morg04666  Fc gamma R-mediated phagocytosis
morg04668  TNF signaling pathway
morg04670  Leukocyte transendothelial migration
KO pathway
ko05171   
LinkDB

DBGET integrated database retrieval system