KEGG   PATHWAY: omy04621
Entry
omy04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Oncorhynchus mykiss (rainbow trout)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
omy04621  NOD-like receptor signaling pathway
omy04621

Organism
Oncorhynchus mykiss (rainbow trout) [GN:omy]
Gene
110511898  nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
110511923  nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
110539162  nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
110508995  receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
110530062  receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
110506391  receptor-interacting serine/threonine-protein kinase 2 isoform X2 [KO:K08846] [EC:2.7.11.1]
110526239  receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
110492712  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110532862  NF-kappa-B essential modulator isoform X1 [KO:K07210]
110491527  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110491813  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110499151  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110536185  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110522049  NF-kappa-B inhibitor alpha [KO:K04734]
100136058  inhibitor of nuclear factor kappa B alpha [KO:K04734]
110497729  NF-kappa-B inhibitor alpha [KO:K04734]
110505735  nfkbiab; NF-kappa-B inhibitor alpha [KO:K04734]
110488722  nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110504918  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
110531834  transcription factor p65 isoform X1 [KO:K04735]
110500691  putative transcription factor p65 homolog isoform X1 [KO:K04735]
110509557  interleukin-1 beta-like [KO:K04519]
100136024  interleukin-1 beta [KO:K04519]
110522811  il1b; interleukin-1 beta [KO:K04519]
110536401  interleukin-1 beta-like [KO:K04519]
100136640  il-18; interleukin 18 [KO:K05482]
100136689  il6; interleukin-6 precursor [KO:K05405]
110496949  interleukin-6-like [KO:K05405]
100136034  tnf-alpha; putative tumour necrosis factor alpha [KO:K03156]
100136064  tnf; tumor necrosis factor [KO:K03156]
110496727  tumor necrosis factor [KO:K03156]
110487867  tnfa; tumor necrosis factor [KO:K03156]
110489463  C-X-C motif chemokine 11-1 [KO:K10030]
100136039  il-8; putative cxc chemokine precursor [KO:K10030]
110538491  C-X-C motif chemokine 2 isoform X3 [KO:K10030]
100529152  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
110522122  mitogen-activated protein kinase kinase kinase 7 isoform X4 [KO:K04427] [EC:2.7.11.25]
110529509  mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
110498078  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
110505368  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
110494935  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
110485597  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
110522153  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
110529530  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
110534958  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
110524038  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
110521892  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110535142  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110525139  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110539092  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110488604  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110502239  mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
110510208  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110536777  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110523975  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110491440  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
110499038  mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
110525944  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110494762  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
110528948  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
110522951  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110490392  mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
110490762  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110497890  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110491903  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
110491913  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
110532174  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110532744  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
110532753  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
110500090  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110500091  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
110508530  transcription factor AP-1 [KO:K04448]
110521616  transcription factor AP-1 isoform X1 [KO:K04448]
100136112  transcription factor AP-1 [KO:K04448]
110523115  transcription factor AP-1 [KO:K04448]
110536876  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
110530532  transcription factor AP-1 [KO:K04448]
110507314  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
110514282  autophagy protein 5 [KO:K08339]
110486995  autophagy protein 5 [KO:K08339]
110537203  ubiquitin-like protein ATG12 [KO:K08336]
118936409  ubiquitin-like protein ATG12 [KO:K08336]
110534218  gamma-aminobutyric acid receptor-associated protein isoform X1 [KO:K08341]
118944417  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
110509134  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
110537275  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
100305187  gbrap; Gamma-aminobutyric acid receptor-associated protein [KO:K08341]
100305205  gbrl2; Gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
110513840  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
110531818  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
110527665  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
110489065  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
110511247  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
110486037  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
110493754  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
118941186  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
110508461  sugt1; protein SGT1 homolog isoform X1 [KO:K12795]
110508618  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K20894]
110530450  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K20894]
110489702  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
110494153  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
110489697  E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
110529988  si:dkey-181m9.8; uncharacterized protein si:dkey-181m9.8 isoform X1 [KO:K11974] [EC:2.3.2.31]
110530336  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
110508709  E3 ubiquitin-protein ligase RNF31 isoform X2 [KO:K11974] [EC:2.3.2.31]
110536554  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
110489126  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
110504588  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
110531727  trip6; thyroid receptor-interacting protein 6 [KO:K12792]
118936359  thyroid receptor-interacting protein 6-like [KO:K12792]
110500597  thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
110500598  thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
110509697  erbin isoform X1 [KO:K12796]
110522834  erbin isoform X1 [KO:K12796]
110514649  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
110533228  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
110509690  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100136087  traf2; tumor necrosis factor receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
110523473  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
110523569  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
110525908  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110486074  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
110493771  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
110506216  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
110506983  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110535743  caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
110525340  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
110502983  tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
100136337  tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
100499614  mavs; mitochondrial antiviral signaling [KO:K12648]
110497707  TNF receptor-associated factor 3-like [KO:K03174]
110505762  TNF receptor-associated factor 3 [KO:K03174]
110512608  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
118936349  serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
110527112  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K05410] [EC:2.7.11.10]
110493262  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
110501503  LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
110520065  TRAF family member-associated NF-kappa-B activator [KO:K12650]
100750229  irf3; interferon regulatory factor 3 [KO:K05411]
110497044  interferon regulatory factor 8 [KO:K09447]
100750228  interferon regulatory factor 7 [KO:K09447]
118951907  interferon a3-like [KO:K05414]
118951912  interferon a3-like [KO:K05414]
118951913  interferon a3-like [KO:K05414]
118951914  interferon a3-like [KO:K05414]
118951915  interferon a3-like [KO:K05414]
118951916  interferon a3-like [KO:K05414]
118951917  interferon a3-like [KO:K05414]
100136140  type I interferon precursor [KO:K05414]
100136273  ifn1; interferon a3 precursor [KO:K05414]
100286821  ifn5; type I interferon 5 precursor [KO:K05414]
100301673  ifn3; type I interferon 3 precursor [KO:K05414]
100301676  ifn2; type I interferon 2 precursor [KO:K05414]
110510821  interferon a3-like [KO:K05414]
110511235  interferon a3 isoform X1 [KO:K05414]
110485144  interferon alpha-3-like [KO:K05414]
110485148  interferon beta-like [KO:K05414]
110538043  interferon a3 isoform X1 [KO:K05414]
110538045  interferon beta [KO:K05414]
110538046  interferon beta-like [KO:K05414]
110538047  interferon beta-like [KO:K05414]
110538048  interferon a3 [KO:K05414]
110538049  interferon a3 [KO:K05414]
110538051  ifnphi1; interferon a3 [KO:K05414]
110538053  interferon beta [KO:K05414]
110538058  interferon a3-like isoform X1 [KO:K05414]
110538059  interferon a3 [KO:K05414]
110517168  interferon a3-like isoform X1 [KO:K05414]
110517705  interferon a3-like [KO:K05414]
110517824  interferon a3-like [KO:K05414]
110538937  interferon beta [KO:K05414]
110538938  interferon tau [KO:K05414]
110538940  LOW QUALITY PROTEIN: interferon a3-like [KO:K05414]
110538941  interferon a3-like [KO:K05414]
110538942  interferon epsilon [KO:K05414]
110539157  interferon a3-like [KO:K05414]
110539158  interferon a3-like [KO:K05414]
110539160  interferon a3-like [KO:K05414]
110539161  interferon a3-like [KO:K05414]
118936262  interferon a3-like [KO:K05414]
118936363  interferon beta-like [KO:K05414]
118936417  interferon beta-like [KO:K05414]
118937708  interferon a3-like [KO:K05414]
118937709  interferon beta-like [KO:K05414]
118937711  interferon a3-like [KO:K05414]
118937713  interferon a3-like [KO:K05414]
118937891  interferon a3-like [KO:K05414]
118937892  interferon a3-like [KO:K05414]
118937893  interferon a3-like [KO:K05414]
118938066  interferon beta-like [KO:K05414]
118938067  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
118938265  interferon beta-like [KO:K05414]
118938266  interferon beta-like [KO:K05414]
118938267  interferon beta-like [KO:K05414]
118938268  interferon beta-like [KO:K05414]
118938269  interferon beta-like [KO:K05414]
118938270  interferon beta-like [KO:K05414]
118938271  interferon beta-like [KO:K05414]
118938272  interferon beta-like [KO:K05414]
118938273  interferon beta-like [KO:K05414]
118938274  interferon beta-like [KO:K05414]
110503546  NLR family member X1 isoform X1 [KO:K12653]
110536021  anthrax toxin receptor 1 isoform X1 [KO:K20909]
110536457  anthrax toxin receptor 2 [KO:K20909]
110523707  antxr1b; anthrax toxin receptor 1 isoform X1 [KO:K20909]
110536997  anthrax toxin receptor 2 [KO:K20909]
110537215  anthrax toxin receptor 1 [KO:K20909]
110491434  anthrax toxin receptor 1 [KO:K20909]
110523927  antxr2b; ANTXR cell adhesion molecule 2b [KO:K20909]
110499033  anthrax toxin receptor 1 [KO:K20909]
110525181  anthrax toxin receptor 2 [KO:K20909]
110525650  anthrax toxin receptor 1 [KO:K20909]
110526097  anthrax toxin receptor 1 [KO:K20909]
110521475  uncharacterized protein LOC110521475 [KO:K12799]
110488391  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
110523645  caspase recruitment domain-containing protein 8 [KO:K12799]
110530050  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
110516260  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
118940262  caspase recruitment domain-containing protein 8-like [KO:K12799]
110503799  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
110507087  caspase-1 [KO:K01370] [EC:3.4.22.36]
110508652  apoptosis regulator Bcl-2 [KO:K02161]
110535287  apoptosis regulator Bcl-2-like [KO:K02161]
110489720  bcl2a; apoptosis regulator Bcl-2 [KO:K02161]
110530404  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
110527901  bcl-2-like protein 1 [KO:K04570]
110492635  bcl-2-like protein 1 [KO:K04570]
110532256  bcl-2-like protein 1 [KO:K04570]
110494565  bcl-2-like protein 1 [KO:K04570]
100135964  ctsbb; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
110497560  cathepsin B [KO:K01363] [EC:3.4.22.1]
110505888  cathepsin B [KO:K01363] [EC:3.4.22.1]
110503806  pannexin-1 [KO:K03443]
110507644  pannexin-1 [KO:K03443]
110533772  pannexin-1 [KO:K03443]
110535894  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
110525512  P2X purinoceptor 4 [KO:K05220]
110502207  trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
110513022  transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
110526654  transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
110510087  casr; extracellular calcium-sensing receptor [KO:K04612]
110511708  G-protein coupled receptor family C group 6 member A [KO:K04622]
110511716  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
110485107  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
110498217  G-protein coupled receptor family C group 6 member A [KO:K04622]
110522448  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110529235  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110529236  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110510780  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
110497805  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110505469  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
110505652  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110500326  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
110521072  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110527884  itpr1b; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
110528182  inositol 1,4,5-trisphosphate receptor type 1 isoform X9 [KO:K04958]
110494246  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110494585  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110522681  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110497694  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110492618  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
110532282  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110537731  voltage-dependent anion-selective channel protein 1 [KO:K05862]
110533382  voltage-dependent anion-selective channel protein 1 [KO:K05862]
110502625  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110502815  voltage-dependent anion-selective channel protein 2 [KO:K15040]
110530588  voltage-dependent anion-selective channel protein 2 [KO:K15040]
110499468  voltage-dependent anion-selective channel protein 2 [KO:K15040]
110536186  vdac3; voltage-dependent anion-selective channel protein 2 isoform X3 [KO:K15041]
110523828  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X2 [KO:K15041]
110537096  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
110525814  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
110492808  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
110518228  calcium uniporter protein, mitochondrial-like [KO:K20858]
110533306  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
110529965  mfn1a; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
110524016  mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
110533192  mitofusin-1 [KO:K21356] [EC:3.6.5.-]
110532171  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
110508625  receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
110530438  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
110521454  receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
110531501  ripk3; receptor-interacting serine/threonine-protein kinase 4 [KO:K08847] [EC:2.7.11.1]
110536015  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
110524698  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
110500027  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
110500222  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
110490269  nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
110500207  nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
110500466  nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
110494490  nampt2; nicotinamide phosphoribosyltransferase 2 isoform X1 [KO:K03462] [EC:2.4.2.12]
100329199  gp91phox; NADPH oxidase 1 [KO:K21421] [EC:1.-.-.-]
118936247  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
100301566  p22-phox; cytochrome b558 alpha-subunit [KO:K08009]
110496349  thioredoxin-interacting protein [KO:K20910]
110513274  thioredoxin-interacting protein [KO:K20910]
110486333  thioredoxin-interacting protein [KO:K20910]
110488228  thioredoxin-interacting protein [KO:K20910]
110512820  thioredoxin-like [KO:K03671]
110531622  thioredoxin [KO:K03671]
110538471  thioredoxin, mitochondrial isoform X2 [KO:K03671]
110486513  thioredoxin, mitochondrial isoform X1 [KO:K03671]
118936858  thioredoxin-like [KO:K03671]
110500479  thioredoxin [KO:K03671]
110521834  serine/threonine-protein kinase Nek7 isoform X2 [KO:K20876] [EC:2.7.11.34]
110524793  serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
110509941  lys-63-specific deubiquitinase BRCC36 isoform X2 [KO:K11864] [EC:3.4.19.-]
110533956  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
100135839  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
110522488  heat shock protein HSP 90-alpha isoform X2 [KO:K04079]
100136599  hsp90bb; heat shock 90kDa protein 1 beta isoform b [KO:K04079]
110529844  heat shock protein HSP 90-alpha [KO:K04079]
110529845  heat shock protein HSP 90-alpha 1 [KO:K04079]
110528612  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110528614  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110528615  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110497194  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110497197  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110511088  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110511715  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110512945  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
110512946  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
110513570  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
110515418  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
110517048  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X3 [KO:K12801]
118936495  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
118936810  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
118936811  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
118936812  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
118936814  NACHT, LRR and PYD domains-containing protein 1 homolog [KO:K12801]
118936856  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
110500402  NACHT, LRR and PYD domains-containing protein 1 homolog isoform X1 [KO:K12801]
110495782  proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
110506762  proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
110526640  proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
110521117  proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
110508466  caspase-8 [KO:K04398] [EC:3.4.22.61]
110502170  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
110530629  caspase-8 [KO:K04398] [EC:3.4.22.61]
101268911  casp8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
110520142  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
110506335  FAS-associated death domain protein [KO:K02373]
110526221  fadd; protein FADD [KO:K02373]
110499420  uncharacterized protein LOC110499420 [KO:K12806]
110527955  protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
110528134  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
110494302  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
110494510  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
100136262  TP53-binding protein 1 isoform X1 [KO:K20915]
110506150  TP53-binding protein 1 isoform X1 [KO:K20915]
110527767  rhoca; rho-related GTP-binding protein RhoA-D [KO:K04513]
110528412  transforming protein RhoA [KO:K04513]
110529252  rho-related GTP-binding protein RhoA-A [KO:K04513]
100305156  rhoa; Transforming protein RhoA [KO:K04513]
110492267  rho-related GTP-binding protein RhoA-C [KO:K04513]
110492312  rho-related GTP-binding protein RhoA-B [KO:K04513]
110532093  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
110532339  rho-related GTP-binding protein RhoA-C [KO:K04513]
110495121  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
110538283  serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
110485853  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
110486506  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
110508219  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
110530089  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
110524885  zgc:153916; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
100136196  14-3-3E1 protein [KO:K06630]
100136197  14-3-3E2 protein [KO:K06630]
110503644  14-3-3 protein epsilon isoform X1 [KO:K06630]
110537675  14-3-3 protein epsilon isoform X2 [KO:K06630]
110501729  guanylate-binding protein 1-like isoform X1 [KO:K20899]
110501730  guanylate-binding protein 1 [KO:K20899]
110501731  guanylate-binding protein 1 [KO:K20899]
110501732  guanylate-binding protein 1 [KO:K20899]
110501733  guanylate-binding protein 1-like [KO:K20899]
110501949  guanylate-binding protein 1 [KO:K20899]
100136162  glycogen synthase kinase binding protein [KO:K20899]
110529748  guanylate-binding protein 1 [KO:K20899]
110527592  interleukin-10 receptor subunit beta [KO:K05130]
110520638  interferon lambda receptor 1-like [KO:K05131]
110501424  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
110521800  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110509035  tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110530021  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110524729  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110538425  non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
110486365  non-receptor tyrosine-protein kinase TYK2 isoform X2 [KO:K11219] [EC:2.7.10.2]
110501544  stat1b; signal transducer and activator of transcription 1b isoform X1 [KO:K11220]
100136755  stat1-1; signal transducer/activator of transcription [KO:K11220]
100137016  stat1-2; signal transducer/activator of transcription [KO:K11220]
110520020  signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
110527523  LOW QUALITY PROTEIN: uncharacterized protein LOC110527523 [KO:K11220]
110494323  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110535315  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110489699  interferon regulatory factor 8 isoform X1 [KO:K04693]
110521348  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
100136123  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
110493646  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
110504688  stimulator of interferon genes protein [KO:K12654]
110487764  stimulator of interferon genes protein-like [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
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The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
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Nat Rev Immunol 12:833-44 (2012)
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PMID:16493424
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Signalling pathways and molecular interactions of NOD1 and NOD2.
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Nat Rev Immunol 6:9-20 (2006)
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PMID:24718315
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IAPs, regulators of innate immunity and inflammation.
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Semin Cell Dev Biol 39:106-14 (2015)
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Reference
PMID:24707857
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Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
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J Med Chem 57:6897-918 (2014)
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Reference
PMID:25526305
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NOD1 and NOD2: signaling, host defense, and inflammatory disease.
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Immunity 41:898-908 (2014)
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PMID:19767725
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Murray PJ
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Beyond peptidoglycan for Nod2.
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Nat Immunol 10:1053-4 (2009)
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Reference
PMID:20643110
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Lecat A, Piette J, Legrand-Poels S
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The protein Nod2: an innate receptor more complex than previously assumed.
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Biochem Pharmacol 80:2021-31 (2010)
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Reference
PMID:26655628
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Man SM, Kanneganti TD
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Converging roles of caspases in inflammasome activation, cell death and innate immunity.
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Nat Rev Immunol 16:7-21 (2016)
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PMID:27291964
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Broz P, Dixit VM
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Inflammasomes: mechanism of assembly, regulation and signalling.
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Nat Rev Immunol 16:407-20 (2016)
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PMID:25879280
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Man SM, Kanneganti TD
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Regulation of inflammasome activation.
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Immunol Rev 265:6-21 (2015)
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Reference
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Jo EK, Kim JK, Shin DM, Sasakawa C
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Molecular mechanisms regulating NLRP3 inflammasome activation.
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Cell Mol Immunol 13:148-59 (2016)
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Reference
PMID:23846113
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Broz P, Monack DM
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Newly described pattern recognition receptors team up against intracellular pathogens.
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Nat Rev Immunol 13:551-65 (2013)
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Reference
PMID:22430786
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Rathinam VA, Vanaja SK, Fitzgerald KA
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Regulation of inflammasome signaling.
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Nat Immunol 13:333-42 (2012)
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Reference
PMID:24840700
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Sutterwala FS, Haasken S, Cassel SL
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Mechanism of NLRP3 inflammasome activation.
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Ann N Y Acad Sci 1319:82-95 (2014)
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Reference
PMID:23702978
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Latz E, Xiao TS, Stutz A
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Activation and regulation of the inflammasomes.
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Nat Rev Immunol 13:397-411 (2013)
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Reference
PMID:25145756
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Blander JM
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A long-awaited merger of the pathways mediating host defence and programmed cell death.
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Nat Rev Immunol 14:601-18 (2014)
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Reference
PMID:23215645
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von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
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Recognition of bacteria by inflammasomes.
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Annu Rev Immunol 31:73-106 (2013)
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PMID:25330206
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Abais JM, Xia M, Zhang Y, Boini KM, Li PL
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Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
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Antioxid Redox Signal 22:1111-29 (2015)
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Reference
PMID:25879288
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Storek KM, Monack DM
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Bacterial recognition pathways that lead to inflammasome activation.
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Immunol Rev 265:112-29 (2015)
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Ubiquitin signaling in immune responses.
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Cell Res 26:457-83 (2016)
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Guo H, Callaway JB, Ting JP
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Inflammasomes: mechanism of action, role in disease, and therapeutics.
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Nat Med 21:677-87 (2015)
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Reference
PMID:26482951
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Man SM, Kanneganti TD
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Gasdermin D: the long-awaited executioner of pyroptosis.
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Cell Res 25:1183-4 (2015)
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Reference
PMID:22819539
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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Cell 150:606-19 (2012)
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Reference
PMID:21575908
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Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
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IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
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Cell Host Microbe 9:363-75 (2011)
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Reference
PMID:29148036
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Function and mechanism of the pyrin inflammasome.
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Eur J Immunol 48:230-238 (2018)
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Reference
PMID:25816776
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RNase L activates the NLRP3 inflammasome during viral infections.
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Cell Host Microbe 17:466-77 (2015)
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Related
pathway
omy04010  MAPK signaling pathway
omy04140  Autophagy - animal
omy04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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