KEGG   PATHWAY: rno05166
Entry
rno05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Rattus norvegicus (rat)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
rno05166  Human T-cell leukemia virus 1 infection
rno05166

Disease
H00009  Adult T-cell leukemia
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100360936  Anapc16; anaphase-promoting complex subunit 16 isoform 1 [KO:K25229]
100360982  Relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
102552980  Fdps-ps3; farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
114090  Egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
114212  Chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
114494  Ccna2; cyclin-A2 [KO:K06627]
114504  Msx3; homeo box, msh-like 3 [KO:K09341]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116562  Il2; interleukin-2 precursor [KO:K05429]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116630  Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
116667  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
117022  Il1r2; interleukin-1 receptor type 2 precursor [KO:K04387]
117526  Tbp; TATA-box-binding protein [KO:K03120]
120093125  RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
134484121  [KO:K00922] [EC:2.7.1.153]
140583  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
140924  Il2rg; cytokine receptor common subunit gamma precursor [KO:K05070]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
170915  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
171046  Tcf3; transcription factor E2-alpha isoform a [KO:K09063]
171369  Cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
171576  Bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
192218  Kat5; histone acetyltransferase KAT5 [KO:K11304] [EC:2.3.1.48]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24223  B2m; beta-2-microglobulin precursor [KO:K08055]
24230  Tspo; translocator protein [KO:K05770]
24330  Egr1; early growth response protein 1 [KO:K09203]
24356  Ets1; protein C-ets-1 [KO:K02678]
24498  Il6; interleukin-6 precursor [KO:K05405]
24516  Jun; transcription factor Jun [KO:K04448]
24525  Kras; GTPase KRas [KO:K07827]
24577  Myc; myc proto-oncogene protein [KO:K04377]
24605  Nras; GTPase NRas [KO:K07828]
246331  Nrp1; neuropilin-1 precursor [KO:K06724]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
24708  Rb1; retinoblastoma-associated protein [KO:K06618]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
24778  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
24835  Tnf; tumor necrosis factor [KO:K03156]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24887  Bax; apoptosis regulator BAX [KO:K02159]
24888  Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570]
24918  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
24932  Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24981  RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
25008  Lta; lymphotoxin-alpha precursor [KO:K05468]
25126  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
25163  Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
25164  Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
25176  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
25193  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25252  Dlg1; disks large homolog 1 isoform 1 [KO:K12076]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
25326  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
25335  Mmp7; matrilysin precursor [KO:K01397] [EC:3.4.24.23]
25336  Nfyb; nuclear transcription factor Y subunit beta [KO:K08065]
25445  Fosl1; fos-related antigen 1 [KO:K04502]
25464  Icam1; intercellular adhesion molecule 1 precursor [KO:K06490]
25483  Msx2; homeobox protein MSX-2 [KO:K09341]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
25631  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
25663  Il1r1; interleukin-1 receptor type 1 precursor [KO:K04386]
25670  Il15; interleukin-15 preproprotein [KO:K05433]
25704  Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068]
25710  Cd3d; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
25717  Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377]
25729  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
25746  Il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069]
287398  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
288471  Trrap; transformation/transcription domain-associated protein [KO:K08874]
288671  Anapc5; anaphase-promoting complex subunit 5 isoform 1 [KO:K03352]
290875  Cdc16; cell division cycle protein 16 homolog [KO:K03353]
291105  E2f3; transcription factor E2F3 [KO:K06620]
29144  Canx; calnexin precursor [KO:K08054]
291689  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
29240  Polb; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
293155  Anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
29357  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
293621  Hras; GTPase HRas [KO:K02833]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
294269  RT1-Da; RT1 class II, locus Da precursor [KO:K06752]
294270  RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752]
294273  RT1-DMb; RT1 class II, DM beta precursor [KO:K06752]
294274  RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752]
295052  Ccna1; cyclin-A1 [KO:K06627]
29591  Tgfbr1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
296558  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
297176  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
297604  Ltbr; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
298400  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
300678  Cd3g; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
300711  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
301164  Kat2b; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
301965  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
303539  Kat2a; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
303604  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
304063  Ets2; protein C-ets-2 [KO:K21932]
304490  Anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
304786  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
305420  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
305897  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
307842  Vac14; protein VAC14 homolog [KO:K15305]
308995  Itgal; integrin alpha-L precursor [KO:K05718]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
309452  Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309621  RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752]
309622  RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
309684  Itgb2; integrin beta-2 precursor [KO:K06464]
310615  Crtc2; CREB-regulated transcription coactivator 2 [KO:K16333]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
311412  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
311658  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
313050  Lck; proto-oncogene tyrosine-protein kinase LCK [KO:K05856] [EC:2.7.10.2]
313163  1700009N14Rikl; uncharacterized protein LOC313163 [KO:K07936]
313494  Tln1; talin-1 [KO:K06271]
314322  Fos; protein c-Fos [KO:K04379]
314436  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
315330  Espl1; separin [KO:K02365] [EC:3.4.22.49]
315609  Cd3e; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
315776  Tln2; talin-2 [KO:K06271]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
360640  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
360643  Cdc27; cell division cycle protein 27 homolog isoform 2 [KO:K03350]
360739  Ranbp1; ran-specific GTPase-activating protein [KO:K15306]
361389  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
361662  Bub3; mitotic checkpoint protein BUB3 [KO:K02180]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
362485  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
362817  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
363088  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
365297  Crtc3; CREB regulated transcription coactivator 3 [KO:K16334]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
365542  RT1-DOb; RT1 class II, DO beta isoform 1 [KO:K06752]
366126  Spi1; transcription factor PU.1 [KO:K09438]
366381  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
399489  E2f1; transcription factor E2F1 [KO:K17454]
406169  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
497941  Gps2; G protein pathway suppressor 2 [KO:K15307]
498030  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
498088  Ranbp1l1; ran-specific GTPase-activating protein-like [KO:K15306]
498885  Slc25a6; solute carrier family 25 member 6 [KO:K05863]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
499402  H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
500871  Slc25a5l1; ADP/ATP translocase 2-like [KO:K05863]
500910  Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
501099  Srf; serum response factor [KO:K04378]
501281  Ranbp3; ran-binding protein 3 [KO:K15304]
50554  Smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
50557  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
54238  Cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
54244  Crebbp; histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
59086  Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
63879  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
64033  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
64193  Pttg1; securin [KO:K06635]
64202  Calr; calreticulin precursor [KO:K08057]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
64515  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
680006  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
680050  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
681314  [KO:K02159]
684111  E2f2; transcription factor E2F2 isoform X2 [KO:K09389]
684527  Crtc1; CREB-regulated transcription coactivator 1 [KO:K15309]
685029  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
685055  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
689030  Tbpl1; TATA box-binding protein-like 1 [KO:K03120]
689108  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
689537  Calr4; calreticulin isoform X1 [KO:K08057]
690369  Il15ra; interleukin-15 receptor subunit alpha precursor [KO:K05074]
751812  Rasl2-9; GTP-binding nuclear protein Ran, testis-specific isoform [KO:K07936]
79255  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
79426  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
81647  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
81710  Msx1; homeobox protein MSX-1 [KO:K09341]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81809  Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
81810  Tgfbr2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
83529  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
83531  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
83532  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
83791  Fdps; farnesyl pyrophosphate synthase [KO:K00787] [EC:2.5.1.1 2.5.1.10]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
84509  Ran; GTP-binding nuclear protein Ran [KO:K07936]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
85252  Xpo1; exportin-1 [KO:K14290]
85333  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
94201  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
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Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
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Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
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BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
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PMID:15040584
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Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
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Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
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PMID:27334587
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Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
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J Virol 90:7607-17 (2016)
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PMID:15988028
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Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
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PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
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Shida H
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
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  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
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The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
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Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
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PMID:23741982
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Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
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The modulation of apoptosis by oncogenic viruses.
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Virol J 10:182 (2013)
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Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
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Viruses 3:714-49 (2011)
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PMID:21994767
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Saggioro D
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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PMID:16036567
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Harhaj EW, Harhaj NS
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Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
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IUBMB Life 57:83-91 (2005)
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Activation of NF-kappaB by HTLV-I and implications for cell transformation.
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Oncogene 24:5952-64 (2005)
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PMID:9710600
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Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Mol Cell Biol 18:5157-65 (1998)
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Reference
PMID:21315773
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Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
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PMID:26797638
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:8 (2016)
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PMID:26324707
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Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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PMID:11264182
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Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
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Azran I, Schavinsky-Khrapunsky Y, Aboud M
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
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Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
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Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
rno03013  Nucleocytoplasmic transport
rno04010  MAPK signaling pathway
rno04064  NF-kappa B signaling pathway
rno04110  Cell cycle
rno04115  p53 signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04350  TGF-beta signaling pathway
rno04612  Antigen processing and presentation
rno04660  T cell receptor signaling pathway
rno04668  TNF signaling pathway
KO pathway
ko05166   

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