KEGG   PATHWAY: vpc04014
Entry
vpc04014                    Pathway                                
Name
Ras signaling pathway - Vicugna pacos (alpaca)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
vpc04014  Ras signaling pathway
vpc04014

Other DBs
GO: 0032318
Organism
Vicugna pacos (alpaca) [GN:vpc]
Gene
102537002  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102525265  TGFA; protransforming growth factor alpha [KO:K08774]
102536166  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102536146  FGF2; fibroblast growth factor 2 [KO:K18497]
102540933  FGF9; fibroblast growth factor 9 [KO:K04358]
102540242  FGF10; fibroblast growth factor 10 [KO:K04358]
102526553  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102532219  FGF20; fibroblast growth factor 20 [KO:K04358]
102526479  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
102529965  FGF8; fibroblast growth factor 8 [KO:K04358]
102544431  FGF6; fibroblast growth factor 6 [KO:K04358]
102537184  FGF18; fibroblast growth factor 18 [KO:K04358]
116285447  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
102526357  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102541492  FGF3; fibroblast growth factor 3 [KO:K04358]
102540992  FGF19; fibroblast growth factor 19 [KO:K22603]
102545650  FGF21; fibroblast growth factor 21 [KO:K22429]
102542330  FGF23; fibroblast growth factor 23 [KO:K22428]
102536531  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
102532564  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
102545739  NTF3; neurotrophin-3 isoform X4 [KO:K04356]
102528888  NTF4; neurotrophin-4 [KO:K12457]
116285510  INS; insulin [KO:K04526]
102527219  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102532626  IGF2; insulin-like growth factor II isoform X4 [KO:K13769]
102532201  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102530206  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102539007  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102541506  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102528464  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102546113  KITLG; kit ligand isoform X1 [KO:K05461]
102537904  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
102536403  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102536226  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102531220  PGF; placenta growth factor isoform X3 [KO:K16859]
102525139  VEGFD; vascular endothelial growth factor D [KO:K05449]
102543259  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102532383  HGF; hepatocyte growth factor [KO:K05460]
102525959  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
102537175  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102533672  ANGPT4; angiopoietin-4 [KO:K05467]
116278622  EFNA2; ephrin-A2 [KO:K05462]
102532195  EFNA5; ephrin-A5 isoform X3 [KO:K05462]
102536251  ephrin-A2 [KO:K05462]
102526222  EFNA3; ephrin-A3 [KO:K05462]
102526483  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102525976  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
102538051  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102531272  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
102535372  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102531487  FGFR3; fibroblast growth factor receptor 3 isoform X6 [KO:K05094] [EC:2.7.10.1]
102531088  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102525766  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102543920  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102536840  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102544508  INSR; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
102535933  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102528303  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102545129  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102545389  CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102528563  KIT; mast/stem cell growth factor receptor Kit isoform X4 [KO:K05091] [EC:2.7.10.1]
102530902  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102530642  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102527355  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102537256  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102538354  MET; hepatocyte growth factor receptor isoform X3 [KO:K05099] [EC:2.7.10.1]
102536292  TEK; angiopoietin-1 receptor isoform X2 [KO:K05121] [EC:2.7.10.1]
102539688  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102532895  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102529162  GAB1; LOW QUALITY PROTEIN: GRB2-associated-binding protein 1 [KO:K09593]
102524978  GAB2; GRB2-associated-binding protein 2 isoform X2 [KO:K08091]
102526482  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102526634  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
102541852  SHC3; SHC-transforming protein 3 [KO:K17448]
102528702  SHC4; SHC-transforming protein 4 [KO:K17449]
102529754  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293] [EC:3.1.3.48]
102539029  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
102541429  SOS2; son of sevenless homolog 2 [KO:K03099]
102543818  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102542680  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102540897  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
102538823  RASGRP1; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1 [KO:K04350]
102542043  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102539130  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102534549  RASGRP4; RAS guanyl-releasing protein 4 isoform X2 [KO:K12363]
116278047  uncharacterized protein LOC116278047 [KO:K10784]
116280840  LOW QUALITY PROTEIN: uncharacterized protein LOC116280840 [KO:K10784]
102535826  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
102535219  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
102527153  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102537006  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
102534586  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
102530911  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
102544072  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
102533271  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
102537024  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
102538024  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
102545167  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
102526370  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116280345  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102536904  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
107033627  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107033717  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102538587  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
102537146  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
107034536  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
102528179  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102534902  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102541827  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
102528807  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102542783  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
102528001  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
102537026  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102531096  CALM2; calmodulin-2 [KO:K02183]
102539425  CALM1; calmodulin-1 [KO:K02183]
102544854  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102532310  calmodulin-like [KO:K02183]
102533842  CALM3; calmodulin-3 [KO:K02183]
102542241  CALML5; calmodulin-like protein 5 [KO:K02183]
102525363  HRAS; GTPase HRas isoform X1 [KO:K02833]
102529990  KRAS; GTPase KRas isoform X2 [KO:K07827]
102534785  NRAS; GTPase NRas [KO:K07828]
102538807  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102526809  RRAS; ras-related protein R-Ras [KO:K07829]
102535239  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102545985  NF1; neurofibromin isoform X1 [KO:K08052]
102534377  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102545882  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
102527450  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
102525518  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
102529007  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X8 [KO:K17631]
102525934  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
102528994  RASAL2; ras GTPase-activating protein nGAP isoform X10 [KO:K17633]
116285069  RASAL3; LOW QUALITY PROTEIN: RAS protein activator like-3 [KO:K17634]
102544169  RASSF1; ras association domain-containing protein 1 [KO:K09850]
102538960  RASSF5; ras association domain-containing protein 5 [KO:K08015]
102534580  STK4; serine/threonine-protein kinase 4 [KO:K04411]
102527012  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
102543993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102541733  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102545613  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102543166  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102537616  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102544290  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
102530768  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102531142  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102540697  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102534196  RHOA; transforming protein RhoA [KO:K04513]
102540289  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102524821  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102543068  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102532395  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102536302  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102536225  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102526860  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102546009  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102542031  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102541871  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102534431  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102528824  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102532161  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102540197  RELA; transcription factor p65 isoform X1 [KO:K04735]
102538813  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
102530957  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
102532078  FOXO4; forkhead box protein O4 [KO:K12358]
102536116  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102544046  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
102540659  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X12 [KO:K25768]
102544922  RALGAPB; ral GTPase-activating protein subunit beta isoform X3 [KO:K25769]
102528835  ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
102536681  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X3 [KO:K17635]
102531108  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
102542835  RALA; ras-related protein Ral-A [KO:K07834]
102532874  RALB; ras-related protein Ral-B [KO:K07835]
102537789  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
102538815  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
102536297  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
102530199  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102529997  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
102528221  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102543430  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102539859  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102538696  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
102530757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102524829  AFDN; afadin [KO:K05702]
102527362  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
102543308  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102530118  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102534668  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102536713  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102528720  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102538870  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
102524678  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102540126  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102525068  PLA2G2E; group IIE secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
102525318  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
102543414  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102543663  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102543910  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102544173  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102541049  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
102539192  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102544166  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102533803  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
102529727  PLA2G4E; LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102535790  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102529998  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
102534320  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102526036  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X9 [KO:K16343] [EC:3.1.1.4]
107035209  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102533469  PLAAT3; phospholipase A and acyltransferase 3 isoform X2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102535434  ETS1; LOW QUALITY PROTEIN: protein C-ets-1 [KO:K02678]
102536589  ETS2; LOW QUALITY PROTEIN: protein C-ets-2 [KO:K21932]
102532849  BRAP; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
102545234  KSR1; LOW QUALITY PROTEIN: kinase suppressor of Ras 1 [KO:K14958]
102542314  KSR2; LOW QUALITY PROTEIN: kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
102529211  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
102544212  RAP1A; ras-related protein Rap-1A [KO:K04353]
102535500  RAP1B; ras-related protein Rap-1b [KO:K07836]
102542888  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
102541926  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102526158  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102542323  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102535601  RIN1; LOW QUALITY PROTEIN: ras and Rab interactor 1 [KO:K17638]
102528583  ABL1; tyrosine-protein kinase ABL1 isoform X2 [KO:K06619] [EC:2.7.10.2]
102531019  ABL2; tyrosine-protein kinase ABL2 isoform X2 [KO:K08887] [EC:2.7.10.2]
102538668  RAB5A; ras-related protein Rab-5A [KO:K07887]
102528941  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
102543269  RAB5C; ras-related protein Rab-5C [KO:K07889]
102542106  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
vpc04010  MAPK signaling pathway
vpc04015  Rap1 signaling pathway
vpc04020  Calcium signaling pathway
vpc04144  Endocytosis
vpc04151  PI3K-Akt signaling pathway
vpc04660  T cell receptor signaling pathway
vpc04720  Long-term potentiation
vpc04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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