KEGG   PATHWAY: stru04621
Entry
stru04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Salmo trutta (river trout)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
stru04621  NOD-like receptor signaling pathway
stru04621

Organism
Salmo trutta (river trout) [GN:stru]
Gene
115165038  nucleotide-binding oligomerization domain-containing protein 1-like isoform X1 [KO:K08727]
115181738  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
115176570  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
115176947  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
115170051  receptor-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K08846] [EC:2.7.11.1]
115156667  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
115168741  NF-kappa-B essential modulator-like [KO:K07210]
115165245  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115158948  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115162780  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
115201018  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115200286  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115174991  NF-kappa-B inhibitor alpha-like [KO:K04734]
115162129  NF-kappa-B inhibitor alpha-like [KO:K04734]
115172401  NF-kappa-B inhibitor alpha-like [KO:K04734]
115196043  NF-kappa-B inhibitor alpha-like [KO:K04734]
115173310  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
115205318  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
115194158  transcription factor p65-like isoform X1 [KO:K04735]
115198165  putative transcription factor p65 homolog [KO:K04735]
115164103  interleukin-1 beta [KO:K04519]
115200532  il1b; interleukin-1 beta [KO:K04519]
115203800  interleukin-1 beta-like [KO:K04519]
115173233  interleukin-6-like [KO:K05405]
115175363  interleukin-6 [KO:K05405]
115174125  tumor necrosis factor-like [KO:K03156]
115175311  tumor necrosis factor-like [KO:K03156]
115170621  permeability factor 2-like [KO:K10030]
115162898  interleukin-8-like [KO:K10030]
115171360  permeability factor 2-like [KO:K10030]
115201607  interleukin-8-like [KO:K10030]
115201616  interleukin-8-like [KO:K10030]
115167029  nucleotide-binding oligomerization domain-containing protein 2-like isoform X1 [KO:K10165]
115174914  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
115162495  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115172787  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115194264  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
115178837  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
115147443  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
115194003  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
115174890  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
115157989  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like isoform X1 [KO:K12793]
115151555  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like [KO:K12793]
115165075  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115192138  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115170800  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115200671  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115152195  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115180302  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115180375  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115169006  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115169019  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115165421  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115165434  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115166089  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115151057  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115207356  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115197396  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115198903  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
115198904  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115192441  transcription factor AP-1-like [KO:K04448]
115169534  transcription factor AP-1-like [KO:K04448]
115158459  transcription factor AP-1-like [KO:K04448]
115157247  transcription factor AP-1-like [KO:K04448]
115149542  transcription factor AP-1-like [KO:K04448]
115160168  transcription factor AP-1-like [KO:K04448]
115162853  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
115176684  autophagy protein 5-like [KO:K08339]
115179301  autophagy protein 5-like [KO:K08339]
115188596  ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
115177056  ubiquitin-like protein ATG12 [KO:K08336]
115188365  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
115176534  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
115154929  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
115166707  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115151878  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115194182  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
115203592  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115198183  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
115168785  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115178512  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115151102  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
115151842  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
115208534  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115196926  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
115204894  microtubule-associated proteins 1A/1B light chain 3C-like isoform X1 [KO:K10435]
115169459  sugt1; protein SGT1 homolog isoform X1 [KO:K12795]
115169623  sharpin; sharpin isoform X1 [KO:K20894]
115157152  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K20894]
115195522  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K10630] [EC:2.3.2.31]
115208017  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
115150784  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
115156584  uncharacterized protein LOC115156584 isoform X1 [KO:K11974] [EC:2.3.2.31]
115157031  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
115169744  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
115195517  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
115168034  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
115205647  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
115194266  thyroid receptor-interacting protein 6-like [KO:K12792]
115198268  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
115198269  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
115198270  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
115198271  thyroid receptor-interacting protein 6-like [KO:K12792]
115159684  erbin-like isoform X1 [KO:K12796]
115203968  erbin-like isoform X1 [KO:K12796]
115153797  inhibitor of apoptosis protein-like isoform X1 [KO:K16060]
115204697  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
115159584  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115159699  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115164249  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115203961  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115204052  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115178274  TNF receptor-associated factor 5-like isoform X1 [KO:K09849]
115208506  TNF receptor-associated factor 5-like isoform X1 [KO:K09849]
115166780  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
115203637  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
115164876  caspase recruitment domain-containing protein 9-like isoform X1 [KO:K12794]
115199787  caspase recruitment domain-containing protein 9-like [KO:K12794]
115152841  tumor necrosis factor alpha-induced protein 3-like [KO:K11859] [EC:3.4.19.12]
115201493  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
115173045  calphotin-like [KO:K12648]
115162102  TNF receptor-associated factor 3-like [KO:K03174]
115172380  TNF receptor-associated factor 3-like [KO:K03174]
115189789  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
115189827  serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
115207524  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]
115156068  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
115160712  TRAF family member-associated NF-kappa-B activator-like isoform X1 [KO:K12650]
115162648  interferon regulatory factor 3-like isoform X1 [KO:K05411]
115152118  interferon regulatory factor 7-like [KO:K09447]
115197304  interferon regulatory factor 3-like [KO:K09447]
115193436  interferon alpha-6-like [KO:K05414]
115170596  interferon beta-like [KO:K05414]
115170660  interferon a3-like [KO:K05414]
115170661  interferon beta-like [KO:K05414]
115170951  interferon a3-like isoform X1 [KO:K05414]
115170955  interferon a3-like isoform X1 [KO:K05414]
115170956  interferon a3-like isoform X1 [KO:K05414]
115170959  interferon a3-like isoform X1 [KO:K05414]
115170960  interferon a3-like isoform X1 [KO:K05414]
115170963  interferon a3-like isoform X1 [KO:K05414]
115170964  interferon a3-like isoform X1 [KO:K05414]
115170966  interferon a3-like [KO:K05414]
115170969  interferon a3-like isoform X1 [KO:K05414]
115170970  interferon a3-like [KO:K05414]
115170971  interferon a3 [KO:K05414]
115196524  interferon alpha-6-like [KO:K05414]
115161438  interferon a3-like isoform X1 [KO:K05414]
115170597  interferon a3-like [KO:K05414]
115170598  interferon a3-like [KO:K05414]
115170662  interferon a3-like [KO:K05414]
115170663  interferon a3-like [KO:K05414]
115170950  interferon a3-like [KO:K05414]
115170952  interferon a3-like [KO:K05414]
115170965  interferon tau-10-like [KO:K05414]
115170967  interferon a3-like [KO:K05414]
115170974  interferon epsilon-like [KO:K05414]
115196551  interferon a3-like [KO:K05414]
115205900  NLR family member X1-like isoform X1 [KO:K12653]
115194031  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
115157651  anthrax toxin receptor 1-like [KO:K20909]
115165027  anthrax toxin receptor 2-like [KO:K20909]
115159156  anthrax toxin receptor 2-like [KO:K20909]
115159429  anthrax toxin receptor 1-like [KO:K20909]
115164534  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
115149162  anthrax toxin receptor 1-like [KO:K20909]
115149393  anthrax toxin receptor 2-like [KO:K20909]
115200604  anthrax toxin receptor 2-like [KO:K20909]
115201113  anthrax toxin receptor 1-like [KO:K20909]
115200114  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
115156654  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
115177037  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
115177544  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
115206220  caspase-1-like [KO:K01370] [EC:3.4.22.36]
115169669  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
115157106  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
115150453  apoptosis regulator Bcl-2-like [KO:K02161]
115195542  apoptosis regulator Bcl-2-like [KO:K02161]
115168617  bcl-2-like protein 1 [KO:K04570]
115165991  bcl-2-like protein 1 [KO:K04570]
115150840  bcl-2-like protein 1 [KO:K04570]
115207590  bcl-2-like protein 1 [KO:K04570]
115161960  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115190111  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115172214  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115154469  panx1; pannexin-1 isoform X1 [KO:K03443]
115206226  pannexin-1-like [KO:K03443]
115164676  P2X purinoceptor 4-like isoform X1 [KO:K05220]
115199958  P2X purinoceptor 4-like [KO:K05220]
115155382  trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
115166972  transient receptor potential cation channel subfamily M member 7-like isoform X1 [KO:K04982] [EC:2.7.11.1]
115203342  transient receptor potential cation channel subfamily M member 7-like isoform X1 [KO:K04982] [EC:2.7.11.1]
115204410  casr; extracellular calcium-sensing receptor isoform X1 [KO:K04612]
115181599  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115176810  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115176993  G-protein coupled receptor family C group 6 member A-like isoform X1 [KO:K04622]
115172162  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115172164  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115172938  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115184997  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174482  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174483  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115162398  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
115172491  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115172765  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115198619  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115199598  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
115150503  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115150859  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207563  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115207911  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
115152168  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115197365  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115168596  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
115165965  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
115154021  voltage-dependent anion-selective channel protein 1 [KO:K05862]
115148557  voltage-dependent anion-selective channel protein 1-like isoform X1 [KO:K05862]
115193589  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115153358  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115153538  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115201712  voltage-dependent anion-selective channel protein 2 [KO:K15040]
115159273  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115164352  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115149285  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115155826  calcium uniporter protein, mitochondrial-like [KO:K20858]
115201747  calcium uniporter protein, mitochondrial-like [KO:K20858]
115153906  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
115157966  mitofusin-1-like isoform X1 [KO:K21356] [EC:3.6.5.-]
115156562  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
115151529  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
115166092  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
115169632  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
115157139  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
115152032  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
115194583  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
115152369  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
115197618  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
115198725  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
115200107  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
115180000  nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
115207669  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
115197667  nicotinamide phosphoribosyltransferase-like isoform X1 [KO:K03462] [EC:2.4.2.12]
115198747  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
115179597  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
115196370  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
115167176  cytochrome b-245 light chain-like [KO:K08009]
115203156  cytochrome b-245 light chain-like [KO:K08009]
115173686  thioredoxin-interacting protein-like [KO:K20910]
115175786  thioredoxin-interacting protein-like [KO:K20910]
115176885  thioredoxin-interacting protein-like [KO:K20910]
115180026  thioredoxin-interacting protein-like isoform X1 [KO:K20910]
115189436  thioredoxin-like [KO:K03671]
115189475  thioredoxin-like [KO:K03671]
115170571  thioredoxin, mitochondrial-like [KO:K03671]
115194408  thioredoxin-like [KO:K03671]
115201431  thioredoxin, mitochondrial-like [KO:K03671]
115198411  thioredoxin-like [KO:K03671]
115192187  serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
115158780  serine/threonine-protein kinase Nek7-like [KO:K20876] [EC:2.7.11.34]
115154649  lys-63-specific deubiquitinase BRCC36-like isoform X1 [KO:K11864] [EC:3.4.19.-]
115204245  LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
115174522  heat shock protein HSP 90-alpha [KO:K04079]
115174523  heat shock protein HSP 90-alpha 1-like [KO:K04079]
115168508  heat shock protein HSP 90-alpha-like [KO:K04079]
115168577  heat shock protein HSP 90-alpha 1 [KO:K04079]
115174992  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
115196028  heat shock protein HSP 90-beta-like [KO:K04079]
115166993  proline-serine-threonine phosphatase-interacting protein 1-like isoform X1 [KO:K12804]
115152003  proline-serine-threonine phosphatase-interacting protein 1-like [KO:K12804]
115196748  proline-serine-threonine phosphatase-interacting protein 1-like [KO:K12804]
115203327  proline-serine-threonine phosphatase-interacting protein 1-like isoform X1 [KO:K12804]
115169467  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115155490  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
115160794  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115157338  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115167502  FAS-associated death domain protein-like [KO:K02373]
115202892  FAS-associated death domain protein-like [KO:K02373]
115150559  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115150786  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
115207643  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115207853  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115166925  TP53-binding protein 1-like isoform X1 [KO:K20915]
115203380  TP53-binding protein 1-like isoform X1 [KO:K20915]
115168240  rho-related GTP-binding protein RhoA-C [KO:K04513]
115168296  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
115165260  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
115165905  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
115166252  rho-related GTP-binding protein RhoA-B [KO:K04513]
115150994  rho-related GTP-binding protein RhoA-D [KO:K04513]
115150254  transforming protein RhoA-like [KO:K04513]
115208179  transforming protein RhoA-like [KO:K04513]
115170534  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
115178288  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
115201351  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
115208729  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
115170007  serine/threonine-protein kinase N2-like [KO:K23691] [EC:2.7.11.13]
115158859  serine/threonine-protein kinase N2-like isoform X1 [KO:K23691] [EC:2.7.11.13]
115156695  serine/threonine-protein kinase N2-like isoform X1 [KO:K23691] [EC:2.7.11.13]
115154109  14-3-3 protein epsilon isoform X1 [KO:K06630]
115163101  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115148621  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115206047  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115174634  guanylate-binding protein 1-like [KO:K20899]
115155453  guanylate-binding protein 1-like isoform X1 [KO:K20899]
115155454  guanylate-binding protein 1-like [KO:K20899]
115155455  guanylate-binding protein 1-like [KO:K20899]
115155690  guanylate-binding protein 1-like isoform X1 [KO:K20899]
115155691  guanylate-binding protein 1-like [KO:K20899]
115155695  guanylate-binding protein 1-like isoform X1 [KO:K20899]
115155696  guanylate-binding protein 1-like [KO:K20899]
115155697  guanylate-binding protein 1-like [KO:K20899]
115155699  guanylate-binding protein 1-like isoform X1 [KO:K20899]
115155702  guanylate-binding protein 1-like [KO:K20899]
115161377  interleukin-10 receptor subunit beta-like [KO:K05131]
115192234  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
115170097  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
115158720  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
115156625  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
115171238  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
115199167  non-receptor tyrosine-protein kinase TYK2-like isoform X1 [KO:K11219] [EC:2.7.10.2]
115156118  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
115160666  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
115195984  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
115207827  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221]
115150804  interferon regulatory factor 8-like [KO:K04693]
115195519  interferon regulatory factor 4-like isoform X1 [KO:K04693]
115192721  TIR domain-containing adapter molecule 1-like [KO:K05842]
115195308  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
115196945  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
115169157  stimulator of interferon genes protein-like [KO:K12654]
115205559  stimulator of interferon genes protein-like [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
stru04010  MAPK signaling pathway
stru04140  Autophagy - animal
stru04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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