KEGG   PATHWAY: ngi05166
Entry
ngi05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
ngi05166  Human T-cell leukemia virus 1 infection
ngi05166

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103741911  Slc2a1; solute carrier family 2 member 1 [KO:K07299]
103745647  Nrp1; neuropilin 1 [KO:K06724]
103743920  Myc; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103726460  Trrap; transformation/transcription domain associated protein [KO:K08874]
103724996  Kat5; lysine acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
103727547  Ccnd2; cyclin D2 [KO:K10151]
103726419  Itgal; integrin subunit alpha L [KO:K05718]
103739950  Itgb2; integrin subunit beta 2 [KO:K06464]
103747569  Icam1; intercellular adhesion molecule 1 [KO:K06490]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103736717  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
103734938  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103736801  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103737276  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103741442  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103726390  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103727506  Cd4; CD4 molecule [KO:K06454]
103741540  Tln1; talin 1 [KO:K06271]
103752301  Tln2; talin 2 [KO:K06271]
103737202  Ranbp3; RAN binding protein 3 [KO:K15304]
103750614  Ran; RAN, member RAS oncogene family [KO:K07936]
103743249  Xpo1; exportin 1 [KO:K14290]
103751874  Calr; calreticulin [KO:K08057]
103730262  calreticulin-like [KO:K08057]
103749377  Canx; calnexin [KO:K08054]
103736944  Ppp3cb; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103747869  Ppp3cc; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103728037  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103734750  Ppp3r1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103749104  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
103748128  Nfatc1; nuclear factor of activated T-cells 1 [KO:K04446]
103735763  Nfatc2; nuclear factor of activated T-cells 2 [KO:K17332]
103734978  Nfatc3; nuclear factor of activated T-cells 3 [KO:K17333]
103739410  Nfatc4; nuclear factor of activated T-cells 4 [KO:K17334]
103748643  Il2rb; interleukin 2 receptor subunit beta [KO:K05069]
103751955  Il2rg; interleukin 2 receptor subunit gamma [KO:K05070]
103732475  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103726892  Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
103735895  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
103735893  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
103746951  Il2; interleukin 2 [KO:K05429]
103738688  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103740578  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
103739356  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
103744250  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
103747894  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103725555  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752329  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103752528  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752527  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103724463  patr class I histocompatibility antigen, A-126 alpha chain [KO:K06751]
103731142  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729790  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729781  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729792  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729784  HLA class I histocompatibility antigen, A-23 alpha chain-like [KO:K06751]
103729783  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
103746859  B2m; beta-2-microglobulin [KO:K08055]
103750841  Fdps; farnesyl diphosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
103729749  Vdac1; voltage dependent anion channel 1 [KO:K05862]
103750480  Slc25a4; solute carrier family 25 member 4 [KO:K05863]
103742868  Slc25a5; solute carrier family 25 member 5 [KO:K05863]
103750115  Slc25a6; solute carrier family 25 member 6 [KO:K05863]
103726219  Slc25a31; solute carrier family 25 member 31 [KO:K05863]
103747445  Vdac2; voltage dependent anion channel 2 [KO:K15040]
103747985  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
103726618  Vdac3; voltage dependent anion channel 3 [KO:K15041]
103743438  Tspo; translocator protein [KO:K05770]
103738106  Tspo2; translocator protein 2 [KO:K05770]
103735631  Vac14; Vac14, PIKFYVE complex component [KO:K15305]
103742054  Ranbp1; RAN binding protein 1 [KO:K15306]
103748681  Mad1l1; MAD1 mitotic arrest deficient like 1 [KO:K06679]
103743357  Mad2l1; MAD2 mitotic arrest deficient-like 1 (yeast) [KO:K02537]
103741499  Bub1b; BUB1 mitotic checkpoint serine/threonine kinase B [KO:K06637] [EC:2.7.11.1]
103729258  Bub3; BUB3, mitotic checkpoint protein [KO:K02180]
103739901  Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
103732602  Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
103724763  Cdc27; cell division cycle 27 [KO:K03350]
103737511  Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
103739071  Anapc5; anaphase promoting complex subunit 5 [KO:K03352]
103730619  Cdc16; cell division cycle 16 [KO:K03353]
103739079  Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
103735159  Cdc23; cell division cycle 23 [KO:K03355]
103729409  Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
103730225  Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
103734527  Cdc26; cell division cycle 26 [KO:K03359]
103750807  Anapc15; anaphase promoting complex subunit 15 [KO:K25228]
103736964  Anapc16; anaphase promoting complex subunit 16 [KO:K25229]
103743855  Cdc20; cell division cycle 20 [KO:K03363]
103737717  securin-like [KO:K06635]
103724556  Pttg1; pituitary tumor-transforming 1 [KO:K06635]
103738516  Espl1; extra spindle pole bodies like 1, separase [KO:K02365] [EC:3.4.22.49]
103737154  Ccnb2; cyclin B2 [KO:K21770]
103730664  Cdkn2b; cyclin dependent kinase inhibitor 2B [KO:K04685]
103730663  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
103742900  Cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103751498  Ccnd1; cyclin D1 [KO:K04503]
103725891  Ccnd3; cyclin D3 [KO:K10152]
103739652  Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625]
103746957  Ccna2; cyclin A2 [KO:K06627]
103731982  Ccna1; cyclin A1 [KO:K06627]
103740830  Ccne1; cyclin E1 [KO:K06626]
103745830  Ccne2; cyclin E2 [KO:K06626]
103746495  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103726779  Rb1; RB transcriptional corepressor 1 [KO:K06618]
103751571  E2f1; E2F transcription factor 1 [KO:K17454]
103746411  E2f2; E2F transcription factor 2 [KO:K09389]
103745641  E2f3; E2F transcription factor 3 [KO:K06620]
103731335  Atm; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
103752518  Atr; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
103735579  Chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
103750875  Chek2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
103752115  Tp53; tumor protein p53 [KO:K04451]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103738531  Dlg1; discs large MAGUK scaffold protein 1 [KO:K12076]
103738044  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103724452  Tnf; tumor necrosis factor [KO:K03156]
103727530  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
103739909  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103752052  Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103735023  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103748972  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103749366  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103737138  Jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103731642  Mmp7; matrix metallopeptidase 7 [KO:K01397] [EC:3.4.24.23]
103744180  Il1r1; interleukin 1 receptor type 1 [KO:K04386]
103744179  Il1r2; interleukin 1 receptor type 2 [KO:K04387]
103748303  Cd3d; CD3d molecule [KO:K06450]
103728619  Cd3e; CD3e molecule [KO:K06451]
103748301  Cd3g; CD3g molecule [KO:K06452]
103744757  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103743976  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103726621  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103731232  Ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103734016  Nfkbia; NFKB inhibitor alpha [KO:K04734]
103728077  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
103724994  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103752148  Gps2; G protein pathway suppressor 2 [KO:K15307]
103727527  Ltbr; lymphotoxin beta receptor [KO:K03159]
103751235  Cd40; CD40 molecule [KO:K03160]
103743462  Tnfrsf13c; TNF receptor superfamily member 13C [KO:K05151]
103738320  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103749175  Relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
103744019  Nfkb2; nuclear factor kappa B subunit 2 [KO:K04469]
103750740  Zfp36; ZFP36 ring finger protein [KO:K15308]
103727306  Il2ra; interleukin 2 receptor subunit alpha [KO:K05068]
103742384  Il15; interleukin 15 [KO:K05433]
103727307  Il15ra; interleukin 15 receptor subunit alpha [KO:K05074]
108490034  interleukin-15 receptor subunit alpha-like [KO:K05074]
103740849  Il6; interleukin 6 [KO:K05405]
103747042  Csf2; colony stimulating factor 2 [KO:K05427]
108490383  lymphotoxin-alpha-like [KO:K05468]
103724453  Lta; lymphotoxin alpha [KO:K05468]
103731080  Bcl2l1; BCL2 like 1 [KO:K04570]
103734850  Xiap; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
103751514  Tgfb1; transforming growth factor beta 1 [KO:K13375]
103728817  Tgfb2; transforming growth factor beta 2 [KO:K13376]
103739777  Tgfb3; transforming growth factor beta 3 [KO:K13377]
103744902  Tgfbr1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
103744639  Tgfbr2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
103727836  Smad2; SMAD family member 2 [KO:K04500]
103736807  Smad3; SMAD family member 3 [KO:K23605]
103726635  Smad4; SMAD family member 4 [KO:K04501]
103741433  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
103735350  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
103746460  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
103739411  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
103741989  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
103750558  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
103730120  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
103743923  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
103744458  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
103751850  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103728095  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103742139  Nfyb; nuclear transcription factor Y subunit beta [KO:K08065]
103748403  SMH class II histocompatibility antigen, beta-1 chain-like [KO:K06752]
103747627  SMH class II histocompatibility antigen, beta-1 chain [KO:K06752]
103747703  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103748487  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
103747994  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103748078  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
103747550  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103729174  rano class II histocompatibility antigen, B-1 beta chain-like [KO:K06752]
103729166  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
103729147  rano class II histocompatibility antigen, B alpha chain [KO:K06752]
103729158  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
103738064  rano class II histocompatibility antigen, B-1 beta chain [KO:K06752]
103739735  SMH class II histocompatibility antigen, beta-1 chain-like [KO:K06752]
103745139  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
103745137  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
103741891  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
103741892  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
103741888  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
103724457  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
103725871  patr class II histocompatibility antigen, DO beta chain-like [KO:K06752]
103731003  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
103731002  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
103730795  Srf; serum response factor [KO:K04378]
103725949  Elk4; ELK4, ETS transcription factor [KO:K04376]
103741629  Elk1; ELK1, ETS transcription factor [KO:K04375]
103742512  Spi1; Spi-1 proto-oncogene [KO:K09438]
103740682  Ets1; ETS proto-oncogene 1, transcription factor [KO:K02678]
103728914  Ets2; ETS proto-oncogene 2, transcription factor [KO:K21932]
103739216  Tbpl2; TATA-box binding protein like 2 [KO:K03120]
103742347  Tbp; TATA-box binding protein [KO:K03120]
103724914  Tbpl1; TATA-box binding protein like 1 [KO:K03120]
103747342  Fos; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103735154  Egr1; early growth response 1 [KO:K09203]
103725010  Fosl1; FOS like 1, AP-1 transcription factor subunit [KO:K04502]
103737476  Egr2; early growth response 2 [KO:K12496]
103744440  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
103737277  Creb3l3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
103741536  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
103748795  Creb3l1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103751688  Creb3l4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
103726130  Creb3l2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
103751761  Atf2; activating transcription factor 2 [KO:K04450]
103748563  Atf4; activating transcription factor 4 [KO:K04374]
103740829  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
103724413  Atf6b; activating transcription factor 6 beta [KO:K09049]
103726938  Crtc1; CREB regulated transcription coactivator 1 [KO:K15309]
103751715  Crtc2; CREB regulated transcription coactivator 2 [KO:K16333]
103749879  Crtc3; CREB regulated transcription coactivator 3 [KO:K16334]
103743486  Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
103744441  Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
103734285  Kat2b; lysine acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
103735888  Kat2a; lysine acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
103737314  Tcf3; transcription factor 3 [KO:K09063]
103726620  Polb; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
103745927  Lck; LCK proto-oncogene, Src family tyrosine kinase [KO:K05856] [EC:2.7.10.2]
103743639  Bax; BCL2 associated X, apoptosis regulator [KO:K02159]
103733571  Cdkn2c; cyclin dependent kinase inhibitor 2C [KO:K06622]
103749674  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
103734226  Msx1; msh homeobox 1 [KO:K09341]
103745412  Msx2; msh homeobox 2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
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PMID:15988028
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Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
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PMID:21994758
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Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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Nakano K, Watanabe T
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HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
DOI:10.3390/v8030058
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PMID:22783232
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Shida H
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
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PMID:23248621
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Bai XT, Nicot C
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
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PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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PMID:20332002
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
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The modulation of apoptosis by oncogenic viruses.
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Virol J 10:182 (2013)
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Viruses 3:714-49 (2011)
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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Harhaj EW, Harhaj NS
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Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
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IUBMB Life 57:83-91 (2005)
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Activation of NF-kappaB by HTLV-I and implications for cell transformation.
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Oncogene 24:5952-64 (2005)
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PMID:9710600
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Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Mol Cell Biol 18:5157-65 (1998)
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PMID:21315773
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Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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PMID:11264182
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Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
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Azran I, Schavinsky-Khrapunsky Y, Aboud M
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
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PMID:11244044
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Yoshida M
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Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
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PMID:12802280
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Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
ngi03013  Nucleocytoplasmic transport
ngi04010  MAPK signaling pathway
ngi04064  NF-kappa B signaling pathway
ngi04110  Cell cycle
ngi04115  p53 signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04210  Apoptosis
ngi04350  TGF-beta signaling pathway
ngi04612  Antigen processing and presentation
ngi04660  T cell receptor signaling pathway
ngi04668  TNF signaling pathway
KO pathway
ko05166   
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