KEGG   PATHWAY: bbis05205
Entry
bbis05205                   Pathway                                
Name
Proteoglycans in cancer - Bison bison bison (American bison)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
bbis05205  Proteoglycans in cancer
bbis05205

Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104982468  CD44; CD44 antigen isoform X1 [KO:K06256]
104980465  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104992513  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
104986926  CTTN; src substrate cortactin [KO:K06106]
104990532  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105000345  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104979739  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
104981704  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
104983330  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
105003692  HRAS; GTPase HRas [KO:K02833]
105000225  KRAS; GTPase KRas isoform X1 [KO:K07827]
104981582  NRAS; GTPase NRas [KO:K07828]
104981453  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105001805  MRAS; ras-related protein M-Ras [KO:K07831]
104999381  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105004742  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
104999018  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
104984678  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
104979900  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104986748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104995620  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104992794  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104989404  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
104981087  CDC42; cell division control protein 42 homolog [KO:K04393]
104989272  ESR1; estrogen receptor [KO:K08550]
104987056  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104992781  ACTB; actin, cytoplasmic 1 [KO:K05692]
105000428  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
104998177  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105004638  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105005180  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
104997209  RHOA; transforming protein RhoA [KO:K04513]
104980280  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
104997365  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
104993262  ankyrin-1-like [KO:K10380]
105002058  ANK2; LOW QUALITY PROTEIN: ankyrin-2 [KO:K09255]
104988170  ANK3; ankyrin-3 isoform X1 [KO:K09259]
104999213  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
104999978  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105001799  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104996058  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104998445  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104992716  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104994333  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104986245  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
104995356  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104989637  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
105003597  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104981253  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
104987069  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104989100  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104989638  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104982594  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
104981869  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
104984178  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
104981403  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
104990190  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
104991589  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105000232  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104995001  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104980419  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105002056  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
104996314  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104997518  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104995482  NANOG; homeobox protein NANOG isoform X1 [KO:K10164]
105000486  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
104998582  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
104990441  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
104995588  TWIST2; twist-related protein 2 [KO:K09069]
105002933  HOXD10; homeobox protein Hox-D10 [KO:K09295]
104982631  DCN; decorin [KO:K04660]
104998318  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
104992840  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104995846  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104988870  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
104986966  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105004076  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105001723  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105000953  RPS6; 40S ribosomal protein S6 [KO:K02991]
104990172  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104981940  CAV1; caveolin-1 isoform X1 [KO:K06278]
104981939  CAV2; caveolin-2 isoform X1 [KO:K12958]
104979860  CAV3; caveolin-3 [KO:K12959]
104988041  CD63; CD63 antigen [KO:K06497]
104982912  LOW QUALITY PROTEIN: CD63 antigen-like [KO:K06497]
104994949  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104985538  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104995381  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
104989153  TLR2; toll-like receptor 2 [KO:K10159]
104994776  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
105002621  PDCD4; programmed cell death protein 4 [KO:K16865]
104983770  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104999734  IL12B; interleukin-12 subunit beta [KO:K05425]
104988058  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105003731  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
104991741  MYC; myc proto-oncogene protein [KO:K04377]
104985336  CTNNB1; catenin beta-1 [KO:K02105]
104994167  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
104988987  TFAP4; transcription factor AP-4 [KO:K09108]
105005203  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105002846  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104981942  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
104981392  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
104998280  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
104994392  THBS1; thrombospondin-1 [KO:K16857]
105004336  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
104985049  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
104982630  LUM; lumican [KO:K08122]
104995820  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104987521  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104989769  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104990761  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
104998204  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
104989326  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
104992948  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
104983590  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
104989012  SDC1; syndecan-1 [KO:K06257]
104997520  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
104997657  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
104988442  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104990617  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105001056  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105002990  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105003960  VTN; vitronectin [KO:K06251]
105002887  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105000519  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105003740  FN1; fibronectin isoform X1 [KO:K05717]
104984522  ITGB5; integrin beta-5 [KO:K06588]
104994516  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105001685  WNT1; proto-oncogene Wnt-1 [KO:K03209]
104988483  FZD1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
105003836  FZD7; frizzled-7 [KO:K02432]
104982980  FZD2; frizzled-2 [KO:K02235]
104988831  FZD3; frizzled-3 [KO:K02329]
104998182  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
105003099  FZD8; frizzled-8 [KO:K02375]
105003847  FZD5; frizzled-5 [KO:K02375]
105005477  FZD6; frizzled-6 isoform X1 [KO:K02376]
104998955  FZD9; frizzled-9 [KO:K02842]
104989558  FZD10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
105001611  ITGA5; integrin alpha-5 [KO:K06484]
104983933  SDC2; syndecan-2 [KO:K16336]
104989250  EZR; ezrin [KO:K08007]
105005020  RDX; radixin isoform X1 [KO:K05762]
104994879  moesin [KO:K05763]
104998457  SDC4; syndecan-4 [KO:K16338]
105003247  FGF2; fibroblast growth factor 2 [KO:K18497]
104987781  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
104989754  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
104980033  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104996105  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
104999941  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104990277  SOS2; son of sevenless homolog 2 [KO:K03099]
104980493  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
104996518  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
105000525  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104986737  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105000236  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
104988923  NUDT16L1; LOW QUALITY PROTEIN: protein syndesmos [KO:K16867]
104980049  PXN; paxillin isoform X1 [KO:K05760]
104984862  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104996202  HBEGF; LOW QUALITY PROTEIN: proheparin-binding EGF-like growth factor [KO:K08523]
104987323  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
104981617  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
104981944  WNT2; protein Wnt-2 [KO:K00182]
104993835  WNT3A; protein Wnt-3a [KO:K00312]
104982954  WNT3; proto-oncogene Wnt-3 [KO:K00312]
104981089  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
104992247  WNT5B; protein Wnt-5b [KO:K00444]
104997262  WNT5A; protein Wnt-5a [KO:K00444]
105003779  WNT6; protein Wnt-6 [KO:K00445]
105004797  WNT7A; protein Wnt-7a [KO:K00572]
104991829  WNT8A; protein Wnt-8a [KO:K00714]
105002712  WNT8B; protein Wnt-8b [KO:K00714]
104993886  WNT9A; protein Wnt-9a [KO:K01064]
104983013  WNT9B; protein Wnt-9b [KO:K01064]
105001684  WNT10B; protein Wnt-10b [KO:K01357]
105003780  WNT10A; protein Wnt-10a [KO:K01357]
104994092  WNT11; protein Wnt-11 [KO:K01384]
104987233  WNT16; protein Wnt-16 [KO:K01558]
104980588  SHH; sonic hedgehog protein [KO:K11988]
105003862  IHH; indian hedgehog protein [KO:K11989]
104985743  PTCH1; protein patched homolog 1 [KO:K06225]
104982396  SMO; smoothened homolog [KO:K06226]
104981234  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
104985708  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
104985727  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
104999887  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105003252  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104981967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104981977  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104994938  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104994939  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105005080  HSPB2; heat shock protein beta-2 [KO:K09543]
104992168  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
bbis04010  MAPK signaling pathway
bbis04020  Calcium signaling pathway
bbis04066  HIF-1 signaling pathway
bbis04150  mTOR signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04210  Apoptosis
bbis04310  Wnt signaling pathway
bbis04340  Hedgehog signaling pathway
bbis04350  TGF-beta signaling pathway
bbis04370  VEGF signaling pathway
bbis04510  Focal adhesion
bbis04520  Adherens junction
bbis04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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