KEGG   PATHWAY: umr05169
Entry
umr05169                    Pathway                                
Name
Epstein-Barr virus infection - Ursus maritimus (polar bear)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
umr05169  Epstein-Barr virus infection
umr05169

Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103657661  complement receptor type 2 isoform X1 [KO:K04012]
103657814  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
103665506  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
103665508  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
103665509  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
103665516  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
103665517  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
103665518  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
103665519  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
103665521  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
103665522  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
103665562  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
103658031  toll-like receptor 2 [KO:K10159]
103680724  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103675405  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
103679690  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103659308  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103676518  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103666926  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103660092  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103658916  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103677059  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103679680  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103666055  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103677947  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103679584  RELA; transcription factor p65 [KO:K04735]
103682322  TNF; tumor necrosis factor [KO:K03156]
103658871  IL6; interleukin-6 [KO:K05405]
103667020  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
103674396  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
103656774  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103656833  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103671004  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103671092  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
103657131  IRF3; interferon regulatory factor 3 [KO:K05411]
103662147  interferon alpha-1/2-like [KO:K05414]
103662148  interferon alpha-1/2-like [KO:K05414]
103662149  interferon alpha-2-like [KO:K05414]
103680385  interferon alpha-1/2-like [KO:K05414]
103680386  interferon alpha-1/2-like [KO:K05414]
103666985  interferon alpha-1/2-like [KO:K05414]
121103043  interferon alpha-1/2-like [KO:K05414]
103662150  IFNB1; interferon beta [KO:K05415]
103673220  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
103673110  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
103663059  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103678725  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
103659933  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103656206  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
103679279  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
103671577  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103661290  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
103661196  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
103665330  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
103682059  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
103661934  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103671072  FADD; FAS-associated death domain protein [KO:K02373]
103659742  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
103675694  BID; BH3-interacting domain death agonist [KO:K04726]
103671504  BCL2L11; bcl-2-like protein 11 isoform X8 [KO:K16341]
103676164  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
103657107  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103665481  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103658902  cytochrome c [KO:K08738]
103662923  cytochrome c-like [KO:K08738]
121104237  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
103660136  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
103666628  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
103680991  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103662338  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
103662336  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
103662337  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
103667447  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
103658639  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
103670329  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
103661036  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
103672921  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
103672308  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
103665634  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
103676082  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
103662680  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
103662209  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
103665659  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
103667431  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
103674226  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
103668940  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 6-like [KO:K03037]
121106099  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 6-like [KO:K03037]
103673708  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
103671026  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
103667517  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
103659502  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
103661007  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
103657400  26S proteasome complex subunit SEM1-like [KO:K10881]
103658750  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
103665513  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103665515  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103665491  tapasin [KO:K08058]
103673527  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103682146  CALR; calreticulin [KO:K08057]
103680441  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
103656357  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
103680561  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103672268  class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
103682344  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
121104340  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
103673380  B2M; beta-2-microglobulin [KO:K08055]
103670735  SNW1; SNW domain-containing protein 1 [KO:K06063]
103678978  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
103676974  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103666443  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
103661248  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
103664560  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
103675973  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
103659581  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
103658384  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
103669875  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
103676171  HES1; transcription factor HES-1 [KO:K06054]
103681737  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X2 [KO:K06468]
103666784  protein lozenge isoform X1 [KO:K09279]
103661697  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103668586  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
103656869  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
103660368  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103665536  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103681651  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103663135  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103663314  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
121100135  growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
103672315  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
103663562  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103672476  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103665883  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
103657178  RELB; transcription factor RelB [KO:K09253]
103659023  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103673673  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
103661015  NFKBIB; LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta [KO:K02581]
103664144  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
103660510  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103681888  MAP2K7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103676947  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103679990  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103667893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103675245  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103664964  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103658475  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103665687  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103674115  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103665451  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103665538  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103674004  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103670861  JUN; transcription factor AP-1 [KO:K04448]
103680467  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
103675256  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
103671702  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
103669702  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
103659318  CD44; CD44 antigen isoform X1 [KO:K06256]
103657863  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
103669446  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
103678731  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103664244  VIM; vimentin [KO:K07606]
103663491  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
103675167  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
103672573  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
103677438  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103663192  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103676773  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103672987  BTK; tyrosine-protein kinase BTK isoform X2 [KO:K07370] [EC:2.7.10.2]
103672241  BLNK; LOW QUALITY PROTEIN: B-cell linker protein [KO:K07371]
103662093  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103664708  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
103677760  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103671139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103675743  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103664092  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
103656694  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103658796  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103661798  CCNA2; cyclin-A2 [KO:K06627]
103664372  CCNA1; cyclin-A1 [KO:K06627]
103661328  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
103661444  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
103682503  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103677688  RB1; retinoblastoma-associated protein [KO:K06618]
103674455  E2F1; transcription factor E2F1 [KO:K17454]
103666789  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
103678383  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
umr03050  Proteasome
umr04010  MAPK signaling pathway
umr04020  Calcium signaling pathway
umr04064  NF-kappa B signaling pathway
umr04110  Cell cycle
umr04115  p53 signaling pathway
umr04210  Apoptosis
umr04612  Antigen processing and presentation
umr04620  Toll-like receptor signaling pathway
umr04622  RIG-I-like receptor signaling pathway
umr04630  JAK-STAT signaling pathway
umr04662  B cell receptor signaling pathway
KO pathway
ko05169   
LinkDB

DBGET integrated database retrieval system