KEGG   PATHWAY: efus04015
Entry
efus04015                   Pathway                                
Name
Rap1 signaling pathway - Eptesicus fuscus (big brown bat)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
efus04015  Rap1 signaling pathway
efus04015

Other DBs
GO: 0007264
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103283126  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
103283254  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082]
103283310  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
103283571  PGF; placenta growth factor isoform X1 [KO:K16859]
103283610  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X2 [KO:K17701]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103283838  TLN2; talin-2 [KO:K06271]
103283955  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
103284166  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103284359  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
103284373  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103284587  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
103284615  [KO:K05689]
103284970  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103284972  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
103284973  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
103285154  KRAS; GTPase KRas isoform X1 [KO:K07827]
103285230  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
103285248  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
103285537  FGF1; fibroblast growth factor 1 [KO:K18496]
103285585  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
103285630  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
103285666  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
103285667  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103285746  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
103285782  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X4 [KO:K04632]
103285814  ANGPT4; angiopoietin-4 [KO:K05467]
103285922  [KO:K04632]
103286119  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
103286155  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103286349  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103286443  TLN1; talin-1 [KO:K06271]
103286667  P2RY1; P2Y purinoceptor 1 [KO:K04270]
103286714  [KO:K04393]
103286725  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103286991  CRKL; crk-like protein [KO:K04438]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103287006  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
103287256  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
103287300  THBS1; thrombospondin-1 [KO:K16857]
103287338  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
103287355  PFN3; profilin-3 [KO:K05759]
103287415  FGF7; fibroblast growth factor 7 [KO:K04358]
103287505  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103287682  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103287731  RALB; ras-related protein Ral-B [KO:K07835]
103287907  FGF5; fibroblast growth factor 5 [KO:K04358]
103288035  FGF6; fibroblast growth factor 6 [KO:K04358]
103288064  KITLG; kit ligand isoform X2 [KO:K05461]
103288115  FGF23; fibroblast growth factor 23 [KO:K22428]
103288414  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
103288651  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103288686  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
103288735  EFNA5; ephrin-A5 isoform X2 [KO:K05462]
103288794  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103288853  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
103288892  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103288953  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103289119  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103289160  [KO:K04393]
103289773  ITGB2; integrin beta-2 [KO:K06464]
103289940  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
103290249  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103290305  FGF20; fibroblast growth factor 20 [KO:K04358]
103290440  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
103290982  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
103291051  FGF3; fibroblast growth factor 3 [KO:K04358]
103291052  FGF4; fibroblast growth factor 4 [KO:K04358]
103291053  FGF19; fibroblast growth factor 19 [KO:K22603]
103291132  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
103291154  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
103291183  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
103291199  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112]
103291212  NRAS; GTPase NRas [KO:K07828]
103291218  NGF; beta-nerve growth factor [KO:K02582]
103291338  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103291562  LCP2; LOW QUALITY PROTEIN: lymphocyte cytosolic protein 2 [KO:K07361]
103291580  CNR1; cannabinoid receptor 1 [KO:K04277]
103291622  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
103291758  CRK; adapter molecule crk isoform X1 [KO:K04438]
103291971  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103292019  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
103292086  RAP1GAP; LOW QUALITY PROTEIN: rap1 GTPase-activating protein 1 [KO:K17700]
103292236  CALM1; calmodulin-1 isoform X2 [KO:K02183]
103292519  RAP1B; ras-related protein Rap-1b [KO:K07836]
103292910  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103293159  ITGB3; integrin beta-3 [KO:K06493]
103293186  [KO:K02183]
103293222  ITGA2B; integrin alpha-IIb [KO:K06476]
103293251  HGF; hepatocyte growth factor [KO:K05460]
103293295  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
103293309  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103293449  ENAH; protein enabled homolog isoform X1 [KO:K05746]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103293502  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
103293788  DRD2; D(2) dopamine receptor isoform X2 [KO:K04145]
103293793  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103293905  RALA; ras-related protein Ral-A [KO:K07834]
103294085  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103294280  DOCK4; dedicator of cytokinesis protein 4 [KO:K17697]
103294302  EFNA2; ephrin-A2 [KO:K05462]
103294320  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
103294502  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
103294577  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103294862  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
103295001  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103295085  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103295224  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103295254  [KO:K04513]
103295368  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295457  VEGFC; vascular endothelial growth factor C [KO:K05449]
103295508  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
103295577  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103295744  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103295746  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103295848  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X3 [KO:K04534]
103295862  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103295948  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103295972  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103296145  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
103296165  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
103296185  MRAS; ras-related protein M-Ras [KO:K07831]
103296210  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103296227  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
103296258  ITGAL; integrin alpha-L [KO:K05718]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103296347  PRKD1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
103296626  VEGFA; vascular endothelial growth factor A [KO:K05448]
103297077  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103297177  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
103297376  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
103297480  RASSF5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
103297653  FGF21; fibroblast growth factor 21 [KO:K22429]
103297693  CALM3; calmodulin-3 isoform X1 [KO:K02183]
103297766  RRAS; ras-related protein R-Ras [KO:K07829]
103297801  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
103297942  CTNNB1; catenin beta-1 [KO:K02105]
103298041  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
103298181  VEGFD; vascular endothelial growth factor D [KO:K05449]
103298235  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103298339  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103298572  CALML5; calmodulin-like protein 5 [KO:K02183]
103298573  [KO:K02183]
103298642  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103298650  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103298707  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103298761  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103298836  FYB1; FYN-binding protein 1 [KO:K17698]
103298865  RHOA; transforming protein RhoA [KO:K04513]
103298904  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
103298905  EFNA3; ephrin-A3 isoform X4 [KO:K05462]
103298906  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
103299146  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103299154  ACTB; actin, cytoplasmic 1 [KO:K05692]
103299170  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103299369  ADORA2B; adenosine receptor A2b [KO:K04267]
103299424  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
103299446  PARD3; partitioning defective 3 homolog isoform X16 [KO:K04237]
103299452  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103299502  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103299839  AFDN; afadin isoform X1 [KO:K05702]
103299860  PFN1; profilin-1 [KO:K05759]
103300381  ADORA2A; adenosine receptor A2a [KO:K04266]
103300825  LAT; linker for activation of T-cells family member 1 [KO:K07362]
103300850  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103300929  F2RL3; proteinase-activated receptor 4 [KO:K04236]
103301270  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103301437  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
103301470  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
103301676  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103301950  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103302042  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
103302044  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103302054  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
103302137  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103302293  CTNND1; catenin delta-1 [KO:K05690]
103302409  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103302464  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103302962  PFN2; profilin-2 isoform X1 [KO:K05759]
103303157  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103303257  INS; insulin [KO:K04526]
103303271  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
103303616  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103303646  FGF16; fibroblast growth factor 16 [KO:K04358]
103303678  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103303954  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
103303990  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
103304154  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
103304460  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
103304916  [KO:K02183]
103305000  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
103305103  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103305203  F2R; proteinase-activated receptor 1 [KO:K03914]
103305414  CALM2; calmodulin-2 [KO:K02183]
103305459  PFN4; profilin-4 isoform X1 [KO:K05759]
103305465  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
103305553  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
114229025  [KO:K05096] [EC:2.7.10.1]
114234667  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129147180  [KO:K04634]
129148572  [KO:K02183]
129149245  FGF2; fibroblast growth factor 2 [KO:K18497]
129149821  [KO:K05210]
129150189  CALML6; calmodulin-like protein 6 [KO:K02183]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
efus04010  MAPK signaling pathway
efus04014  Ras signaling pathway
efus04020  Calcium signaling pathway
efus04151  PI3K-Akt signaling pathway
efus04510  Focal adhesion
efus04520  Adherens junction
efus04660  T cell receptor signaling pathway
efus04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

DBGET integrated database retrieval system