KEGG   PATHWAY: mthb05417
Entry
mthb05417                   Pathway                                
Name
Lipid and atherosclerosis - Macaca thibetana thibetana (Pere David's macaque)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
mthb05417  Lipid and atherosclerosis
mthb05417

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126934124  apolipoprotein B-100 [KO:K14462]
126936333  apolipoprotein A-IV [KO:K08760]
126936335  apolipoprotein A-I [KO:K08757]
126942505  low-density lipoprotein receptor isoform X1 [KO:K12473]
126930027  oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
126941747  LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
126936364  interstitial collagenase [KO:K01388] [EC:3.4.24.7]
126948741  transforming protein RhoA [KO:K04513]
126933801  rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
126951570  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126943600  apoptosis regulator BAX isoform X1 [KO:K02159]
126935617  bcl2-associated agonist of cell death [KO:K02158]
126964283  bcl-2-like protein 1 isoform X1 [KO:K04570]
126941201  apoptosis regulator Bcl-2 [KO:K02161]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126953664  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126936581  POU domain, class 2, transcription factor 3 [KO:K09364]
126941578  POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
126941755  POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
126963852  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
126946644  CD40 ligand [KO:K03161]
126960000  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
126942029  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
126962030  cytochrome P450 2C20 isoform X1 [KO:K17718] [EC:1.14.14.1]
126962037  cytochrome P450 2C20 [KO:K17718] [EC:1.14.14.1]
126962028  cytochrome P450 2C9-like isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
126962032  cytochrome P450 2C9 isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
126962785  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
126953221  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
126945851  NADPH oxidase 1 [KO:K08008]
126946357  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
126950372  neutrophil cytosol factor 1 [KO:K08011]
126944340  cytochrome b-245 light chain isoform X1 [KO:K08009]
126940149  neutrophil cytosol factor 2 isoform X1 [KO:K08010]
126963740  neutrophil cytosol factor 4 isoform X1 [KO:K08012]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126964210  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126937558  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
126938424  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
126956242  cell division control protein 42 homolog isoform X1 [KO:K04393]
126953277  cell division control protein 42 homolog [KO:K04393]
126939572  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
126942652  dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
126959543  protein c-Fos [KO:K04379]
126962798  transcription factor Jun [KO:K04448]
126939582  C-C motif chemokine 2 [KO:K14624]
126942602  intercellular adhesion molecule 1 [KO:K06490]
126954919  interleukin-8 [KO:K10030]
126939044  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
126939854  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
126952773  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
126952775  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126929437  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126929447  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126950527  E-selectin [KO:K06494]
126950549  P-selectin isoform X1 [KO:K06496]
126964385  vascular cell adhesion protein 1 [KO:K06527]
126936369  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
126963805  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
126963192  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
126933366  interleukin-1 beta [KO:K04519]
126950025  interleukin-6 isoform X1 [KO:K05405]
126953141  tumor necrosis factor isoform X1 [KO:K03156]
126955185  60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
126932138  60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
126943192  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
126934789  heat shock cognate 71 kDa protein [KO:K03283]
126953203  heat shock 70 kDa protein 1B [KO:K03283]
126953204  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A-like [KO:K03283]
126953205  heat shock 70 kDa protein 1-like [KO:K03283]
126959751  heat shock-related 70 kDa protein 2 [KO:K26598]
126955978  heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
126955457  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
126958418  heat shock protein HSP 90-alpha [KO:K04079]
126952392  heat shock protein HSP 90-beta [KO:K04079]
126930897  endoplasmin [KO:K09487]
126955690  toll-like receptor 2 [KO:K10159]
126964226  lipopolysaccharide-binding protein [KO:K05399]
126957322  monocyte differentiation antigen CD14 [KO:K04391]
126961705  lymphocyte antigen 96 isoform X1 [KO:K05400]
126936830  toll-like receptor 4 isoform X1 [KO:K10160]
126934871  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
126948486  myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
126931312  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
126945458  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
126936615  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126963720  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
126952491  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
126952936  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126959170  NF-kappa-B inhibitor alpha [KO:K04734]
126956247  TIR domain-containing adapter molecule 2 [KO:K05409]
126942532  TIR domain-containing adapter molecule 1 [KO:K05842]
126959960  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
126951545  E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
126941279  E3 ubiquitin-protein ligase MIB1 isoform X1 [KO:K10645] [EC:2.3.2.27]
126932944  TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
126938771  inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
126930857  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
126935835  interferon regulatory factor 7 isoform X1 [KO:K09447]
126943112  interferon regulatory factor 3 isoform X1 [KO:K05411]
126937598  interferon alpha-14 [KO:K05414]
126937600  interferon alpha-4-like [KO:K05414]
126937601  interferon alpha-17 [KO:K05414]
126937602  interferon alpha-17-like [KO:K05414]
126937603  interferon alpha-17-like [KO:K05414]
126937604  interferon alpha-17-like [KO:K05414]
126937605  LOW QUALITY PROTEIN: interferon alpha-10-like [KO:K05414]
126937606  interferon alpha-10-like [KO:K05414]
126937607  interferon alpha-1/13-like [KO:K05414]
126937608  interferon alpha-1/13 [KO:K05414]
126937609  interferon alpha-1/13-like [KO:K05414]
126937610  interferon alpha-6 [KO:K05414]
126937611  interferon alpha-4 [KO:K05414]
126937612  interferon alpha-8 [KO:K05414]
126937613  interferon alpha-2 [KO:K05414]
126937615  interferon alpha-21 [KO:K05414]
126947451  interferon alpha-10-like [KO:K05414]
126937702  interferon beta [KO:K05415]
126951242  platelet glycoprotein 4 [KO:K06259]
126949058  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
126936987  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
126952745  retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
126941840  retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
126961723  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
126961367  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126942510  proto-oncogene vav [KO:K05730]
126936911  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
126947777  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
126955454  toll-like receptor 6 [KO:K10169]
126930173  ras-related protein Rap-1A [KO:K04353]
126930986  ras-related protein Rap-1b [KO:K07836]
126937705  ras-related protein Rap-1b-like [KO:K07836]
126939528  C-C motif chemokine 5 [KO:K12499]
126939308  C-C motif chemokine 3-like 1 isoform X1 [KO:K05408]
126939310  C-C motif chemokine 3-like 1 [KO:K05408]
126939314  C-C motif chemokine 3 isoform X1 [KO:K05408]
126954905  C-X-C motif chemokine 2 [KO:K05505]
126954911  growth-regulated alpha protein-like [KO:K05505]
126954917  growth-regulated alpha protein [KO:K05505]
126955314  growth-regulated alpha protein-like [KO:K05505]
126949358  interleukin-12 subunit alpha isoform X1 [KO:K05406]
126957215  interleukin-12 subunit beta [KO:K05425]
126943144  NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
126935802  interleukin-18 isoform X1 [KO:K05482]
126937190  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
126930406  DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
126958549  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
126947659  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
126962427  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
126955622  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
126956598  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
126950160  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
126933911  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
126958657  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
126963745  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126939534  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
126936973  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
126952847  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
126963975  LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
126937939  phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
126951517  ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
126932076  nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
126944252  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
126936244  caspase-1-like [KO:K01370] [EC:3.4.22.36]
126936247  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
126936524  caspase-1-like [KO:K01370] [EC:3.4.22.36]
126937970  very low-density lipoprotein receptor isoform X1 [KO:K20053]
126944637  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
126944712  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126941512  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
126964374  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
126944052  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126964414  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126959796  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
126964415  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126935554  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126963902  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126961592  calmodulin-1-like [KO:K02183]
126962311  calmodulin-like protein 5 [KO:K02183]
126962328  calmodulin-like protein 3 [KO:K02183]
126943484  calmodulin-3 isoform X1 [KO:K02183]
126958173  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
126951481  calmodulin-1-like [KO:K02183]
126934255  calmodulin-2 [KO:K02183]
126952282  calmodulin-like protein 6 [KO:K02183]
126959699  calmodulin-1 isoform X1 [KO:K02183]
126954988  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
126962430  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126961264  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126937786  calcineurin subunit B type 2 [KO:K06268]
126934067  calcineurin subunit B type 1 isoform X1 [KO:K06268]
126948360  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
126961267  tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
126961271  tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
126930443  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
126941397  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126932110  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
126929772  BH3-interacting domain death agonist [KO:K04726]
126949081  cytochrome c-like [KO:K08738]
126961774  cytochrome c-like [KO:K08738]
126936610  cytochrome c-like [KO:K08738]
126937973  cytochrome c-like [KO:K08738]
126944405  cytochrome c-like [KO:K08738]
126932751  cytochrome c-like [KO:K08738]
126951393  cytochrome c [KO:K08738]
126947125  cytochrome c-like [KO:K08738]
126941401  cytochrome c-like [KO:K08738]
126952962  cytochrome c-like [KO:K08738]
126942126  cytochrome c-like [KO:K08738]
126931282  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
126929188  LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
126954943  caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
126954341  caspase-3 [KO:K02187] [EC:3.4.22.56]
126962014  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
126939707  cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
Am J Physiol Cell Physiol 298:C1180-7 (2010)
DOI:10.1152/ajpcell.00483.2009
Reference
PMID:27073018
  Authors
Salvador B, Arranz A, Francisco S, Cordoba L, Punzon C, Llamas MA, Fresno M
  Title
Modulation of endothelial function by Toll like receptors.
  Journal
Pharmacol Res 108:46-56 (2016)
DOI:10.1016/j.phrs.2016.03.038
Reference
PMID:23995626
  Authors
Moore KJ, Sheedy FJ, Fisher EA
  Title
Macrophages in atherosclerosis: a dynamic balance.
  Journal
Nat Rev Immunol 13:709-21 (2013)
DOI:10.1038/nri3520
Reference
PMID:25403963
  Authors
Butoi E, Gan AM, Manduteanu I
  Title
Molecular and functional interactions among monocytes/macrophages and smooth muscle cells and their relevance for atherosclerosis.
  Journal
Crit Rev Eukaryot Gene Expr 24:341-55 (2014)
DOI:10.1615/critreveukaryotgeneexpr.2014012157
Reference
PMID:24048132
  Authors
Sheedy FJ, Moore KJ
  Title
IL-1 signaling in atherosclerosis: sibling rivalry.
  Journal
Nat Immunol 14:1030-2 (2013)
DOI:10.1038/ni.2711
Reference
PMID:21529710
  Authors
Moore KJ, Tabas I
  Title
Macrophages in the pathogenesis of atherosclerosis.
  Journal
Cell 145:341-55 (2011)
DOI:10.1016/j.cell.2011.04.005
Reference
PMID:22577254
  Authors
Gui T, Shimokado A, Sun Y, Akasaka T, Muragaki Y
  Title
Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.
  Journal
Mediators Inflamm 2012:693083 (2012)
DOI:10.1155/2012/693083
Reference
PMID:17442283
  Authors
Collot-Teixeira S, Martin J, McDermott-Roe C, Poston R, McGregor JL
  Title
CD36 and macrophages in atherosclerosis.
  Journal
Cardiovasc Res 75:468-77 (2007)
DOI:10.1016/j.cardiores.2007.03.010
Reference
PMID:19065049
  Authors
Park YM, Febbraio M, Silverstein RL
  Title
CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima.
  Journal
J Clin Invest 119:136-45 (2009)
DOI:10.1172/JCI35535
Reference
PMID:24903227
  Authors
Park YM
  Title
CD36, a scavenger receptor implicated in atherosclerosis.
  Journal
Exp Mol Med 46:e99 (2014)
DOI:10.1038/emm.2014.38
Reference
PMID:21035758
  Authors
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I
  Title
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
  Journal
Cell Metab 12:467-82 (2010)
DOI:10.1016/j.cmet.2010.09.010
Reference
PMID:25869517
  Authors
Nimgulkar C, Ghosh S, Sankar AB, Uday KP, Surekha MV, Madhusudhanachary P, Annapurna BR, Raghu P, Bharatraj DK
  Title
Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis.
  Journal
Vascul Pharmacol 72:53-63 (2015)
DOI:10.1016/j.vph.2015.02.014
Reference
PMID:23928573
  Authors
Canton J, Neculai D, Grinstein S
  Title
Scavenger receptors in homeostasis and immunity.
  Journal
Nat Rev Immunol 13:621-34 (2013)
DOI:10.1038/nri3515
Reference
PMID:20375591
  Authors
Erridge C
  Title
The roles of Toll-like receptors in atherosclerosis.
  Journal
J Innate Immun 1:340-9 (2009)
DOI:10.1159/000191413
Reference
PMID:21884686
  Authors
Seneviratne AN, Sivagurunathan B, Monaco C
  Title
Toll-like receptors and macrophage activation in atherosclerosis.
  Journal
Clin Chim Acta 413:3-14 (2012)
DOI:10.1016/j.cca.2011.08.021
Reference
PMID:21252151
  Authors
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL
  Title
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.
  Journal
Circ Res 108:235-48 (2011)
DOI:10.1161/CIRCRESAHA.110.223875
Reference
PMID:20884885
  Authors
Tabas I
  Title
The role of endoplasmic reticulum stress in the progression of atherosclerosis.
  Journal
Circ Res 107:839-50 (2010)
DOI:10.1161/CIRCRESAHA.110.224766
Reference
PMID:29360955
  Authors
Grootaert MOJ, Moulis M, Roth L, Martinet W, Vindis C, Bennett MR, De Meyer GRY
  Title
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.
  Journal
Cardiovasc Res 114:622-634 (2018)
DOI:10.1093/cvr/cvy007
Reference
PMID:12730091
  Authors
Lipskaia L, Pourci ML, Delomenie C, Combettes L, Goudouneche D, Paul JL, Capiod T, Lompre AM
  Title
Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation.
  Journal
Circ Res 92:1115-22 (2003)
DOI:10.1161/01.RES.0000074880.25540.D0
Reference
PMID:28230726
  Authors
Cervantes Gracia K, Llanas-Cornejo D, Husi H
  Title
CVD and Oxidative Stress.
  Journal
J Clin Med 6:E22 (2017)
DOI:10.3390/jcm6020022
Reference
PMID:21321594
  Authors
Hansson GK, Hermansson A
  Title
The immune system in atherosclerosis.
  Journal
Nat Immunol 12:204-12 (2011)
DOI:10.1038/ni.2001
Reference
PMID:19301036
  Authors
Roy H, Bhardwaj S, Yla-Herttuala S
  Title
Molecular genetics of atherosclerosis.
  Journal
Hum Genet 125:467-91 (2009)
DOI:10.1007/s00439-009-0654-5
Reference
PMID:15451808
  Authors
Lusis AJ, Fogelman AM, Fonarow GC
  Title
Genetic basis of atherosclerosis: part I: new genes and pathways.
  Journal
Circulation 110:1868-73 (2004)
DOI:10.1161/01.CIR.0000143041.58692.CC
Reference
PMID:15485348
  Authors
Lusis AJ, Mar R, Pajukanta P
  Title
Genetics of atherosclerosis.
  Journal
Annu Rev Genomics Hum Genet 5:189-218 (2004)
DOI:10.1146/annurev.genom.5.061903.175930
Related
pathway
mthb04020  Calcium signaling pathway
mthb04115  p53 signaling pathway
mthb04141  Protein processing in endoplasmic reticulum
mthb04151  PI3K-Akt signaling pathway
mthb04210  Apoptosis
mthb04620  Toll-like receptor signaling pathway
mthb04621  NOD-like receptor signaling pathway
mthb04668  TNF signaling pathway
mthb04670  Leukocyte transendothelial migration
mthb04975  Fat digestion and absorption
mthb04979  Cholesterol metabolism
mthb05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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