KEGG   PATHWAY: pleu05169
Entry
pleu05169                   Pathway                                
Name
Epstein-Barr virus infection - Peromyscus leucopus (white-footed mouse)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
pleu05169  Epstein-Barr virus infection
pleu05169

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114687531  Cr2; complement receptor type 2 isoform X1 [KO:K04012]
114686676  Cd19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
114700321  LOW QUALITY PROTEIN: B-lymphocyte antigen CD19 [KO:K06465]
114686347  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
114686357  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
114686361  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
114686362  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
114686363  class II histocompatibility antigen, M alpha chain isoform X1 [KO:K06752]
114689124  rano class II histocompatibility antigen, A beta chain [KO:K06752]
114689125  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
114705818  H-2 class II histocompatibility antigen, I-E beta chain isoform X1 [KO:K06752]
114705822  H-2 class II histocompatibility antigen, A-K alpha chain [KO:K06752]
114705823  H-2 class II histocompatibility antigen, A-F alpha chain [KO:K06752]
114705840  H-2 class II histocompatibility antigen, I-E beta chain [KO:K06752]
114705842  H-2 class II histocompatibility antigen, E-D beta chain-like [KO:K06752]
114705843  H-2 class II histocompatibility antigen, A beta chain [KO:K06752]
114705896  H-2 class II histocompatibility antigen, E-K alpha chain [KO:K06752]
114710188  Tlr2; toll-like receptor 2 [KO:K10159]
114682503  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114693067  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114706205  Irak1; interleukin-1 receptor-associated kinase 1 isoform X3 [KO:K04730] [EC:2.7.11.1]
114710754  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114694280  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
114686371  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
114695419  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114693378  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114682099  Rela; transcription factor p65 [KO:K04735]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114689756  Il6; interleukin-6 [KO:K05405]
114703265  Ddx58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
114699515  Mavs; LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein [KO:K12648]
114697589  TNF receptor-associated factor 3-like [KO:K03174]
114703073  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
114693293  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114698057  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
114693632  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
114687156  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
114685140  interferon alpha-12-like [KO:K05414]
114685141  interferon alpha-12-like [KO:K05414]
114685144  interferon alpha-12-like [KO:K05414]
114685147  interferon alpha-12-like [KO:K05414]
114685149  interferon alpha-12-like [KO:K05414]
114685150  interferon alpha-12-like [KO:K05414]
114685151  interferon alpha-12-like [KO:K05414]
114685152  interferon alpha-12-like [KO:K05414]
114685154  interferon alpha-12-like [KO:K05414]
114685155  interferon alpha-12-like [KO:K05414]
114688453  interferon alpha-12-like [KO:K05414]
114688454  interferon alpha-12-like [KO:K05414]
114688456  interferon alpha-12-like [KO:K05414]
114688459  interferon alpha-13-like [KO:K05414]
114688460  interferon alpha-12-like [KO:K05414]
114688461  interferon alpha-12-like [KO:K05414]
114688462  interferon alpha-12-like [KO:K05414]
114688463  interferon alpha-12-like [KO:K05414]
114689321  interferon alpha-13-like [KO:K05414]
114689322  interferon alpha-12-like [KO:K05414]
119087415  interferon alpha-3-like [KO:K05414]
119087496  interferon alpha-3-like [KO:K05414]
114698348  interferon alpha-3-like [KO:K05414]
114685139  Ifnb1; interferon beta [KO:K05415]
114698435  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
114698437  Ifnar2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
114693732  Jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114695212  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
114705035  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
114681747  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
114708668  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
114695816  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
114681897  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
114681904  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
114681905  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
114699623  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
114699624  Oas3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
114699625  Oas2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
114701754  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
114708271  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
114694438  Fadd; FAS-associated death domain protein [KO:K02373]
114704437  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114700736  Bid; BH3-interacting domain death agonist [KO:K04726]
114709516  Bcl2l11; LOW QUALITY PROTEIN: bcl-2-like protein 11 [KO:K16341]
114702810  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114706143  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
114689745  cytochrome c, somatic [KO:K08738]
114697928  cytochrome c-like [KO:K08738]
114693819  cytochrome c, somatic-like [KO:K08738]
114700813  cytochrome c, testis-specific [KO:K08738]
114695408  cytochrome c, somatic-like [KO:K08738]
114709020  cytochrome c, somatic-like [KO:K08738]
114703574  cytochrome c, somatic-like [KO:K08738]
114710287  cytochrome c, somatic-like [KO:K08738]
114700550  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114691295  Cd3e; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
114691293  Cd3g; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
114691294  Cd3d; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
114689925  Cd247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
114707978  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
114684579  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
114705017  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
114681547  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
114694740  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6B-like [KO:K03063]
114700704  26S proteasome regulatory subunit 10B-like [KO:K03064]
114696051  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
114699678  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
114690413  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
114683312  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
114697868  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
114706920  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
114690433  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
114691544  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
114710373  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
114706728  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
114693426  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
114683197  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
114691595  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
114684987  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
114704207  Adrm1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
114686350  Tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
114686351  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
114706134  tapasin [KO:K08058]
114691448  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
114699590  Pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
114687088  Calr; calreticulin [KO:K08057]
114707623  calreticulin-like [KO:K08057]
114686366  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X10 [KO:K06751]
114687018  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
114687019  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
114687020  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
114687933  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
114687935  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
114688482  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
114688490  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
114688492  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114688790  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
114688816  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, K-B alpha chain-like [KO:K06751]
114688817  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
114682640  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
114682644  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
114682645  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
114682649  HLA class I histocompatibility antigen, alpha chain F-like isoform X3 [KO:K06751]
114682653  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
114682654  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
114682655  HLA class I histocompatibility antigen, alpha chain G [KO:K06751]
114682656  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X1 [KO:K06751]
114682666  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
114682671  class I histocompatibility antigen, Gogo-A*0201 alpha chain-like [KO:K06751]
114682672  patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751]
114682673  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
114682677  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
114682685  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
114682688  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
114705846  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
114699604  B2m; beta-2-microglobulin [KO:K08055]
114686833  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
114697695  SNW domain-containing protein 1 [KO:K06063]
114690326  Sin3a; paired amphipathic helix protein Sin3a [KO:K11644]
114683075  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
114705645  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
114696875  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
114710202  Ncor2; LOW QUALITY PROTEIN: nuclear receptor corepressor 2 [KO:K06065]
114706779  Sap30; histone deacetylase complex subunit SAP30 [KO:K19202]
114700422  Sap30l; histone deacetylase complex subunit SAP30L [KO:K19202]
114700834  Cir1; LOW QUALITY PROTEIN: corepressor interacting with RBPJ 1 [KO:K06066]
114690907  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
114692613  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
114699826  LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless-like [KO:K06053]
114707351  Hes1; transcription factor HES-1 [KO:K06054]
114683170  Fcer2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
114697153  Runx3; runt-related transcription factor 3 [KO:K09279]
114701991  Myc; myc proto-oncogene protein [KO:K04377]
114695529  Usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
114693314  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114706157  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114688301  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114689482  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114700921  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114699687  Ddb2; DNA damage-binding protein 2 [KO:K10140]
114694653  Polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
114702410  Traf5; TNF receptor-associated factor 5 [KO:K09849]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114702264  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X2 [KO:K04466] [EC:2.7.11.25]
114709874  Relb; transcription factor RelB isoform X1 [KO:K09253]
114696755  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
114681076  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114684706  Nfkbib; NF-kappa-B inhibitor beta [KO:K02581]
114707855  Nfkbie; NF-kappa-B inhibitor epsilon [KO:K05872]
114693118  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114686066  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114692795  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
114701254  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
114683276  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
114690458  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114681272  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
114692762  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
114706867  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
114692638  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
114699009  Cd44; CD44 antigen isoform X6 [KO:K06256]
114704367  Itgal; integrin alpha-L isoform X1 [KO:K05718]
114695207  Icam1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
114693939  Vim; vimentin [KO:K07606]
114686120  Tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
114687957  Jak3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
114682786  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
114710233  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
114689480  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
114690610  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114697015  Btk; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
114706878  Blnk; B-cell linker protein [KO:K07371]
114697457  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114681382  S-phase kinase-associated protein 2-like [KO:K03875]
114697360  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
114710338  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114701440  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114705331  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114704814  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114688249  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114707180  Ccna2; cyclin-A2 [KO:K06627]
114695883  Ccna1; cyclin-A1 [KO:K06627]
114698889  Ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114694576  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
114681779  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114698792  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
114706553  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
114697224  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
114701050  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
pleu03050  Proteasome
pleu04010  MAPK signaling pathway
pleu04020  Calcium signaling pathway
pleu04064  NF-kappa B signaling pathway
pleu04110  Cell cycle
pleu04115  p53 signaling pathway
pleu04210  Apoptosis
pleu04612  Antigen processing and presentation
pleu04620  Toll-like receptor signaling pathway
pleu04622  RIG-I-like receptor signaling pathway
pleu04630  JAK-STAT signaling pathway
pleu04662  B cell receptor signaling pathway
KO pathway
ko05169   
LinkDB

DBGET integrated database retrieval system