KEGG   PATHWAY: cmy04010
Entry
cmy04010                    Pathway                                
Name
MAPK signaling pathway - Chelonia mydas (green sea turtle)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cmy04010  MAPK signaling pathway
cmy04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Chelonia mydas (green sea turtle) [GN:cmy]
Gene
102929344  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102929419  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102929430  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102929455  SRF; LOW QUALITY PROTEIN: serum response factor [KO:K04378]
102929489  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102929495  FGF4; fibroblast growth factor 4 [KO:K04358]
102929542  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
102929576  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102929649  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
102929703  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
102929710  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
102929722  FGF3; fibroblast growth factor 3 [KO:K04358]
102929769  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102929773  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102929829  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102929883  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102929975  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102930031  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102930227  STK4; serine/threonine-protein kinase 4 isoform X2 [KO:K04411]
102930286  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102930305  STMN1; stathmin isoform X2 [KO:K04381]
102930345  [KO:K05096] [EC:2.7.10.1]
102930367  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102930493  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102930539  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102930570  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102930624  STK3; LOW QUALITY PROTEIN: serine/threonine-protein kinase 3 [KO:K04412]
102930677  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
102930792  [KO:K16342] [EC:3.1.1.4]
102930962  [KO:K04345] [EC:2.7.11.11]
102930971  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
102930987  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102931022  AREG; amphiregulin [KO:K09782]
102931142  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102931217  FGF23; fibroblast growth factor 23 [KO:K22428]
102931244  EREG; proepiregulin [KO:K09784]
102931254  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102931327  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102931357  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102931440  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102931442  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
102931444  FGF2; fibroblast growth factor 2 [KO:K18497]
102931859  [KO:K04421] [EC:2.7.11.25]
102931885  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102931893  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102931972  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102931997  FGF1; fibroblast growth factor 1 [KO:K18496]
102932012  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
102932073  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102932086  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102932108  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
102932129  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
102932179  FGF22; fibroblast growth factor 22 [KO:K04358]
102932180  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102932199  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102932240  EFNA3; ephrin-A3 [KO:K05462]
102932263  IGF1; insulin-like growth factor I [KO:K05459]
102932325  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X9 [KO:K04431] [EC:2.7.12.2]
102932331  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102932343  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102932399  FGF5; fibroblast growth factor 5 [KO:K04358]
102932440  MAPT; microtubule-associated protein tau isoform X8 [KO:K04380]
102932483  NRTN; neurturin [KO:K25414]
102932554  FGF18; fibroblast growth factor 18 [KO:K04358]
102932555  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102932583  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102932640  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
102932671  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102932696  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K05448]
102932780  [KO:K04438]
102932800  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102932835  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
102932951  NTF3; neurotrophin-3 [KO:K04356]
102932979  [KO:K03283]
102933073  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
102933086  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102933302  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102933326  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
102933361  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
102933465  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102933709  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X15 [KO:K04344]
102933711  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
102933784  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
102933894  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
102933972  [KO:K04519]
102934200  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102934282  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102934468  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102934528  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
102934531  TP53; cellular tumor antigen p53 [KO:K04451]
102934696  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X3 [KO:K04373] [EC:2.7.11.1]
102934703  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
102934812  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
102934859  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
102934881  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102934890  FGF10; fibroblast growth factor 10 [KO:K04358]
102935187  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102935205  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102935251  PGF; placenta growth factor isoform X1 [KO:K16859]
102935322  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
102935334  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X10 [KO:K04849]
102935471  [KO:K03283]
102935478  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102935599  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102935642  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102935667  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102935680  INS; insulin [KO:K04526]
102935697  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102935730  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102935862  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102935902  IGF2; insulin-like growth factor II [KO:K13769]
102936034  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X3 [KO:K04426] [EC:2.7.11.25]
102936049  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102936052  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102936072  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102936088  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
102936123  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102936228  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
102936298  [KO:K04519]
102936332  TNF; tumor necrosis factor [KO:K03156]
102936451  FGF17; fibroblast growth factor 17 [KO:K04358]
102936491  KITLG; kit ligand [KO:K05461]
102936511  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102936738  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102936755  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
102936766  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102936869  [KO:K16342] [EC:3.1.1.4]
102936928  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102937092  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102937094  [KO:K16342] [EC:3.1.1.4]
102937131  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102937264  JUN; transcription factor AP-1 [KO:K04448]
102937323  [KO:K16342] [EC:3.1.1.4]
102937370  VEGFC; vascular endothelial growth factor C isoform X3 [KO:K05449]
102937444  MAX; protein max isoform X1 [KO:K04453]
102937481  FGF6; fibroblast growth factor 6 [KO:K04358]
102937532  [KO:K04386]
102937534  [KO:K04345] [EC:2.7.11.11]
102937553  [KO:K16342] [EC:3.1.1.4]
102937724  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102937758  [KO:K04345] [EC:2.7.11.11]
102937778  [KO:K16342] [EC:3.1.1.4]
102937915  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102937986  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
102937993  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
102938087  MAPK11; mitogen-activated protein kinase 11 isoform X6 [KO:K04441] [EC:2.7.11.24]
102938233  [KO:K16342] [EC:3.1.1.4]
102938285  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102938327  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
102938363  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
102938366  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
102938426  [KO:K04358]
102938448  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102938518  DUSP3; dual specificity protein phosphatase 3 isoform X2 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102938554  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102938595  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102938636  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102938812  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
102938959  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
102938969  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
102939092  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
102939099  PDGFC; platelet-derived growth factor C [KO:K05450]
102939131  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102939169  VEGFD; vascular endothelial growth factor D isoform X2 [KO:K05449]
102939329  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102939584  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
102939596  PSPN; persephin [KO:K25416]
102939626  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102939720  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
102939834  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
102939884  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
102939942  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
102939944  [KO:K05466]
102939991  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102940175  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102940198  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102940215  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102940270  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102940314  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102940369  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
102940624  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
102940652  [KO:K04723]
102940676  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102940803  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X3 [KO:K04469]
102940828  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
102940899  FOS; proto-oncogene c-Fos [KO:K04379]
102940901  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102941062  MAPK8IP2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102941067  TRAF2; TNF receptor-associated factor 2 isoform X3 [KO:K03173] [EC:2.3.2.27]
102941071  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102941136  RELB; transcription factor RelB isoform X1 [KO:K09253]
102941166  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
102941224  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102941236  FGF21; fibroblast growth factor 21 [KO:K22429]
102941279  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102941338  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102941356  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X2 [KO:K04420] [EC:2.7.11.25]
102941364  KRAS; GTPase KRas isoform X1 [KO:K07827]
102941410  ARTN; artemin [KO:K25415]
102941482  NF1; neurofibromin isoform X1 [KO:K08052]
102941563  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
102941618  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102941663  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
102941686  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102941746  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102941845  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102941872  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102941988  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102942001  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102942062  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102942074  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102942197  BDNF; brain-derived neurotrophic factor isoform X3 [KO:K04355]
102942211  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102942218  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102942219  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102942323  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102942399  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102942404  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
102942415  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
102942492  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102942493  [KO:K05462]
102942619  CRKL; crk-like protein [KO:K04438]
102942749  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X8 [KO:K03158]
102942789  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102942878  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
102942934  [KO:K16342] [EC:3.1.1.4]
102942953  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102943017  [KO:K07827]
102943068  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
102943108  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102943256  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
102943305  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102943336  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102943511  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102943951  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
102944043  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102944134  MECOM; histone-lysine N-methyltransferase MECOM isoform X5 [KO:K04462] [EC:2.1.1.367]
102944213  MRAS; ras-related protein M-Ras [KO:K07831]
102944320  NGF; beta-nerve growth factor [KO:K02582]
102944420  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102944436  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102944566  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102944582  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
102944650  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102944657  MEF2C; myocyte-specific enhancer factor 2C isoform X10 [KO:K04454]
102944721  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X2 [KO:K18019] [EC:3.1.3.48]
102944744  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102944754  ANGPT4; angiopoietin-4 [KO:K05467]
102944836  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X2 [KO:K04859]
102944895  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102944927  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
102944956  CRK; adapter molecule crk isoform X1 [KO:K04438]
102944991  HSPB1; heat shock protein beta-1 [KO:K04455]
102945157  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
102945306  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102945353  FGF20; fibroblast growth factor 20 [KO:K04358]
102945511  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102945547  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102945688  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102945814  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
102945867  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102946051  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102946100  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
102946116  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
102946225  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
102946253  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102946454  HRAS; GTPase HRas [KO:K02833]
102946534  [KO:K04388] [EC:2.7.11.30]
102946618  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
102946701  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102946734  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
102946856  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102946954  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
102947001  FGF16; fibroblast growth factor 16 [KO:K04358]
102947040  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102947056  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
102947093  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102947120  [KO:K03283]
102947238  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102947354  RELA; transcription factor p65 isoform X1 [KO:K04735]
102947389  TGFA; protransforming growth factor alpha [KO:K08774]
102947510  [KO:K16342] [EC:3.1.1.4]
102947603  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102947630  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102947682  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
102947735  [KO:K16342] [EC:3.1.1.4]
102947773  [KO:K02583]
102947916  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
102948045  RAP1A; ras-related protein Rap-1A [KO:K04353]
102948279  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102948283  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102948383  FGF19; fibroblast growth factor 19 [KO:K22603]
114020194  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
114020321  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
114021289  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
114022153  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
114022375  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
119564339  PPM1N; probable protein phosphatase 1N [KO:K04457] [EC:3.1.3.16]
119564394  [KO:K16859]
119564816  [KO:K04345] [EC:2.7.11.11]
119564937  RRAS; ras-related protein R-Ras [KO:K07830]
119566508  [KO:K04468] [EC:2.7.11.24]
119567853  [KO:K16342] [EC:3.1.1.4]
122463396  [KO:K04347]
122466341  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cmy04070  Phosphatidylinositol signaling system
cmy04110  Cell cycle
cmy04115  p53 signaling pathway
cmy04210  Apoptosis
cmy04310  Wnt signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system