KEGG   PATHWAY: mcc05164
Entry
mcc05164                    Pathway                                
Name
Influenza A - Macaca mulatta (rhesus monkey)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcc05164  Influenza A
mcc05164

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100425930  tryptase alpha/beta-1 isoform X3 [KO:K01340] [EC:3.4.21.59]
699599  tryptase alpha/beta-1 isoform X1 [KO:K01340] [EC:3.4.21.59]
703891  PLG; plasminogen precursor [KO:K01315] [EC:3.4.21.7]
698352  PRSS2; trypsin-2 precursor [KO:K01312] [EC:3.4.21.4]
698729  PRSS1; trypsin-1 precursor [KO:K01312] [EC:3.4.21.4]
716882  putative trypsin-6 isoform X1 [KO:K01312] [EC:3.4.21.4]
698859  putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
114677048  trypsin-2-like isoform X1 [KO:K01312] [EC:3.4.21.4]
114677057  trypsin-3-like [KO:K01312] [EC:3.4.21.4]
699109  putative trypsin-6 [KO:K01312] [EC:3.4.21.4]
715138  TMPRSS2; transmembrane protease serine 2 isoform X3 [KO:K09633] [EC:3.4.21.122]
704604  TMPRSS4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
711510  TMPRSS11D; transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
712265  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
712401  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
712342  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
715647  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
718890  DNAJB1; dnaJ homolog subfamily B member 1 isoform X2 [KO:K09507]
695757  DNAJC3; dnaJ homolog subfamily C member 3 precursor [KO:K09523]
708912  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
710150  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
712588  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
704638  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
702024  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
703981  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
717616  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
694844  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
697836  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
574378  TLR3; toll-like receptor 3 precursor [KO:K05401]
574294  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
693961  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
695607  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
706258  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
704331  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
574360  TLR4; toll-like receptor 4 precursor [KO:K10160]
574291  TLR7; toll-like receptor 7 [KO:K05404]
696494  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
700568  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
699578  IRF7; interferon regulatory factor 7 [KO:K09447]
700193  IL1A; interleukin-1 alpha precursor [KO:K04383]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
705819  IL6; interleukin-6 precursor [KO:K05405]
703205  IL12A; interleukin-12 subunit alpha [KO:K05406]
694747  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
715467  TNF; tumor necrosis factor [KO:K03156]
613028  CXCL8; interleukin-8 precursor [KO:K10030]
574138  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
574178  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
574243  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
712280  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709755  IFNA8; interferon alpha-8 [KO:K05414]
710751  interferon alpha-17-like [KO:K05414]
694631  interferon alpha-1/13-like [KO:K05414]
710487  interferon alpha-14 [KO:K05414]
710528  interferon alpha-1/13 [KO:K05414]
710568  interferon alpha-4-like [KO:K05414]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
711252  IFNA21; interferon alpha-21 [KO:K05414]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
711088  interferon alpha-17-like [KO:K05414]
106992322  interferon alpha-17 [KO:K05414]
710848  interferon alpha-17 [KO:K05414]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
114672663  interferon alpha-17-like [KO:K05414]
114672664  interferon alpha-17-like [KO:K05414]
711414  IFNB1; interferon beta precursor [KO:K05415]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
574130  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
715680  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
693650  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
712694  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
715335  IRF9; interferon regulatory factor 9 [KO:K04693]
715186  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
780935  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
718759  ADAR; double-stranded RNA-specific adenosine deaminase isoform X5 [KO:K12968] [EC:3.5.4.37]
700379  PML; protein PML [KO:K10054] [EC:2.3.2.-]
574282  IFNG; interferon gamma precursor [KO:K04687]
100423877  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
699489  IFNGR2; interferon gamma receptor 2 [KO:K05133]
694184  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
710761  CIITA; MHC class II transactivator isoform X7 [KO:K08060] [EC:2.7.11.1]
692100  MAMU-DRB1; major histocompatibility complex, class II, DR beta 1 precursor [KO:K06752]
717870  MAMU-DMA; major histocompatibility complex, class II, DM alpha precursor [KO:K06752]
717969  MAMU-DPB; major histocompatibility complex, class II, DP beta [KO:K06752]
717947  MAMU-DOA; major histocompatibility complex, class II, DO alpha precursor [KO:K06752]
717992  MAMU-DPA; major histocompatibility complex, class II, DP alpha [KO:K06752]
717702  MAMU-DOB; major histocompatibility complex, class II, DO beta precursor [KO:K06752]
100187587  MAMU-DRA; mamu class II histocompatibility antigen, DR alpha chain precursor [KO:K06752]
720582  MAMU-DQA1; major histocompatibility complex, class II, DQ alpha 1 precursor [KO:K06752]
716823  MAMU-DQB1; major histocompatibility complex, class II, DQ beta 1 precursor [KO:K06752]
100429857  MAMU-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
100428228  MAMU-DRB5; LOW QUALITY PROTEIN: MHC class II antigen, Mamu-DRB5 [KO:K06752]
100428435  HLA class II histocompatibility antigen, DRB1-3 chain [KO:K06752]
114669810  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
114675357  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
106997902  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
701278  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
713563  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
706568  caspase-1 [KO:K01370] [EC:3.4.22.36]
100426388  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
574151  IL18; interleukin-18 [KO:K05482]
717301  IL33; interleukin-33 isoform X1 [KO:K12967]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
715650  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
694451  TNFSF10; tumor necrosis factor ligand superfamily member 10 precursor [KO:K04721]
716826  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
716650  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
722033  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
708606  FADD; FAS-associated death domain protein [KO:K02373]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100426724  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
718948  BAX; apoptosis regulator BAX [KO:K02159]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
114675515  bcl-2 homologous antagonist/killer-like [KO:K14021]
710045  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
695102  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
710042  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
719811  ADP/ATP translocase 3 [KO:K05863]
693502  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
705449  cytochrome c-like [KO:K08738]
716056  cytochrome c-like [KO:K08738]
711309  cytochrome c-like [KO:K08738]
698225  cytochrome c-like [KO:K08738]
701246  cytochrome c-like [KO:K08738]
699951  cytochrome c-like [KO:K08738]
702488  cytochrome c-like [KO:K08738]
100425223  CYCS; cytochrome c [KO:K08738]
106995399  cytochrome c-like [KO:K08738]
712148  cytochrome c-like [KO:K08738]
694164  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
708119  CPSF4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
698279  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X1 [KO:K14404]
721624  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
718420  NXF1; nuclear RNA export factor 1 [KO:K14284]
706140  nuclear RNA export factor 2 isoform X1 [KO:K14284]
695351  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
693880  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
704593  NXT2; NTF2-related export protein 2 [KO:K14285]
711846  NXT1; NTF2-related export protein 1 [KO:K14285]
722135  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2 [KO:K15047]
696706  RAE1; mRNA export factor isoform X1 [KO:K14298]
717608  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
708720  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
709287  LOW QUALITY PROTEIN: farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
717761  FDPS; farnesyl pyrophosphate synthase isoform X2 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
713687  ACTG1; actin, cytoplasmic 2 [KO:K05692]
574285  ACTB; actin, cytoplasmic 1 [KO:K05692]
705671  actin, cytoplasmic 2-like [KO:K05692]
714144  RAB11A; ras-related protein Rab-11A [KO:K07904]
707462  RAB11B; ras-related protein Rab-11B [KO:K07905]
718063  XPO1; exportin-1 [KO:K14290]
692082  KPNA1; importin subunit alpha-5 [KO:K23940]
100430009  KPNA2; importin subunit alpha-1 [KO:K15043]
707357  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
718406  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
706812  KPNA6; importin subunit alpha-7 [KO:K15042]
718041  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
mcc00900  Terpenoid backbone biosynthesis
mcc03013  Nucleocytoplasmic transport
mcc03015  mRNA surveillance pathway
mcc04010  MAPK signaling pathway
mcc04110  Cell cycle
mcc04144  Endocytosis
mcc04210  Apoptosis
mcc04620  Toll-like receptor signaling pathway
mcc04621  NOD-like receptor signaling pathway
mcc04622  RIG-I-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc05416  Viral myocarditis
KO pathway
ko05164   
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