KEGG   PATHWAY: setr04014
Entry
setr04014                   Pathway                                
Name
Ras signaling pathway - Suncus etruscus (white-toothed pygmy shrew)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
setr04014  Ras signaling pathway
setr04014

Other DBs
GO: 0032318
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
126027570  EGF; pro-epidermal growth factor [KO:K04357]
126024677  TGFA; protransforming growth factor alpha [KO:K08774]
126027928  FGF1; fibroblast growth factor 1 [KO:K18496]
126003833  FGF2; fibroblast growth factor 2 [KO:K18497]
126011901  FGF18; fibroblast growth factor 18 [KO:K04358]
126003322  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
125994821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
126030532  FGF22; fibroblast growth factor 22 [KO:K04358]
126015702  FGF9; fibroblast growth factor 9 [KO:K04358]
126006634  FGF6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
126006877  FGF20; fibroblast growth factor 20 [KO:K04358]
126032628  FGF5; fibroblast growth factor 5 [KO:K04358]
126001075  FGF10; fibroblast growth factor 10 [KO:K04358]
126018801  FGF3; fibroblast growth factor 3 [KO:K04358]
126019083  FGF4; fibroblast growth factor 4 [KO:K04358]
126020032  FGF7; fibroblast growth factor 7 [KO:K04358]
126018800  FGF19; fibroblast growth factor 19 [KO:K22603]
126028612  FGF21; fibroblast growth factor 21 [KO:K22429]
126006944  FGF23; fibroblast growth factor 23 [KO:K22428]
125997353  NGF; beta-nerve growth factor [KO:K02582]
126019007  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
126006607  NTF3; neurotrophin-3 [KO:K04356]
126027220  NTF4; neurotrophin-4 [KO:K12457]
126019098  INS; insulin [KO:K04526]
126022310  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
126019086  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
126030482  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126006376  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
126003432  PDGFC; platelet-derived growth factor C [KO:K05450]
126016055  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
125997278  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
126022954  KITLG; kit ligand [KO:K05461]
126028621  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
125996266  VEGFA; vascular endothelial growth factor A [KO:K05448]
126017939  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
126004091  PGF; placenta growth factor [KO:K16859]
126007180  VEGFC; vascular endothelial growth factor C [KO:K05449]
125998737  VEGFD; vascular endothelial growth factor D [KO:K05449]
126008496  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
126009505  ANGPT1; angiopoietin-1 [KO:K05465]
126033630  ANGPT2; angiopoietin-2 [KO:K05466]
126017359  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
126001958  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
126029639  EFNA2; ephrin-A2 [KO:K05462]
126020759  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
126020762  EFNA1; ephrin-A1 [KO:K05462]
126020137  EFNA4; ephrin-A4 [KO:K05462]
126013961  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
126006406  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125994891  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
126032236  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
126012016  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
126018196  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126020472  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
126004189  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
126031127  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
126021814  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
126032431  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126006402  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126006483  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126032299  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
126015636  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
126015921  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126015747  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
126032296  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126004843  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
126004527  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
126006516  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
126003551  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
126004441  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
126018145  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
126020709  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
126030826  SHC2; SHC-transforming protein 2 [KO:K17447]
126003375  SHC3; SHC-transforming protein 3 [KO:K17448]
126020007  SHC4; SHC-transforming protein 4 [KO:K17449]
126002199  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
126031062  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
126023864  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125999018  SOS2; son of sevenless homolog 2 [KO:K03099]
126017276  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126027269  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126032385  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
126019028  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126023857  RASGRP3; LOW QUALITY PROTEIN: ras guanyl-releasing protein 3 [KO:K12362]
126028506  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
126024149  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
126029540  LAT; linker for activation of T-cells family member 1 [KO:K07362]
125994875  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
126011605  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126031035  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126006589  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126012077  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126002081  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125999572  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126017910  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
126030791  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126005956  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126026239  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126031195  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126028279  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126020263  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126003829  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126023960  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024701  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126033760  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125999484  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126000312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126010869  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126010895  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126020118  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024681  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126030830  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126010822  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126001569  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126024671  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126020139  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126022691  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
125997691  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
126020805  GRIN1; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1 [KO:K05208]
126001222  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
126022424  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
126003621  CALM1; calmodulin-1 [KO:K02183]
126013297  calmodulin-like protein 3 [KO:K02183]
126013298  calmodulin-4-like [KO:K02183]
126023953  CALM2; calmodulin-2 [KO:K02183]
126015982  CALML4; calmodulin-like protein 4 [KO:K02183]
126031280  calmodulin-1-like [KO:K02183]
126001307  calmodulin-1-like [KO:K02183]
126028268  CALM3; calmodulin-3 [KO:K02183]
126019084  HRAS; GTPase HRas [KO:K02833]
126022823  KRAS; GTPase KRas isoform X1 [KO:K07827]
125997372  NRAS; GTPase NRas [KO:K07828]
126012178  MRAS; ras-related protein M-Ras [KO:K07831]
126027209  RRAS; ras-related protein R-Ras [KO:K07829]
126018972  RRAS2; ras-related protein R-Ras2 [KO:K07830]
126007754  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
126001889  RASA1; ras GTPase-activating protein 1 [KO:K04352]
126025533  RASA2; ras GTPase-activating protein 2 [KO:K08053]
126015557  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
126029604  RASA4B; ras GTPase-activating protein 4B [KO:K17630]
125996220  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
126029501  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
126013348  RALGPS2; ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1 [KO:K17633]
126029416  RASAL3; RAS protein activator like-3 [KO:K17634]
126014079  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
126004546  RASSF5; ras association domain-containing protein 5 [KO:K08015]
126017350  STK4; serine/threonine-protein kinase 4 [KO:K04411]
126026136  TIAM1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
126030488  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126006381  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126013731  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
126013242  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
126017532  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
126012201  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126022427  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
125999512  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
126027603  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
126018108  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
126024722  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
126014129  RHOA; LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
126012035  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126012036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126011501  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
126030200  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126011086  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126001552  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
126013417  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126033346  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126028133  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125999080  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
126033816  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
126006407  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126027544  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126019025  RELA; transcription factor p65 [KO:K04735]
126017861  BAD; bcl2-associated agonist of cell death [KO:K02158]
126017437  BCL2L1; bcl-2-like protein 1 [KO:K04570]
125999208  FOXO4; forkhead box protein O4 isoform X1 [KO:K12358]
125998321  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
126010737  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
126017271  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
126009524  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
126013377  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
125995678  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
126020426  RALA; ras-related protein Ral-A [KO:K07834]
126008878  RALB; ras-related protein Ral-B [KO:K07835]
126011919  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
126012160  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
125996164  EXOC2; exocyst complex component 2 [KO:K17637]
126021869  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
126024364  REL; proto-oncogene c-Rel [KO:K09254]
126015663  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126032054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126033690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126003714  RALBP1; ralA-binding protein 1 [KO:K08773]
125994825  cell division control protein 42 homolog [KO:K04393]
126024665  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
125998704  cell division control protein 42 homolog [KO:K04393]
126018299  cell division control protein 42 homolog [KO:K04393]
126011308  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
126028736  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
126024707  AFDN; afadin isoform X1 [KO:K05702]
126033782  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
125998044  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126021920  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126029670  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
126029893  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126033704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126026202  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
126029781  PLA2G3; LOW QUALITY PROTEIN: group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126006641  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
126006644  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
126006645  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
126030951  PLA2G12B; group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
126006982  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126006983  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126006984  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126006985  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
126006987  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
126006989  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
126006991  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126001021  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
126001022  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
126001611  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
126001612  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
126014260  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
126020067  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
126020108  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
126020233  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
126020234  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
126006213  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
126017864  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
126018770  phospholipase A and acyltransferase 2-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
125999215  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
126015652  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
126025596  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
126031063  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
126007850  KSR1; LOW QUALITY PROTEIN: kinase suppressor of Ras 1 [KO:K14958]
126030561  KSR2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
126025574  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
125997373  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
126021897  RAP1B; ras-related protein Rap-1b [KO:K07836]
126006387  ras-related protein Rap-1b [KO:K07836]
126033783  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126018784  RIN1; ras and Rab interactor 1 [KO:K17638]
126009522  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
126013362  ABL2; tyrosine-protein kinase ABL2 [KO:K08887] [EC:2.7.10.2]
125997961  RAB5A; ras-related protein Rab-5A [KO:K07887]
126023030  RAB5B; ras-related protein Rab-5B [KO:K07888]
126019115  RAB5C; ras-related protein Rab-5C [KO:K07889]
125999524  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
setr04010  MAPK signaling pathway
setr04015  Rap1 signaling pathway
setr04020  Calcium signaling pathway
setr04144  Endocytosis
setr04151  PI3K-Akt signaling pathway
setr04660  T cell receptor signaling pathway
setr04720  Long-term potentiation
setr04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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