Entry
Name
Spliceosome - Nicotiana tabacum (common tobacco)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Nicotiana tabacum (common tobacco) [GN:
nta ]
Gene
107825164 small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086 ]
107807996 transcription initiation factor TFIID subunit 15b-like [KO:K13098 ]
107832244 transcription initiation factor TFIID subunit 15b-like [KO:K13098 ]
107775077 transcription initiation factor TFIID subunit 15b-like [KO:K13098 ]
107780234 transcription initiation factor TFIID subunit 15b-like [KO:K13098 ]
107765141 survival of motor neuron-related-splicing factor 30-like [KO:K12839 ]
107804027 survival of motor neuron-related-splicing factor 30-like [KO:K12839 ]
107813967 DNA-damage-repair/toleration protein DRT111, chloroplastic-like [KO:K12840 ]
107780693 DNA-damage-repair/toleration protein DRT111, chloroplastic-like [KO:K12840 ]
107800703 U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662 ]
107801611 U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662 ]
107775019 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846 ]
107762655 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
107773820 116 kDa U5 small nuclear ribonucleoprotein component-like [KO:K12852 ]
107800224 116 kDa U5 small nuclear ribonucleoprotein component-like [KO:K12852 ]
107782719 U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857 ]
107793862 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
107803795 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
107779834 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
107817083 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
107780879 apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875 ]
107807454 apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875 ]
107794577 GTBP1; heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741 ]
107787039 glycine-rich RNA-binding protein 3, mitochondrial-like [KO:K12741 ]
107765935 GTBP3; heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741 ]
107829053 glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741 ]
107830030 GTBP2; heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741 ]
107797091 glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741 ]
107776960 RGP-2; glycine-rich RNA-binding protein 4, mitochondrial-like [KO:K12741 ]
107763441 glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741 ]
107818798 glycine-rich RNA-binding protein 4, mitochondrial-like [KO:K12741 ]
107817115 serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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