KEGG   PATHWAY: efus05164
Entry
efus05164                   Pathway                                
Name
Influenza A - Eptesicus fuscus (big brown bat)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
efus05164  Influenza A
efus05164

Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103300807  tryptase-like [KO:K01340] [EC:3.4.21.59]
103304969  tryptase beta-2-like isoform X1 [KO:K01340] [EC:3.4.21.59]
103304644  tryptase beta-2-like [KO:K01340] [EC:3.4.21.59]
103299826  PLG; plasminogen isoform X1 [KO:K01315] [EC:3.4.21.7]
103294073  cationic trypsin-3-like [KO:K01312] [EC:3.4.21.4]
103297283  anionic trypsin [KO:K01312] [EC:3.4.21.4]
103289898  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
103293821  TMPRSS4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
103301739  transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
103296210  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103293910  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
103287239  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
129148092  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
103287240  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
103290117  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
103300982  DNAJB1; dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
103288272  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
103305673  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103283643  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103291807  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
103286489  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
103283368  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103293715  NLRX1; NLR family member X1 [KO:K12653]
103285642  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103284340  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
103301979  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103297088  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
103295446  TLR3; toll-like receptor 3 [KO:K05401]
103294388  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103301807  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
103292497  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103297481  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103297623  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103286158  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
103288832  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
103295671  TLR4; toll-like receptor 4 [KO:K10160]
103299728  TLR7; toll-like receptor 7 [KO:K05404]
103298161  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103285212  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
103302547  IRF7; interferon regulatory factor 7 [KO:K09447]
103303238  IL1A; interleukin-1 alpha [KO:K04383]
103303246  IL1B; interleukin-1 beta [KO:K04519]
103292051  IL6; interleukin-6 [KO:K05405]
103286786  IL12A; interleukin-12 subunit alpha [KO:K05406]
103291598  IL12B; interleukin-12 subunit beta [KO:K05425]
103300478  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129150475  interleukin-8-like [KO:K10030]
129150773  CXCL8; interleukin-8 [KO:K10030]
103291683  C-C motif chemokine 2 [KO:K14624]
103297029  CCL5; C-C motif chemokine 5 [KO:K12499]
103304839  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
103301176  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103289195  IFNB1; interferon beta [KO:K05415]
103289928  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103289837  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103284092  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103301133  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
103298250  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103290572  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103292429  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103301487  IRF9; interferon regulatory factor 9 [KO:K04693]
103289805  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
103289804  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
103298918  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
103300198  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
103292513  IFNG; interferon gamma [KO:K04687]
103285013  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103289926  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103289149  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
103286116  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
103303049  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103303050  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
103304353  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X2 [KO:K06752]
103304486  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
103304511  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
103300442  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
103295592  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
103303036  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
103304919  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
103303047  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
103304352  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
129150533  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
103303048  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
103303037  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
103304354  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
103304514  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
103295113  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
103296229  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
103299256  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
103293786  IL18; interleukin-18 isoform X1 [KO:K05482]
103289159  IL33; interleukin-33 [KO:K12967]
103290400  interleukin-33-like [KO:K12967]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103301919  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103292479  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
103292850  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
103286737  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103295138  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
103289966  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103296397  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103289002  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103284564  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103291049  FADD; FAS-associated death domain protein [KO:K02373]
103290541  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103303807  BID; BH3-interacting domain death agonist isoform X3 [KO:K04726]
103297647  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103303014  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103286741  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103287676  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
103293308  ADP/ATP translocase 3-like [KO:K05863]
103299975  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103295438  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129150056  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
103292869  cytochrome c-like [KO:K08738]
103291881  cytochrome c [KO:K08738]
103305670  cytochrome c-like [KO:K08738]
103303075  cytochrome c-like [KO:K08738]
129150288  cytochrome c-like [KO:K08738]
103300565  cytochrome c-like [KO:K08738]
103289111  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
103292032  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103295435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103285962  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X4 [KO:K14404]
103299437  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
103301511  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
103284753  PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396]
103303729  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
103299724  nuclear RNA export factor 2 [KO:K14284]
103302184  NXF3; nuclear RNA export factor 3 [KO:K14284]
103302189  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
103299725  nuclear RNA export factor 2-like [KO:K14284]
103285718  NXT1; NTF2-related export protein 1 [KO:K14285]
103288242  NTF2-related export protein 1-like [KO:K14285]
103288954  NTF2-related export protein 1-like [KO:K14285]
103303099  NXT2; NTF2-related export protein 2 [KO:K14285]
103284289  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
103285771  RAE1; mRNA export factor RAE1 [KO:K14298]
103293654  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
103305606  RSAD2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 [KO:K15045]
103298890  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
103285669  farnesyl pyrophosphate synthase-like [KO:K00787] [EC:2.5.1.1 2.5.1.10]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103299154  ACTB; actin, cytoplasmic 1 [KO:K05692]
103298235  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103283797  RAB11A; ras-related protein Rab-11A isoform X1 [KO:K07904]
103295037  RAB11B; ras-related protein Rab-11B [KO:K07905]
103305373  XPO1; exportin-1 [KO:K14290]
103290748  KPNA1; importin subunit alpha-5 [KO:K23940]
103290188  KPNA7; importin subunit alpha-8 [KO:K15043]
103293128  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
103300720  importin subunit alpha-1-like [KO:K15043]
103283700  KPNA5; importin subunit alpha-6 [KO:K15042]
103300149  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
efus00900  Terpenoid backbone biosynthesis
efus03013  Nucleocytoplasmic transport
efus03015  mRNA surveillance pathway
efus04010  MAPK signaling pathway
efus04110  Cell cycle
efus04144  Endocytosis
efus04210  Apoptosis
efus04620  Toll-like receptor signaling pathway
efus04621  NOD-like receptor signaling pathway
efus04622  RIG-I-like receptor signaling pathway
efus04630  JAK-STAT signaling pathway
efus05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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