Entry
Name
Salmonella infection - Vicugna pacos (alpaca)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Vicugna pacos (alpaca) [GN:
vpc ]
Gene
102538248 PIK3C3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914 ] [EC:2.7.1.137 ]
102544579 PLEKHM1; LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 1 [KO:K23282 ]
102536600 VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X2 [KO:K20179 ]
102539105 VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X2 [KO:K20180 ]
102525165 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
102532291 VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
102538291 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
102533680 DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413 ]
102527058 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X3 [KO:K10414 ]
102533107 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
102532218 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X6 [KO:K10415 ]
102531345 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
102544492 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
102545065 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
102538423 DYNLRB2; dynein light chain roadblock-type 2 isoform X2 [KO:K10419 ]
102541296 DYNLRB1; dynein light chain roadblock-type 1 isoform X2 [KO:K10419 ]
102529628 FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954 ]
102538008 PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348 ]
102529987 GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282 ]
102534213 AHNAK; neuroblast differentiation-associated protein AHNAK isoform X3 [KO:K23934 ]
102531681 ELMO1; engulfment and cell motility protein 1 isoform X4 [KO:K12366 ]
102525524 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
102533574 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
102531586 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
102544842 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
102528871 FHOD1; FH1/FH2 domain-containing protein 1 isoform X2 [KO:K23938 ]
102530757 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
102543993 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
102541241 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X2 [KO:K05749 ]
102532619 WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
102533014 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
102540289 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102524821 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102543068 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
102538381 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [KO:K21289 ] [EC:2.7.1.153 ]
102535923 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923 ] [EC:2.7.1.154 ]
102543602 PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X3 [KO:K00923 ] [EC:2.7.1.154 ]
102526233 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
102532829 WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
102540249 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
102538305 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
102530894 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
102534039 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
102545976 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793 ]
102534431 CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467 ] [EC:2.7.11.10 ]
102532161 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
102542675 NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
102544341 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
102526687 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
102537869 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
107033437 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
116286113 tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722 ]
102527680 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
102539442 NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807 ]
102537334 NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805 ]
102532249 apoptosis-associated speck-like protein containing a CARD isoform X2 [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
vpc04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
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