KEGG   PATHWAY: pgeo04510
Entry
pgeo04510                   Pathway                                
Name
Focal adhesion - Pseudochaenichthys georgianus (South Georgia icefish)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pgeo04510  Focal adhesion
pgeo04510

Other DBs
GO: 0005925
Organism
Pseudochaenichthys georgianus (South Georgia icefish) [GN:pgeo]
Gene
117464657  col1a1b; collagen, type I, alpha 1b [KO:K06236]
117455300  col1a2; collagen alpha-2(I) chain [KO:K06236]
117455301  LOW QUALITY PROTEIN: collagen alpha-2(I) chain-like [KO:K06236]
117444715  LOW QUALITY PROTEIN: collagen alpha-1(I) chain-like [KO:K06236]
117449168  col2a1a; collagen, type II, alpha 1a [KO:K19719]
117446211  col2a1b; collagen, type II, alpha 1b [KO:K19719]
117466275  col4a2; collagen alpha-2(IV) chain [KO:K06237]
117466276  col4a1; collagen alpha-1(IV) chain [KO:K06237]
117462733  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
117462734  collagen alpha-5(IV) chain-like [KO:K06237]
117463697  col4a5; LOW QUALITY PROTEIN: collagen alpha-5(IV) chain [KO:K06237]
117464071  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
117466458  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
117466842  col6a3; collagen alpha-3(VI) chain [KO:K06238]
117462177  col6a1; collagen alpha-1(VI) chain [KO:K06238]
117462286  col6a2; collagen alpha-2(VI) chain [KO:K06238]
117440810  collagen alpha-6(VI) chain-like [KO:K06238]
117443611  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain-like [KO:K06238]
117459409  col9a1b; LOW QUALITY PROTEIN: collagen, type IX, alpha 1b [KO:K08131]
117455408  col9a2; collagen alpha-2(IX) chain [KO:K08131]
117448989  col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
117453153  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
117439461  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
117462253  laminin subunit alpha-3-like isoform X1 [KO:K06240]
117449648  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
117439688  lama4; laminin subunit alpha-4 [KO:K06241]
117439002  lamb1b; laminin subunit beta-1b [KO:K05636]
117449351  lamb2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
117449602  lamb2l; laminin subunit beta-2 [KO:K06243]
117446208  si:ch1073-15f12.3; laminin subunit beta-3 isoform X1 [KO:K06244]
117441229  lamc2; laminin subunit gamma-2 [KO:K06246]
117456600  lamc3; laminin subunit gamma-3 [KO:K06247]
117464763  chad; chondroadherin [KO:K06248]
117448084  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
117467640  thrombospondin-1-like isoform X1 [KO:K16857]
117439911  thbs1b; thrombospondin-1 [KO:K16857]
117459762  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
117465050  thrombospondin-2-like [KO:K04659]
117445427  comp; cartilage oligomeric matrix protein [KO:K04659]
117453065  thbs4a; LOW QUALITY PROTEIN: thrombospondin-4a [KO:K04659]
117466813  fibronectin-like isoform X1 [KO:K05717]
117458755  vtnb; vitronectin b [KO:K06251]
117457700  vtna; vitronectin a [KO:K06251]
117460653  tnxba; tenascin [KO:K06252]
117461811  tnn; tenascin-N [KO:K06252]
117462542  tnr; tenascin-R isoform X1 [KO:K06252]
117455114  tenascin isoform X1 [KO:K06252]
117455746  tenascin-like isoform X1 [KO:K06252]
117453021  tnc; tenascin isoform X1 [KO:K06252]
117447685  vwf; von Willebrand factor [KO:K03900]
117443127  itga1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
117453186  itga2.2; integrin alpha-2 [KO:K06481]
117464371  itga3b; integrin alpha-3b [KO:K06482]
117466703  itga4; integrin alpha-4 [KO:K06483]
117449041  itga5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
117466424  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
117462873  integrin alpha-6-like isoform X1 [KO:K06485]
117446749  itga7; integrin alpha-7 isoform X1 [KO:K06583]
117461447  itga8; integrin alpha-8 [KO:K06584]
117459701  itga9; integrin alpha-9 [KO:K06585]
117461320  itga10; integrin alpha-10 [KO:K06586]
117465242  itga11a; integrin alpha-11a [KO:K06587]
117443084  LOW QUALITY PROTEIN: integrin alpha-11-like [KO:K06587]
117465739  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
117460819  integrin beta-1-like [KO:K05719]
117464826  itgb3b; integrin beta-3b [KO:K06493]
117450945  itgb3a; integrin beta-3a [KO:K06493]
117464632  integrin beta-4-like [KO:K06525]
117443692  itgb4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
117466188  itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
117463797  itgb6; integrin beta-6 [KO:K06589]
117454704  itgb8; integrin beta-8 [KO:K06591]
117451607  emp2; epithelial membrane protein 2 [KO:K26256]
117451375  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
117441258  uncharacterized protein LOC117441258 [KO:K17386]
117457479  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
117453372  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
117453993  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
117439185  igf1; insulin-like growth factor I [KO:K05459]
117448931  insulin-like growth factor I [KO:K05459]
117460971  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
117439689  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
117444901  vegfba; vascular endothelial growth factor A [KO:K05448]
117467727  pgfb; placenta growth factor [KO:K16859]
117439727  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
117460549  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
117461708  vegfd; vascular endothelial growth factor D [KO:K05449]
117451904  vegfc; vascular endothelial growth factor C [KO:K05449]
117451913  vascular endothelial growth factor C-like [KO:K05449]
117468338  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
117447549  hepatocyte growth factor [KO:K05460]
117445902  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117453732  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117448090  igf1ra; LOW QUALITY PROTEIN: insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117445385  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117462222  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117465546  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117453653  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117454462  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117464942  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117451085  epithelial membrane protein 2-like [KO:K26255]
117445904  emp1; epithelial membrane protein 1 [KO:K26255]
117449444  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117446643  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117458387  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
117457348  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
117440748  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
117449082  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117450100  rho-related GTP-binding protein RhoA-D [KO:K04513]
117450101  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117450179  rho-related GTP-binding protein RhoA-C [KO:K04513]
117446482  rho-related GTP-binding protein RhoA-B [KO:K04513]
117461973  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
117468191  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
117439791  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117441865  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like isoform X1 [KO:K10351]
117446801  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
117452733  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
117446922  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
117465648  myl12.1; myosin, light chain 12, genome duplicate 1 isoform X1 [KO:K12757]
117462815  myl12.2; myosin, light chain 12, genome duplicate 2 isoform X1 [KO:K12757]
117464956  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
117451346  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
117467708  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117463459  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117464953  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
117439526  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117450971  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
117452384  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
117468356  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
117449426  protein phosphatase 1 regulatory subunit 12A-like [KO:K12329]
117458064  ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
117447913  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
117462694  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117464856  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
117445928  mylk4b; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117450984  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
117460781  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117461710  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117455655  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
117456379  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117445892  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117452615  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
117447644  actb1; actin, cytoplasmic 1 [KO:K05692]
117451022  actin, cytoplasmic 1-like [KO:K05692]
117451156  actin, cytoplasmic 1-like [KO:K05692]
117451232  actin, cytoplasmic 1-like [KO:K05692]
117451766  actin, cytoplasmic 1 [KO:K05692]
117451768  actin, cytoplasmic 1-like [KO:K05692]
117448146  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
117443104  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
117459873  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117459874  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117441997  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117467964  actn1; alpha-actinin-1 [KO:K05699]
117442487  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
117455988  tln1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
117439991  tln2a; talin-2a [KO:K06271]
117448182  tln2b; talin-2 isoform X1 [KO:K06271]
117449191  flna; filamin-A isoform X1 [KO:K04437]
117447237  filamin-B isoform X1 [KO:K27392]
117446305  mucin-5AC-like isoform X1 [KO:K05760]
117452860  mucin-5AC-like isoform X1 [KO:K05760]
117458898  ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
117457461  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
117443221  LOW QUALITY PROTEIN: zyxin-like [KO:K06273]
117457161  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117459459  vinculin-like isoform X1 [KO:K05700]
117464649  vinculin isoform X1 [KO:K05700]
117448199  parvb; beta-parvin isoform X1 [KO:K06275]
117448596  parvaa; parvin, alpha a [KO:K06275]
117448661  parvg; gamma-parvin isoform X1 [KO:K06275]
117464693  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117459577  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117467542  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117458421  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117456863  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117450800  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117466245  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117460556  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
117454920  catenin beta-1-like [KO:K02105]
117441773  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117451160  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117447993  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117451436  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
117461588  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117461154  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
117455505  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
117462023  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117457177  pik3cb; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117449291  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117445314  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117462047  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117462274  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117455737  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117445092  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117445659  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117459599  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117462443  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
117465544  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
117455862  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
117449600  proto-oncogene vav-like isoform X1 [KO:K05730]
117464310  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117451605  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117451504  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117465195  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
117457314  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117467530  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
117458208  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
117457837  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
117439709  pak7; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
117467363  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
117460934  cdc42l; cell division cycle 42, like [KO:K04393]
117454985  cell division control protein 42 homolog [KO:K04393]
117448852  cell division control protein 42 homolog isoform X1 [KO:K04393]
117443153  cell division control protein 42 homolog isoform X1 [KO:K04393]
117448018  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
117456019  crkl; crk-like protein [KO:K04438]
117443656  adapter molecule crk-like [KO:K04438]
117444311  crk; adapter molecule crk [KO:K04438]
117464556  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
117455835  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
117446294  ras-related protein Rap-1A [KO:K04353]
117442901  ras-related protein Rap-1b [KO:K07836]
117459620  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117464330  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117453597  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117455943  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117462217  transcription factor AP-1-like [KO:K04448]
117455908  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117445372  jun; transcription factor AP-1 [KO:K04448]
117468322  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117448133  cav1; caveolin-1 [KO:K06278]
117447066  zgc:172270; caveolin-2 [KO:K12958]
117448164  cav2; caveolin-2 [KO:K12958]
117450159  zgc:158296; caveolin-2 isoform X1 [KO:K12958]
117446174  caveolin-2-like [KO:K12958]
117446173  cav3; caveolin-3 [KO:K12959]
117467933  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
117439700  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
117460302  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
117445506  shc2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
117456357  shc3; SHC-transforming protein 3 [KO:K17448]
117466482  SHC-transforming protein 4-like [KO:K17449]
117451368  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
117467966  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117448041  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117449273  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117447861  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117451293  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117451854  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117448201  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117441044  G1/S-specific cyclin-D1-like [KO:K04503]
117468457  G1/S-specific cyclin-D2-like [KO:K10151]
117447816  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
117451689  ccndx; cyclin Dx [KO:K10151]
117446571  ccnd3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
117458383  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117454071  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
117463516  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
117462238  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pgeo04010  MAPK signaling pathway
pgeo04060  Cytokine-cytokine receptor interaction
pgeo04070  Phosphatidylinositol signaling system
pgeo04110  Cell cycle
pgeo04310  Wnt signaling pathway
pgeo04512  ECM-receptor interaction
pgeo04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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