KEGG   PATHWAY: rno05203
Entry
rno05203                    Pathway                                
Name
Viral carcinogenesis - Rattus norvegicus (rat)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
rno05203  Viral carcinogenesis
rno05203

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100359692  H2bc9; histone H2B [KO:K11252]
100359916  [KO:K12886]
100362738  Pkml1; pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
100364835  H2bc6; H2B clustered histone 6 [KO:K11252]
100365043  H2bc12l1; histone cluster 1, H2bd-like [KO:K11252]
100910200  H2bcl1; histone H2B type 1-C/E/G-like [KO:K11252]
100912338  H2bc18; H2B clustered histone 18 [KO:K11252]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
102549061  [KO:K11252]
103690887  H2bw2l; histone H2B-like [KO:K11252]
108348065  Hdac6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
114090  Egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
114483  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114494  Ccna2; cyclin-A2 [KO:K06627]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117027  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
117029  Ccr5; C-C chemokine receptor type 5 [KO:K04180]
117263  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
117273  Rhoa; transforming protein RhoA [KO:K04513]
117282  Hnrnpk; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
117526  Tbp; TATA-box-binding protein [KO:K03120]
117535  Chd4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
120093125  RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
134484121  [KO:K00922] [EC:2.7.1.153]
140583  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
170915  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
171054  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
24232  C3; complement C3 precursor [KO:K03990]
24516  Jun; transcription factor Jun [KO:K04448]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
24708  Rb1; retinoblastoma-associated protein [KO:K06618]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
24829  H2bc1; histone H2B type 1-A [KO:K11252]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24887  Bax; apoptosis regulator BAX [KO:K02159]
24918  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
25125  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
25126  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
25148  Egr3; early growth response protein 3 [KO:K12497]
25155  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
25163  Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
25164  Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
25193  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
25205  Il6st; interleukin-6 receptor subunit beta precursor [KO:K05060]
25252  Dlg1; disks large homolog 1 isoform 1 [KO:K12076]
25326  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25576  Ywhah; 14-3-3 protein eta [KO:K16198]
25577  Ywhaq; 14-3-3 protein theta [KO:K16197]
25578  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
25597  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
25630  Pkm; pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
25729  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
288651  Gtf2h3; general transcription factor IIH subunit 3 [KO:K03143]
289014  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
291152  Hist1h4m; histone H4 [KO:K11254]
291157  Hist1h2bo; histone cluster 1 H2B family member O [KO:K11252]
29135  Hpn; serine protease hepsin precursor [KO:K08665] [EC:3.4.21.106]
291969  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
29240  Polb; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
293621  Hras; GTPase HRas [KO:K02833]
293624  Irf7; interferon regulatory factor 7 [KO:K09447]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
294230  Mrps18b; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
294236  Gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]
294693  Gtf2h2; general transcription factor IIH subunit 2 [KO:K03142]
294790  Skp2; S-phase kinase-associated protein 2 [KO:K03875]
295052  Ccna1; cyclin-A1 [KO:K06627]
295274  Hist2h2be; histone cluster 2 H2B family member E [KO:K11252]
295277  H4c14; histone H4 [KO:K11254]
296654  Gsn; gelsolin precursor [KO:K05768]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
297453  Hdac11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
29753  Ywhae; 14-3-3 protein epsilon [KO:K06630]
297604  Ltbr; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
297893  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
297932  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
298400  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
298975  Scin; scinderin [KO:K05768]
301066  Ccr8; C-C chemokine receptor type 8 [KO:K04183]
301164  Kat2b; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
303175  Hist3h2ba; histone cluster 3, H2ba [KO:K11252]
303539  Kat2a; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
303918  Gtf2e1; general transcription factor IIE subunit 1 [KO:K03136]
305584  Rel; proto-oncogene c-Rel [KO:K09254]
305896  Irf9; interferon regulatory factor 9 [KO:K04693]
306516  Gtf2e2; transcription initiation factor IIE subunit beta [KO:K03137]
306945  Hist1h2bq; histone cluster 1 H2B family member Q [KO:K11252]
306969  H2bc8; histone cluster 1 H2B family member l [KO:K11252]
307842  Vac14; protein VAC14 homolog [KO:K15305]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309452  Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
313658  Ubr4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
316711  Gtf2a1l; TFIIA-alpha and beta-like factor [KO:K03122]
317335  Ddx3x; ATP-dependent RNA helicase DDX3X isoform 1 [KO:K11594] [EC:5.6.2.7]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
360471  Usp7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
360481  Dnaja3; dnaJ homolog subfamily A member 3, mitochondrial isoform 1 [KO:K09504]
360739  Ranbp1; ran-specific GTPase-activating protein [KO:K15306]
360820  Pxn; paxillin isoform 1 [KO:K05760]
361247  Hist1h2bd; histone cluster 1 H2B family member D [KO:K11252]
361580  Gtf2h1; general transcription factor IIH subunit 1 [KO:K03141]
361585  Ube3a; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362268  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
362485  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
362817  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
362938  Scrib; protein scribble homolog [KO:K16175]
362981  Hdac10; polyamine deacetylase HDAC10 isoform 2 [KO:K18671] [EC:3.5.1.98]
363287  Hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
363481  Hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
364073  Ddx3; DEAD-box helicase 3 [KO:K11594] [EC:5.6.2.7]
364723  Hist1h2ao; histone H2A type 1-E [KO:K11254]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
406169  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
492821  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
498088  Ranbp1l1; ran-specific GTPase-activating protein-like [KO:K15306]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
499402  H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
500695  Snw1; SNW domain-containing protein 1 [KO:K06063]
501099  Srf; serum response factor [KO:K04378]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54237  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
54244  Crebbp; histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
54287  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
56010  Ywhag; 14-3-3 protein gamma [KO:K16198]
56011  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
63836  Actn4; alpha-actinin-4 [KO:K05699]
64033  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
64470  Ddb1; DNA damage-binding protein 1 [KO:K10610]
64515  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
64627  Hist1h4b; histone H4 [KO:K11254]
64635  Snd1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
64647  Hist1h2bg; histone H2B type 1 [KO:K11252]
679028  Rbpj; recombining binding protein suppressor of hairless isoform 1 [KO:K06053]
680006  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
680050  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
680111  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
680312  H2bc12; histone H2B [KO:K11252]
680403  Hist1h2bc; histone cluster 1, H2bc [KO:K11252]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
681314  [KO:K02159]
684173  Traf5; TNF receptor-associated factor 5 [KO:K09849]
684444  H2bl1; uncharacterized protein LOC684444 [KO:K11252]
684797  H2bcl2; H2B clustered histone like 2 [KO:K11252]
687001  Hdac9; histone deacetylase 9 [KO:K11409] [EC:3.5.1.98]
687813  Traf1; TNF receptor-associated factor 1 [KO:K03172]
689030  Tbpl1; TATA box-binding protein-like 1 [KO:K03120]
691488  H2bu1; H2B.U histone 1 [KO:K11252]
79255  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
81515  Lyn; tyrosine-protein kinase Lyn isoform A [KO:K05854] [EC:2.7.10.2]
81634  Actn1; alpha-actinin-1 [KO:K05699]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
81647  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
81673  Gtf2b; transcription initiation factor IIB [KO:K03124]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81758  Rbl2; retinoblastoma-like protein 2 [KO:K16332]
83532  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
83571  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
83828  Gtf2a2; transcription initiation factor IIA subunit 2 [KO:K03123]
83830  Gtf2a1; transcription initiation factor IIA subunit 1 [KO:K03122]
84576  Hdac1l; histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
84577  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
84578  Hdac3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
84580  Hdac5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
84582  Hdac7; histone deacetylase 7 [KO:K11408] [EC:3.5.1.98]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
94201  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
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Virus Res 92:131-40 (2003)
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  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
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Adv Cancer Res 103:75-109 (2009)
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Viral hepatocarcinogenesis: from infection to cancer.
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Liver Int 28:175-88 (2008)
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Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Mol Cell 19:159-70 (2005)
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  Title
Liver cell transformation in chronic HBV infection.
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Viruses 1:630-46 (2009)
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  Journal
Cancer Lett 289:140-50 (2010)
DOI:10.1016/j.canlet.2009.07.004
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:10855768
  Authors
Schulz TF
  Title
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.
  Journal
J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
rno03022  Basal transcription factors
rno03320  PPAR signaling pathway
rno04010  MAPK signaling pathway
rno04062  Chemokine signaling pathway
rno04064  NF-kappa B signaling pathway
rno04110  Cell cycle
rno04115  p53 signaling pathway
rno04142  Lysosome
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04630  JAK-STAT signaling pathway
rno04662  B cell receptor signaling pathway
rno04810  Regulation of actin cytoskeleton
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05169  Epstein-Barr virus infection
KO pathway
ko05203   

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