Entry
Name
Salmonella infection - Ursus americanus (American black bear)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Ursus americanus (American black bear) [GN:
uar ]
Gene
123802907 PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
123792642 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
123799065 VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180 ]
123775612 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
123779532 VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
123789428 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
123778196 DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413 ]
123792507 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
123780770 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
123789260 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
123803458 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
123778626 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
123775964 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
123798234 DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419 ]
123780078 FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954 ]
123785745 ARL8A; ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955 ]
123777784 PLEKHM2; LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 2 [KO:K15348 ]
123775971 GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282 ]
123789834 AHNAK; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934 ]
123801947 ARHGEF26; rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744 ]
123789062 ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366 ]
123797058 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
123779111 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351 ]
123789626 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
123784777 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
123803506 FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
123782153 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
123790740 CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749 ]
123791962 WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
123787979 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
123786407 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
123788422 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
123779078 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
123789397 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
123785698 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
123781709 PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923 ] [EC:2.7.1.154 ]
123791675 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
123792727 toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
123792836 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
123790266 CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391 ]
123780921 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
123797428 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
123780100 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
123795860 CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467 ] [EC:2.7.11.10 ]
123788912 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
123789109 NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
123799645 TCF7L1; LOW QUALITY PROTEIN: transcription factor 7-like 1 [KO:K04490 ]
123781572 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
123803514 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
123786394 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
123798082 LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738 ]
123796485 NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800 ]
123800254 LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807 ]
123784680 apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
uar04621 NOD-like receptor signaling pathway
KO pathway
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