KEGG   PATHWAY: ccad04015
Entry
ccad04015                   Pathway                                
Name
Rap1 signaling pathway - Cervus canadensis (wapiti)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
ccad04015  Rap1 signaling pathway
ccad04015

Other DBs
GO: 0007264
Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122436539  RAP1A; ras-related protein Rap-1A [KO:K04353]
122427076  RAP1B; ras-related protein Rap-1b [KO:K07836]
122445280  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
122438194  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
122438369  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
122442399  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
122433444  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
122423939  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122420755  CALM3; calmodulin-3 [KO:K02183]
122420753  calmodulin-1-like [KO:K02183]
122448900  calmodulin-2/4-like [KO:K02183]
122448285  calmodulin-like [KO:K02183]
122441648  CALM2; calmodulin-2 [KO:K02183]
122453208  calmodulin-1-like [KO:K02183]
122443081  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122451732  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
122443955  CALM1; calmodulin-1 isoform X1 [KO:K02183]
122445547  calmodulin-1 [KO:K02183]
122442989  F2R; proteinase-activated receptor 1 [KO:K03914]
122439370  F2RL3; proteinase-activated receptor 4 [KO:K04236]
122445020  P2RY1; P2Y purinoceptor 1 [KO:K04270]
122432004  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
122440799  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
122436761  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
122435397  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
122423815  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
122419704  ADORA2A; adenosine receptor A2a [KO:K04266]
122444716  ADORA2B; adenosine receptor A2b [KO:K04267]
122448612  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
122448614  neuroendocrine secretory protein 55 [KO:K04632]
122454307  uncharacterized protein LOC122454307 [KO:K04632]
122438514  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
122454210  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122441999  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122443147  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
122444643  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122427399  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
122421548  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
122451315  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122432769  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122427721  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
122453597  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
122453031  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122448381  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448380  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122430651  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
122443383  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122441553  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122430799  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122422171  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
122439770  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122453183  FGF2; fibroblast growth factor 2 [KO:K18497]
122447460  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
122431192  FGF3; fibroblast growth factor 3 [KO:K04358]
122431410  FGF4; fibroblast growth factor 4 [KO:K04358]
122431666  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122424018  FGF6; fibroblast growth factor 6 [KO:K04358]
122432473  FGF20; fibroblast growth factor 20 [KO:K04358]
122435907  FGF16; fibroblast growth factor 16 [KO:K04358]
122443630  FGF7; fibroblast growth factor 7 [KO:K04358]
122454587  FGF18; fibroblast growth factor 18 [KO:K04358]
122454543  FGF10; fibroblast growth factor 10 [KO:K04358]
122446136  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122428216  FGF5; fibroblast growth factor 5 [KO:K04358]
122431275  FGF19; fibroblast growth factor 19 [KO:K22603]
122421659  FGF21; fibroblast growth factor 21 [KO:K22429]
122424008  FGF23; fibroblast growth factor 23 [KO:K22428]
122435827  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
122430981  INS; insulin [KO:K04526]
122423293  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122433132  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122449654  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122453611  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122436569  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122427126  KITLG; kit ligand isoform X1 [KO:K05461]
122429439  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122430796  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122443865  PGF; placenta growth factor isoform X1 [KO:K16859]
122432225  VEGFC; vascular endothelial growth factor C [KO:K05449]
122434746  VEGFD; vascular endothelial growth factor D [KO:K05449]
122438250  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122451126  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
122432503  ANGPT2; angiopoietin-2 [KO:K05466]
122448519  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
122439478  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
122439964  EFNA2; ephrin-A2 [KO:K05462]
122432667  EFNA1; ephrin-A1 [KO:K05462]
122432713  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
122432722  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
122424243  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122432228  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122445860  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122442295  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
122428025  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122440044  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122443065  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122440366  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122454848  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122427991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
122439706  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122439712  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
122428200  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122447130  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122440569  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122428068  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122438342  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
122452906  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122426316  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122447839  CRK; adapter molecule crk isoform X1 [KO:K04438]
122455174  CRKL; crk-like protein [KO:K04438]
122442291  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
122421110  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
122421517  CDH1; cadherin-1 isoform X1 [KO:K05689]
122425067  CTNNB1; catenin beta-1 [KO:K02105]
122424302  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
122438258  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
122436206  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
122453356  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122440134  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
122444227  uncharacterized protein LOC122444227 [KO:K10784]
122433147  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
122454427  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
122454326  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
122442569  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
122448704  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
122424748  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122433081  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122420171  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122420869  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
122441566  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
122419812  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
122449743  DRD2; D(2) dopamine receptor [KO:K04145]
122422866  CNR1; cannabinoid receptor 1 [KO:K04277]
122424468  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 [KO:K04630]
122436579  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
122438257  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 [KO:K04630]
122420097  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
122426485  rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
122443817  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
122430631  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
122446653  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
122421681  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
122448668  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
122443364  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
122442306  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
122438558  RALA; ras-related protein Ral-A [KO:K07834]
122453526  RALB; ras-related protein Ral-B [KO:K07835]
122448567  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122433321  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122423661  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122438676  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122448165  amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
122443528  TLN2; talin-2 isoform X1 [KO:K06271]
122452819  TLN1; talin-1 [KO:K06271]
122440505  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
122439965  ITGB3; integrin beta-3 [KO:K06493]
122440035  PFN3; profilin-3 [KO:K05759]
122442009  PFN4; profilin-4 [KO:K05759]
122446616  PFN1; profilin-1 [KO:K05759]
122426218  profilin-1-like [KO:K05759]
122434533  profilin-2-like [KO:K05759]
122445056  PFN2; profilin-2 [KO:K05759]
122420260  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
122452247  ENAH; protein enabled homolog isoform X1 [KO:K05746]
122419686  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
122438358  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122432952  ACTB; actin, cytoplasmic 1 [KO:K05692]
122439781  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
122424963  RHOA; transforming protein RhoA [KO:K04513]
122448145  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122437338  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
122426807  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122440314  VAV1; proto-oncogene vav [KO:K05730]
122442367  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
122436609  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
122428727  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
122448866  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
122451294  LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
122420789  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
122448703  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
122425525  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
122452072  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
122444946  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
122434206  AFDN; afadin isoform X1 [KO:K05702]
122449718  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
122438079  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
122440037  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
122451811  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
122433358  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
122433397  ITGAM; integrin alpha-M [KO:K06461]
122445429  ITGB2; integrin beta-2 [KO:K06464]
122447938  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
122438725  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122425059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122443062  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122440231  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122440910  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122446062  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122447261  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122443696  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122429019  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122429123  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122429963  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122423531  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122423529  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122451688  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122445271  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122444906  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122440740  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122454626  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122437038  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122446118  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
122430591  HRAS; GTPase HRas isoform X1 [KO:K02833]
122423876  KRAS; GTPase KRas isoform X1 [KO:K07827]
122446047  GTPase KRas [KO:K07827]
122435924  NRAS; GTPase NRas [KO:K07828]
122421012  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
ccad04010  MAPK signaling pathway
ccad04014  Ras signaling pathway
ccad04020  Calcium signaling pathway
ccad04151  PI3K-Akt signaling pathway
ccad04510  Focal adhesion
ccad04520  Adherens junction
ccad04660  T cell receptor signaling pathway
ccad04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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