KEGG   PATHWAY: ppam04014
Entry
ppam04014                   Pathway                                
Name
Ras signaling pathway - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
ppam04014  Ras signaling pathway
ppam04014

Other DBs
GO: 0032318
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129085287  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129081363  TGFA; protransforming growth factor alpha [KO:K08774]
129066585  FGF1; fibroblast growth factor 1 [KO:K18496]
129061435  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
129068332  FGF4; fibroblast growth factor 4 [KO:K04358]
129068458  FGF3; fibroblast growth factor 3 [KO:K04358]
129074873  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
129082327  FGF9; fibroblast growth factor 9 [KO:K04358]
129077291  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
129064258  FGF7; fibroblast growth factor 7 [KO:K04358]
129084108  FGF5; fibroblast growth factor 5 [KO:K04358]
129064694  FGF20; fibroblast growth factor 20 [KO:K04358]
129065350  FGF16; fibroblast growth factor 16 [KO:K04358]
129071959  FGF10; fibroblast growth factor 10 [KO:K04358]
129072488  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
129066345  FGF18; fibroblast growth factor 18 [KO:K04358]
129074224  FGF6; fibroblast growth factor 6 [KO:K04358]
129068333  FGF19; fibroblast growth factor 19 [KO:K22603]
129082796  FGF21; fibroblast growth factor 21 [KO:K22429]
129074223  FGF23; fibroblast growth factor 23 [KO:K22428]
129063964  NGF; beta-nerve growth factor [KO:K02582]
129080496  BDNF; brain-derived neurotrophic factor [KO:K04355]
129071284  NTF3; neurotrophin-3 [KO:K04356]
129082927  NTF4; neurotrophin-4 [KO:K12457]
129068502  INS; insulin [KO:K04526]
129071377  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
129068503  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
129065324  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
129077932  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
129072575  PDGFC; platelet-derived growth factor C [KO:K05450]
129086014  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
129063699  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
129075936  KITLG; kit ligand isoform X1 [KO:K05461]
129082804  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
129067485  VEGFA; vascular endothelial growth factor A [KO:K05448]
129068614  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
129065733  PGF; placenta growth factor [KO:K16859]
129076969  VEGFD; vascular endothelial growth factor D [KO:K05449]
129064900  VEGFC; vascular endothelial growth factor C [KO:K05449]
129063396  HGF; hepatocyte growth factor [KO:K05460]
129084274  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
129064909  ANGPT2; angiopoietin-2 [KO:K05466]
129070500  ANGPT4; angiopoietin-4 [KO:K05467]
129062187  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
129062396  EFNA3; ephrin-A3 [KO:K05462]
129062397  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
129083924  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
129080087  EFNA2; ephrin-A2 [KO:K05462]
129068919  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129064807  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129077222  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129077479  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129066457  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
129080218  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129062360  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
129078231  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
129064990  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
129061268  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129077631  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
129066549  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
129066552  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
129077640  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
129073410  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
129071112  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
129073492  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129064979  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
129077642  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
129063382  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129082381  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
129075629  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
129086587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129062066  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
129072784  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
129062405  SHC1; SHC-transforming protein 1 [KO:K06279]
129072430  SHC2; SHC-transforming protein 2 [KO:K17447]
129082357  SHC3; SHC-transforming protein 3 [KO:K17448]
129064266  SHC4; SHC-transforming protein 4 [KO:K17449]
129087362  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129064134  son of sevenless homolog 2 isoform X1 [KO:K03099]
129066034  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129070698  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
129075160  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129063058  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
129068603  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
129066346  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
129083119  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
129071919  T cell receptor alpha chain MC.7.G5-like [KO:K10784]
129071926  uncharacterized protein LOC129071926 [KO:K10784]
129080183  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
129078088  LAT; linker for activation of T-cells family member 1 [KO:K07362]
129069819  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
129079133  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
129083812  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
129071446  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
129076697  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
129063670  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
129066038  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
129068639  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
129072091  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
129069849  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
129077188  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129084020  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
129071162  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
129084761  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
129065166  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129085896  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129066388  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129066389  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129074288  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
129077794  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04543]
129081344  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
129082769  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
129079351  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
129063518  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
129062534  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
129071314  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
129083348  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
129062953  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
129080121  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
129061554  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129065641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129082621  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
129074653  RASGRF2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
129079149  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
129083674  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
129085005  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
129063259  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129082875  CALM3; calmodulin-3 [KO:K02183]
129084580  calmodulin-like [KO:K02183]
129065634  CALM2; calmodulin-2 [KO:K02183]
129065835  CALM1; calmodulin-1 [KO:K02183]
129078752  CALML6; calmodulin-like protein 6 [KO:K02183]
129086576  calmodulin-alpha-like [KO:K02183]
129087301  CALML3; calmodulin-like protein 3 [KO:K02183]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129063946  NRAS; GTPase NRas [KO:K07828]
129088421  MRAS; ras-related protein M-Ras [KO:K07831]
129082806  RRAS; ras-related protein R-Ras [KO:K07829]
129080543  RRAS2; ras-related protein R-Ras2 [KO:K07830]
129070273  NF1; neurofibromin isoform X1 [KO:K08052]
129074666  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
129088320  RASA2; ras GTPase-activating protein 2 [KO:K08053]
129064766  RASA3; ras GTPase-activating protein 3 [KO:K12380]
129083435  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
129067383  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
129087412  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
129082012  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
129074802  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
129087612  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
129062347  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
129070671  STK4; serine/threonine-protein kinase 4 [KO:K04411]
129074137  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
129078413  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129071250  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
129086649  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
129072772  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
129071792  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
129073649  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
129076178  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
129076651  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
129070859  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
129064359  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
129085967  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
129087688  RHOA; transforming protein RhoA [KO:K04513]
129074464  transforming protein RhoA-like isoform X1 [KO:K04513]
129075675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129076577  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129088291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129074969  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129069407  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129074590  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129076641  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129066231  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129073033  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129074378  IKBKG; NF-kappa-B essential modulator [KO:K07210]
129077110  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129064790  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129068571  RELA; transcription factor p65 [KO:K04735]
129068612  BAD; bcl2-associated agonist of cell death [KO:K02158]
129070790  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
129071131  FOXO4; forkhead box protein O4 [KO:K12358]
129081899  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129082271  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
129070909  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
129070704  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
129079186  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
129081981  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
129067361  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
129063346  RALA; ras-related protein Ral-A [KO:K07834]
129071736  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
129076361  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
129072342  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
129085556  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
129075846  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
129072034  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
129069687  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129065007  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129085376  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129081678  RALBP1; ralA-binding protein 1 [KO:K08773]
129069153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129088138  AFDN; afadin isoform X1 [KO:K05702]
129077174  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
129088423  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129069644  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
129068955  group IIE secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129068956  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
129068958  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129068959  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129069435  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
129069436  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129069889  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
129083699  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
129085290  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129087145  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129087450  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
129081965  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
129064043  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
129064044  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
129064045  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
129064047  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
129077817  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
129068478  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129068480  phospholipase A and acyltransferase 2-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129068629  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
129065226  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
129075370  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
129074560  ETS2; protein C-ets-2 [KO:K21932]
129087386  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
129070286  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
129087397  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
129063126  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
129063844  RAP1A; ras-related protein Rap-1A [KO:K04353]
129075864  RAP1B; ras-related protein Rap-1b [KO:K07836]
129070029  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
129070225  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129076731  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129081586  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
129068375  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
129079203  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
129082005  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
129088376  RAB5A; ras-related protein Rab-5A [KO:K07887]
129075760  ras-related protein Rab-5B [KO:K07888]
129075761  RAB5B; ras-related protein Rab-5B [KO:K07888]
129086904  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
129064138  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
ppam04010  MAPK signaling pathway
ppam04015  Rap1 signaling pathway
ppam04020  Calcium signaling pathway
ppam04144  Endocytosis
ppam04151  PI3K-Akt signaling pathway
ppam04660  T cell receptor signaling pathway
ppam04720  Long-term potentiation
ppam04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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