KEGG   PATHWAY: rno05206
Entry
rno05206                    Pathway                                
Name
MicroRNAs in cancer - Rattus norvegicus (rat)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
rno05206  MicroRNAs in cancer
rno05206

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100313972  Mirlet7d; rno-let-7d-5p [KO:K16980]
100313974  Mir330; rno-miR-330-5p [KO:K17373]
100313980  Mir342; rno-miR-342-5p [KO:K17132]
100313984  Mir129-2; rno-miR-129-5p [KO:K17368]
100313987  Mir135b; rno-miR-135b-5p [KO:K17144]
100313988  Mir101-2; rno-miR-101b-5p [KO:K17129]
100313989  Mirlet7a-2; rno-let-7a-5p [KO:K16980]
100313990  Mirlet7b; rno-let-7b-5p [KO:K16980]
100313991  Mirlet7e; rno-let-7e-5p [KO:K16980]
100313992  Mirlet7f2; rno-let-7f-5p [KO:K16980]
100313993  Mirlet7i; rno-let-7i-5p [KO:K16980]
100313994  Mir9-1; rno-miR-9a-5p [KO:K16977]
100313995  Mir9-2; rno-miR-9a-5p [KO:K16977]
100313996  Mir10a; rno-miR-10a-5p [KO:K16864]
100313997  Mir16; rno-miR-16-5p [KO:K16988]
100313998  Mir17; rno-miR-17-5p [KO:K17002]
100313999  Mir19b2; rno-miR-19b-2-5p [KO:K17005]
100314000  Mir21; rno-miR-21-5p [KO:K16863]
100314002  Mir23b; rno-miR-23b-5p [KO:K17165]
100314004  Mir25; rno-miR-25-5p [KO:K17038]
100314005  Mir27b; rno-miR-27b-5p [KO:K17112]
100314006  Mir27a; rno-miR-27a-5p [KO:K17112]
100314007  Mir29b2; rno-miR-29b-5p [KO:K16995]
100314008  Mir29b1; rno-miR-29b-1-5p [KO:K16995]
100314009  Mir30c1; rno-miR-30c-5p [KO:K17110]
100314010  Mir30d; rno-miR-30d-5p [KO:K17110]
100314011  Mir30a; rno-miR-30a-5p [KO:K17110]
100314012  Mir30c2; rno-miR-30c-5p [KO:K17110]
100314013  Mir32; rno-miR-32-5p [KO:K17039]
100314014  Mir34c; rno-miR-34c-5p [KO:K16982]
100314015  Mir34a; rno-miR-34a-5p [KO:K16982]
100314016  Mir92a2; rno-miR-92a-2-5p [KO:K17008]
100314017  Mir96; rno-miR-96-5p [KO:K17114]
100314018  Mir98; rno-miR-98-5p [KO:K16980]
100314019  Mir99a; rno-miR-99a-5p [KO:K17367]
100314020  Mir103a2; rno-miR-103-2-5p [KO:K16989]
100314021  Mir103a1; rno-miR-103-1-5p [KO:K16989]
100314022  Mir107; rno-miR-107-5p [KO:K17396]
100314023  Mir122; rno-miR-122-5p [KO:K17020]
100314024  Mir124-2; rno-miR-124-5p [KO:K17126]
100314025  Mir125b2; rno-miR-125b-5p [KO:K16993]
100314026  Mir128-1; rno-miR-128-1-5p [KO:K17130]
100314027  Mir128-2; rno-miR-128-2-5p [KO:K17130]
100314030  Mir133a1; rno-miR-133a-5p [KO:K16970]
100314031  Mir137; rno-miR-137-5p [KO:K17369]
100314035  Mir143; rno-miR-143-5p [KO:K17023]
100314036  Mir145; rno-miR-145-5p [KO:K16974]
100314037  Mir152; rno-miR-152-5p [KO:K17370]
100314040  Mir181b1; rno-miR-181b-5p [KO:K17025]
100314041  Mir183; rno-miR-183-5p [KO:K17116]
100314046  Mir194-1; rno-miR-194-5p [KO:K17371]
100314047  Mir194-2; rno-miR-194-5p [KO:K17371]
100314049  Mir200c; rno-miR-200c-5p [KO:K17015]
100314050  Mir200b; rno-miR-200b-5p [KO:K17015]
100314052  Mir206; rno-miR-206-5p [KO:K16973]
100314053  Mir210; rno-miR-210-5p [KO:K17178]
100314059  Mir222; rno-miR-222-5p [KO:K17011]
100314060  Mir223; rno-miR-223-5p [KO:K17001]
100314068  Mir449a; rno-miR-449a-5p [KO:K17377]
100314070  Mir451a; rno-miR-451-5p [KO:K17172]
100314074  Mir215; rno-miR-215 [KO:K17167]
100314075  Mir224; rno-miR-224-5p [KO:K17042]
100314077  Mir1; rno-miR-1-5p [KO:K16972]
100314078  Mir133b; rno-miR-133b-5p [KO:K16970]
100314082  Mir494; rno-miR-494-5p [KO:K17378]
100314101  Mir106a; rno-miR-17-5p [KO:K17034]
100314121  Mir146b; rno-miR-146b-5p [KO:K17012]
100314129  Mir615; rno-miR-615 [KO:K17380]
100314147  Mir345; rno-miR-345-5p [KO:K17375]
100314148  Mir7-1; rno-miR-7a-5p [KO:K17365]
100314149  Mir9-3; rno-miR-9a-5p [KO:K16977]
100314150  Mir15b; rno-miR-15b-5p [KO:K16986]
100314151  Mir19a; rno-miR-19a-5p [KO:K17005]
100314152  Mir28; rno-miR-28-5p [KO:K17366]
100314153  Mir30e; rno-miR-30e-5p [KO:K17110]
100314155  Mir124-3; rno-miR-124-5p [KO:K17126]
100314156  Mir125b1; rno-miR-125b-5p [KO:K16993]
100314157  Mir129-1; rno-miR-129-5p [KO:K17368]
100314158  Mir150; rno-miR-150-5p [KO:K17024]
100314159  Mir181b2; rno-miR-181b-5p [KO:K17025]
100314161  Mir203; rno-miR-203a-5p [KO:K16975]
100314163  Mir221; rno-miR-221-5p [KO:K17010]
100314169  Mir363; rno-miR-363-5p [KO:K17036]
100314181  Mir324; rno-miR-324-5p [KO:K17152]
100314184  Mirlet7c1; rno-let-7c-5p [KO:K16980]
100314185  Mir9; rno-miR-7b [KO:K17365]
100314186  Mir19b1; rno-miR-19b-1-5p [KO:K17005]
100314187  Mir29c; rno-miR-29c-5p [KO:K16995]
100314188  Mir34b; rno-miR-34b-5p [KO:K16982]
100314189  Mir99b; rno-miR-99b-5p [KO:K17367]
100314193  Mir192; rno-miR-192-5p [KO:K17131]
100314194  Mir200a; rno-miR-200a-5p [KO:K17015]
100314195  Mir181a-1; rno-miR-181a-5p [KO:K17025]
100314198  Mir483; rno-miR-483-5p [KO:K17137]
100314201  Mir20b; rno-miR-20b-5p [KO:K17006]
100314213  Mirlet7a1; rno-let-7a-5p [KO:K16980]
100314215  Mir141; rno-miR-141-5p [KO:K17018]
100314222  Mir20a; rno-miR-20a-5p [KO:K17006]
100314224  Mirlet7c2; rno-let-7c-5p [KO:K16980]
100314225  Mir8; rno-miR-7a-5p [KO:K17365]
100314226  Mir10b; rno-miR-10b-5p [KO:K16864]
100314227  Mir18a; rno-miR-18a-5p [KO:K17003]
100314228  Mir23a; rno-miR-23a-5p [KO:K17165]
100314229  Mir26b; rno-miR-26b-5p [KO:K16984]
100314230  Mir29a; rno-miR-29a-5p [KO:K16995]
100314231  Mir30b; rno-miR-30b-5p [KO:K17110]
100314232  Mir31; rno-miR-31a-5p [KO:K17183]
100314233  Mir92a1; rno-miR-92a-1-5p [KO:K17008]
100314234  Mir100; rno-miR-100-5p [KO:K17041]
100314235  Mir106b; rno-miR-106b-5p [KO:K17034]
100314236  Mir125a; rno-miR-125a-5p [KO:K16993]
100314237  Mir126b; rno-miR-126a-5p [KO:K16978]
100314241  Mir146a; rno-miR-146a-5p [KO:K17012]
100314242  Mir181c; rno-miR-181c-5p [KO:K17025]
100314245  Mir199a2; rno-miR-199a-5p [KO:K17118]
100314246  Mir205; rno-miR-205 [KO:K17150]
100314262  Mir181d; rno-miR-181d-5p [KO:K17025]
100314264  Mir423; rno-miR-423-5p [KO:K17376]
100314277  Mirlet7f-1os; rno-let-7f-5p [KO:K16980]
100314279  Mir101a; rno-miR-101a-5p [KO:K17129]
100314280  Mir135a; rno-miR-135a-5p [KO:K17144]
100314281  Mir195; rno-miR-195-5p [KO:K17029]
100314290  Mir26a; rno-miR-26a-5p [KO:K16984]
100314291  Mir124-1; rno-miR-124-5p [KO:K17126]
100314292  Mir181a2; rno-miR-181a-5p [KO:K17025]
100359916  [KO:K12886]
100526564  Mir3545; rno-miR-203b-5p [KO:K16975]
100526570  Mir3553; rno-miR-3553 [KO:K17116]
100526572  Mir3556b; rno-miR-3556b [KO:K16995]
100526574  Mirlet7f-1; rno-miR-3596d [KO:K16980]
100526581  Mir3597-1; rno-miR-9b-5p [KO:K16977]
100526596  Mir3596b; rno-miR-3596b [KO:K16980]
100526597  Mir3582; rno-miR-133c [KO:K16970]
100526599  Mir3596c; rno-miR-3596c [KO:K16980]
100526602  Mir3587; rno-miR-3587 [KO:K16995]
100526604  Mir3588; rno-miR-3588 [KO:K16993]
100526608  Mir3591; rno-miR-3591 [KO:K17020]
100526617  Mir3597-3; rno-miR-9b-5p [KO:K16977]
100526629  Mir449c; rno-miR-449c-5p [KO:K17377]
100526636  Mir3597-2; rno-miR-9b-5p [KO:K16977]
100526642  Mir3596a; rno-miR-3596a [KO:K16980]
102465831  Mir155; rno-miR-155-5p [KO:K17009]
102546674  [KO:K04381]
102551813  [KO:K04381]
104796289  Mir1b; rno-miR-1b [KO:K16972]
104796557  Mirlet7g; rno-let-7g-5p [KO:K16980]
104797223  Mir193b; rno-miR-193b-5p [KO:K17148]
114093  St14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
114483  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114509  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
116589  Serpinb5; serpin B5 [KO:K10139]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116640  Tnc; tenascin precursor [KO:K06252]
116683  Efna5; ephrin-A5 precursor [KO:K05462]
117273  Rhoa; transforming protein RhoA [KO:K04513]
117282  Hnrnpk; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
120103068  [KO:K10577]
134484121  [KO:K00922] [EC:2.7.1.153]
140590  Bmpr2; bone morphogenetic protein receptor type-2 precursor [KO:K04671] [EC:2.7.11.30]
140942  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170901  Efna3; ephrin-A3 isoform X1 [KO:K05462]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
170913  Abcb1a; ATP binding cassette subfamily B member 1A [KO:K05658] [EC:7.6.2.2]
170915  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
171102  Cdc25a; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
171103  Cdc25b; M-phase inducer phosphatase 2 isoform 1 [KO:K05866] [EC:3.1.3.48]
192268  Gls2; glutaminase liver isoform, mitochondrial isoform 1 [KO:K01425] [EC:3.5.1.2]
24205  Apc; adenomatous polyposis coli protein [KO:K02085]
24224  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24337  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
24398  Gls; glutaminase kidney isoform, mitochondrial isoform a [KO:K01425] [EC:3.5.1.2]
24451  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
24525  Kras; GTPase KRas [KO:K07827]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
24565  Abcc1; multidrug resistance-associated protein 1 [KO:K05665] [EC:7.6.2.3]
24577  Myc; myc proto-oncogene protein [KO:K04377]
24605  Nras; GTPase NRas [KO:K07828]
246142  Bmf; bcl-2-modifying factor isoform 1 [KO:K17460]
24628  Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
24629  Pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
246334  Tp63; tumor protein 63 isoform a [KO:K10149]
24646  Abcb1b; ATP-dependent translocase ABCB1 [KO:K05658] [EC:7.6.2.2]
24649  Pim1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24851  Tpm1; tropomyosin alpha-1 chain isoform Tpm1.6cy [KO:K10373]
24882  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
25125  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
25163  Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
25266  Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
25279  Cyp24a1; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor [KO:K07436] [EC:1.14.15.16]
252971  Socs1; suppressor of cytokine signaling 1 [KO:K04694]
25358  Timp3; metalloproteinase inhibitor 3 precursor [KO:K16866]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
25405  Ccng1; cyclin-G1 [KO:K10145]
25406  Cd44; CD44 antigen precursor [KO:K06256]
25426  Cyp1b1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
25467  Irs1; insulin receptor substrate 1 [KO:K16172]
25496  Notch1; neurogenic locus notch homolog protein 1 precursor [KO:K02599]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25567  Tnr; tenascin-R precursor [KO:K06252]
25573  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
25603  Marcks; myristoylated alanine-rich C-kinase substrate [KO:K12561]
25619  Plau; urokinase-type plasminogen activator precursor [KO:K01348] [EC:3.4.21.73]
25648  Slc7a1; high affinity cationic amino acid transporter 1 [KO:K13863]
25705  Zeb1; zinc finger E-box-binding homeobox 1 [KO:K09299]
25729  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
266715  Fzd3; frizzled-3 precursor [KO:K02329]
287871  Rptor; regulatory-associated protein of mTOR [KO:K07204]
287942  Crkl; crk-like protein [KO:K04438]
291105  E2f3; transcription factor E2F3 [KO:K06620]
292756  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
29332  Stmn1; stathmin [KO:K04381]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
29340  Prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
293621  Hras; GTPase HRas [KO:K02833]
29376  Irs2; insulin receptor substrate 2 [KO:K07187]
29492  Notch2; neurogenic locus notch homolog protein 2 precursor [KO:K20994]
29496  Erbb3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
29527  Ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
297480  Foxp1; forkhead box protein P1 [KO:K23582]
297893  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
299284  Dicer1; endoribonuclease Dicer [KO:K11592] [EC:3.1.26.-]
299611  Apc2; adenomatous polyposis coli protein 2 [KO:K02085]
300711  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
301042  Trim71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
303181  Wnt3a; protein Wnt-3a precursor [KO:K00312]
303477  Igf2bp1; insulin-like growth factor 2 mRNA-binding protein 1 [KO:K17391]
303991  Hoxd10; homeobox protein Hox-D10 [KO:K09295]
304785  Slc45a3; solute carrier family 45 member 3 [KO:K15379]
304798  Mdm4; protein Mdm4 [KO:K10127]
304913  Tnn; tenascin-N precursor [KO:K06252]
306141  Spry2; protein sprouty homolog 2 [KO:K17383]
307151  Bmi1; polycomb complex protein BMI-1 [KO:K11459]
307511  Cdc25c; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
309757  Sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
310643  Efna4; ephrin-A4 precursor [KO:K05462]
311071  Zeb2; zinc finger E-box-binding homeobox 2 [KO:K23560]
311860  Abl1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
312299  Ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
313488  Reck; reversion-inducing cysteine-rich protein with Kazal motifs precursor [KO:K17461]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
314384  Rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
314930  Zfpm2; zinc finger protein ZFPM2 [KO:K17442]
315346  Itga5; integrin alpha-5 [KO:K06484]
315655  Rdx; radixin [KO:K05762]
315740  Kif23; kinesin-like protein KIF23 [KO:K17387]
362485  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
363140  Rassf1; ras association domain-containing protein 1 isoform 2 [KO:K09850]
363287  Hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
364712  Sox4; transcription factor SOX-4 [KO:K23581]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
399489  E2f1; transcription factor E2F1 [KO:K17454]
406162  Notch4; neurogenic locus notch homolog protein 4 precursor [KO:K20996]
444984  Dnmt3a; DNA (cytosine-5)-methyltransferase 3A isoform 1 [KO:K17398] [EC:2.1.1.37]
444985  Dnmt3b; DNA (cytosine-5)-methyltransferase 3B [KO:K17398] [EC:2.1.1.37]
445442  Thbs1; thrombospondin-1 isoform 1 precursor [KO:K16857]
497672  Brca1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
50557  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54244  Crebbp; histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
54245  Crk; adapter molecule crk [KO:K04438]
54319  Ezr; ezrin [KO:K08007]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
56761  Notch3; neurogenic locus notch homolog protein 3 precursor [KO:K20995]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
60430  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
60434  Bcl2l2; bcl-2-like protein 2 [KO:K02163]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64031  Pdcd4; programmed cell death protein 4 [KO:K16865]
64033  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
64547  Bcl2l11; bcl-2-like protein 11 [KO:K16341]
65205  Mmp16; matrix metalloproteinase-16 precursor [KO:K07996] [EC:3.4.24.-]
679845  Shc4; SHC-transforming protein 4 [KO:K17449]
683788  Fscn1; fascin [KO:K23551]
684111  E2f2; transcription factor E2F2 isoform X2 [KO:K09389]
684771  Cdca5; sororin [KO:K17390]
686151  Cdca5l1; sororin-like [KO:K17390]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
81687  Mmp9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
81809  Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
81818  Vim; vimentin [KO:K07606]
83571  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
84017  Hmga2; high mobility group protein HMGI-C [KO:K09283]
84350  Dnmt1; DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84358  Efna2; ephrin-A2 precursor [KO:K05462]
84489  Fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
84576  Hdac1l; histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
84577  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
84580  Hdac5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
85385  Shc1; SHC-transforming protein 1 isoform b [KO:K06279]
94268  Efna1; ephrin-A1 precursor [KO:K05462]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
rno05210  Colorectal cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05219  Bladder cancer
rno05222  Small cell lung cancer
rno05223  Non-small cell lung cancer
KO pathway
ko05206   

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