KEGG   PATHWAY: mmu04510
Entry
mmu04510                    Pathway                                
Name
Focal adhesion - Mus musculus (house mouse)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mmu04510  Focal adhesion
mmu04510

Other DBs
GO: 0005925
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
104099  Itga9; integrin alpha-9 isoform a precursor [KO:K06585]
107589  Mylk; myosin light chain kinase, smooth muscle isoform 1 [KO:K00907] [EC:2.7.11.18]
107746  Rapgef1; rap guanine nucleotide exchange factor 1 isoform 2 [KO:K06277]
109700  Itga1; integrin alpha-1 precursor [KO:K06480]
109711  Actn1; alpha-actinin-1 isoform 1 [KO:K05699]
109880  Braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
109905  Rap1a; ras-related protein Rap-1A [KO:K04353]
110157  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform 1 [KO:K04366] [EC:2.7.11.1]
11461  Actb; actin, cytoplasmic 1 [KO:K05692]
11465  Actg1; actin, cytoplasmic 2 isoform 1 [KO:K05692]
11651  Akt1; RAC-alpha serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
11796  Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
11797  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
11798  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
11848  Rhoa; transforming protein RhoA precursor [KO:K04513]
11855  Arhgap5; rho GTPase-activating protein 5 isoform 1 [KO:K13709]
12015  Bad; bcl2-associated agonist of cell death isoform 1 [KO:K02158]
12043  Bcl2; apoptosis regulator Bcl-2 isoform 1 [KO:K02161]
12334  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
12387  Ctnnb1; catenin beta-1 [KO:K02105]
12389  Cav1; caveolin-1 isoform 1 [KO:K06278]
12390  Cav2; caveolin-2 isoform 1 [KO:K12958]
12391  Cav3; caveolin-3 [KO:K12959]
12443  Ccnd1; G1/S-specific cyclin-D1 isoform 2 [KO:K04503]
12444  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
12445  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
12540  Cdc42; cell division control protein 42 homolog isoform 2 [KO:K04393]
12643  Chad; chondroadherin precursor [KO:K06248]
12824  Col2a1; collagen alpha-1(II) chain isoform 1 preproprotein [KO:K19719]
12826  Col4a1; collagen alpha-1(IV) chain precursor [KO:K06237]
12827  Col4a2; collagen alpha-2(IV) chain precursor [KO:K06237]
12828  Col4a3; collagen alpha-3(IV) chain precursor [KO:K06237]
12829  Col4a4; collagen alpha-4(IV) chain precursor [KO:K06237]
12830  Col4a5; collagen alpha-5(IV) chain isoform 1 precursor [KO:K06237]
12833  Col6a1; collagen alpha-1(VI) chain precursor [KO:K06238]
12834  Col6a2; collagen alpha-2(VI) chain isoform 1 precursor [KO:K06238]
12835  Col6a3; collagen alpha-3(VI) chain isoform 1 precursor [KO:K06238]
12839  Col9a1; collagen alpha-1(IX) chain isoform 2 precursor [KO:K08131]
12840  Col9a2; collagen alpha-2(IX) chain precursor [KO:K08131]
12841  Col9a3; collagen alpha-3(IX) chain isoform 1 precursor [KO:K08131]
12842  Col1a1; collagen alpha-1(I) chain preproprotein [KO:K06236]
12843  Col1a2; collagen alpha-2(I) chain preproprotein [KO:K06236]
12845  Comp; cartilage oligomeric matrix protein precursor [KO:K04659]
12927  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform B [KO:K05726]
12928  Crk; adapter molecule crk isoform 2 [KO:K04438]
12929  Crkl; crk-like protein isoform 1 [KO:K04438]
13367  Diaph1; protein diaphanous homolog 1 isoform 2 [KO:K05740]
13645  Egf; pro-epidermal growth factor isoform 1 preproprotein [KO:K04357]
13649  Egfr; epidermal growth factor receptor isoform 1 precursor [KO:K04361] [EC:2.7.10.1]
13712  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
13730  Emp1; epithelial membrane protein 1 isoform a [KO:K26255]
13731  Emp2; epithelial membrane protein 2 [KO:K26256]
13866  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
14083  Ptk2; focal adhesion kinase 1 isoform 1 [KO:K05725] [EC:2.7.10.2]
14205  Vegfd; vascular endothelial growth factor D isoform VEGF-D358 preproprotein [KO:K05449]
14254  Flt1; vascular endothelial growth factor receptor 1 isoform 1 precursor [KO:K05096] [EC:2.7.10.1]
14257  Flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
14268  Fn1; fibronectin isoform a precursor [KO:K05717]
14360  Fyn; tyrosine-protein kinase Fyn isoform a [KO:K05703] [EC:2.7.10.2]
14784  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
15234  Hgf; hepatocyte growth factor isoform 1 preproprotein [KO:K05460]
15461  Hras; GTPase HRas isoform 1 [KO:K02833]
15891  Ibsp; bone sialoprotein 2 precursor [KO:K06253]
16000  Igf1; insulin-like growth factor I isoform 4 preproprotein [KO:K05459]
16001  Igf1r; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
16202  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
16398  Itga2; integrin alpha-2 precursor [KO:K06481]
16399  Itga2b; integrin alpha-IIb precursor [KO:K06476]
16400  Itga3; integrin alpha-3 isoform 1 preproprotein [KO:K06482]
16401  Itga4; integrin alpha-4 precursor [KO:K06483]
16402  Itga5; integrin alpha-5 isoform 1 preproprotein [KO:K06484]
16403  Itga6; integrin alpha-6 isoform 2 precursor [KO:K06485]
16404  Itga7; integrin alpha-7 isoform 2 precursor [KO:K06583]
16410  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
16412  Itgb1; integrin beta-1 precursor [KO:K05719]
16416  Itgb3; integrin beta-3 precursor [KO:K06493]
16419  Itgb5; integrin beta-5 isoform 1 precursor [KO:K06588]
16420  Itgb6; integrin beta-6 precursor [KO:K06589]
16421  Itgb7; integrin beta-7 precursor [KO:K06590]
16476  Jun; transcription factor Jun [KO:K04448]
16542  Kdr; vascular endothelial growth factor receptor 2 isoform 1 precursor [KO:K05098] [EC:2.7.10.1]
16772  Lama1; laminin subunit alpha-1 precursor [KO:K05637]
16773  Lama2; laminin subunit alpha-2 precursor [KO:K05637]
16774  Lama3; laminin subunit alpha-3 isoform 3B precursor [KO:K06240]
16775  Lama4; laminin subunit alpha-4 precursor [KO:K06241]
16776  Lama5; laminin subunit alpha-5 precursor [KO:K06240]
16777  Lamb1; laminin subunit beta-1 precursor [KO:K05636]
16779  Lamb2; laminin subunit beta-2 precursor [KO:K06243]
16780  Lamb3; laminin subunit beta-3 precursor [KO:K06244]
16782  Lamc2; laminin subunit gamma-2 precursor [KO:K06246]
170736  Parvb; beta-parvin [KO:K06275]
170758  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
17295  Met; hepatocyte growth factor receptor isoform a precursor [KO:K05099] [EC:2.7.10.1]
17898  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
17906  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 1 [KO:K10351]
17907  Mylpf; myosin regulatory light chain 11 isoform 1 [KO:K12758]
17931  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform 1 [KO:K06270]
18479  Pak1; serine/threonine-protein kinase PAK 1 isoform 2 [KO:K04409] [EC:2.7.11.1]
18481  Pak3; serine/threonine-protein kinase PAK 3 isoform C [KO:K05733] [EC:2.7.11.1]
18590  Pdgfa; platelet-derived growth factor subunit A isoform 2 precursor [KO:K04359]
18591  Pdgfb; platelet-derived growth factor subunit B isoform 2 [KO:K17386]
18595  Pdgfra; platelet-derived growth factor receptor alpha isoform 1 precursor [KO:K04363] [EC:2.7.10.1]
18596  Pdgfrb; platelet-derived growth factor receptor beta isoform 2 precursor [KO:K05089] [EC:2.7.10.1]
18607  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform A [KO:K06276] [EC:2.7.11.1]
18654  Pgf; placenta growth factor isoform 1 precursor [KO:K16859]
18706  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 [KO:K02649]
18709  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform 1 [KO:K02649]
18710  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 [KO:K02649]
18717  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1 [KO:K00889] [EC:2.7.1.68]
18719  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
18720  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2 [KO:K00889] [EC:2.7.1.68]
18750  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C gamma type isoform 1 [KO:K19663] [EC:2.7.11.13]
19045  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
19046  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
19047  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16]
19211  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
192176  Flna; filamin-A isoform 3 [KO:K04437]
192897  Itgb4; integrin beta-4 isoform 1 precursor [KO:K06525]
19303  Pxn; paxillin isoform 3 [KO:K05760]
19353  Rac1; ras-related C3 botulinum toxin substrate 1 isoform 2 [KO:K04392]
19354  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
19417  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform 1 [KO:K04349]
19699  Reln; reelin isoform 1 precursor [KO:K06249] [EC:3.4.21.-]
19877  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
19878  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
20416  Shc1; SHC-transforming protein 1 isoform a [KO:K06279]
20418  Shc3; SHC-transforming protein 3 [KO:K17448]
20662  Sos1; son of sevenless homolog 1 [KO:K03099]
20663  Sos2; son of sevenless homolog 2 [KO:K03099]
20750  Spp1; osteopontin isoform 4 precursor [KO:K06250]
20779  Src; proto-oncogene tyrosine-protein kinase Src isoform 2 [KO:K05704] [EC:2.7.10.2]
213119  Itga10; integrin alpha-10 precursor [KO:K06586]
213435  Mylk3; myosin light chain kinase 3 isoform 1 [KO:K00907] [EC:2.7.11.18]
214230  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
215449  Rap1b; ras-related protein Rap-1b [KO:K07836]
216148  Shc2; SHC-transforming protein 2 [KO:K17447]
21825  Thbs1; thrombospondin-1 isoform 2 precursor [KO:K16857]
21826  Thbs2; thrombospondin-2 precursor [KO:K04659]
21827  Thbs3; thrombospondin-3 precursor [KO:K04659]
21828  Thbs4; thrombospondin-4 precursor [KO:K04659]
21894  Tln1; talin-1 [KO:K06271]
21923  Tnc; tenascin isoform 1 precursor [KO:K06252]
21960  Tnr; tenascin-R precursor [KO:K06252]
22323  Vasp; vasodilator-stimulated phosphoprotein isoform 1 [KO:K06274]
22324  Vav1; proto-oncogene vav isoform 1 [KO:K05730]
22325  Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730]
22330  Vcl; vinculin [KO:K05700]
22339  Vegfa; vascular endothelial growth factor A, long form isoform 1 [KO:K05448]
22340  Vegfb; vascular endothelial growth factor B isoform Vegf-b186 precursor [KO:K16858]
22341  Vegfc; vascular endothelial growth factor C precursor [KO:K05449]
22370  Vtn; vitronectin precursor [KO:K06251]
22371  Vwf; von Willebrand factor precursor [KO:K03900]
224105  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
226519  Lamc1; laminin subunit gamma-1 precursor [KO:K05635]
22793  Zyx; zyxin isoform a [KO:K06273]
228785  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
232807  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform 1 [KO:K17457]
232906  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
23797  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
238564  Mylk4; myosin light chain kinase family member 4 isoform 1 [KO:K00907] [EC:2.7.11.18]
23928  Lamc3; laminin subunit gamma-3 precursor [KO:K06247]
241226  Itga8; integrin alpha-8 isoform 1 preproprotein [KO:K06584]
241656  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
245026  Col6a6; collagen alpha-6(VI) chain isoform 1 precursor [KO:K06238]
26395  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 isoform 1 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 isoform beta2 [KO:K04440] [EC:2.7.11.24]
271849  Shc4; SHC-transforming protein 4 [KO:K17449]
286940  Flnb; filamin-B isoform a [KO:K27392]
319480  Itga11; integrin alpha-11 precursor [KO:K06587]
320910  Itgb8; integrin beta-8 precursor [KO:K06591]
329251  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform 2 [KO:K12329]
329278  Tnn; tenascin-N precursor [KO:K06252]
330662  Dock1; dedicator of cytokinesis protein 1 [KO:K13708]
434233  Ppp1ccb; protein phosphatase 1 catalytic subunit gamma B [KO:K06269] [EC:3.1.3.16]
54635  Pdgfc; platelet-derived growth factor C isoform 1 precursor [KO:K05450]
56637  Gsk3b; glycogen synthase kinase-3 beta isoform 1 [KO:K03083] [EC:2.7.11.26]
57257  Vav3; guanine nucleotide exchange factor VAV3 isoform 1 [KO:K05730]
57342  Parva; alpha-parvin [KO:K06275]
59310  Myl10; myosin regulatory light chain 10 isoform 2 [KO:K12756]
60595  Actn4; alpha-actinin-4 isoform 1 [KO:K05699]
64099  Parvg; gamma-parvin isoform 2 [KO:K06275]
665033  Col6a5; collagen alpha-5(VI) chain precursor [KO:K06238]
67268  Myl12a; myosin light chain, regulatory B-like isoform 2 [KO:K12757]
67653  4930544G11Rik; ras homolog gene family, member A-like [KO:K04513]
67938  Myl12b; myosin regulatory light chain 12B [KO:K12757]
68553  Col6a4; collagen alpha-4(VI) chain precursor [KO:K06238]
70549  Tln2; talin-2 isoform 1 [KO:K06271]
70584  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
71785  Pdgfd; platelet-derived growth factor D isoform 1 precursor [KO:K05450]
74769  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
81877  Tnxb; tenascin-X precursor [KO:K06252]
94216  Col4a6; collagen alpha-6(IV) chain precursor [KO:K06237]
98932  Myl9; myosin regulatory light polypeptide 9 isoform a [KO:K12755]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mmu04010  MAPK signaling pathway
mmu04060  Cytokine-cytokine receptor interaction
mmu04070  Phosphatidylinositol signaling system
mmu04110  Cell cycle
mmu04151  PI3K-Akt signaling pathway
mmu04310  Wnt signaling pathway
mmu04512  ECM-receptor interaction
mmu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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