KEGG   PATHWAY: anu05165
Entry
anu05165                    Pathway                                
Name
Human papillomavirus infection - Arvicanthis niloticus (African grass rat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
anu05165  Human papillomavirus infection
anu05165

Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117719132  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
117707808  Wnt2b; protein Wnt-2b [KO:K00182]
117720625  Wnt2; protein Wnt-2 [KO:K00182]
117711043  Wnt3a; protein Wnt-3a [KO:K00312]
117711124  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
117708522  Wnt4; protein Wnt-4 [KO:K00408]
117714850  Wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
117705984  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
117705525  Wnt6; protein Wnt-6 [KO:K00445]
117715606  Wnt7a; protein Wnt-7a [KO:K00572]
117718736  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
117723524  Wnt8b; protein Wnt-8b [KO:K00714]
117719527  Wnt8a; LOW QUALITY PROTEIN: protein Wnt-8a [KO:K00714]
117711739  Wnt9b; protein Wnt-9b [KO:K01064]
117711758  Wnt9a; protein Wnt-9a [KO:K01064]
117705409  Wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
117719001  Wnt10b; protein Wnt-10b [KO:K01357]
117723911  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
117720614  Wnt16; protein Wnt-16 [KO:K01558]
117706218  Fzd7; frizzled-7 [KO:K02432]
117720668  Fzd1; frizzled-1 [KO:K02432]
117711178  Fzd2; frizzled-2 [KO:K02235]
117706086  Fzd3; frizzled-3 [KO:K02329]
117722634  Fzd4; frizzled-4 [KO:K02354]
117705098  Fzd5; frizzled-5 [KO:K02375]
117714080  Fzd8; frizzled-8 [KO:K02375]
117719203  Fzd6; frizzled-6 [KO:K02376]
117698106  Fzd9; frizzled-9 [KO:K02842]
117698132  Fzd10; frizzled-10 [KO:K02842]
117711752  Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
117717957  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
117708963  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
117718295  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117710223  Axin1; axin-1 isoform X1 [KO:K02157]
117710764  Axin2; axin-2 [KO:K04385]
117719879  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
117696137  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
117693212  Ctnnb1; catenin beta-1 [KO:K02105]
117719836  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
117723948  Tert; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
117710774  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
117715247  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
117718257  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
117695194  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
117721248  Tlr3; toll-like receptor 3 [KO:K05401]
117704938  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
117697234  Traf3; TNF receptor-associated factor 3 [KO:K03174]
117716315  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
117696401  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
117708685  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
117709633  Ifnb1; interferon beta [KO:K05415]
117718741  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
117710697  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
117714668  Tada3; transcriptional adapter 3 isoform X1 [KO:K11315]
117710574  Tp53; cellular tumor antigen p53 [KO:K04451]
117714733  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
117697279  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117722857  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
117704526  Pard6b; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
117723270  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
117720011  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
117706861  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117708435  Prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
117708461  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117718883  Scrib; protein scribble homolog isoform X1 [KO:K16175]
117718155  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
117693998  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
117694133  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
117709982  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
117710525  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
117705498  Crb3; protein crumbs homolog 3 [KO:K06090]
117697171  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
117715558  Vwf; von Willebrand factor [KO:K03900]
117704005  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
117707069  Thbs3; thrombospondin-3 [KO:K04659]
117700280  Thbs2; thrombospondin-2 [KO:K04659]
117700524  Thbs4; thrombospondin-4 [KO:K04659]
117721589  Comp; cartilage oligomeric matrix protein [KO:K04659]
117705295  Fn1; fibronectin isoform X1 [KO:K05717]
117711501  Col1a1; collagen alpha-1(I) chain [KO:K06236]
117720776  Col1a2; collagen alpha-2(I) chain [KO:K06236]
117718719  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
117722158  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
117722162  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
117694087  Col4a5; LOW QUALITY PROTEIN: collagen alpha-5(IV) chain [KO:K06237]
117694384  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
117721417  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
117721418  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
117722245  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
117724316  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
117724576  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
117693496  collagen alpha-6(VI) chain isoform X1 [KO:K06238]
117693537  collagen alpha-4(VI) chain-like [KO:K06238]
117693548  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
117722307  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
117709458  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
117704287  Col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
117700968  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
117693448  Lama1; laminin subunit alpha-1 [KO:K05637]
117703277  Lama5; laminin subunit alpha-5 [KO:K06240]
117719995  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
117724440  Lama4; laminin subunit alpha-4 [KO:K06241]
117716971  Lamb1; laminin subunit beta-1 [KO:K05636]
117693318  Lamb2; laminin subunit beta-2 [KO:K06243]
117716578  Lamb3; laminin subunit beta-3 [KO:K06244]
117716136  Lamc1; laminin subunit gamma-1 [KO:K05635]
117716126  Lamc2; laminin subunit gamma-2 [KO:K06246]
117704476  Lamc3; laminin subunit gamma-3 isoform X1 [KO:K06247]
117711072  Chad; chondroadherin [KO:K06248]
117720577  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
117699635  Spp1; osteopontin [KO:K06250]
117711008  Vtn; vitronectin [KO:K06251]
117716105  Tnr; tenascin-R isoform X1 [KO:K06252]
117716302  Tnn; tenascin-N isoform X1 [KO:K06252]
117724585  Tnxb; tenascin-X [KO:K06252]
117708179  Tnc; tenascin isoform X1 [KO:K06252]
117699951  Ibsp; bone sialoprotein 2 [KO:K06253]
117723779  Itga1; integrin alpha-1 [KO:K06480]
117723944  Itga2; integrin alpha-2 [KO:K06481]
117709947  Itga2b; integrin alpha-IIb [KO:K06476]
117710875  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
117703740  Itga4; integrin alpha-4 isoform X1 [KO:K06483]
117718748  Itga5; integrin alpha-5 [KO:K06484]
117703057  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
117696405  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
117714271  Itga8; integrin alpha-8 [KO:K06584]
117693574  Itga9; integrin alpha-9 [KO:K06585]
117707106  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
117699096  Itga11; integrin alpha-11 [KO:K06587]
117702960  Itgav; integrin alpha-V isoform X1 [KO:K06487]
117723085  Itgb1; integrin beta-1 [KO:K05719]
117710850  Itgb3; integrin beta-3 [KO:K06493]
117709978  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
117717678  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
117702325  Itgb6; integrin beta-6 [KO:K06589]
117718555  Itgb7; integrin beta-7 [KO:K06590]
117697287  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
117718495  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117697756  Pxn; paxillin isoform X1 [KO:K05760]
117724681  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
117714946  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117723297  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
117716367  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
117700780  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117710030  Fadd; FAS-associated death domain protein [KO:K02373]
117704983  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
117721984  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
117711668  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
117709998  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117721629  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117699505  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
117700879  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
117705373  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
117719763  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
117710161  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
117712931  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
117716880  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
117699466  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
117693399  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
117697124  Ppp2r5e; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
117722325  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
117697356  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
117715951  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
117712739  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
117711068  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
117703026  Tsc1; hamartin isoform X1 [KO:K07206]
117710404  Tsc2; tuberin isoform X1 [KO:K07207]
117694570  GTP-binding protein Rheb-like [KO:K07208]
117694603  GTP-binding protein Rheb-like [KO:K07208]
117720863  Rheb; GTP-binding protein Rheb [KO:K07208]
117709409  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117721241  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
117710017  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117714029  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
117724492  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
117706557  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
117719688  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117706649  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117693421  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117708986  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117721973  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117723761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117708961  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
117697536  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117706636  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117721481  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117706979  Foxo1; forkhead box protein O1 [KO:K07201]
117715314  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
117724897  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
117711496  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
117714829  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
117722295  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
117696408  Cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
117720333  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
117698572  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
117717876  LOW QUALITY PROTEIN: G1/S-specific cyclin-E2-like [KO:K06626]
117712916  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
117696564  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
117705264  Rb1; retinoblastoma-associated protein [KO:K06618]
117704483  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
117723339  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
117697399  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
117702649  E2f1; transcription factor E2F1 [KO:K17454]
117706717  Ccna2; cyclin-A2 [KO:K06627]
117707276  Ccna1; cyclin-A1 [KO:K06627]
117699494  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
117693267  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
117722213  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
117701914  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117712831  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117721547  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117695513  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117707042  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117722582  Rela; transcription factor p65 [KO:K04735]
117696339  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
117708473  Nfx1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
117724593  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
117709000  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
117714910  Chd4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
117709821  Irf1; interferon regulatory factor 1 [KO:K09444]
117711370  Tbpl2; TATA box-binding protein-like protein 2 isoform X1 [KO:K03120]
117700159  Tbp; TATA-box-binding protein [KO:K03120]
117700876  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
117724191  H-2 class I histocompatibility antigen, D-K alpha chain-like isoform X1 [KO:K06751]
117724193  H-2 class I histocompatibility antigen, D-B alpha chain-like isoform X1 [KO:K06751]
117724194  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117724195  H-2 class I histocompatibility antigen, D-P alpha chain-like isoform X1 [KO:K06751]
117724198  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
117724199  H-2 class I histocompatibility antigen, D-P alpha chain-like isoform X1 [KO:K06751]
117724200  H-2 class I histocompatibility antigen, D-B alpha chain-like [KO:K06751]
117724203  H-2 class I histocompatibility antigen, D-B alpha chain-like isoform X1 [KO:K06751]
117724204  H-2 class I histocompatibility antigen, D-P alpha chain-like isoform X1 [KO:K06751]
117724206  H-2 class I histocompatibility antigen, D-P alpha chain-like isoform X1 [KO:K06751]
117724208  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
117724209  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
117724217  H-2 class I histocompatibility antigen, Q7 alpha chain-like isoform X1 [KO:K06751]
117724218  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
117724232  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
117724273  H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
117724288  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
117724289  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
117724290  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
117724484  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
117724820  H-2 class I histocompatibility antigen, D-K alpha chain-like isoform X1 [KO:K06751]
117724821  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117724824  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
117724825  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117724936  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
117701609  H-2 class I histocompatibility antigen, D-P alpha chain-like isoform X1 [KO:K06751]
117701710  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X1 [KO:K06751]
117702316  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
117702317  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
117694397  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
117717713  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117707709  LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
117715679  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
117721401  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
117716911  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
117719104  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
117697170  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
117715308  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
117717293  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
117709352  V-type proton ATPase subunit F-like [KO:K02151]
117720644  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
117716596  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
117724963  Atp6v1g2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
117709546  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
117698634  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
117697792  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
117719332  Tcirg1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
117720582  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
117711166  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
117723206  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
117698667  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
117711905  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
117720909  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
117710145  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
117709399  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
117694687  Atp6ap1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
117707556  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
117712744  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117711195  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
117716781  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117716983  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117706664  Hras; GTPase HRas isoform X1 [KO:K02833]
117714902  Kras; GTPase KRas isoform X1 [KO:K07827]
117706966  Nras; GTPase NRas [KO:K07828]
117715476  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117699009  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117696143  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
117717711  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117693439  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117716475  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
117723672  Ptger4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
117703732  neuroendocrine secretory protein 55 [KO:K04632]
117703734  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
117723055  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117706647  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117722249  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
117705049  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
117704442  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
117707799  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
117709015  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
117720532  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
117696466  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
117720600  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
117709584  Ubr4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
117710126  tubulin gamma-1 chain [KO:K10389]
117710712  tubulin gamma-2 chain [KO:K10389]
117699104  Pkm; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
117720999  LOW QUALITY PROTEIN: pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
117708733  interferon alpha-12-like [KO:K05414]
117709002  interferon alpha-12-like [KO:K05414]
117709023  interferon alpha-9 [KO:K05414]
117709053  interferon alpha-1-like [KO:K05414]
117709056  interferon alpha-1-like isoform X1 [KO:K05414]
117709071  interferon alpha-7-like [KO:K05414]
117709072  interferon alpha-12-like [KO:K05414]
117709075  interferon alpha-12-like [KO:K05414]
117709078  interferon alpha-12-like [KO:K05414]
117709079  interferon alpha-1 [KO:K05414]
117709081  interferon alpha-12-like [KO:K05414]
117709083  interferon alpha-12-like [KO:K05414]
117709084  interferon alpha-7 [KO:K05414]
117709085  interferon alpha-12-like [KO:K05414]
117709086  interferon alpha-7-like [KO:K05414]
117709102  interferon alpha-1-like [KO:K05414]
117718162  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
117718170  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
117709127  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
117713684  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
117705244  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
117696619  Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
117706177  Irf9; interferon regulatory factor 9 [KO:K04693]
117717229  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
117701826  LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
117697665  2'-5'-oligoadenylate synthase-like protein 1 isoform X1 [KO:K14608]
117698244  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
117717483  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
117717924  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
117709183  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
117703754  Jag1; protein jagged-1 [KO:K06052]
117710516  Notch1; neurogenic locus notch homolog protein 1 [KO:K02599]
117706733  Notch2; neurogenic locus notch homolog protein 2 [KO:K20994]
117696497  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
117724864  Notch4; neurogenic locus notch homolog protein 4 [KO:K20996]
117697133  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
117711743  Rfng; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
117698372  Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
117718792  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
117707114  Maml3; mastermind-like protein 3 [KO:K06061]
117699903  Maml2; mastermind-like protein 2 [KO:K06061]
117711122  Maml1; mastermind-like protein 1 [KO:K06061]
117704473  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
117712581  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
117718230  Hes1; transcription factor HES-1 [KO:K06054]
117722172  Hes6; transcription cofactor HES-6 [KO:K09087]
117711608  Hes7; transcription factor HES-7 isoform X1 [KO:K09087]
117708945  Hes2; transcription factor HES-2 [KO:K09087]
117708185  Hes3; transcription factor HES-3 [KO:K09088]
117708524  Hes5; transcription factor HES-5 [KO:K06055]
117708176  Heyl; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
117701127  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
117719385  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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The molecular biology of cervical cancer.
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Pathogens 5:E8 (2016)
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Reference
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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Reference
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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  Title
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  Journal
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Related
pathway
anu04064  NF-kappa B signaling pathway
anu04110  Cell cycle
anu04115  p53 signaling pathway
anu04150  mTOR signaling pathway
anu04151  PI3K-Akt signaling pathway
anu04210  Apoptosis
anu04310  Wnt signaling pathway
anu04330  Notch signaling pathway
anu04510  Focal adhesion
anu04520  Adherens junction
anu04530  Tight junction
anu04612  Antigen processing and presentation
anu04620  Toll-like receptor signaling pathway
anu04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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