KEGG   PATHWAY: pon05166
Entry
pon05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Pongo abelii (Sumatran orangutan)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
pon05166  Human T-cell leukemia virus 1 infection
pon05166

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100173447  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100171901  NRP1; neuropilin-1 precursor [KO:K06724]
100456735  MYC; myc proto-oncogene protein [KO:K04377]
100455280  TRRAP; transformation/transcription domain-associated protein isoform X4 [KO:K08874]
100174410  KAT5; histone acetyltransferase KAT5 [KO:K11304] [EC:2.3.1.48]
100457978  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100451665  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100451938  ITGB2; integrin beta-2 [KO:K06464]
100437727  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100459427  HRAS; GTPase HRas [KO:K02833]
100462513  KRAS; GTPase KRas isoform X1 [KO:K07827]
100174317  NRAS; GTPase NRas precursor [KO:K07828]
100446021  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100450988  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100169740  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100431824  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100452381  CD4; T-cell surface glycoprotein CD4 isoform X3 [KO:K06454]
100451531  TLN2; talin-2 isoform X1 [KO:K06271]
100441699  TLN1; talin-1 [KO:K06271]
100173886  RANBP3; ran-binding protein 3 [KO:K15304]
100173539  RAN; GTP-binding nuclear protein Ran isoform 1 [KO:K07936]
100937596  GTP-binding nuclear protein Ran-like [KO:K07936]
100433969  XPO1; exportin-1 [KO:K14290]
100451803  CALR; calreticulin [KO:K08057]
100174065  CANX; calnexin precursor [KO:K08054]
100174530  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100455542  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100436675  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X9 [KO:K04348] [EC:3.1.3.16]
100461146  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103889825  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100436209  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100450332  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100458008  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
100461543  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100460977  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
100454903  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
100433477  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100433988  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100461695  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
100462537  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
100455248  IL2; interleukin-2 [KO:K05429]
100173719  DKFZP469M1914; major histocompatibility complex, class I, C precursor [KO:K06751]
100189734  DKFZP469I0912 protein isoform X1 [KO:K06751]
100432875  HLA class I histocompatibility antigen, alpha chain F isoform X1 [KO:K06751]
100456603  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100440558  popy class I histocompatibility antigen, alpha chain E isoform X3 [KO:K06751]
100438533  patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
100435866  popy Class I histocompatibility antigen, A-1 alpha chain [KO:K06751]
100450716  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100452132  class I histocompatibility antigen, Gogo-B*0102 alpha chain isoform X1 [KO:K06751]
100435133  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100449631  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
100174579  B2M; beta-2-microglobulin isoform X1 [KO:K08055]
100172538  FDPS; farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
100460133  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100437258  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100432368  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100173820  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100445977  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100445983  ADP/ATP translocase 3-like [KO:K05863]
100456290  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100174591  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100435253  TSPO; translocator protein [KO:K05770]
100445077  TSPO2; translocator protein 2 [KO:K05770]
100453757  VAC14; protein VAC14 homolog [KO:K15305]
100458525  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
100454918  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
100447417  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100455824  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
100172494  BUB3; mitotic checkpoint protein BUB3 [KO:K02180]
100446905  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
100433310  ANAPC2; anaphase-promoting complex subunit 2 isoform X2 [KO:K03349]
100444022  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
100172595  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
100171787  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
100434328  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
100460069  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
100449732  CDC23; cell division cycle protein 23 homolog [KO:K03355]
100434748  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
100450168  anaphase-promoting complex subunit 10 [KO:K03357]
100173127  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
100174448  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
100174391  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100440736  ANAPC15; anaphase-promoting complex subunit 15 isoform X3 [KO:K25228]
100171709  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
100443203  CDC20; cell division cycle protein 20 homolog [KO:K03363]
100448211  LOW QUALITY PROTEIN: cell division cycle protein 20 homolog [KO:K03363]
100443374  PTTG1; securin [KO:K06635]
100453913  PTTG2; securin-2 [KO:K06635]
100446105  LOW QUALITY PROTEIN: putative pituitary tumor-transforming gene 3 protein [KO:K06635]
100444516  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
100438917  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100459175  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100461015  cyclin-dependent kinase inhibitor 2A [KO:K06621]
100443314  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100171625  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100452570  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100453682  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100449200  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100453784  CCNA2; cyclin-A2 [KO:K06627]
100438282  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100461587  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
100446748  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100462155  RB1; retinoblastoma-associated protein [KO:K06618]
100435851  E2F1; transcription factor E2F1 [KO:K17454]
100458002  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100448297  E2F3; transcription factor E2F3 isoform X3 [KO:K06620]
100451505  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100454403  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100436550  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
100461345  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
100435218  TP53; cellular tumor antigen p53 [KO:K04451]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100444925  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
100171828  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100447558  TNF; tumor necrosis factor [KO:K03156]
100438667  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100453309  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100439299  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100174482  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100459133  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100437424  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100450292  JUN; transcription factor AP-1 [KO:K04448]
100458458  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
100172810  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
100440034  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
112128523  uncharacterized protein LOC112128523 [KO:K10785]
100440740  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
100440004  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
100440370  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X2 [KO:K06452]
100444678  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X3 [KO:K04421] [EC:2.7.11.25]
100174735  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100440586  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100449496  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
100459445  NF-kappa-B inhibitor alpha [KO:K04734]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100456049  RELA; transcription factor p65 [KO:K04735]
100457891  GPS2; G protein pathway suppressor 2 [KO:K15307]
100171849  LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
100460237  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
100456696  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
100436201  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100451053  RELB; transcription factor RelB isoform X2 [KO:K09253]
100462387  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100444984  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
100440118  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
100456813  IL15; interleukin-15 [KO:K05433]
100439247  IL15RA; interleukin-15 receptor subunit alpha isoform X6 [KO:K05074]
100453941  IL6; interleukin-6 isoform X2 [KO:K05405]
100447424  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100446211  LTA; lymphotoxin-alpha [KO:K05468]
100453051  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100449741  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
100937717  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100459982  TGFB1; transforming growth factor beta-1 [KO:K13375]
100461291  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
100433208  TGFB3; transforming growth factor beta-3 [KO:K13377]
100450864  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100459236  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100173357  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
100448249  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100439171  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100449504  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
100445431  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100431221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100460806  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100454138  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100438178  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100436577  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100461383  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
103889530  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100174748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
100431906  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
100437102  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100453860  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
100458290  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100453254  HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1 [KO:K06752]
100443317  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100442956  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100442586  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
100443682  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100448477  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
100448112  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100460187  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100438181  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
100444477  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
100456477  HLA class II histocompatibility antigen, DR beta 5 chain isoform X1 [KO:K06752]
100457574  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3 [KO:K06752]
100456830  HLA class II histocompatibility antigen, DR beta 4 chain-like [KO:K06752]
100443747  HLA class II histocompatibility antigen, DRB1-9 beta chain isoform X1 [KO:K06752]
100442225  HLA class II histocompatibility antigen, DRB1-4 beta chain isoform X1 [KO:K06752]
100449199  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
100436127  SRF; serum response factor isoform X1 [KO:K04378]
100457748  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100432611  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100449540  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
100444400  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
100173608  ETS2; protein C-ets-2 [KO:K21932]
100173239  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
100437756  TBP; TATA-box-binding protein [KO:K03120]
100454972  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
100462290  FOS; proto-oncogene c-Fos [KO:K04379]
100453426  EGR1; early growth response protein 1 [KO:K09203]
100454350  FOSL1; fos-related antigen 1 [KO:K04502]
100450873  EGR2; E3 SUMO-protein ligase EGR2 [KO:K12496]
100294619  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100432292  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100436186  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100438869  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100127093  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100441756  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100450554  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100462459  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100431578  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
100439720  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100172895  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
100446802  CRTC1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
100438416  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100450653  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
100455260  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100445634  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
100434727  KAT2A; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
100461857  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
100439917  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
100441812  POLB; DNA polymerase beta isoform X2 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
100436326  LCK; LOW QUALITY PROTEIN: tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
100450682  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100459088  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100936787  LOW QUALITY PROTEIN: telomerase reverse transcriptase-like [KO:K11126] [EC:2.7.7.49]
100936620  TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
100440299  MSX1; homeobox protein MSX-1 [KO:K09341]
100445307  MSX2; homeobox protein MSX-2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
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Related
pathway
pon03013  Nucleocytoplasmic transport
pon04010  MAPK signaling pathway
pon04064  NF-kappa B signaling pathway
pon04110  Cell cycle
pon04115  p53 signaling pathway
pon04151  PI3K-Akt signaling pathway
pon04210  Apoptosis
pon04350  TGF-beta signaling pathway
pon04612  Antigen processing and presentation
pon04660  T cell receptor signaling pathway
pon04668  TNF signaling pathway
KO pathway
ko05166   
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