KEGG   PATHWAY: mrv04010
Entry
mrv04010                    Pathway                                
Name
MAPK signaling pathway - Mauremys reevesii (Reeves's turtle)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mrv04010  MAPK signaling pathway
mrv04010

Other DBs
GO: 0000165
Organism
Mauremys reevesii (Reeves's turtle) [GN:mrv]
Gene
120390882  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120386663  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
120408934  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120409125  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120369933  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
120388192  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
120383191  voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854]
120373013  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
120372145  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120403655  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
120394404  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
120409322  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
120368552  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
120409009  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
120392202  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
120397991  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
120391312  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
120374744  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
120383594  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
120396462  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
120372774  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
120383688  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
120383681  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
120388342  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
120388336  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
120388357  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
120404799  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
120369997  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120391063  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
120391064  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120391216  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
120383347  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
120372765  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120388263  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
120373445  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
120406317  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120397556  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120368549  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120373493  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
120408715  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
120403385  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
120368749  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
120402105  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
120388723  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
120405555  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
120387156  NF1; neurofibromin isoform X1 [KO:K08052]
120407784  RASA1; ras GTPase-activating protein 1 [KO:K04352]
120404195  RAP1A; ras-related protein Rap-1A [KO:K04353]
120383281  RAP1B; ras-related protein Rap-1b [KO:K07836]
120407021  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120399018  TGFA; protransforming growth factor alpha [KO:K08774]
120407054  EREG; proepiregulin [KO:K09784]
120405519  AREG; amphiregulin [KO:K09782]
120370342  FGF1; fibroblast growth factor 1 [KO:K18496]
120406846  FGF2; fibroblast growth factor 2 [KO:K18497]
120370461  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
120391801  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
120372642  FGF16; fibroblast growth factor 16 [KO:K04358]
120372905  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
120395461  FGF9; fibroblast growth factor 9 [KO:K04358]
120404612  FGF4; fibroblast growth factor 4 [KO:K04358]
120404940  FGF3; fibroblast growth factor 3 [KO:K04358]
120405310  FGF6; fibroblast growth factor 6 [KO:K04358]
120397095  FGF17; fibroblast growth factor 17 [KO:K04358]
120406438  fibroblast growth factor 18-like isoform X1 [KO:K04358]
120406518  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
120406582  FGF20; fibroblast growth factor 20 [KO:K04358]
120407440  FGF10; fibroblast growth factor 10 [KO:K04358]
120408993  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120404894  FGF19; fibroblast growth factor 19 [KO:K22603]
120388352  FGF21; fibroblast growth factor 21 [KO:K22429]
120405304  FGF23; fibroblast growth factor 23 [KO:K22428]
120402881  NGF; beta-nerve growth factor [KO:K02582]
120404509  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
120380070  NTF3; neurotrophin-3 [KO:K04356]
120388361  NTF4; LOW QUALITY PROTEIN: neurotrophin-4 [KO:K12457]
120404835  INS; insulin [KO:K04526]
120372555  IGF1; insulin-like growth factor I [KO:K05459]
120404869  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
120373866  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120391070  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
120407035  PDGFC; platelet-derived growth factor C [KO:K05450]
120368976  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
120404953  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
120395819  KITLG; kit ligand isoform X1 [KO:K05461]
120388479  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
120401331  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
120408910  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K05448]
120403267  PGF; placenta growth factor [KO:K16859]
120388700  snake venom vascular endothelial growth factor toxin apiscin-like [KO:K16859]
120386782  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
120407116  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
120394336  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
120398672  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
120401612  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
120389021  angiopoietin-2-like [KO:K05466]
120381338  ANGPT4; angiopoietin-4 [KO:K05467]
120391838  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
120390317  EFNA3; ephrin-A3 [KO:K05462]
120390340  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
120390413  EFNA1; ephrin-A1 [KO:K05462]
120408461  EFNA5; ephrin-A5 [KO:K05462]
120408595  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
120391870  NRTN; neurturin isoform X1 [KO:K25414]
120369788  ARTN; artemin [KO:K25415]
120390790  PSPN; persephin [KO:K25416]
120397061  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120392163  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120390926  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120374435  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
120397459  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120368575  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120406018  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120375536  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
120375538  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
120375622  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
120370519  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120392304  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
120398180  tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583]
120390665  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
120407553  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
120391598  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120372851  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120407146  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
120369946  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
120370458  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
120407027  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
120395772  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
120383535  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120371478  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
120370388  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120406892  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
120387625  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120408416  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
120387920  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
120369304  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
120383202  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
120402208  SOS1; son of sevenless homolog 1 [KO:K03099]
120404572  SOS2; son of sevenless homolog 2 [KO:K03099]
120405072  HRAS; GTPase HRas [KO:K02833]
120388368  ras-like protein isoform X1 [KO:K07827]
120407327  KRAS; GTPase KRas isoform X1 [KO:K07827]
120404663  NRAS; GTPase NRas [KO:K07828]
120405054  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
120388364  RRAS; ras-related protein R-Ras [KO:K07830]
120374898  MRAS; ras-related protein M-Ras [KO:K07831]
120388490  ARAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120369343  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
120409502  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120373628  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120391732  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120406208  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
120386132  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120404454  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120370438  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
120391682  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
120371772  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
120406142  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
120389042  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120400260  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
120377804  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120388920  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
120404643  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
120398075  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
120400994  SRF; LOW QUALITY PROTEIN: serum response factor [KO:K04378]
120405405  FOS; proto-oncogene c-Fos [KO:K04379]
120392018  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
120389092  STMN1; stathmin [KO:K04381]
120392593  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120403377  PLA2G4B; LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
120384955  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120404423  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
120404471  LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404486  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404503  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404532  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404546  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120405295  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
120380092  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380093  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380100  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380338  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380930  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120370232  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
120392459  TNF; tumor necrosis factor isoform X1 [KO:K03156]
120397289  interleukin-1 beta-like [KO:K04519]
120399668  interleukin-1 beta-like [KO:K04519]
120388881  transforming growth factor beta-1 proprotein-like isoform X1 [KO:K13375]
120402154  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
120405439  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
120400408  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
120395314  interleukin-1 receptor-like 2 isoform X1 [KO:K04386]
120406214  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
120372292  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
120396661  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
120375044  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
120398476  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
120370739  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120368627  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120372984  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120389073  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120383388  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120387901  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120384429  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120406161  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
120392446  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120392485  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120386646  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120394904  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
120397823  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120388499  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
120386280  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
120404545  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
120370396  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120391837  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
120408769  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120372053  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
120400767  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
120386949  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like [KO:K04405]
120390796  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
120402382  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
120401389  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
120372554  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
120388800  MAP4K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
120391328  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120372347  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120380432  STK4; serine/threonine-protein kinase 4 [KO:K04411]
120397782  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
120409121  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
120397005  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
120407790  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
120369247  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
120374714  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
120392173  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
120398118  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
120403502  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
120388410  mitogen-activated protein kinase kinase kinase 10-like isoform X1 [KO:K04418] [EC:2.7.11.25]
120401339  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
120391078  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
120372134  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
120374775  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
120389122  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
120402164  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
120400505  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120400708  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
120386013  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
120404463  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
120387244  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
120383189  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
120373319  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
120383171  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
120403539  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
120395689  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
120373953  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
120388642  FLNA; filamin-A isoform X1 [KO:K04437]
120402850  crk-like protein [KO:K04438]
120385987  CRKL; crk-like protein [KO:K04438]
120387321  CRK; adapter molecule crk isoform X1 [KO:K04438]
120381927  ARRB2; LOW QUALITY PROTEIN: beta-arrestin-2 [KO:K04439]
120398292  beta-arrestin-1 isoform X1 [KO:K04439]
120405833  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120368657  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120369865  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120403531  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120404342  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120389525  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
120389611  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
120385892  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
120403398  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
120369337  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
120403872  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
120369095  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
120406589  LOW QUALITY PROTEIN: M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
120398167  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120384851  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120370011  JUN; transcription factor AP-1 [KO:K04448]
120391830  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
120375150  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120381866  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120391088  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
120404691  MAX; protein max isoform X1 [KO:K04453]
120407822  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
120387600  HSPB1; heat shock protein beta-1 [KO:K04455]
120405059  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120388568  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120401029  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120403788  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
120388820  PPM1N; probable protein phosphatase 1N [KO:K04457] [EC:3.1.3.16]
120396002  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
120404840  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
120370112  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
120404568  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120396576  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120406971  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120369354  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120381299  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120409392  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120395758  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
120388640  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
120401941  DUSP10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120368781  dual specificity protein phosphatase 10-like isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
120392065  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
120388929  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
120401253  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
120385035  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
120385043  heat shock cognate 71 kDa protein-like [KO:K03283]
120393855  heat shock cognate 71 kDa protein-like [KO:K03283]
120375455  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
120390270  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
120390410  heat shock 70 kDa protein 1A-like [KO:K03283]
120372281  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
120373331  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
120403296  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
120391182  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
120385126  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120368653  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
120397038  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120388769  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120404133  LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
120387128  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
120405938  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120409111  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
120369204  RELA; transcription factor p65 isoform X1 [KO:K04735]
120388097  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mrv04070  Phosphatidylinositol signaling system
mrv04110  Cell cycle
mrv04115  p53 signaling pathway
mrv04210  Apoptosis
mrv04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system