KEGG   PATHWAY: stru04020
Entry
stru04020                   Pathway                                
Name
Calcium signaling pathway - Salmo trutta (river trout)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
stru04020  Calcium signaling pathway
stru04020

Other DBs
GO: 0019722
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115161885  sodium/calcium exchanger 3-like [KO:K05849]
115193602  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
115153336  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
115154144  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
115154666  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
115163173  sodium/calcium exchanger 2-like [KO:K05849]
115177735  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
115172984  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
115208491  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
115204264  sodium/calcium exchanger 1-like [KO:K05849]
115206122  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
115180445  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
115192764  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
115168230  plasma membrane calcium-transporting ATPase 3-like isoform X1 [KO:K05850] [EC:7.2.2.10]
115168795  plasma membrane calcium-transporting ATPase 3-like [KO:K05850] [EC:7.2.2.10]
115165896  plasma membrane calcium-transporting ATPase 3-like isoform X1 [KO:K05850] [EC:7.2.2.10]
115149967  atp2b2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
115150301  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
115207212  plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
115208132  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
115197041  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
115199125  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
115154707  muscarinic acetylcholine receptor M1-like [KO:K04129]
115183656  muscarinic acetylcholine receptor M3-like [KO:K04131]
115183995  muscarinic acetylcholine receptor M3-like [KO:K04131]
115193687  muscarinic acetylcholine receptor M3-like [KO:K04131]
115152673  muscarinic acetylcholine receptor M3-like [KO:K04131]
115174380  muscarinic acetylcholine receptor M5-like [KO:K04133]
115162729  muscarinic acetylcholine receptor M5-like [KO:K04133]
115172648  muscarinic acetylcholine receptor M5-like [KO:K04133]
115156779  muscarinic acetylcholine receptor M5-like [KO:K04133]
115159652  adenosine receptor A2b-like [KO:K04266]
115204003  adenosine receptor A2b-like [KO:K04266]
115199962  adenosine receptor A2a-like [KO:K04266]
115155094  adenosine receptor A2b-like [KO:K04267]
115148855  adenosine receptor A2b-like [KO:K04267]
115168228  beta-2 adrenergic receptor-like [KO:K04142]
115153952  beta-2 adrenergic receptor-like [KO:K04142]
115148488  beta-2 adrenergic receptor [KO:K04142]
115205627  beta-2 adrenergic receptor-like [KO:K04142]
115164526  beta-1 adrenergic receptor-like isoform X1 [KO:K04143]
115149164  beta-1 adrenergic receptor-like [KO:K04143]
115200119  beta-1 adrenergic receptor-like isoform X1 [KO:K04143]
115168085  D(1) dopamine receptor-like [KO:K04144]
115187345  D(1) dopamine receptor-like [KO:K04144]
115153971  D(1)-like dopamine receptor [KO:K04144]
115148506  D(1)-like dopamine receptor [KO:K04144]
115206753  D(1) dopamine receptor-like [KO:K04144]
115187371  D(1) dopamine receptor-like [KO:K04144]
115193381  D(1C) dopamine receptor-like [KO:K05840]
115153292  D(1C) dopamine receptor-like [KO:K05840]
115148531  D(5)-like dopamine receptor [KO:K05840]
115149853  D(1B) dopamine receptor-like [KO:K05840]
115200796  D(5)-like dopamine receptor [KO:K05840]
115207109  D(1B) dopamine receptor-like [KO:K05840]
115173856  histamine H2 receptor-like [KO:K04150]
115154619  histamine H2 receptor-like isoform X1 [KO:K04150]
115204888  histamine H2 receptor-like [KO:K04150]
115191617  5-hydroxytryptamine receptor 4-like [KO:K04160]
115174726  5-hydroxytryptamine receptor 4-like [KO:K04160]
115159316  5-hydroxytryptamine receptor 4-like [KO:K04160]
115149262  5-hydroxytryptamine receptor 4-like [KO:K04160]
115205435  5-hydroxytryptamine receptor 4-like isoform X1 [KO:K04160]
115205432  5-hydroxytryptamine receptor 4-like [KO:K04160]
115148330  5-hydroxytryptamine receptor 5A-like [KO:K04161]
115195828  5-hydroxytryptamine receptor 5A-like [KO:K04161]
115168876  5-hydroxytryptamine receptor 6-like [KO:K04162]
115164326  5-hydroxytryptamine receptor 7-like [KO:K04163]
115148465  5-hydroxytryptamine receptor 7-like [KO:K04163]
115148517  5-hydroxytryptamine receptor 7-like [KO:K04163]
115200870  5-hydroxytryptamine receptor 7-like [KO:K04163]
115201155  5-hydroxytryptamine receptor 7-like [KO:K04163]
115200328  5-hydroxytryptamine receptor 7-like [KO:K04163]
115168329  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
115166205  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
115170218  guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
115150015  guanine nucleotide-binding protein G(olf) subunit alpha-like isoform X1 [KO:K04633]
115195582  guanine nucleotide-binding protein G(olf) subunit alpha-like isoform X1 [KO:K04633]
115169640  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115158652  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115157130  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
115173833  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
115175633  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
115191681  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
115175579  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115177411  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115167552  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
115203287  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
115161910  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
115156513  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
115171775  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
115178829  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
115147400  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
115206444  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
115157937  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115181703  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
115169621  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
115171557  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115178387  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
115157154  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115204162  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115193323  cardiac phospholamban-like [KO:K05852]
115174839  cardiac phospholamban-like isoform X1 [KO:K05852]
115204959  sln; sarcolipin [KO:K22642]
115191877  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
115192141  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
115153910  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
115170806  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
115162267  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
115159647  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
115164666  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
115148446  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
115202150  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
115204006  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
115199968  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
115155007  stromal interaction molecule 1-like isoform X1 [KO:K16059]
115163693  stromal interaction molecule 1-like isoform X1 [KO:K16059]
115206568  stromal interaction molecule 1-like isoform X1 [KO:K16059]
115194105  stromal interaction molecule 2-like isoform X1 [KO:K18196]
115187365  stromal interaction molecule 2-like [KO:K18196]
115187366  stromal interaction molecule 2-like [KO:K18196]
115198108  stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
115159415  orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
115164624  calcium release-activated calcium channel protein 1-like [KO:K16056]
115149173  calcium release-activated calcium channel protein 1-like [KO:K16056]
115200015  calcium release-activated calcium channel protein 1-like isoform X1 [KO:K16056]
115154251  orai2; protein orai-2 isoform X1 [KO:K16057]
115148786  protein orai-2-like [KO:K16057]
115168317  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
115166217  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
115208210  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
115168069  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
115166484  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
115167827  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
115150281  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
115208150  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
115191199  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
115170706  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
115196908  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
115164721  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
115159666  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
115203982  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
115199912  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
115192489  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
115169613  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
115158399  probable voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
115157164  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
115163176  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
115201237  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
115186229  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
115170710  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
115147878  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
115205003  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
115191635  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115176061  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
115177205  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115177207  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
115177267  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115172121  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115166808  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115173282  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115202480  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
115197124  CHRNA7-FAM7A fusion protein-like isoform X1 [KO:K04809]
115203520  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
115205210  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
115159511  glutamate receptor ionotropic, NMDA 1-like isoform X1 [KO:K05208]
115167675  glutamate receptor ionotropic, NMDA 1-like isoform X1 [KO:K05208]
115204130  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
115171334  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
115178076  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
115147307  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
115200387  grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
115171425  glutamate receptor ionotropic, NMDA 2C-like isoform X1 [KO:K05211]
115163182  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
115200801  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
115202479  glutamate receptor ionotropic, NMDA 2C-like isoform X1 [KO:K05211]
115176134  uncharacterized protein LOC115176134 [KO:K05212]
115176163  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
115173146  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
115159837  glutamate receptor ionotropic, NMDA 3A-like [KO:K05213]
115149516  glutamate receptor ionotropic, NMDA 3A-like [KO:K05213]
115158947  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
115151654  glutamate receptor ionotropic, NMDA 3A-like [KO:K05214]
115195153  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
115153907  P2X purinoceptor 1-like isoform X1 [KO:K05215]
115148444  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
115164867  P2X purinoceptor 2-like [KO:K05216]
115199611  P2X purinoceptor 2-like [KO:K05216]
115191875  P2X purinoceptor 3-like [KO:K05217]
115171901  P2X purinoceptor 3-like [KO:K05217]
115202032  P2X purinoceptor 3-like [KO:K05217]
115204882  P2X purinoceptor 3-like [KO:K05217]
115159998  P2X purinoceptor 4-like [KO:K05218]
115199959  P2X purinoceptor 4-like [KO:K05218]
115154311  P2X purinoceptor 5-like isoform X1 [KO:K05219]
115148850  P2X purinoceptor 5-like isoform X1 [KO:K05219]
115206315  P2X purinoceptor 5-like isoform X1 [KO:K05219]
115164676  P2X purinoceptor 4-like isoform X1 [KO:K05220]
115199958  P2X purinoceptor 4-like [KO:K05220]
115154755  ryanodine receptor 1-like isoform X1 [KO:K04961]
115204363  ryanodine receptor 1-like [KO:K04961]
115206697  ryanodine receptor 3-like [KO:K04961]
115190095  ryanodine receptor 2-like [KO:K04962]
115190128  ryr2; ryanodine receptor 2 [KO:K04962]
115193688  ryanodine receptor 2-like isoform X1 [KO:K04962]
115162368  ryanodine receptor 3-like [KO:K04963]
115156643  ryanodine receptor 3-like isoform X1 [KO:K04963]
115172651  ryanodine receptor 3-like [KO:K04963]
115174858  titin-like isoform X1 [KO:K23449]
115191726  nucleolar protein dao-5-like [KO:K23449]
115169498  calsequestrin-1-like [KO:K23468]
115157308  calsequestrin-1-like [KO:K23468]
115194556  calsequestrin-1-like isoform X1 [KO:K23468]
115198528  calsequestrin-1-like isoform X1 [KO:K23468]
115155798  calsequestrin-2-like [KO:K23445]
115179176  calsequestrin-2-like [KO:K23445]
115161136  calsequestrin-2-like [KO:K23445]
115196126  calsequestrin-2-like [KO:K23445]
115150347  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
115195553  uncharacterized abhydrolase domain-containing protein DDB_G0269086-like isoform X1 [KO:K00476] [EC:1.14.11.16]
115169866  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
115166066  cysteinyl leukotriene receptor 1-like [KO:K04322]
115150382  cysteinyl leukotriene receptor 2-like [KO:K04322]
115208047  cysteinyl leukotriene receptor 2-like isoform X1 [KO:K04322]
115205800  cysteinyl leukotriene receptor 1-like isoform X1 [KO:K04322]
115154509  cysteinyl leukotriene receptor 2-like [KO:K04323]
115163843  cysteinyl leukotriene receptor 2-like [KO:K04323]
115149049  cysteinyl leukotriene receptor 2-like [KO:K04323]
115152155  muscarinic acetylcholine receptor M2-like [KO:K04130]
115180074  muscarinic acetylcholine receptor M2-like [KO:K04130]
115199012  muscarinic acetylcholine receptor M2-like [KO:K04130]
115159486  alpha-1A adrenergic receptor-like [KO:K04135]
115164571  alpha-1A adrenergic receptor-like [KO:K04135]
115202609  alpha-1A adrenergic receptor-like [KO:K04135]
115200073  alpha-1A adrenergic receptor-like [KO:K04135]
115174707  alpha-1A adrenergic receptor-like [KO:K04136]
115153932  alpha-1A adrenergic receptor-like [KO:K04136]
115148470  alpha-1A adrenergic receptor-like [KO:K04136]
115205430  alpha-1A adrenergic receptor-like [KO:K04136]
115192017  alpha-1D adrenergic receptor-like [KO:K04137]
115202086  alpha-1D adrenergic receptor-like [KO:K04137]
115148957  type-1 angiotensin II receptor-like [KO:K04166]
115195314  type-1 angiotensin II receptor-like [KO:K04166]
115191794  endothelin receptor type B-like [KO:K04197]
115202232  endothelin receptor type B-like [KO:K04197]
115188958  endothelin receptor type B-like [KO:K04198]
115169457  endothelin receptor type B-like [KO:K04198]
115160563  endothelin receptor type B-like [KO:K04198]
115157349  endothelin receptor type B-like [KO:K04198]
115159723  proteinase-activated receptor 1-like [KO:K03914]
115203946  proteinase-activated receptor 1-like isoform X1 [KO:K03914]
115200275  f2r; proteinase-activated receptor 1 [KO:K03914]
115161988  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115174449  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115172241  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115179270  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
115191138  metabotropic glutamate receptor 5-like [KO:K04604]
115202675  metabotropic glutamate receptor 5-like [KO:K04604]
115190089  gastrin-releasing peptide receptor-like [KO:K04169]
115188752  gastrin-releasing peptide receptor-like [KO:K04169]
115160546  gastrin-releasing peptide receptor-like [KO:K04169]
115156322  gastrin-releasing peptide receptor-like [KO:K04169]
115149979  hrh1; histamine H1 receptor [KO:K04149]
115207057  histamine H1 receptor-like [KO:K04149]
115157961  5-hydroxytryptamine receptor 2B-like [KO:K04157]
115154864  5-hydroxytryptamine receptor 2C-like [KO:K04157]
115155687  5-hydroxytryptamine receptor 2A-like [KO:K04157]
115161032  htr2a; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
115151518  5-hydroxytryptamine receptor 2B-like [KO:K04157]
115195000  5-hydroxytryptamine receptor 2C-like [KO:K04157]
115204479  5-hydroxytryptamine receptor 2C-like [KO:K04157]
115198605  5-hydroxytryptamine receptor 2C-like [KO:K04157]
115152811  lutropin-choriogonadotropic hormone receptor-like isoform X1 [KO:K04248]
115200822  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
115201534  lutropin-choriogonadotropic hormone receptor-like isoform X1 [KO:K04248]
115168769  neurotensin receptor type 1-like [KO:K04211]
115166002  ntsr1; neurotensin receptor type 1 [KO:K04211]
115150526  isotocin receptor-like [KO:K04229]
115150337  isotocin receptor-like [KO:K04229]
115207890  isotocin receptor-like [KO:K04229]
115208089  isotocin receptor-like [KO:K04229]
115192682  arg8-vasotocin receptor-like [KO:K04226]
115196981  arg8-vasotocin receptor-like [KO:K04226]
115197924  arg8-vasotocin receptor-like isoform X1 [KO:K04226]
115169506  leukotriene B4 receptor 1-like isoform X1 [KO:K04297]
115157292  leukotriene B4 receptor 1-like [KO:K04297]
115162575  ptafr; platelet-activating factor receptor [KO:K04279]
115172878  platelet-activating factor receptor-like isoform X1 [KO:K04279]
115170704  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
115178314  prostaglandin E2 receptor EP1 subtype-like isoform X1 [KO:K04258]
115147332  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
115201261  prostaglandin E2 receptor EP1 subtype-like isoform X1 [KO:K04258]
115158974  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
115151290  ptgfr; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
115175219  B2 bradykinin receptor-like [KO:K03916]
115162151  B2 bradykinin receptor-like [KO:K03916]
115168405  B2 bradykinin receptor-like [KO:K03916]
115162715  B1 bradykinin receptor-like [KO:K03916]
115172117  B2 bradykinin receptor-like [KO:K03916]
115173054  B2 bradykinin receptor-like isoform X1 [KO:K03916]
115159784  substance-P receptor-like isoform X1 [KO:K04222]
115164278  substance-P receptor-like [KO:K04222]
115203872  substance-P receptor-like [KO:K04222]
115200374  substance-P receptor-like [KO:K04222]
115153464  neuromedin-K receptor-like [KO:K04223]
115201638  neuromedin-K receptor-like [KO:K04223]
115182348  neuromedin-K receptor-like [KO:K04224]
115191930  neuromedin-K receptor-like isoform X1 [KO:K04224]
115192031  neuromedin-K receptor-like [KO:K04224]
115202078  neuromedin-K receptor-like [KO:K04224]
115202120  neuromedin-K receptor-like [KO:K04224]
115157972  thromboxane A2 receptor-like isoform X1 [KO:K04264]
115151537  thromboxane A2 receptor-like isoform X1 [KO:K04264]
115168819  thyrotropin-releasing hormone receptor-like [KO:K04282]
115175980  thyrotropin-releasing hormone receptor-like [KO:K04282]
115176845  thyrotropin-releasing hormone receptor-like [KO:K04282]
115173193  thyrotropin-releasing hormone receptor-like [KO:K04282]
115151909  thyrotropin-releasing hormone receptor-like [KO:K04282]
115196670  thyrotropin-releasing hormone receptor-like [KO:K04282]
115194107  cholecystokinin receptor type A-like [KO:K04194]
115155825  cholecystokinin receptor-like [KO:K04194]
115161186  cholecystokinin receptor-like [KO:K04194]
115179650  cholecystokinin receptor-like [KO:K04194]
115195121  cholecystokinin receptor-like [KO:K04194]
115198109  cholecystokinin receptor type A-like [KO:K04194]
115169470  C-X-C chemokine receptor type 4-like [KO:K04189]
115156111  C-X-C chemokine receptor type 4-like [KO:K04189]
115160672  C-X-C chemokine receptor type 4-like [KO:K04189]
115157336  C-X-C chemokine receptor type 4-like [KO:K04189]
115164831  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
115159209  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
115149346  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
115199825  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
115192595  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
115158280  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
115179716  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
115196175  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
115164830  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
115199826  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
115192594  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
115158284  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04637]
115205115  egf; pro-epidermal growth factor [KO:K04357]
115150355  protransforming growth factor alpha-like [KO:K08774]
115208075  protransforming growth factor alpha-like [KO:K08774]
115171767  platelet-derived growth factor subunit A-like [KO:K04359]
115178656  platelet-derived growth factor subunit A-like [KO:K04359]
115147415  platelet-derived growth factor subunit A-like [KO:K04359]
115207403  platelet-derived growth factor subunit A-like [KO:K04359]
115177744  putative uncharacterized protein DDB_G0291608 isoform X1 [KO:K17386]
115147481  ell-associated factor Eaf-like isoform X1 [KO:K17386]
115170724  platelet-derived growth factor C-like isoform X1 [KO:K05450]
115163701  platelet-derived growth factor D-like isoform X1 [KO:K05450]
115206602  platelet-derived growth factor D-like [KO:K05450]
115205109  platelet-derived growth factor C-like [KO:K05450]
115153981  putative fibroblast growth factor 1 isoform X1 [KO:K18496]
115167514  putative fibroblast growth factor 1 [KO:K18496]
115171295  fibroblast growth factor 2-like [KO:K18497]
115205150  fgf2; fibroblast growth factor 2 [KO:K18497]
115152235  fibroblast growth factor 6-like [KO:K04358]
115152356  fibroblast growth factor 3-like isoform X1 [KO:K04358]
115152357  fibroblast growth factor 4B-like [KO:K04358]
115165107  fibroblast growth factor 5-like [KO:K04358]
115173540  fibroblast growth factor 18-like isoform X1 [KO:K04358]
115180347  fibroblast growth factor 4B-like [KO:K04358]
115191501  fibroblast growth factor 20-like [KO:K04358]
115191682  fibroblast growth factor 20-like [KO:K04358]
115183765  fibroblast growth factor 16-like [KO:K04358]
115192647  fibroblast growth factor 10-like [KO:K04358]
115193861  fibroblast growth factor 8 isoform X1 [KO:K04358]
115153145  fibroblast growth factor 8-like [KO:K04358]
115158229  fibroblast growth factor 10-like [KO:K04358]
115154603  fibroblast growth factor 18-like isoform X1 [KO:K04358]
115165185  fgf17; fibroblast growth factor 17 [KO:K04358]
115171213  fibroblast growth factor 18-like isoform X1 [KO:K04358]
115159321  fibroblast growth factor 10-like [KO:K04358]
115166269  fgf16; fibroblast growth factor 16 [KO:K04358]
115178537  fibroblast growth factor 8b-like [KO:K04358]
115160820  fibroblast growth factor 4A-like isoform X1 [KO:K04358]
115164226  fibroblast growth factor 10-like [KO:K04358]
115166962  fibroblast growth factor 7-like [KO:K04358]
115167494  fibroblast growth factor 4B-like isoform X1 [KO:K04358]
115167495  fibroblast growth factor 3-like [KO:K04358]
115147242  fibroblast growth factor 8b-like [KO:K04358]
115149255  fibroblast growth factor 10-like [KO:K04358]
115202690  fibroblast growth factor 3-like [KO:K04358]
115202691  fibroblast growth factor 4B-like [KO:K04358]
115196688  fibroblast growth factor 3-like [KO:K04358]
115203351  fibroblast growth factor 7-like [KO:K04358]
115197441  fibroblast growth factor 6-like [KO:K04358]
115197602  fibroblast growth factor 4B-like [KO:K04358]
115205143  fibroblast growth factor 18-like isoform X1 [KO:K04358]
115205341  fibroblast growth factor 18-like isoform X1 [KO:K04358]
115198919  fibroblast growth factor 4B-like [KO:K04358]
115199655  fibroblast growth factor 10-like [KO:K04358]
115205539  fibroblast growth factor 20-like [KO:K04358]
115199675  fibroblast growth factor 5-like [KO:K04358]
115199920  fibroblast growth factor 17-like isoform X1 [KO:K04358]
115167493  fibroblast growth factor 19-like [KO:K22603]
115163301  fgf21; fibroblast growth factor 21 [KO:K22429]
115180376  fibroblast growth factor 23-like [KO:K22428]
115197927  fibroblast growth factor 23-like [KO:K22428]
115198918  fibroblast growth factor 23-like [KO:K22428]
115197444  fibroblast growth factor 23-like [KO:K22428]
115152237  fibroblast growth factor 23-like isoform X1 [KO:K22428]
115191647  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
115168826  vascular endothelial growth factor A-like [KO:K05448]
115174690  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
115175507  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
115177426  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
115186266  vascular endothelial growth factor D-like [KO:K05449]
115191832  vascular endothelial growth factor C-like [KO:K05449]
115188765  vascular endothelial growth factor D-like [KO:K05449]
115154890  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
115202198  vascular endothelial growth factor C-like [KO:K05449]
115204521  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
115166403  nerve growth factor-like [KO:K02582]
115151005  nerve growth factor-like [KO:K02582]
115207427  nerve growth factor-like [KO:K02582]
115180143  hepatocyte growth factor-like [KO:K05460]
115152048  hepatocyte growth factor-like [KO:K05460]
115196709  hepatocyte growth factor-like isoform X1 [KO:K05460]
115199105  hepatocyte growth factor-like [KO:K05460]
115150945  hepatocyte growth factor-like protein [KO:K23441]
115207483  hepatocyte growth factor-like protein [KO:K23441]
115165195  glial cell line-derived neurotrophic factor-like isoform X1 [KO:K05452]
115159371  glial cell line-derived neurotrophic factor-like [KO:K05452]
115149212  glial cell line-derived neurotrophic factor-like [KO:K05452]
115169555  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
115157224  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
115150387  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
115195550  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
115162108  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
115167852  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
115165511  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
115150566  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
115207844  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
115155636  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
115179194  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115160978  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115196466  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115192386  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
115158529  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
115174164  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
115154887  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
115205391  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
115159756  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
115164552  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
115203912  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
115200093  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
115194075  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
115162870  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
115161812  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
115183113  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
115154282  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
115148813  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
115172609  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
115195269  uncharacterized protein LOC115195269 [KO:K05096] [EC:2.7.10.1]
115205263  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
115190173  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
115192384  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
115176899  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
115178403  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
115164837  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
115159210  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
115149342  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
115199819  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
115182693  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
115151838  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
115196928  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
115152322  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
115197549  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
115150855  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
115150972  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
115207569  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
115194005  proto-oncogene tyrosine-protein kinase receptor Ret-like isoform X1 [KO:K05126] [EC:2.7.10.1]
115153007  proto-oncogene tyrosine-protein kinase receptor Ret-like isoform X1 [KO:K05126] [EC:2.7.10.1]
115161858  immunoglobulin lambda-1 light chain-like [KO:K10785]
115157572  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
115161823  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
115183969  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
115171063  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
115156159  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
115160654  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
115179479  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
115195303  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
115195986  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like isoform X1 [KO:K05857] [EC:3.1.4.11]
115197449  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
115184997  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174482  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174483  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115162398  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
115172491  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115172765  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115198619  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115199598  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
115168907  plcg1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
115158661  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
115151896  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
115193594  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like isoform X1 [KO:K05860] [EC:3.1.4.11]
115153352  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like [KO:K05860] [EC:3.1.4.11]
115157344  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like isoform X1 [KO:K05860] [EC:3.1.4.11]
115201144  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like isoform X1 [KO:K05860] [EC:3.1.4.11]
115196636  plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
115150503  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115150859  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207563  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207911  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
115152168  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115197365  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115168596  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
115165965  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
115195719  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
115195720  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
115164413  two pore calcium channel protein 1-like isoform X1 [KO:K16896]
115200228  tpcn1; two pore calcium channel protein 1 [KO:K16896]
115167488  two pore calcium channel protein 2-like [KO:K14077]
115202960  two pore calcium channel protein 2-like [KO:K14077]
115170544  mucolipin-1-like [KO:K04992]
115177804  mucolipin-1-like [KO:K04992]
115201301  mucolipin-1-like [KO:K04992]
115208613  mucolipin-1-like isoform X1 [KO:K04992]
115157923  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
115169546  mucolipin-3-like [KO:K04994]
115158699  mucolipin-3-like isoform X1 [KO:K04994]
115189202  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
115176532  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
115171387  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
115178789  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
115201917  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
115208636  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
115155826  calcium uniporter protein, mitochondrial-like [KO:K20858]
115201747  calcium uniporter protein, mitochondrial-like [KO:K20858]
115154021  voltage-dependent anion-selective channel protein 1 [KO:K05862]
115148557  voltage-dependent anion-selective channel protein 1-like isoform X1 [KO:K05862]
115193589  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115153358  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115153538  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115201712  voltage-dependent anion-selective channel protein 2 [KO:K15040]
115159273  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115164352  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115149285  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115192065  slc25a4; ADP/ATP translocase 1 [KO:K05863]
115154811  ADP/ATP translocase 2-like [KO:K05863]
115172575  ADP/ATP translocase 2-like [KO:K05863]
115202056  ADP/ATP translocase 2 [KO:K05863]
115204416  ADP/ATP translocase 2-like [KO:K05863]
115205255  ADP/ATP translocase 2-like [KO:K05863]
115193610  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
115155613  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
115201763  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
115168239  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
115168391  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
115166146  troponin C, slow skeletal and cardiac muscles [KO:K05865]
115168622  troponin C, skeletal muscle-like [KO:K12042]
115168623  troponin C, skeletal muscle-like [KO:K12042]
115165983  troponin C, skeletal muscle [KO:K12042]
115193937  calmodulin [KO:K02183]
115174612  calmodulin [KO:K02183]
115153074  calmodulin [KO:K02183]
115158469  calmodulin [KO:K02183]
115162136  calm1; calmodulin-1 [KO:K02183]
115154660  calmodulin [KO:K02183]
115162984  calmodulin [KO:K02183]
115166807  calmodulin-like protein 4 isoform X1 [KO:K02183]
115172411  calmodulin [KO:K02183]
115150950  calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
115203522  calmodulin-like protein 4 [KO:K02183]
115197130  calmodulin-like protein 4 isoform X1 [KO:K02183]
115204259  calmodulin-A isoform X1 [KO:K02183]
115205945  calmodulin [KO:K02183]
115159526  phosphorylase b kinase gamma catalytic chain, liver/testis isoform-like [KO:K00871] [EC:2.7.11.19]
115163369  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
115206297  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like isoform X1 [KO:K00871] [EC:2.7.11.19]
115188775  phosphorylase b kinase regulatory subunit alpha, liver isoform-like isoform X1 [KO:K07190]
115167420  phosphorylase b kinase regulatory subunit beta-like isoform X1 [KO:K07190]
115194651  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform-like isoform X1 [KO:K07190]
115202915  phosphorylase b kinase regulatory subunit beta-like isoform X1 [KO:K07190]
115161360  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115192295  myosin light chain kinase family member 4-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115168262  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115169625  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115158633  myosin light chain kinase family member 4-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115171123  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115156095  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115160690  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115167428  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115157147  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115202922  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
115198091  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
115167932  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
115180382  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
115150756  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
115150276  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
115150331  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
115207677  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
115208100  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
115208156  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
115198838  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
115194123  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115189418  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115180818  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
115193805  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
115153189  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115154883  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
115159892  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115164110  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
115156739  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115200524  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115201212  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115203793  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115198135  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115204505  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115158046  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
115159212  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
115149339  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
115151258  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
115169125  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115154819  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115159283  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115164273  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115149273  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115194217  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115204432  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115198233  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115205560  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115200380  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115177589  calcineurin subunit B type 1 [KO:K06268]
115156000  calcineurin subunit B type 1-like [KO:K06268]
115201738  calcineurin subunit B type 1-like [KO:K06268]
115208572  calcineurin subunit B type 1 [KO:K06268]
115184956  transcription factor EB-like [KO:K15590]
115188645  transcription factor EB-like isoform X1 [KO:K15590]
115176114  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
115176121  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
115177327  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
115173373  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
115167938  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
115165591  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
115150081  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
115152297  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
115203318  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
115197507  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
115169508  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X1 [KO:K17334]
115157289  nuclear factor of activated T-cells, cytoplasmic 4-like [KO:K17334]
115164132  nitric oxide synthase, brain-like isoform X1 [KO:K13240] [EC:1.14.13.39]
115200502  LOW QUALITY PROTEIN: nitric oxide synthase, brain-like [KO:K13240] [EC:1.14.13.39]
115206488  nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
115153346  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
115170255  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
115155665  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
115161006  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
115150059  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
115207313  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
115175167  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
115172956  protein-tyrosine kinase 2-beta-like isoform X1 [KO:K05871] [EC:2.7.10.2]
115147339  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
115192475  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
115174768  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
115154508  inositol-trisphosphate 3-kinase C-like isoform X1 [KO:K00911] [EC:2.7.1.127]
115162498  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
115162954  inositol-trisphosphate 3-kinase A-like isoform X1 [KO:K00911] [EC:2.7.1.127]
115172790  inositol-trisphosphate 3-kinase A-like isoform X1 [KO:K00911] [EC:2.7.1.127]
115149047  inositol-trisphosphate 3-kinase C-like isoform X1 [KO:K00911] [EC:2.7.1.127]
115205904  inositol-trisphosphate 3-kinase B-like isoform X1 [KO:K00911] [EC:2.7.1.127]
115171658  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115177626  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115208609  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115205322  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
115181935  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
115182231  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
stru04010  MAPK signaling pathway
stru04070  Phosphatidylinositol signaling system
stru04210  Apoptosis
KO pathway
ko04020   
LinkDB

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