KEGG   PATHWAY: ecb05161
Entry
ecb05161                    Pathway                                
Name
Hepatitis B - Equus caballus (horse)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
ecb05161  Hepatitis B
ecb05161

Organism
Equus caballus (horse) [GN:ecb]
Gene
100071701  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
100064290  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
100033900  TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
100050377  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
111771316  transforming growth factor beta-2-like isoform X1 [KO:K13376]
100051765  TGFB3; transforming growth factor beta-3 [KO:K13377]
100034117  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100033860  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100033845  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100064022  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100052608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100057961  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100051798  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
100062890  EGR2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100057675  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
100055626  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100069613  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100052326  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100059606  DDB1; DNA damage-binding protein 1 [KO:K10610]
100051180  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100061688  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100056060  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100056084  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100057123  YWHAQ; 14-3-3 protein theta [KO:K16197]
100073094  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100058000  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100057483  RELA; transcription factor p65 [KO:K04735]
100056599  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100071639  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100061802  FADD; FAS-associated death domain protein [KO:K02373]
100066502  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100068201  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
100054988  BID; BH3-interacting domain death agonist [KO:K04726]
100054674  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100052552  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100053958  CYCS; cytochrome c [KO:K08738]
111768755  cytochrome c, testis-specific [KO:K08738]
100054331  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100069290  caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
100050808  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100147188  CCNA1; cyclin-A1 [KO:K06627]
100072219  CCNA2; cyclin-A2 [KO:K06627]
100051790  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100055302  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100053882  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100057080  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
100069192  E2F1; transcription factor E2F1 [KO:K17454]
100057866  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
100052248  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100630677  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100052657  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100053856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100054213  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100033834  TNF; tumor necrosis factor [KO:K03156]
100054008  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100051487  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100147451  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100146182  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100034011  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100069633  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100052513  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100054693  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100052904  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100052954  signal transducer and activator of transcription 5B isoform X3 [KO:K11224]
100050053  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100050036  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100054547  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100033846  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100053304  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100062307  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100064828  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100057002  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100067794  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100063153  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100054803  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100059348  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100037400  CXCL8; interleukin-8 precursor [KO:K10030]
100052065  PCNA; proliferating cell nuclear antigen [KO:K04802]
100061212  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100051388  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100009701  TLR2; toll-like receptor 2 precursor [KO:K10159]
100053940  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100064503  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
100066890  TLR4; toll-like receptor 4 precursor [KO:K10160]
111771935  toll-like receptor 4 [KO:K10160]
100054848  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100059262  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100052296  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100070300  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
100060433  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100065841  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
100034196  IL6; interleukin-6 precursor [KO:K05405]
100053481  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100053056  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100147230  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100529854  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
100009703  TLR3; toll-like receptor 3 precursor [KO:K05401]
100062414  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100067920  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
100061257  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100066212  MAVS; mitochondrial antiviral-signaling protein isoform X2 [KO:K12648]
100055110  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
100055384  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
100051650  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100058480  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
100055868  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100055087  IRF7; interferon regulatory factor 7 isoform X6 [KO:K09447]
100064468  interferon alpha-2-like [KO:K05414]
100064551  interferon alpha-2-like [KO:K05414]
100052921  interferon alpha-4 precursor [KO:K05414]
100052818  IFN-ALPHA2; interferon alpha-2 precursor [KO:K05414]
100629951  interferon alpha-1 [KO:K05414]
100053110  interferon alpha-4 [KO:K05414]
100053022  IFNA1; interferon alpha-1 precursor [KO:K05414]
100053210  interferon alpha-2-like [KO:K05414]
100064612  interferon alpha-2-like [KO:K05414]
100064731  IFND1; interferon delta 1 precursor [KO:K05414]
100064975  IFND2; interferon-delta 2 precursor [KO:K05414]
100629885  interferon alpha-2-like [KO:K05414]
100052545  IFNB1; interferon beta precursor [KO:K05415]
100052658  interferon beta-like [KO:K05415]
100147174  interferon beta [KO:K05415]
100063402  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
ecb04010  MAPK signaling pathway
ecb04064  NF-kappa B signaling pathway
ecb04110  Cell cycle
ecb04115  p53 signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04210  Apoptosis
ecb04620  Toll-like receptor signaling pathway
ecb04622  RIG-I-like receptor signaling pathway
ecb04630  JAK-STAT signaling pathway
KO pathway
ko05161   
LinkDB

DBGET integrated database retrieval system