KEGG   PATHWAY: sdul03040
Entry
sdul03040                   Pathway                                
Name
Spliceosome - Solanum dulcamara (climbing nightshade)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
sdul03040  Spliceosome
sdul03040

Other DBs
GO: 0005681
Organism
Solanum dulcamara (climbing nightshade) [GN:sdul]
Gene
129883198  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
129899126  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:5.6.2.7]
129899692  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
129889146  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
129893789  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1-like isoform X1 [KO:K12813] [EC:5.6.2.6]
129873727  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1-like isoform X1 [KO:K12813] [EC:5.6.2.6]
129875935  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
129874619  uncharacterized protein LOC129874619 isoform X1 [KO:K12816]
129882820  uncharacterized protein LOC129882820 [KO:K12817]
129885362  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 isoform X1 [KO:K12818] [EC:5.6.2.6]
129870003  ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
129880463  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 isoform X1 [KO:K12818] [EC:5.6.2.6]
129893397  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 isoform X1 [KO:K12818] [EC:5.6.2.6]
129882022  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
129898191  ATP-dependent RNA helicase DEAH11, chloroplastic-like isoform X1 [KO:K12818] [EC:5.6.2.6]
129899214  pre-mRNA-splicing factor SLU7-like [KO:K12819]
129887096  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 [KO:K12820] [EC:5.6.2.6]
129880656  uncharacterized protein LOC129880656 [KO:K11086]
129899329  small nuclear ribonucleoprotein SmD1b-like [KO:K11087]
129899331  small nuclear ribonucleoprotein SmD1b [KO:K11087]
129882945  uncharacterized protein LOC129882945 isoform X1 [KO:K11096]
129874643  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
129874727  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
129901310  uncharacterized protein LOC129901310 [KO:K11097]
129896795  uncharacterized protein LOC129896795 [KO:K11097]
129877399  probable small nuclear ribonucleoprotein F isoform X1 [KO:K11098]
129900116  probable small nuclear ribonucleoprotein G [KO:K11099]
129881082  probable small nuclear ribonucleoprotein G [KO:K11099]
129873721  U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
129882952  U1 small nuclear ribonucleoprotein A [KO:K11091]
129898795  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
129887235  U1 small nuclear ribonucleoprotein C-like isoform X1 [KO:K11095]
129903692  pre-mRNA-processing protein 40A-like isoform X1 [KO:K12821]
129893487  pre-mRNA-processing protein 40A [KO:K12821]
129880331  RNA-binding motif protein 25 isoform X1 [KO:K12822]
129887398  DEAD-box ATP-dependent RNA helicase 46-like [KO:K12823] [EC:5.6.2.7]
129901381  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
129893831  ATP-dependent RNA helicase-like protein DB10 [KO:K12823] [EC:5.6.2.7]
129882538  ATP-dependent RNA helicase DBP2-like [KO:K12823] [EC:5.6.2.7]
129873971  ATP-dependent RNA helicase-like protein DB10 [KO:K12823] [EC:5.6.2.7]
129896675  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
129871703  pre-mRNA-processing protein 40C isoform X1 [KO:K12824]
129898843  transcription initiation factor TFIID subunit 15b [KO:K13098]
129899389  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
129896220  U2 small nuclear ribonucleoprotein A' [KO:K11092]
129900328  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
129900459  probable splicing factor 3A subunit 1 [KO:K12825]
129870013  probable splicing factor 3A subunit 1 [KO:K12825]
129882056  uncharacterized protein LOC129882056 [KO:K12826]
129894982  splicing factor SF3a60 homolog [KO:K12827]
129875879  uncharacterized protein LOC129875879 [KO:K12828]
129873614  uncharacterized protein LOC129873614 [KO:K12829]
129895492  uncharacterized protein LOC129895492 [KO:K12829]
129870004  spliceosome-associated protein 130 A [KO:K12830]
129875532  pre-mRNA-splicing factor prp12 isoform X1 [KO:K12830]
129904633  uncharacterized protein LOC129904633 isoform X1 [KO:K12831]
129894030  uncharacterized protein LOC129894030 [KO:K12831]
129882202  uncharacterized protein LOC129882202 [KO:K12831]
129889462  uncharacterized protein At4g14342 [KO:K12832]
129885228  splicing factor 3B subunit 6-like protein [KO:K12833]
129891511  PHD finger-like domain-containing protein 5A [KO:K12834]
129893077  PHD finger-like domain-containing protein 5A [KO:K12834]
129887104  DEAD-box ATP-dependent RNA helicase 24 isoform X1 [KO:K12835] [EC:5.6.2.7]
129887620  splicing factor U2af small subunit B-like [KO:K12836]
129902239  splicing factor U2af small subunit B-like [KO:K12836]
129876025  splicing factor U2af small subunit B-like [KO:K12836]
129870161  splicing factor U2af large subunit A-like isoform X1 [KO:K12837]
129872359  splicing factor U2af large subunit A isoform X1 [KO:K12837]
129872882  splicing factor U2af large subunit B isoform X1 [KO:K12837]
129883168  uncharacterized protein LOC129883168 [KO:K12837]
129875062  splicing factor U2af large subunit B-like isoform X1 [KO:K12837]
129885949  uncharacterized protein LOC129885949 [KO:K12839]
129874045  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
129896859  protein RRC1-like isoform X1 [KO:K12842]
129899547  sm-like protein LSM2 [KO:K12621]
129882858  sm-like protein LSM2 [KO:K12621]
129901318  sm-like protein LSM3A [KO:K12622]
129892596  sm-like protein LSM3A [KO:K12622]
129886146  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
129883236  sm-like protein LSM5 [KO:K12624]
129877166  sm-like protein LSM36B [KO:K12625]
129882132  sm-like protein LSM7 [KO:K12626]
129901189  sm-like protein LSM8 [KO:K12627]
129887396  protein RDM16-like [KO:K12843]
129870768  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
129886400  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
129889835  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
129877804  uncharacterized protein LOC129877804 [KO:K12845]
129882298  uncharacterized protein LOC129882298 [KO:K12845]
129891172  uncharacterized protein LOC129891172 [KO:K12846]
129873808  uncharacterized protein LOC129873808 [KO:K12847]
129899070  SART-1 family protein DOT2 [KO:K11984]
129886099  uncharacterized protein LOC129886099 [KO:K12848]
129886122  pre-mRNA-splicing factor 38 [KO:K12849]
129870281  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
129891462  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
129899185  DExH-box ATP-dependent RNA helicase DExH12-like [KO:K12854] [EC:5.6.2.6]
129900767  protein STABILIZED1-like [KO:K12855]
129900769  protein STABILIZED1-like [KO:K12855]
129891305  pre-mRNA-processing-splicing factor 8A [KO:K12856]
129870857  uncharacterized protein LOC129870857 [KO:K12857]
129872966  DEAD-box ATP-dependent RNA helicase 21-like [KO:K12858] [EC:5.6.2.7]
129873318  thioredoxin-like protein YLS8 [KO:K12859]
129882786  pre-mRNA-processing factor 19 homolog 2-like isoform X1 [KO:K10599] [EC:2.3.2.27]
129883182  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
129870058  cell division cycle 5-like protein [KO:K12860]
129895820  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
129886591  protein pleiotropic regulatory locus 1-like [KO:K12862]
129877535  uncharacterized protein LOC129877535 [KO:K12863]
129873635  uncharacterized protein LOC129873635 [KO:K12864]
129885903  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
129887715  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
129902044  heat shock cognate 70 kDa protein 2-like [KO:K03283]
129902761  heat shock 70 kDa protein 7, chloroplastic-like [KO:K03283]
129903443  heat shock cognate 70 kDa protein [KO:K03283]
129870007  heat shock cognate 70 kDa protein 2-like [KO:K03283]
129893108  heat shock 70 kDa protein-like [KO:K03283]
129882231  heat shock cognate 70 kDa protein 2-like [KO:K03283]
129894335  heat shock 70 kDa protein-like [KO:K03283]
129894986  heat shock 70 kDa protein-like [KO:K03283]
129898600  heat shock cognate 70 kDa protein 1 [KO:K03283]
129875987  heat shock cognate 70 kDa protein 2 [KO:K03283]
129903226  uncharacterized protein LOC129903226 [KO:K12865]
129870173  SNW/SKI-interacting protein A [KO:K06063]
129886951  uncharacterized protein LOC129886951 [KO:K12867]
129877887  uncharacterized protein LOC129877887 isoform X1 [KO:K12868]
129895673  LOW QUALITY PROTEIN: uncharacterized protein LOC129895673 [KO:K12869]
129874180  uncharacterized protein LOC129874180 [KO:K12869]
129880770  uncharacterized protein LOC129880770 isoform X1 [KO:K12870]
129882176  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
129901120  uncharacterized protein LOC129901120 [KO:K12871]
129876181  zinc finger CCCH domain-containing protein 49-like [KO:K12872]
129870394  zinc finger CCCH domain-containing protein 49-like [KO:K12872]
129902874  protein BUD31 homolog 1-like [KO:K12873]
129882112  protein BUD31 homolog 2 [KO:K12873]
129887045  uncharacterized protein LOC129887045 [KO:K12874]
129902331  uncharacterized protein LOC129902331 [KO:K12875]
129904105  uncharacterized protein LOC129904105 [KO:K12875]
129870262  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
129900774  RNA-binding protein Y14A-like [KO:K12876]
129904252  RNA-binding protein Y14A-like [KO:K12876]
129901241  protein mago nashi homolog [KO:K12877]
129896363  protein mago nashi homolog [KO:K12877]
129886391  THO complex subunit 1 [KO:K12878]
129902126  THO complex subunit 2-like [KO:K12879]
129903568  THO complex subunit 2-like [KO:K12879]
129876059  LOW QUALITY PROTEIN: THO complex subunit 2-like [KO:K12879]
129892142  THO complex subunit 3 [KO:K12880]
129902053  THO complex subunit 4A isoform X1 [KO:K12881]
129870103  THO complex subunit 4D-like [KO:K12881]
129897109  THO complex subunit 4D-like isoform X1 [KO:K12881]
129875992  THO complex subunit 4A-like [KO:K12881]
129877850  nuclear cap-binding protein subunit 1 [KO:K12882]
129903653  nuclear cap-binding protein subunit 2-like [KO:K12883]
129872172  nuclear cap-binding protein subunit 2 [KO:K12883]
129887650  UBP1-associated protein 2A-like [KO:K12741]
129877343  glycine-rich RNA-binding protein 4, mitochondrial-like [KO:K12741]
129870302  UBP1-associated protein 2A-like [KO:K12741]
129892072  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
129870553  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
129870801  UBP1-associated protein 2C-like [KO:K12741]
129872817  glycine-rich RNA-binding protein 4, mitochondrial-like [KO:K12741]
129873827  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
129896166  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
129874496  glycine-rich RNA-binding protein 3, mitochondrial-like [KO:K12741]
129875168  UBP1-associated protein 2C-like [KO:K12741]
129876153  UBP1-associated protein 2A-like [KO:K12741]
129886140  serine/arginine-rich splicing factor SR30 isoform X1 [KO:K12890]
129894476  serine/arginine-rich splicing factor SR34A [KO:K12890]
129882941  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
129898633  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
129885787  serine/arginine-rich splicing factor SC35-like isoform X1 [KO:K12891]
129902214  serine/arginine-rich splicing factor SC35-like [KO:K12891]
129886429  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
129886638  serine/arginine-rich splicing factor RS41-like isoform X1 [KO:K12893]
129902288  serine/arginine-rich splicing factor RS31-like [KO:K12893]
129877242  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
129895283  serine/arginine-rich splicing factor RS31 isoform X1 [KO:K12893]
129888896  serine/arginine-rich splicing factor RSZ22A isoform X1 [KO:K12896]
129889476  serine/arginine-rich splicing factor RSZ22A-like [KO:K12896]
129881052  serine/arginine-rich splicing factor RS2Z32-like [KO:K12896]
129874398  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor SR45a [KO:K12897]
129887221  serine/arginine-rich SC35-like splicing factor SCL28 isoform X1 [KO:K12900]
129887838  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
129884300  serine/arginine-rich SC35-like splicing factor SCL30A isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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