KEGG   PATHWAY: pcw05161
Entry
pcw05161                    Pathway                                
Name
Hepatitis B - Phascolarctos cinereus (koala)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcw05161  Hepatitis B
pcw05161

Disease
H00412  Hepatitis B
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110192034  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
110192620  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110193352  KRAS; GTPase KRas isoform X1 [KO:K07827]
110193756  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
110193880  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110193934  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
110194271  TP53; cellular tumor antigen p53 [KO:K04451]
110194623  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:3.6.4.13]
110194791  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
110195227  CCNA1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
110195387  DDB1; DNA damage-binding protein 1 [KO:K10610]
110195467  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110195563  RELA; transcription factor p65 isoform X1 [KO:K04735]
110195790  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110196285  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
110196387  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110196425  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
110197002  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
110197028  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
110197140  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
110197147  FADD; FAS-associated death domain protein [KO:K02373]
110197193  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
110197337  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
110197380  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
110197417  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110197489  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
110197863  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110198138  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
110198372  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
110198412  [KO:K11224]
110198414  [KO:K11223]
110198824  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
110198951  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
110199045  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
110199211  [KO:K05415]
110199212  [KO:K05415]
110199213  [KO:K05415]
110199216  [KO:K05415]
110199218  [KO:K05415]
110199230  [KO:K05414]
110199240  [KO:K05414]
110199247  [KO:K05414]
110199249  [KO:K05414]
110199250  [KO:K05414]
110199251  [KO:K05414]
110199253  [KO:K05414]
110199254  [KO:K05414]
110199255  [KO:K05414]
110199397  TNF; tumor necrosis factor [KO:K03156]
110199423  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
110199476  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
110200334  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110200350  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
110200427  EGR3; LOW QUALITY PROTEIN: early growth response protein 3 [KO:K12497]
110200846  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:3.6.4.13]
110201017  ARAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
110201031  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
110201183  [KO:K05414]
110201199  [KO:K05414]
110201202  [KO:K05414]
110201203  [KO:K05414]
110201388  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
110201451  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
110201533  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110202112  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110202309  [KO:K07828]
110202366  TGFB1; transforming growth factor beta-1 [KO:K13375]
110202713  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110202954  HRAS; GTPase HRas isoform X1 [KO:K02833]
110202995  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
110203042  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110203137  [KO:K08738]
110203410  [KO:K07828]
110203411  [KO:K07828]
110204454  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110204892  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110205475  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110205565  TGFB2; LOW QUALITY PROTEIN: transforming growth factor beta-2 [KO:K13376]
110205796  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
110205802  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110205826  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110205871  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
110205920  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
110205921  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110205943  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110206031  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
110206051  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
110206529  PTK2B; LOW QUALITY PROTEIN: protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
110206594  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
110206666  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110207433  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
110207637  PCNA; proliferating cell nuclear antigen [KO:K04802]
110208219  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110208305  TGFB3; transforming growth factor beta-3 [KO:K13377]
110208312  FOS; proto-oncogene c-Fos [KO:K04379]
110208533  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
110208713  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
110208752  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110209293  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110209686  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
110209710  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110209794  [KO:K10030]
110210380  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110210908  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110210934  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110210962  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
110211020  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110211357  TLR4; toll-like receptor 4 [KO:K10160]
110211455  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110211588  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
110211774  SOS2; son of sevenless homolog 2 [KO:K03099]
110211795  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
110211994  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110212616  YWHAQ; 14-3-3 protein theta [KO:K16197]
110212891  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110212948  JUN; transcription factor AP-1 [KO:K04448]
110212998  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
110213063  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110213115  IL6; interleukin-6 [KO:K05405]
110213139  [KO:K08738]
110213248  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
110213328  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
110213446  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
110213633  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
110213919  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110214168  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
110214481  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
110214564  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
110214622  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110214751  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
110214849  [KO:K05130]
110214950  [KO:K04741] [EC:3.4.22.-]
110215167  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110215514  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110215703  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
110216083  MYC; myc proto-oncogene protein [KO:K04377]
110216252  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110216339  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110216430  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
110216530  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110216709  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110216806  E2F1; transcription factor E2F1 [KO:K17454]
110217257  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
110217326  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110217327  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110218003  [KO:K08738]
110218147  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
110218307  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110218357  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
110218411  [KO:K08738]
110218747  BID; BH3-interacting domain death agonist [KO:K04726]
110219182  NRAS; GTPase NRas [KO:K07828]
110219266  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110219359  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110219596  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
110219776  BAX; apoptosis regulator BAX [KO:K02159]
110219913  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
110220000  [KO:K06627]
110220182  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110220699  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
110220730  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:3.6.4.13]
110221618  JAK2; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110221734  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
110221918  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110222594  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110222610  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
110222963  CCNA2; cyclin-A2 [KO:K06627]
110223168  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
110223284  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110223345  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110223395  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110223919  DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
110224036  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
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J Biol Chem 272:16482-9 (1997)
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Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
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Reference
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Related
pathway
pcw04010  MAPK signaling pathway
pcw04064  NF-kappa B signaling pathway
pcw04110  Cell cycle
pcw04115  p53 signaling pathway
pcw04151  PI3K-Akt signaling pathway
pcw04210  Apoptosis
pcw04620  Toll-like receptor signaling pathway
pcw04622  RIG-I-like receptor signaling pathway
pcw04630  JAK-STAT signaling pathway
KO pathway
ko05161   

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