KEGG   PATHWAY: opi04810
Entry
opi04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Ochotona princeps (American pika)
Class
Cellular Processes; Cell motility
Pathway map
opi04810  Regulation of actin cytoskeleton
opi04810

Other DBs
GO: 0030036
Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101531567  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101526026  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101535560  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101531765  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101532824  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
101532462  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101528466  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
101527899  F2R; proteinase-activated receptor 1 [KO:K03914]
101533865  insulin isoform X2 [KO:K04526]
101536206  EGF; pro-epidermal growth factor [KO:K04357]
101529368  FGF1; fibroblast growth factor 1 [KO:K18496]
101520285  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101535653  FGF20; fibroblast growth factor 20 [KO:K04358]
101519475  FGF4; fibroblast growth factor 4 [KO:K04358]
101519725  FGF3; fibroblast growth factor 3 [KO:K04358]
101535784  FGF5; fibroblast growth factor 5 [KO:K04358]
101519353  FGF10; fibroblast growth factor 10 [KO:K04358]
101532472  FGF16; fibroblast growth factor 16 [KO:K04358]
101518744  FGF9; fibroblast growth factor 9 [KO:K04358]
101520631  FGF7; fibroblast growth factor 7 [KO:K04358]
101522068  FGF17; fibroblast growth factor 17 [KO:K04358]
101533103  FGF18; fibroblast growth factor 18 [KO:K04358]
101521180  FGF22; fibroblast growth factor 22 [KO:K04358]
101524610  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101528594  FGF6; fibroblast growth factor 6 [KO:K04358]
101519227  FGF19; fibroblast growth factor 19 [KO:K22603]
101533375  FGF21; fibroblast growth factor 21 [KO:K22429]
101528351  FGF23; fibroblast growth factor 23 [KO:K22428]
101522887  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101529308  PDGFC; platelet-derived growth factor C [KO:K05450]
101529042  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101528237  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
101534918  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101531872  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101521291  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101523935  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101516125  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101516431  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101524206  FN1; fibronectin isoform X1 [KO:K05717]
101525898  ITGA1; integrin alpha-1 [KO:K06480]
101526149  ITGA2; integrin alpha-2 [KO:K06481]
101520786  ITGA2B; integrin alpha-IIb [KO:K06476]
101530218  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101530158  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
101526395  ITGA5; integrin alpha-5 [KO:K06484]
101530070  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101533998  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101536231  ITGA8; integrin alpha-8 [KO:K06584]
101516513  ITGA9; integrin alpha-9 [KO:K06585]
101516820  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
101530576  ITGA11; integrin alpha-11 [KO:K06587]
101535157  ITGAV; integrin alpha-V [KO:K06487]
101536679  ITGAL; integrin alpha-L [KO:K05718]
101523123  ITGAM; integrin alpha-M [KO:K06461]
101523366  integrin alpha-X [KO:K06462]
101534411  ITGAE; integrin alpha-E [KO:K06524]
101516514  integrin beta-1 [KO:K05719]
101532669  LOW QUALITY PROTEIN: integrin beta-1-like [KO:K05719]
101518820  ITGB2; integrin beta-2 [KO:K06464]
101535964  ITGB3; integrin beta-3 [KO:K06493]
101524034  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101525317  ITGB5; integrin beta-5 [KO:K06588]
101525955  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101522465  ITGB7; integrin beta-7 [KO:K06590]
101523918  ITGB8; integrin beta-8 [KO:K06591]
101534400  KNG1; LOW QUALITY PROTEIN: kininogen-1 [KO:K03898]
101522951  BDKRB1; B1 bradykinin receptor [KO:K03915]
101529531  BDKRB2; B2 bradykinin receptor [KO:K03916]
101526608  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101532237  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101529171  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101530695  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
101526778  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101517435  C5; complement C5 [KO:K03994]
101522789  C6; complement component C6 [KO:K03995]
101522297  C7; complement component C7 [KO:K03996]
101530038  C8A; complement component C8 alpha chain [KO:K03997]
101530295  C8B; complement component C8 beta chain [KO:K03998]
101529562  C8G; complement component C8 gamma chain [KO:K03999]
101521549  C9; complement component C9 isoform X1 [KO:K04000]
101525794  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
101522146  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
101524512  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101519866  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101526935  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
101517366  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
101527700  PTK2; focal adhesion kinase 1 isoform X21 [KO:K05725] [EC:2.7.10.2]
101522546  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
101527001  CRK; adapter molecule crk isoform X1 [KO:K04438]
101519209  CRKL; crk-like protein [KO:K04438]
105941538  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
101517070  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101534610  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101525349  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101531636  HRAS; GTPase HRas [KO:K02833]
101534080  KRAS; GTPase KRas isoform X1 [KO:K07827]
101524465  NRAS; GTPase NRas [KO:K07828]
101522344  RRAS; ras-related protein R-Ras [KO:K07829]
101521899  RRAS2; ras-related protein R-Ras2 [KO:K07830]
101520719  ras-related protein M-Ras-like [KO:K07831]
101532780  MRAS; ras-related protein M-Ras [KO:K07831]
101526327  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101528030  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101530917  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101531375  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
101523885  VAV1; proto-oncogene vav [KO:K05730]
101526247  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101529871  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101526188  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
101534290  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101535911  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105942099  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101525427  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101519727  RGCC; regulator of cell cycle RGCC [KO:K26108]
101527019  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
101524556  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
101535885  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101525255  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101535305  transforming protein RhoA-like isoform X1 [KO:K04513]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101527518  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101531979  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101529472  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101532470  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101535581  cell division control protein 42 homolog [KO:K04393]
101527484  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101520957  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101531364  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101523798  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101517756  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101529832  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
101525875  ARHGEF7; rho guanine nucleotide exchange factor 7 [KO:K13710]
101524195  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
101530829  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
101533973  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101517477  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
101526040  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101526659  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101526925  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101525073  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101522201  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101533284  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101529033  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101523577  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
101533680  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101533043  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101522199  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
101535284  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101535208  MYL10; myosin regulatory light chain 10 [KO:K12756]
101517508  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
101533077  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
101533474  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
101536586  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
101521747  MYH10; myosin-10 isoform X1 [KO:K10352]
101516265  MYH11; myosin-11 isoform X1 [KO:K10352]
101517353  MYH14; myosin-14 isoform X1 [KO:K10352]
101535376  MYH9; myosin-9 [KO:K10352]
101526160  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
101534323  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
101536442  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
101533422  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101527580  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101524273  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101526720  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
101522970  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
101518269  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
101530658  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
101523041  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
101532959  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
101528194  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
101535793  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
101518123  ENAH; protein enabled homolog [KO:K05746]
101523307  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101533912  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
101531666  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
101518667  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
101525894  NCKAP1L; nck-associated protein 1-like [KO:K05750]
101529165  NCKAP1; nck-associated protein 1 [KO:K05750]
101517772  ABI2; abl interactor 2 isoform X5 [KO:K05751]
101530593  BRK1; protein BRICK1 [KO:K05752]
101519420  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
101525978  ACTR2; actin-related protein 2 [KO:K17260]
101534657  ACTR3B; actin-related protein 3B [KO:K18584]
101528569  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
101528031  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101530009  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101522008  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
101533772  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101528933  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
101517018  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101518992  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
101525072  ACTB; actin, cytoplasmic 1 [KO:K05692]
101518086  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101528546  PFN4; profilin-4 [KO:K05759]
101522663  profilin-1 [KO:K05759]
105942340  profilin-1-like [KO:K05759]
101519557  PFN1; profilin-1 [KO:K05759]
101521721  PFN3; profilin-3 [KO:K05759]
101528185  profilin-1-like [KO:K05759]
101531767  profilin-1-like [KO:K05759]
101523218  PXN; paxillin isoform X1 [KO:K05760]
101531128  EZR; ezrin isoform X1 [KO:K08007]
101533563  RDX; radixin isoform X1 [KO:K05762]
101529154  MSN; moesin [KO:K05763]
101536527  cofilin-1-like [KO:K05765]
101534223  CFL2; cofilin-2 [KO:K05765]
101528596  CFL1; cofilin-1 [KO:K05765]
101534914  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101528169  SSH1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101523462  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101529934  VCL; vinculin isoform X1 [KO:K05700]
101524450  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101528151  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
101526493  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
101520246  SCIN; adseverin isoform X1 [KO:K05768]
101532724  GSN; gelsolin isoform X1 [KO:K05768]
101519262  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
101519558  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101516222  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101526321  APC; adenomatous polyposis coli protein [KO:K02085]
101517613  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
101524019  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
opi04010  MAPK signaling pathway
opi04510  Focal adhesion
opi04520  Adherens junction
KO pathway
ko04810   
LinkDB

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