KEGG   PATHWAY: rtp05132
Entry
rtp05132                    Pathway                                
Name
Salmonella infection - Rhincodon typus (whale shark)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
rtp05132  Salmonella infection
rtp05132

Organism
Rhincodon typus (whale shark) [GN:rtp]
Gene
109936986  ras-related protein Rab-5C [KO:K07887]
109925288  ras-related protein Rab-5B isoform X1 [KO:K07888]
109914020  rab5b; ras-related protein Rab-5B [KO:K07888]
109922509  ras-related protein Rab-5C-like [KO:K07889]
109924008  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K00914] [EC:2.7.1.137]
109918745  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109925048  ras-related protein Rab-7a-like [KO:K07897]
109922896  rab7a; ras-related protein Rab-7a [KO:K07897]
109934029  LOW QUALITY PROTEIN: ras-related protein Rab-7b-like [KO:K07898]
109922570  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
109924053  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
109931608  vps33a; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
109937106  vps39; vam6/Vps39-like protein [KO:K20183]
109935310  vps41; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184]
109936405  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
109928522  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
109937212  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
109931378  cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
109934371  cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
109936059  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X2 [KO:K10417]
109924756  dynein light chain LC6, flagellar outer arm [KO:K10418]
109931365  dynein light chain 2, cytoplasmic [KO:K10418]
109923524  dynein light chain roadblock-type 2 [KO:K10419]
109914921  dynein light chain roadblock-type 2-like [KO:K10419]
109926734  dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
109915515  dynein light chain Tctex-type 1-like isoform X1 [KO:K10420]
109927716  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
109913528  dctn3; dynactin subunit 3 [KO:K10425]
109923564  dctn4; dynactin subunit 4 [KO:K10426]
109910483  dctn5; dynactin subunit 5 [KO:K10427]
109912600  dynactin subunit 6-like [KO:K10428]
109916741  alpha-centractin [KO:K16575]
109922154  actr1b; actin related protein 1B [KO:K16575]
109916345  actr10; actin-related protein 10 [KO:K16576]
109936906  tubulin alpha chain-like [KO:K07374]
109936908  tubulin alpha-1D chain [KO:K07374]
109924346  tubulin alpha-1C chain isoform X1 [KO:K07374]
109925445  tubulin alpha chain [KO:K07374]
109921125  tubulin alpha-1B chain-like [KO:K07374]
125480938  tubulin alpha-1D chain-like [KO:K07374]
109936907  tubulin alpha-4A chain-like [KO:K07374]
109924431  tubulin alpha chain-like [KO:K07374]
109919235  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
109938200  tubulin alpha-3 chain-like [KO:K07374]
109938199  tubulin alpha-3 chain-like [KO:K07374]
109910662  tubulin beta-4B chain [KO:K07375]
109919686  tubulin beta-5 chain [KO:K07375]
109930153  tubulin beta chain-like [KO:K07375]
109914558  tubulin beta chain-like isoform X1 [KO:K07375]
109938363  tubulin beta-4 chain-like isoform X1 [KO:K07375]
109916023  tubulin beta chain-like isoform X1 [KO:K07375]
125481339  tubulin beta-3 chain [KO:K07375]
109931241  tubulin beta-4B chain-like isoform X1 [KO:K07375]
109926158  tubulin beta chain [KO:K07375]
109931240  tubulin beta-4B chain-like [KO:K07375]
109937237  tubulin beta chain-like [KO:K07375]
109935308  FYVE and coiled-coil domain-containing protein 1-like [KO:K21954]
109920095  fyco1a; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
109927769  ADP-ribosylation factor-like protein 8B-A [KO:K07955]
109915209  ADP-ribosylation factor-like protein 8A [KO:K07955]
109937461  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
109919500  kinesin heavy chain [KO:K10396]
109931738  kinesin-1 heavy chain isoform X1 [KO:K10396]
109921384  kinesin light chain 1-like isoform X1 [KO:K10407]
109918818  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
109923736  klc1b; kinesin light chain 1b [KO:K10407]
109911121  transforming protein RhoA isoform X1 [KO:K04513]
125484326  rab9a; ras-related protein Rab-9A [KO:K07899]
109918603  profilin-3-like [KO:K05759]
109917783  profilin-2-like [KO:K05759]
109938968  profilin-3-like [KO:K05759]
109920346  profilin-3-like [KO:K05759]
109921829  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
109927848  exoc5; exocyst complex component 5 [KO:K19984]
109914152  exoc4; exocyst complex component 4 isoform X1 [KO:K06111]
109928286  exoc2; exocyst complex component 2 [KO:K17637]
109920565  ralaa; ras-related protein Ral-A [KO:K07834]
109911698  actin, cytoplasmic type 5 [KO:K05692]
109920530  actin, cytoplasmic 1 [KO:K05692]
109925500  actin-3-like [KO:K05692]
109915807  actin, cytoplasmic type 5-like [KO:K05692]
109924177  protein S100-A11-like [KO:K17274]
109925547  annexin A2-like [KO:K17092]
109933415  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
109912054  rhoj; rho-related GTP-binding protein RhoJ [KO:K07864]
109926264  rho-related GTP-binding protein RhoG-like [KO:K07863]
109935002  rho-related GTP-binding protein RhoG [KO:K07863]
109935556  rho-related GTP-binding protein RhoG-like [KO:K07863]
109930997  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
109916283  engulfment and cell motility protein 2 [KO:K18985]
109915504  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
109935120  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109933356  myosin light chain 5 [KO:K12753]
109932924  myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
109933200  myosin regulatory light polypeptide 9 [KO:K12755]
109915750  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K12756]
109927812  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
109937536  fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
109936137  cdc42; cell division control protein 42 homolog [KO:K04393]
109938489  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
109913495  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109924676  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109928080  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
109925934  nck-associated protein 1-like [KO:K05750]
109938014  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
109931978  abi1a; abl interactor 1a isoform X1 [KO:K23649]
109911116  brk1; probable protein BRICK1 [KO:K05752]
109922577  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
109910391  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
109922016  actr2a; actin-related protein 2-A [KO:K17260]
109922571  actin-related protein 3 [KO:K18584]
109933155  actin-related protein 3B [KO:K18584]
109921031  actin-related protein 2/3 complex subunit 1A-B [KO:K05757]
109920336  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
109922679  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
109911398  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
109910866  arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
109914071  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
109939010  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
109911891  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
109913106  myo6a; myosin VIa [KO:K10358]
109915990  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109925119  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
109934354  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
125485812  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta-like [KO:K00923] [EC:2.7.1.154]
109928242  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
109917633  cytohesin-3-like isoform X1 [KO:K18441]
109912927  cyth3a; cytohesin-3 isoform X1 [KO:K18441]
109917540  ADP-ribosylation factor 6-like [KO:K07941]
109916811  ADP-ribosylation factor 6-like [KO:K07941]
109918061  ADP-ribosylation factor 6 [KO:K07941]
109912903  ADP-ribosylation factor 3-like [KO:K07937]
109926329  ADP-ribosylation factor-like isoform X1 [KO:K07937]
109911994  snx18a; sorting nexin-18a [KO:K17923]
109920759  snx33; sorting nexin-33 [KO:K17923]
125481460  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
109919903  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
109912800  toll-like receptor 2 type-2 [KO:K10159]
109928617  toll-like receptor 2 [KO:K10159]
109924105  toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
109927021  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109935969  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109936672  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109927672  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109917334  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
109931376  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
109918795  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
109927975  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109916828  NF-kappa-B inhibitor alpha-like [KO:K04734]
109913166  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
109918515  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109917055  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
109921558  nucleotide-binding oligomerization domain-containing protein 1-like isoform X1 [KO:K08727]
125487159  nucleotide-binding oligomerization domain-containing protein 1-like isoform X1 [KO:K08727]
109921310  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
109936404  heat shock protein HSP 90-alpha [KO:K04079]
109917879  hsp90b1; endoplasmin [KO:K09487]
109911129  receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
109927741  cse1l; exportin-2 [KO:K18423]
109916516  importin subunit alpha-5 [KO:K23940]
109921677  importin subunit alpha-4-like [KO:K23583]
109912639  kpna4; importin subunit alpha-3 [KO:K23583]
109927071  kpna3; importin subunit alpha-4 [KO:K23583]
109937764  rps3; 40S ribosomal protein S3 [KO:K02985]
109915744  GTPase HRas [KO:K02833]
109911534  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109922810  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
109918415  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109922694  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04432] [EC:2.7.12.2]
109927220  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109932340  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
109914201  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
109911816  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
109927876  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109917844  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109917855  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109925076  protein c-Fos-like [KO:K04379]
109925743  jun; transcription factor AP-1 [KO:K04448]
109910851  tumor necrosis factor-like [KO:K03156]
109910853  tumor necrosis factor-like [KO:K03156]
109916901  lymphotoxin-alpha-like [KO:K03156]
125488288  tumor necrosis factor-like [KO:K03156]
109910852  tumor necrosis factor-like [KO:K03156]
109925335  interleukin-6-like [KO:K05405]
109925317  il6; interleukin-6 [KO:K05405]
125485471  interleukin-6-like [KO:K05405]
109932570  interleukin-8-like [KO:K10030]
109932587  interleukin-8-like [KO:K10030]
109915679  interleukin-8-like [KO:K10030]
109915680  interleukin-8-like [KO:K10030]
109932542  interleukin-8-like [KO:K10030]
109936586  interleukin-8-like [KO:K10030]
125484474  interleukin-8-like [KO:K10030]
125480937  interleukin-8-like [KO:K10030]
125481556  interleukin-8-like [KO:K10030]
109912476  ctnnb1; catenin beta-1 [KO:K02105]
109926936  tcf7l2; transcription factor 7-like 2 isoform X6 [KO:K04491]
109916636  myc proto-oncogene protein-like [KO:K04377]
109923817  mych; myelocytomatosis oncogene homolog [KO:K04377]
109919269  fbxo22; F-box only protein 22 isoform X1 [KO:K10302]
109934365  S-phase kinase-associated protein 1-like isoform X1 [KO:K03094]
109912239  S-phase kinase-associated protein 1 [KO:K03094]
109922055  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109916783  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109936083  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
125481585  inhibitor of apoptosis protein-like [KO:K16060]
109931682  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
109938453  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
109916874  fadd; protein FADD [KO:K02373]
109929740  caspase-8-like [KO:K04398] [EC:3.4.22.61]
109918844  zgc:153993; apoptosis regulator BAX [KO:K02159]
109917897  bcl-2 homologous antagonist/killer-like [KO:K14021]
109911651  bcl-2 homologous antagonist/killer isoform X3 [KO:K14021]
109910711  cytochrome c [KO:K08738]
109932546  cytochrome c, somatic [KO:K08738]
109930204  apoptosis regulator Bcl-2-like isoform X2 [KO:K02161]
109923449  caspase-3-like isoform X1 [KO:K04397] [EC:3.4.22.60]
109929106  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
109910510  rho-related GTP-binding protein RhoB-like isoform X1 [KO:K07856]
109910511  rho-related GTP-binding protein RhoB-like [KO:K07856]
109923304  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
109931632  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109916533  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109915552  mixed lineage kinase domain-like protein isoform X2 [KO:K08849] [EC:2.7.11.1]
109922800  txn2; thioredoxin, mitochondrial [KO:K03671]
109928384  thioredoxin-like [KO:K03671]
109928393  thioredoxin-like isoform X2 [KO:K03671]
109926905  thioredoxin-like [KO:K03671]
109926917  thioredoxin-like [KO:K03671]
109917725  baculoviral IAP repeat-containing protein 1-like isoform X1 [KO:K12807]
109939060  NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805]
109916765  caspase-1-like isoform X3 [KO:K01370] [EC:3.4.22.36]
109919113  uncharacterized protein LOC109919113 [KO:K05482]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
rtp04010  MAPK signaling pathway
rtp04210  Apoptosis
rtp04217  Necroptosis
rtp04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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