Entry Name ECM-receptor interaction - Labeo rohita (rohu)
Description The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Labeo rohita (rohu) [GN:
lroh ]
Gene 127168880 col4a6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237 ]
127171385 col6a3; LOW QUALITY PROTEIN: uncharacterized protein col6a3 [KO:K06238 ]
127173493 col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238 ]
127172647 col9a1a; LOW QUALITY PROTEIN: collagen, type IX, alpha 1a [KO:K08131 ]
127154221 frem1b; FRAS1-related extracellular matrix protein 1b [KO:K23380 ]
127177383 frem2b; FRAS1-related extracellular matrix protein 2b [KO:K23380 ]
127172454 frem2a; FRAS1-related extracellular matrix protein 2a [KO:K23380 ]
127168602 frem1a; LOW QUALITY PROTEIN: FRAS1-related extracellular matrix protein 1a [KO:K23380 ]
127155170 hspg2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255 ]
127176078 hmmr; hyaluronan mediated motility receptor isoform X1 [KO:K06267 ]
Compound Reference Authors van der Flier A, Sonnenberg A.
Title Function and interactions of integrins.
Journal Reference Authors Reddy KV, Mangale SS.
Title Integrin receptors: the dynamic modulators of endometrial function.
Journal Reference Authors Milner R, Campbell IL.
Title The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal Reference Authors Cichy J, Pure E.
Title The liberation of CD44.
Journal Reference Authors Elenius K, Jalkanen M.
Title Function of the syndecans--a family of cell surface proteoglycans.
Journal J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference Authors Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
Title The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal Reference Authors Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
Title Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal Reference Authors Canobbio I, Balduini C, Torti M.
Title Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal Reference Authors Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
Title Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal Reference Authors Martin PT.
Title Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal Reference Authors Toole BP.
Title Hyaluronan: from extracellular glue to pericellular cue.
Journal Reference Authors Bosman FT, Stamenkovic I.
Title Functional structure and composition of the extracellular matrix.
Journal Reference Authors van der Ven AT, Vivante A, Hildebrandt F
Title Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal Related KO pathway LinkDB All DBs
