KEGG   PATHWAY: cgob04010
Entry
cgob04010                   Pathway                                
Name
MAPK signaling pathway - Cottoperca gobio
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cgob04010  MAPK signaling pathway
cgob04010

Other DBs
GO: 0000165
Organism
Cottoperca gobio [GN:cgob]
Gene
115012056  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344]
115005468  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
115012934  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
115016833  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
115028206  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
115008852  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
115006824  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
115022612  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
115005436  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
115011426  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
115024904  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
115011810  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
115011749  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
115007829  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
115010609  LOW QUALITY PROTEIN: dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
115009736  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
115028087  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
115007738  cacna2d2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
115008089  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
115008314  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
115010677  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
115009147  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
115028294  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
115011732  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
115025303  cacnb2; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
115010642  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
115010710  voltage-dependent L-type calcium channel subunit beta-3-like isoform X1 [KO:K04864]
115019250  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
115026075  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
115012513  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
115007076  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
115012840  cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
115012037  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
115011390  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
115012819  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
115014282  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
115012232  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
115010152  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
115021671  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
115016186  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
115015805  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
115021818  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
115015593  LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
115021786  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
115011693  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
115006619  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115022186  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115010783  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
115011646  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115012036  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115017865  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115021190  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
115008038  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
115012614  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
115007473  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
115022533  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115018537  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115014020  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115014313  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115023688  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115006528  calcineurin subunit B type 1 isoform X1 [KO:K06268]
115019711  calcineurin subunit B type 1-like [KO:K06268]
115025090  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
115009719  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
115013794  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
115016440  ras-specific guanine nucleotide-releasing factor 2-like [KO:K12326]
115018298  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
115027612  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
115023498  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
115020482  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
115015125  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
115017913  nf1; neurofibromin isoform X1 [KO:K08052]
115013216  rasa1; ras GTPase-activating protein 1 [KO:K04352]
115017545  rasa2; ras GTPase-activating protein 2 [KO:K08053]
115006261  ras-related protein Rap-1A [KO:K04353]
115007899  ras-related protein Rap-1A-like [KO:K04353]
115004964  ras-related protein Rap-1A [KO:K04353]
115014303  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
115007757  cell wall integrity and stress response component 1-like isoform X1 [KO:K08774]
115014112  ereg; proepiregulin [KO:K09784]
115019345  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
115014730  putative fibroblast growth factor 1 [KO:K18496]
115014705  fgf2; fibroblast growth factor 2 [KO:K18497]
115005816  fgf3; fibroblast growth factor 3 [KO:K04358]
115012147  fibroblast growth factor 20-like [KO:K04358]
115007299  fgf22; fibroblast growth factor 22 [KO:K04358]
115013545  fgf10; fibroblast growth factor 10 [KO:K04358]
115013581  fgf17; fibroblast growth factor 17 [KO:K04358]
115026283  fgf7; fibroblast growth factor 7 [KO:K04358]
115013888  fgf5; fibroblast growth factor 5 [KO:K04358]
115020095  fibroblast growth factor 8 [KO:K04358]
115014348  fibroblast growth factor 8b-like [KO:K04358]
115014370  fibroblast growth factor 4-like [KO:K04358]
115026717  fibroblast growth factor 4A-like [KO:K04358]
115014635  fibroblast growth factor 20-like [KO:K04358]
115014703  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
115009184  fgf6; fibroblast growth factor 6 [KO:K04358]
115015171  fibroblast growth factor 18-like isoform X1 [KO:K04358]
115015182  fibroblast growth factor 18-like [KO:K04358]
115028558  fibroblast growth factor 6-like [KO:K04358]
115004857  fgf4; fibroblast growth factor 4 [KO:K04358]
115006252  fgf19; fibroblast growth factor 19 [KO:K22603]
115025061  fgf21; fibroblast growth factor 21 isoform X1 [KO:K22429]
115028556  fgf23; fibroblast growth factor 23 [KO:K22428]
115010252  fibroblast growth factor 23-like [KO:K22428]
115008416  nerve growth factor-like [KO:K02582]
115010778  nerve growth factor-like [KO:K02582]
115010779  LOW QUALITY PROTEIN: nerve growth factor-like [KO:K02582]
115028088  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
115028547  ntf3; neurotrophin-3 [KO:K04356]
115018585  ins; insulin [KO:K04526]
115014742  insulin-like [KO:K04526]
115020429  insulin-like growth factor I [KO:K05459]
115028254  igf1; insulin-like growth factor I [KO:K05459]
115009855  igf2; insulin-like growth factor II [KO:K13769]
115006184  platelet-derived growth factor subunit A-like [KO:K04359]
115012768  platelet-derived growth factor subunit A-like [KO:K04359]
115014680  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
115017290  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
115009993  kitlg; kit ligand isoform X1 [KO:K05461]
115028426  uncharacterized protein LOC115028426 [KO:K05461]
115015179  vegfb; vascular endothelial growth factor B [KO:K05448]
115021761  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
115028848  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
115026992  placenta growth factor-like isoform X1 [KO:K16859]
115003575  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
115025807  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
115016863  vascular endothelial growth factor C-like [KO:K05449]
115009747  hgf; hepatocyte growth factor [KO:K05460]
115028611  hepatocyte growth factor-like isoform X1 [KO:K05460]
115008542  angiopoietin-1-like [KO:K05465]
115016058  angpt1; angiopoietin-1 [KO:K05465]
115019949  angpt2; angiopoietin-2 [KO:K05466]
115015630  angiopoietin-2-like [KO:K05466]
115007613  ephrin-A2-like [KO:K05462]
115013589  efna5; ephrin-A5 isoform X1 [KO:K05462]
115020771  ephrin-A4-like [KO:K05462]
115027368  ephrin-A2-like isoform X1 [KO:K05462]
115015304  LOW QUALITY PROTEIN: ephrin-A1-like [KO:K05462]
115021524  efna1; ephrin-A1 [KO:K05462]
115021793  ephrin-A3-like isoform X1 [KO:K05462]
115015961  ephrin-A3-like isoform X1 [KO:K05462]
115016897  ephrin-A5-like [KO:K05462]
115013744  glial cell line-derived neurotrophic factor-like [KO:K05452]
115016617  glial cell line-derived neurotrophic factor-like [KO:K05452]
115022911  nrtn; neurturin [KO:K25414]
115022485  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
115024277  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
115008140  erbb3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
115010612  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
115017944  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115026094  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
115013012  LOW QUALITY PROTEIN: fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
115017856  tyrosine kinase receptor Cad96Ca-like [KO:K05093] [EC:2.7.10.1]
115017933  tyrosine kinase receptor Cad96Ca-like [KO:K05093] [EC:2.7.10.1]
115019690  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
115027139  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
115018698  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
115024297  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
115012370  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
115020780  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
115021582  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
115013223  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
115016885  LOW QUALITY PROTEIN: BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
115022820  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
115006808  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
115009816  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115006742  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
115019444  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
115014733  pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
115018832  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
115014344  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
115006950  kit; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
115014745  mast/stem cell growth factor receptor kita-like [KO:K05091] [EC:2.7.10.1]
115025366  flt3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
115025365  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
115014595  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
115014811  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
115007113  kdr; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
115010196  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
115008000  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
115010687  epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
115020027  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
115012209  growth factor receptor-bound protein 2 [KO:K04364]
115027245  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
115009535  hras; GTPase HRas [KO:K02833]
115012331  GTPase HRas-like [KO:K07827]
115009461  kras; GTPase KRas [KO:K07827]
115012363  rras; ras-related protein R-Ras [KO:K07830]
115025720  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
115026107  mras; ras-related protein M-Ras [KO:K07831]
115028355  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
115010471  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
115009830  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115007241  map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
115022522  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115027438  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
115012254  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115013460  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
115006668  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
115007031  MAP kinase-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K04372] [EC:2.7.11.1]
115027042  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
115015091  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
115004707  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
115004842  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
115012736  atf4; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
115005792  ETS domain-containing protein Elk-3-like [KO:K04375]
115008458  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
115025812  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
115005048  transcriptional regulator Myc-like isoform X1 [KO:K04377]
115019677  srf; serum response factor isoform X1 [KO:K04378]
115005577  serum response factor-like isoform X1 [KO:K04378]
115027399  proto-oncogene c-Fos-like [KO:K04379]
115003606  proto-oncogene c-Fos-like [KO:K04379]
115003607  proto-oncogene c-Fos-like [KO:K04379]
115025050  microtubule-associated protein tau-like isoform X1 [KO:K04380]
115021284  stathmin-like [KO:K04381]
115015930  stathmin-like [KO:K04381]
115006750  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
115006752  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
115012463  pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
115015660  tumor necrosis factor-like [KO:K03156]
115016975  uncharacterized protein LOC115016975 [KO:K03156]
115013355  il1b; interleukin-1 beta [KO:K04519]
115017895  LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein-like [KO:K13375]
115014648  transforming growth factor beta-2 proprotein-like [KO:K13376]
115021567  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
115027215  tgfb3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
115003471  transforming growth factor beta-3 proprotein-like [KO:K13377]
115011263  tumor necrosis factor receptor superfamily member 25-like [KO:K03158]
115026861  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
115005781  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115005886  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115015457  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
115007592  faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
115014829  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
115019686  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
115024458  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
115011622  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
115006129  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
115024221  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
115020751  cell division control protein 42 homolog [KO:K04393]
115008836  cell division control protein 42 homolog isoform X1 [KO:K04393]
115021104  cell division control protein 42 homolog [KO:K04393]
115015367  cell division control protein 42 homolog [KO:K04393]
115010449  cell division control protein 42 homolog isoform X1 [KO:K04393]
115028375  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
115014922  caspase-3-like [KO:K02187] [EC:3.4.22.56]
115010976  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
115013664  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115016433  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
115016852  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115015600  daxx; death domain-associated protein 6 [KO:K02308]
115025518  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
115009385  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
115025996  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
115006935  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
115013399  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115027307  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115016679  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115016775  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115023092  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
115005482  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
115028960  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
115023413  ecsit; LOW QUALITY PROTEIN: evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
115019699  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
115026836  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
115016903  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
115017848  pak1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
115007491  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
115008449  serine/threonine-protein kinase 4-like [KO:K04411]
115015637  serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
115023668  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
115025450  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
115023572  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
115017317  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 2-like [KO:K04420] [EC:2.7.11.25]
115025332  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
115027785  map3k9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
115018000  map3k10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
115020020  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21-like [KO:K17534] [EC:2.7.11.25]
115008143  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
115011424  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
115026620  map3k13; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
115026677  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
115022136  mitogen-activated protein kinase kinase kinase 7-like [KO:K04424] [EC:2.7.11.25]
115021489  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
115003836  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
115028876  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
115019839  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
115024278  LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
115018605  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
115014137  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
115017102  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
115017484  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
115024389  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115012187  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
115007203  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
115024590  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
115012637  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
115006162  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
115009114  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
115009414  LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
115011726  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
115011433  filamin-A-like isoform X1 [KO:K04437]
115017907  adapter molecule crk-like isoform X1 [KO:K04438]
115019204  adapter molecule crk-like [KO:K04438]
115016623  crkl; crk-like protein [KO:K04438]
115018066  arrb1; beta-arrestin-1 [KO:K04439]
115018552  arrestin red cell isoform X1 [KO:K04439]
115023434  arrestin red cell-like [KO:K04439]
115024543  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115020041  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115015104  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115016627  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115007966  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115010037  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115028334  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115028365  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115010507  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115011084  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115013356  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
115007960  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
115011375  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
115008376  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
115008781  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
115027161  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
115018474  ribosomal protein S6 kinase alpha-4-like [KO:K16510] [EC:2.7.11.1]
115027812  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
115016101  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
115021892  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
115009569  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
115004653  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
115007435  transcription factor AP-1-like [KO:K04448]
115016821  transcription factor AP-1-like [KO:K04448]
115022963  jun; transcription factor AP-1 [KO:K04448]
115007521  transcription factor jun-D-like [KO:K04449]
115023074  transcription factor jun-D-like [KO:K04449]
115026508  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
115023713  cellular tumor antigen p53-like [KO:K04451]
115008101  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
115027838  protein max-like [KO:K04453]
115028760  protein max-like isoform X1 [KO:K04453]
115013251  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
115005557  LOW QUALITY PROTEIN: myocyte-specific enhancer factor 2C-like [KO:K04454]
115019289  heat shock protein beta-1-like [KO:K04455]
115016796  heat shock protein beta-1-like [KO:K04455]
115018604  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115019820  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115027720  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115017525  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115017947  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
115019308  protein phosphatase 1B-like [KO:K04457] [EC:3.1.3.16]
115026969  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
115010056  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
115010828  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
115014913  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
115012343  probable dual specificity protein phosphatase DDB_G0281963 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115014136  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115014681  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115009546  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115016445  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115005397  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115011370  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115009626  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
115003585  dusp10; LOW QUALITY PROTEIN: dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
115012366  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
115025083  LOW QUALITY PROTEIN: dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
115018222  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
115024223  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
115019930  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
115006097  heat shock 70 kDa protein 1 [KO:K03283]
115019083  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
115021117  heat shock cognate 70 kDa protein-like [KO:K03283]
115010496  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
115017571  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
115017293  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
115005674  map2k5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
115024627  LOW QUALITY PROTEIN: mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
115008150  probable nuclear hormone receptor HR38 [KO:K04465]
115024164  uncharacterized protein LOC115024164 [KO:K04466] [EC:2.7.11.25]
115012791  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
115024640  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115019941  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
115013798  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115010596  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115017440  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
115023463  transcription factor p65-like isoform X1 [KO:K04735]
115017458  transcription factor p65-like isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cgob04070  Phosphatidylinositol signaling system
cgob04110  Cell cycle
cgob04115  p53 signaling pathway
cgob04210  Apoptosis
cgob04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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