KEGG   PATHWAY: tup04151
Entry
tup04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Tupaia chinensis (Chinese tree shrew)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
tup04151  PI3K-Akt signaling pathway
tup04151

Other DBs
GO: 0043491
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102467660  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
102467775  ITGA5; integrin subunit alpha 5 [KO:K06484]
102467951  [KO:K04542]
102467954  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102468023  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102468245  [KO:K09048]
102468317  CCNE1; cyclin E1 [KO:K06626]
102468360  EFNA2; ephrin A2 [KO:K05462]
102468545  NTF4; neurotrophin 4 [KO:K12457]
102468670  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
102469074  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
102469110  OSM; oncostatin M [KO:K05418]
102469167  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102469239  LAMB4; laminin subunit beta 4 [KO:K06245]
102469401  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102469446  ITGB7; integrin subunit beta 7 [KO:K06590]
102469574  [KO:K05414]
102469649  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
102469659  LAMB1; laminin subunit beta 1 [KO:K05636]
102469844  IL4R; interleukin 4 receptor [KO:K05071]
102469850  ITGAV; integrin subunit alpha V [KO:K06487]
102469999  COL1A1; collagen type I alpha 1 chain [KO:K06236]
102470048  FGF3; fibroblast growth factor 3 [KO:K04358]
102470123  LAMC3; laminin subunit gamma 3 [KO:K06247]
102470174  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102470277  RXRA; retinoid X receptor alpha [KO:K08524]
102470303  COL2A1; collagen type II alpha 1 chain [KO:K19719]
102470324  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
102470471  FGF4; fibroblast growth factor 4 [KO:K04358]
102470522  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
102470795  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102470889  FGF19; fibroblast growth factor 19 [KO:K22603]
102470940  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102470973  FGF20; fibroblast growth factor 20 [KO:K04358]
102471059  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
102471230  COL6A2; collagen type VI alpha 2 chain [KO:K06238]
102471395  [KO:K02991]
102471654  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
102471695  ANGPT1; angiopoietin 1 [KO:K05465]
102471806  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
102471895  LAMA5; laminin subunit alpha 5 [KO:K06240]
102471928  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
102471949  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
102472146  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
102472172  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102472273  [KO:K05466]
102472442  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
102472485  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
102472561  MCL1; BCL2 family apoptosis regulator [KO:K02539]
102472577  PSPN; persephin [KO:K25416]
102472653  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
102472932  FGF1; fibroblast growth factor 1 [KO:K18496]
102472952  [KO:K05414]
102473395  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
102473406  ATF2; activating transcription factor 2 [KO:K04450]
102473496  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102473520  COL6A1; collagen type VI alpha 1 chain [KO:K06238]
102473679  [KO:K06856]
102473924  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102474175  FGF21; fibroblast growth factor 21 [KO:K22429]
102474235  CHAD; chondroadherin [KO:K06248]
102474297  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102474421  [KO:K06238]
102474592  BCL2; BCL2, apoptosis regulator [KO:K02161]
102475056  [KO:K05414]
102475159  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102475227  GHR; growth hormone receptor [KO:K05080]
102475289  BDNF; brain derived neurotrophic factor [KO:K04355]
102475423  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102475482  [KO:K05414]
102475541  NRTN; neurturin [KO:K25414]
102475723  EREG; epiregulin [KO:K09784]
102475884  [KO:K05414]
102476004  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
102476020  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
102476022  ITGA2; integrin subunit alpha 2 [KO:K06481]
102476038  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102476072  FGF7; fibroblast growth factor 7 [KO:K04358]
102476130  AREG; amphiregulin [KO:K09782]
102476294  COMP; cartilage oligomeric matrix protein [KO:K04659]
102476496  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102476704  GNG13; G protein subunit gamma 13 [KO:K04547]
102476721  RBL2; RB transcriptional corepressor like 2 [KO:K16332]
102476747  ITGA3; integrin subunit alpha 3 [KO:K06482]
102476758  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102476855  ITGA1; integrin subunit alpha 1 [KO:K06480]
102476928  GNG7; G protein subunit gamma 7 [KO:K04543]
102477222  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102477308  EFNA1; ephrin A1 [KO:K05462]
102477439  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102477477  EPO; erythropoietin [KO:K05437]
102477630  COL6A6; collagen type VI alpha 6 chain [KO:K06238]
102477745  EFNA4; ephrin A4 [KO:K05462]
102477904  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
102477924  FGF17; fibroblast growth factor 17 [KO:K04358]
102478065  COL6A5; collagen type VI alpha 5 chain [KO:K06238]
102478154  ATF4; activating transcription factor 4 [KO:K04374]
102478162  COL9A3; collagen type IX alpha 3 chain [KO:K08131]
102478229  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
102478564  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
102478615  IL2; interleukin 2 [KO:K05429]
102478652  FGF6; fibroblast growth factor 6 [KO:K04358]
102479073  FGF23; fibroblast growth factor 23 [KO:K22428]
102479102  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102479112  EPOR; erythropoietin receptor [KO:K05079]
102479161  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102479628  FOXO3; forkhead box O3 [KO:K09408]
102479902  CCND2; cyclin D2 [KO:K10151]
102479923  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
102480253  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102480300  PGF; placental growth factor [KO:K16859]
102480773  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
102480799  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102480823  [KO:K22603]
102480847  TNN; tenascin N [KO:K06252]
102480854  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
102480902  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102480906  PHLPP1; PH domain and leucine rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
102480923  LAMC2; laminin subunit gamma 2 [KO:K06246]
102481048  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
102481058  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
102481125  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
102481191  INS; insulin [KO:K04526]
102481486  LAMA2; laminin subunit alpha 2 [KO:K05637]
102481608  IGF2; insulin like growth factor 2 [KO:K13769]
102481685  COL9A1; collagen type IX alpha 1 chain [KO:K08131]
102481738  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
102482008  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102482199  ANGPT4; angiopoietin 4 [KO:K05467]
102482352  GNB1; G protein subunit beta 1 [KO:K04536]
102482498  TLR2; toll like receptor 2 [KO:K10159]
102482500  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102482524  THEM4; thioesterase superfamily member 4 [KO:K16339] [EC:3.1.2.2]
102482686  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
102482918  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102482921  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
102482967  ITGA11; integrin subunit alpha 11 [KO:K06587]
102483057  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102483329  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102483369  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102483469  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
102483474  TSC1; tuberous sclerosis 1 [KO:K07206]
102483687  VWF; von Willebrand factor [KO:K03900]
102483689  HGF; hepatocyte growth factor [KO:K05460]
102483700  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102483778  IL4; interleukin 4 [KO:K05430]
102484080  ATF6B; activating transcription factor 6 beta [KO:K09049]
102484087  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102484102  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102484212  GNB2; G protein subunit beta 2 [KO:K04537]
102484276  TSC2; tuberous sclerosis 2 [KO:K07207]
102484355  NTF3; neurotrophin 3 [KO:K04356]
102484403  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102484444  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102484500  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102484646  LAMB2; laminin subunit beta 2 [KO:K06243]
102484826  ITGA8; integrin subunit alpha 8 [KO:K06584]
102485007  PDGFD; platelet derived growth factor D [KO:K05450]
102485065  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
102485200  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
102485262  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102485304  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102485527  THBS4; thrombospondin 4 [KO:K04659]
102485560  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102485830  ITGB6; integrin subunit beta 6 [KO:K06589]
102485847  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102485895  F2R; coagulation factor II thrombin receptor [KO:K03914]
102486007  VEGFD; vascular endothelial growth factor D [KO:K05449]
102486100  COL4A5; collagen type IV alpha 5 chain [KO:K06237]
102486101  ITGB3; integrin subunit beta 3 [KO:K06493]
102486201  ARTN; artemin [KO:K25415]
102486216  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102486224  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102486324  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102486479  PKN2; protein kinase N2 [KO:K23691]
102486626  BCL2L1; BCL2 like 1 [KO:K04570]
102486669  SPP1; secreted phosphoprotein 1 [KO:K06250]
102487006  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
102487110  VTN; vitronectin [KO:K06251]
102487164  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102487275  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
102487364  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102487413  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102487522  PDGFC; platelet derived growth factor C [KO:K05450]
102487526  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
102487568  GNB5; G protein subunit beta 5 [KO:K04539]
102487722  OSMR; oncostatin M receptor [KO:K05057]
102487950  [KO:K04382] [EC:3.1.3.16]
102487954  IL7; interleukin 7 [KO:K05431]
102488180  IBSP; integrin binding sialoprotein [KO:K06253]
102488182  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
102488187  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102488207  ITGB4; integrin subunit beta 4 [KO:K06525]
102488432  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102488546  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102488646  LAMA1; laminin subunit alpha 1 [KO:K05637]
102488678  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
102488757  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
102489000  COL4A6; collagen type IV alpha 6 chain [KO:K06237]
102489064  TCL1A; T-cell leukemia/lymphoma 1A [KO:K10167]
102489114  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102489246  Mucin-1; thrombospondin-3 [KO:K04659]
102489284  ITGB1; integrin subunit beta 1 [KO:K05719]
102489294  FGF9; fibroblast growth factor 9 [KO:K04358]
102489301  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102489381  ITGB5; integrin subunit beta 5 [KO:K06588]
102489392  RPS6; ribosomal protein S6 [KO:K02991]
102489476  TCL1B; T-cell leukemia/lymphoma 1B [KO:K16836]
102489981  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102490087  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
102490159  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102490245  FN1; fibronectin 1 [KO:K05717]
102490248  IGF1; insulin like growth factor 1 [KO:K05459]
102490423  EGF; epidermal growth factor [KO:K04357]
102490451  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102490545  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
102490651  CCND1; cyclin D1 [KO:K04503]
102490693  LAMC1; laminin subunit gamma 1 [KO:K05635]
102490695  GNG2; G protein subunit gamma 2 [KO:K07826]
102490723  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102490934  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102490996  [KO:K05405]
102491119  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102491362  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
102491576  ITGA7; integrin subunit alpha 7 [KO:K06583]
102491581  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102491630  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102491681  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102491753  TNXB; tenascin XB [KO:K06252]
102491914  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
102492088  CCNE2; cyclin E2 [KO:K06626]
102492187  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
102492339  GNG11; G protein subunit gamma 11 [KO:K04546]
102492413  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102492567  ITGA4; integrin subunit alpha 4 [KO:K06483]
102492771  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102492922  [KO:K06585]
102492960  CSF1; colony stimulating factor 1 [KO:K05453]
102492980  FGF5; fibroblast growth factor 5 [KO:K04358]
102492996  IL6R; interleukin 6 receptor [KO:K05055]
102493011  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102493080  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102493152  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102493161  CSF3; colony stimulating factor 3 [KO:K05423]
102493219  [KO:K05438]
102493230  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102493291  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102493338  CDC37; cell division cycle 37 [KO:K09554]
102493625  [KO:K05438]
102493758  GNG4; G protein subunit gamma 4 [KO:K04541]
102493858  IFNB1; interferon beta 1 [KO:K05415]
102493874  GNG8; G protein subunit gamma 8 [KO:K04544]
102493954  ITGA2B; integrin subunit alpha 2b [KO:K06476]
102494016  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
102494068  COL6A3; collagen type VI alpha 3 chain [KO:K06238]
102494131  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
102494278  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
102494441  MYB; MYB proto-oncogene, transcription factor [KO:K09420]
102494532  FGF22; fibroblast growth factor 22 [KO:K04358]
102494629  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102494657  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102494703  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
102494761  VEGFB; vascular endothelial growth factor B [KO:K16858]
102494820  GNG3; G protein subunit gamma 3 [KO:K04540]
102494934  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
102495199  ITGB8; integrin subunit beta 8 [KO:K06591]
102495645  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
102495706  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102495875  TNR; tenascin R [KO:K06252]
102495954  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102495978  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
102495986  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
102496034  COL1A2; collagen type I alpha 2 chain [KO:K06236]
102496046  TNC; tenascin C [KO:K06252]
102496137  IL6; interleukin-6 [KO:K05405]
102496453  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102496463  LAMA3; laminin subunit alpha 3 [KO:K06240]
102496534  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102496545  FGF8; fibroblast growth factor 8 [KO:K04358]
102496619  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
102496620  IRS1; insulin receptor substrate 1 [KO:K16172]
102496805  SGK2; SGK2, serine/threonine kinase 2 [KO:K13303] [EC:2.7.11.1]
102496902  [KO:K06253]
102496950  FGF18; fibroblast growth factor 18 [KO:K04358]
102497228  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102497318  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
102497488  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102497563  [KO:K04360] [EC:2.7.10.1]
102497602  THBS1; thrombospondin 1 [KO:K16857]
102497633  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102497659  COL9A2; collagen type IX alpha 2 chain [KO:K08131]
102497817  TGFA; transforming growth factor alpha [KO:K08774]
102498017  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102498026  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
102498069  BAD; BCL2 associated agonist of cell death [KO:K02158]
102498256  MTCP1; mature T-cell proliferation 1 [KO:K16837]
102498386  [KO:K05414]
102498502  VEGFC; vascular endothelial growth factor C [KO:K05449]
102498614  NGFR; nerve growth factor receptor [KO:K02583]
102498637  FGF2; fibroblast growth factor 2 [KO:K18497]
102498935  [KO:K06856]
102499235  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102499303  VEGFA; vascular endothelial growth factor A [KO:K05448]
102499491  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
102499577  CCND3; cyclin D3 [KO:K10152]
102499643  IL7R; interleukin 7 receptor [KO:K05072]
102499937  ITGA10; integrin subunit alpha 10 [KO:K06586]
102499967  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
102500015  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102500020  ANGPT2; angiopoietin 2 [KO:K05466]
102500031  FGF10; fibroblast growth factor 10 [KO:K04358]
102500041  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102500069  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102500081  ITGA6; integrin subunit alpha 6 [KO:K06485]
102500092  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102500173  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102500251  PRL; prolactin [KO:K05439]
102500353  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102500460  PKN3; protein kinase N3 [KO:K23692]
102500485  BCL2L11; BCL2 like 11 [KO:K16341]
102500530  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102500681  CD19; CD19 molecule [KO:K06465]
102500746  PRLR; prolactin receptor [KO:K05081]
102500824  FGF16; fibroblast growth factor 16 [KO:K04358]
102500888  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102500921  LAMB3; laminin subunit beta 3 [KO:K06244]
102501166  RELN; reelin [KO:K06249] [EC:3.4.21.-]
102501235  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
102501308  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102501383  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
102501429  KITLG; KIT ligand [KO:K05461]
102501464  TLR4; toll like receptor 4 [KO:K10160]
102501535  GNG12; G protein subunit gamma 12 [KO:K04347]
102501945  NGF; nerve growth factor [KO:K02582]
102501999  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102502106  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
102502139  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
102502163  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102502251  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
102502351  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102502422  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102502516  RHEB; Ras homolog enriched in brain [KO:K07208]
102502758  THBS2; thrombospondin 2 [KO:K04659]
102502764  EFNA5; ephrin A5 [KO:K05462]
102502878  FASLG; Fas ligand [KO:K04389]
102503025  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
102503029  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102503225  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
102503238  TP53; tumor protein p53 [KO:K04451]
102503265  GNB3; G protein subunit beta 3 [KO:K07825]
106733346  [KO:K05414]
106733357  [KO:K05405]
106733358  [KO:K05405]
106733485  [KO:K06856]
106733545  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
106733575  [KO:K05405]
106733746  [KO:K05405]
106734037  [KO:K05405]
106734038  [KO:K05405]
106734039  [KO:K05405]
106735195  [KO:K02991]
106735707  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
106735751  [KO:K02991]
106736453  [KO:K00922] [EC:2.7.1.153]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
tup00010  Glycolysis / Gluconeogenesis
tup04010  MAPK signaling pathway
tup04012  ErbB signaling pathway
tup04062  Chemokine signaling pathway
tup04064  NF-kappa B signaling pathway
tup04068  FoxO signaling pathway
tup04110  Cell cycle
tup04115  p53 signaling pathway
tup04150  mTOR signaling pathway
tup04210  Apoptosis
tup04370  VEGF signaling pathway
tup04510  Focal adhesion
tup04620  Toll-like receptor signaling pathway
tup04630  JAK-STAT signaling pathway
tup04662  B cell receptor signaling pathway
tup04910  Insulin signaling pathway
KO pathway
ko04151   

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