KEGG   PATHWAY: tup05205
Entry
tup05205                    Pathway                                
Name
Proteoglycans in cancer - Tupaia chinensis (Chinese tree shrew)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
tup05205  Proteoglycans in cancer
tup05205

Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102479674  CD44; CD44 molecule (Indian blood group) [KO:K06256]
102491807  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102497910  HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
102486767  CTTN; cortactin [KO:K06106]
102487164  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102493080  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102488378  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
102467864  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
102485614  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
102493230  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102500069  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102496534  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102491386  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
106734036  ras-related protein R-Ras2-like [KO:K07830]
102496329  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102468234  MRAS; muscle RAS oncogene homolog [KO:K07831]
102477389  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102497488  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102493239  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102476496  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102483700  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102496453  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102483057  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102479102  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102471568  IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
102488344  CDC42; cell division cycle 42 [KO:K04393]
102494763  ELK1; ELK1, ETS transcription factor [KO:K04375]
102497715  ESR1; estrogen receptor 1 [KO:K08550]
102490651  CCND1; cyclin D1 [KO:K04503]
102479926  ACTB; actin beta [KO:K05692]
102498431  ACTG1; actin gamma 1 [KO:K05692]
102493536  FLNA; filamin A [KO:K04437]
102495430  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102500733  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
102484536  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
102487039  RHOA; ras homolog family member A [KO:K04513]
102481136  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102490242  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102479911  ankyrin-1-like [KO:K10380]
102487222  ANK2; ankyrin 2 [KO:K09255]
102499860  ANK3; ankyrin 3 [KO:K09259]
102497468  GAB1; GRB2 associated binding protein 1 [KO:K09593]
102500530  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102502163  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102483329  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106736453  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102469401  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102484444  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102484500  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102472172  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102492771  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102474297  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102501147  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
102476316  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
102496931  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
102469176  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102477186  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
102473894  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
102500634  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
102475906  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102469549  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
102499439  PLCE1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
102473622  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102482868  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102475587  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102494625  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
102482912  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
102472689  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
102503259  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
102486970  NANOG; Nanog homeobox [KO:K10164]
102503342  DDX5; DEAD-box helicase 5 [KO:K12823] [EC:5.6.2.7]
102499302  DROSHA; drosha ribonuclease III [KO:K03685] [EC:3.1.26.3]
102492738  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
104796035  MIR21; microRNA 21 [KO:K16863]
102500466  TWIST1; twist family bHLH transcription factor 1 [KO:K09069]
102474387  TWIST2; twist family bHLH transcription factor 2 [KO:K09069]
104796030  MIR10B-2; microRNA 10b-2 [KO:K17393]
104797526  MIR10B-1; microRNA 10b-1 [KO:K17393]
102469298  HOXD10; homeobox D10 [KO:K09295]
102474976  DCN; decorin [KO:K04660]
102490248  IGF1; insulin like growth factor 1 [KO:K05459]
102473496  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102485262  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102497633  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102493152  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102475423  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102500353  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102489392  RPS6; ribosomal protein S6 [KO:K02991]
102471395  40S ribosomal protein S6 [KO:K02991]
106735751  uncharacterized LOC106735751 [KO:K02991]
106735195  40S ribosomal protein S6-like [KO:K02991]
102485304  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102486553  CAV1; caveolin 1 [KO:K06278]
102486965  CAV2; caveolin 2 [KO:K12958]
102481829  CAV3; caveolin 3 [KO:K12959]
102493522  CD63; CD63 molecule [KO:K06497]
102490159  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102487119  caspase-3-like [KO:K02187] [EC:3.4.22.56]
102472926  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102488524  TGFB1; transforming growth factor beta 1 [KO:K13375]
102482498  TLR2; toll like receptor 2 [KO:K10159]
102501464  TLR4; toll like receptor 4 [KO:K10160]
102491772  PDCD4; programmed cell death 4 [KO:K16865]
102497973  TNF; tumor necrosis factor [KO:K03156]
102499876  IL12B; interleukin 12B [KO:K05425]
102468023  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102482008  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102501999  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102472740  CTNNB1; catenin beta 1 [KO:K02105]
102486959  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
102476108  TFAP4; transcription factor AP-4 [KO:K09108]
102499303  VEGFA; vascular endothelial growth factor A [KO:K05448]
102489981  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102485847  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102469580  CBL; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
102490502  TIMP3; TIMP metallopeptidase inhibitor 3 [KO:K16866]
102497602  THBS1; thrombospondin 1 [KO:K16857]
102483061  MMP2; matrix metallopeptidase 2 [KO:K01398] [EC:3.4.24.24]
102487885  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
102474556  LUM; lumican [KO:K08122]
102502878  FASLG; Fas ligand [KO:K04389]
102476587  FAS; Fas cell surface death receptor [KO:K04390]
102473924  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102503238  TP53; tumor protein p53 [KO:K04451]
102500482  TGFB2; transforming growth factor beta 2 [KO:K13376]
102499541  SMAD2; SMAD family member 2 [KO:K04500]
102501533  HPSE; heparanase [KO:K07964] [EC:3.2.1.166]
102495912  HPSE2; heparanase 2 (inactive) [KO:K07965] [EC:3.2.1.-]
102496982  SDC1; syndecan 1 [KO:K06257]
102472140  PLAU; plasminogen activator, urokinase [KO:K01348] [EC:3.4.21.73]
102500504  PLAUR; plasminogen activator, urokinase receptor [KO:K03985]
102469999  COL1A1; collagen type I alpha 1 chain [KO:K06236]
102496034  COL1A2; collagen type I alpha 2 chain [KO:K06236]
102476022  ITGA2; integrin subunit alpha 2 [KO:K06481]
102489284  ITGB1; integrin subunit beta 1 [KO:K05719]
102487110  VTN; vitronectin [KO:K06251]
102469850  ITGAV; integrin subunit alpha V [KO:K06487]
102486101  ITGB3; integrin subunit beta 3 [KO:K06493]
102490245  FN1; fibronectin 1 [KO:K05717]
102489381  ITGB5; integrin subunit beta 5 [KO:K06588]
102483689  HGF; hepatocyte growth factor [KO:K05460]
102499190  WNT1; Wnt family member 1 [KO:K03209]
102492163  FZD7; frizzled class receptor 7 [KO:K02432]
102499195  FZD1; frizzled class receptor 1 [KO:K02432]
102479307  FZD2; frizzled class receptor 2 [KO:K02235]
102474963  FZD3; frizzled class receptor 3 [KO:K02329]
102491949  FZD4; frizzled class receptor 4 [KO:K02354]
102475157  FZD5; frizzled class receptor 5 [KO:K02375]
102487480  FZD8; frizzled class receptor 8 [KO:K02375]
102492375  FZD6; frizzled class receptor 6 [KO:K02376]
102479813  FZD10; frizzled class receptor 10 [KO:K02842]
102481011  FZD9; frizzled class receptor 9 [KO:K02842]
102467775  ITGA5; integrin subunit alpha 5 [KO:K06484]
102499120  SDC2; syndecan 2 [KO:K16336]
102490073  EZR; ezrin [KO:K08007]
102473546  RDX; radixin [KO:K05762]
102493334  MSN; moesin [KO:K05763]
102487577  SDC4; syndecan 4 [KO:K16338]
102498637  FGF2; fibroblast growth factor 2 [KO:K18497]
102484087  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102468408  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
102485136  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102498455  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
102494629  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102477222  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102469651  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102483786  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102495954  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102469271  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102497204  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102481869  NUDT16L1; nudix hydrolase 16 like 1 [KO:K16867]
102499461  PXN; paxillin [KO:K05760]
102483369  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102498262  HBEGF; heparin binding EGF like growth factor [KO:K08523]
102489090  GPC1; glypican 1 [KO:K08107]
102481608  IGF2; insulin like growth factor 2 [KO:K13769]
102489947  GPC3; glypican 3 [KO:K08109]
102479831  WNT2B; Wnt family member 2B [KO:K00182]
102483867  WNT2; Wnt family member 2 [KO:K00182]
102501628  WNT3A; Wnt family member 3A [KO:K00312]
102489001  WNT3; Wnt family member 3 [KO:K00312]
102493340  WNT4; Wnt family member 4 [KO:K00408]
102489573  WNT5A; Wnt family member 5A [KO:K00444]
102467720  WNT5B; Wnt family member 5B [KO:K00444]
102483667  WNT6; Wnt family member 6 [KO:K00445]
102484353  WNT7A; Wnt family member 7A [KO:K00572]
102500004  WNT7B; Wnt family member 7B [KO:K00572]
102468229  WNT8B; Wnt family member 8B [KO:K00714]
102490209  WNT8A; Wnt family member 8A [KO:K00714]
102496226  WNT9A; Wnt family member 9A [KO:K01064]
102489417  WNT9B; Wnt family member 9B [KO:K01064]
102481567  WNT10B; Wnt family member 10B [KO:K01357]
102483253  WNT10A; Wnt family member 10A [KO:K01357]
102494826  WNT11; Wnt family member 11 [KO:K01384]
102497530  WNT16; Wnt family member 16 [KO:K01558]
102483981  SHH; sonic hedgehog [KO:K11988]
102481154  IHH; indian hedgehog [KO:K11989]
102471693  PTCH1; patched 1 [KO:K06225]
102498407  SMO; smoothened, frizzled class receptor [KO:K06226]
102493755  HSPG2; heparan sulfate proteoglycan 2 [KO:K06255]
102475532  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102501936  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
102500813  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102491255  cruzipain-like [KO:K01365] [EC:3.4.22.15]
102490430  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102502506  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102478525  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102487603  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102501733  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102495693  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102481241  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102488290  PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
tup04010  MAPK signaling pathway
tup04020  Calcium signaling pathway
tup04066  HIF-1 signaling pathway
tup04150  mTOR signaling pathway
tup04151  PI3K-Akt signaling pathway
tup04210  Apoptosis
tup04310  Wnt signaling pathway
tup04340  Hedgehog signaling pathway
tup04350  TGF-beta signaling pathway
tup04370  VEGF signaling pathway
tup04510  Focal adhesion
tup04520  Adherens junction
tup04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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