KEGG   PATHWAY: rno05169
Entry
rno05169                    Pathway                                
Name
Epstein-Barr virus infection - Rattus norvegicus (rat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
rno05169  Epstein-Barr virus infection
rno05169

Disease
H00367  Infectious mononucleosis
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100360982  Relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
100361294  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100362121  Ddb2; DNA damage-binding protein 2 [KO:K10140]
100911527  Ifna4l1; interferon alpha-11-like [KO:K05414]
100912314  [KO:K05414]
100912356  [KO:K05414]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114483  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114494  Ccna2; cyclin-A2 [KO:K06627]
114495  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117262  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
117263  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
120093125  RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
120099910  [KO:K08738]
134484121  [KO:K00922] [EC:2.7.1.153]
134487075  [KO:K05414]
134487077  [KO:K05414]
156726  Runx3; runt-related transcription factor 3 isoform 2 [KO:K09279]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
171075  Fcer2; low affinity immunoglobulin epsilon Fc receptor isoform a [KO:K06468]
171369  Cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
171525  Polk; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
192281  Oas1a; 2'-5'-oligoadenylate synthase 1A [KO:K14216] [EC:2.7.7.84]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24223  B2m; beta-2-microglobulin precursor [KO:K08055]
24224  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
24481  Ifnb1; interferon beta precursor [KO:K05415]
24498  Il6; interleukin-6 precursor [KO:K05405]
24516  Jun; transcription factor Jun [KO:K04448]
24577  Myc; myc proto-oncogene protein [KO:K04377]
245920  Cxcl10; C-X-C motif chemokine 10 precursor [KO:K12671]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
246268  Oas1b; inactive 2'-5'-oligoadenylate synthase 1B [KO:K14216] [EC:2.7.7.84]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
24708  Rb1; retinoblastoma-associated protein [KO:K06618]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
24811  Tap1; antigen peptide transporter 1 precursor [KO:K05653] [EC:7.4.2.14]
24812  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
24835  Tnf; tumor necrosis factor [KO:K03156]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
24887  Bax; apoptosis regulator BAX [KO:K02159]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24981  RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
25112  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
25124  Stat1; signal transducer and activator of transcription 1-alpha/beta isoform beta [KO:K11220]
25125  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
25155  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
25193  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
25217  Tapbp; tapasin precursor [KO:K08058]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
25300  Cd247; T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor [KO:K06453]
25309  Cycs; cytochrome c, somatic [KO:K08738]
25310  Cyct; cytochrome c, testis-specific [KO:K08738]
25326  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
25406  Cd44; CD44 antigen precursor [KO:K06256]
25464  Icam1; intercellular adhesion molecule 1 precursor [KO:K06490]
25489  Nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25581  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
25710  Cd3d; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
25729  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
287398  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
287670  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
287772  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
287984  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
288264  Ifnar1; interferon alpha/beta receptor 1 isoform 1 precursor [KO:K05130]
288774  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
289395  Cr2; complement receptor type 2 precursor [KO:K04012]
289924  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
289990  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
290019  Cycsl3; cytochrome c, somatic-like [KO:K08738]
291005  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
291105  E2f3; transcription factor E2F3 [KO:K06620]
292766  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
293624  Irf7; interferon regulatory factor 7 [KO:K09447]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
294269  RT1-Da; RT1 class II, locus Da precursor [KO:K06752]
294270  RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752]
294273  RT1-DMb; RT1 class II, DM beta precursor [KO:K06752]
294274  RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752]
29468  Pdia3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
294790  Skp2; S-phase kinase-associated protein 2 [KO:K03875]
295052  Ccna1; cyclin-A1 [KO:K06627]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
29577  Hes1; transcription factor HES-1 [KO:K06054]
29677  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
297602  Tapbpl; tapasin-related protein precursor [KO:K28445]
297893  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
297989  Rig1; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298693  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
299626  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
300177  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
300678  Cd3g; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
301059  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
303200  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
303353  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
304507  Oas1i; 2 ' -5 ' oligoadenylate synthetase 1I [KO:K14216] [EC:2.7.7.84]
305896  Irf9; interferon regulatory factor 9 [KO:K04693]
306886  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
307821  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
308267  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
308995  Itgal; integrin alpha-L precursor [KO:K05718]
309165  Rela; transcription factor p65 [KO:K04735]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
309452  Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309621  RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752]
309622  RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
310553  Tlr2; toll-like receptor 2 precursor [KO:K10159]
311078  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
311430  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
313121  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
315139  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
315609  Cd3e; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
316077  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
316241  Nfkbie; NF-kappa-B inhibitor epsilon [KO:K05872]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
360471  Usp7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
360531  Sap30l; histone deacetylase complex subunit SAP30L [KO:K19202]
360640  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
360801  Ncor2; nuclear receptor corepressor 2 [KO:K06065]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
362149  Cir1; corepressor interacting with RBPJ 1 [KO:K06066]
362268  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
362485  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
362788  Traf3; TNF receptor-associated factor 3 [KO:K03174]
362817  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
363067  Sin3a; paired amphipathic helix protein Sin3a [KO:K11644]
363520  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
363855  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431] [EC:2.7.12.2]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
363938  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
363984  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
365367  Cd19; B-lymphocyte antigen CD19 precursor [KO:K06465]
365388  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
365542  RT1-DOb; RT1 class II, DO beta isoform 1 [KO:K06752]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
367149  Bax-ps1; apoptosis regulator BAX-like [KO:K02159]
367901  Btk; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
399489  E2f1; transcription factor E2F1 [KO:K17454]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
494202  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
499356  Blnk; B-cell linker protein [KO:K07371]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
499402  H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
500491  Ifna16l1; interferon, alpha 16-like 1 precursor [KO:K05414]
500695  Snw1; SNW domain-containing protein 1 [KO:K06063]
502959  Ifna1l1; similar to put. precursor MuIFN-alpha 5 precursor [KO:K05414]
502961  Ifna4l2; similar to Interferon alpha-1 precursor [KO:K05414]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
54287  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
58918  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
613267  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
64033  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
64044  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
64202  Calr; calreticulin precursor [KO:K08057]
64519  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
64547  Bcl2l11; bcl-2-like protein 11 [KO:K16341]
64625  Bid; BH3-interacting domain death agonist [KO:K04726]
65138  Adrm1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
679028  Rbpj; recombining binding protein suppressor of hairless isoform 1 [KO:K06053]
679794  Cycsl1; cytochrome c, somatic-like [KO:K08738]
680122  Sap30; histone deacetylase complex subunit SAP30 [KO:K19202]
680532  Sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
681314  [KO:K02159]
683206  Tnfaip3; TNF alpha induced protein 3 [KO:K11859] [EC:3.4.19.12]
684111  E2f2; transcription factor E2F2 isoform X2 [KO:K09389]
684173  Traf5; TNF receptor-associated factor 5 [KO:K09849]
686326  Ifnar2; interferon alpha and beta receptor subunit 2 isoform 1 precursor [KO:K05131]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
689537  Calr4; calreticulin isoform X1 [KO:K08057]
690675  Cycsl2; cytochrome c, somatic-like [KO:K08738]
690894  Ifna1; interferon alpha family, gene 5 precursor [KO:K05414]
78963  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
81515  Lyn; tyrosine-protein kinase Lyn isoform A [KO:K05854] [EC:2.7.10.2]
81525  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
81818  Vim; vimentin [KO:K07606]
81827  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
83499  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
83571  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
83806  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
84576  Hdac1l; histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
84577  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
94201  Cdk4; cyclin-dependent kinase 4 isoform 1 [KO:K02089] [EC:2.7.11.22]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
rno03050  Proteasome
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04064  NF-kappa B signaling pathway
rno04110  Cell cycle
rno04115  p53 signaling pathway
rno04210  Apoptosis
rno04612  Antigen processing and presentation
rno04620  Toll-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04630  JAK-STAT signaling pathway
rno04662  B cell receptor signaling pathway
KO pathway
ko05169   

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